Nicolas Lindegger, PhD

Affiliations: 
Novartis, Basel, Basel-Stadt, France 
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"Nicolas Lindegger"
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Publications

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Lindegger N, Sidharta PN, Reseski K, et al. (2014) Macitentan, a dual endothelin receptor antagonist for the treatment of pulmonary arterial hypertension, does not affect cardiac repolarization in healthy subjects. Pulmonary Pharmacology & Therapeutics. 29: 41-8
Sidharta PN, Lindegger N, Ul? I, et al. (2014) Pharmacokinetics of the novel dual endothelin receptor antagonist macitentan in subjects with hepatic or renal impairment. Journal of Clinical Pharmacology. 54: 291-300
Shan J, Kushnir A, Betzenhauser MJ, et al. (2010) Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice. The Journal of Clinical Investigation. 120: 4388-98
Lindegger N, Hagen BM, Marks AR, et al. (2009) Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine. Journal of Molecular and Cellular Cardiology. 47: 326-34
Lindegger N, Mongillo M. (2008) Look beyond the hERG mutation: a neutral SCN5A variant may turn lidocaine into a threat. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 5: 1575-6
Kass RS, Lindegger N, Hagen B, et al. (2008) Another calcium paradox in heart failure. Journal of Molecular and Cellular Cardiology. 45: 28-31
Lehnart SE, Mongillo M, Bellinger A, et al. (2008) Leaky Ca2+ release channel/ryanodine receptor 2 causes seizures and sudden cardiac death in mice. The Journal of Clinical Investigation. 118: 2230-45
Lindegger N, Kass RS. (2008) K+ channelopathies (I Ks and i Kr) Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. 194-206
Fredj S, Lindegger N, Sampson KJ, et al. (2006) Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes. Circulation Research. 99: 1225-32
Momotake A, Lindegger N, Niggli E, et al. (2006) The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells. Nature Methods. 3: 35-40
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