Shaozhen Xie, Ph.D.

2007 University of Rochester, Rochester, NY 
Molecular Biology
"Shaozhen Xie"
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Chawnshang Chang grad student 2007 Rochester
 (Role of testicular orphan receptor TR4 in atherosclerosis and regulation of TR4 activity by acetylation.)
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Liu Z, Wang Y, Kabraji S, et al. (2019) Improving orthotopic mouse models of patient-derived breast cancer brain metastases by a modified intracarotid injection method. Scientific Reports. 9: 622
Kabraji S, Ni J, Lin N, et al. (2018) Drug resistance in HER2-positive breast cancer brain metastases: blame the barrier or the brain? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research
Cizmecioglu O, Ni J, Xie S, et al. (2016) Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss. Elife. 5
Ni J, Xie S, Ramkissoon SH, et al. (2016) Tyrosine receptor kinase B is a drug target in astrocytomas. Neuro-Oncology
Fan W, Xie S, Zhao X, et al. (2016) IFN-λ4 desensitizes the response to IFN-α treatment in chronic hepatitis C through long-term induction of USP18. The Journal of General Virology
Ni J, Ramkissoon SH, Xie S, et al. (2016) Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases. Nature Medicine
Luo W, Chen Y, Wang T, et al. (2015) Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities. Bioorganic & Medicinal Chemistry
Gao T, Gao Y, Chang C, et al. (2012) Atomic-scale morphology and electronic structure of manganese atomic layers underneath epitaxial graphene on SiC(0001). Acs Nano. 6: 6562-8
Ni J, Liu Q, Xie S, et al. (2012) Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent. Cancer Discovery. 2: 425-33
Xie S, Ni J, Lee YF, et al. (2011) Increased acetylation in the DNA-binding domain of TR4 nuclear receptor by the coregulator ARA55 leads to suppression of TR4 transactivation. The Journal of Biological Chemistry. 286: 21129-36
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