Clinton E. Canal

Affiliations: 
University of Illinois, Urbana, IL, United States 
Area:
Amygdala, Memory Modulation, Norepinephrine, Dopamine, Serotonin
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"Clinton Canal"
Mean distance: 16.42 (cluster 19)
 
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Paul E. Gold grad student 2000-2006 UIUC
 (Protein synthesis inhibitors impair memory by disrupting release of neurotransmitters important for memory modulation.)
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Publications

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Canal CE, Felsing DE, Liu Y, et al. (2015) An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist That Corrects Motor Stereotypy in Mouse Models. Acs Chemical Neuroscience
Sakhuja R, Kondabolu K, Córdova-Sintjago T, et al. (2015) Novel 4-substituted-N,N-dimethyltetrahydronaphthalen-2-amines: synthesis, affinity, and in silico docking studies at serotonin 5-HT2-type and histamine H1 G protein-coupled receptors. Bioorganic & Medicinal Chemistry. 23: 1588-600
Canal CE, Morgan D, Felsing D, et al. (2014) A novel aminotetralin-type serotonin (5-HT) 2C receptor-specific agonist and 5-HT2A competitive antagonist/5-HT2B inverse agonist with preclinical efficacy for psychoses. The Journal of Pharmacology and Experimental Therapeutics. 349: 310-8
Canal CE, Cordova-Sintjago T, Liu Y, et al. (2013) Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligands. The Journal of Pharmacology and Experimental Therapeutics. 347: 705-16
Canal CE, Booth RG, Morgan D. (2013) Support for 5-HT2C receptor functional selectivity in vivo utilizing structurally diverse, selective 5-HT2C receptor ligands and the 2,5-dimethoxy-4-iodoamphetamine elicited head-twitch response model. Neuropharmacology. 70: 112-21
Córdova-Sintjago T, Sakhuja R, Kondabolu K, et al. (2012) Molecular Determinants for Ligand Binding at Serotonin 5-HT2A and 5-HT2C GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies. International Journal of Quantum Chemistry. 112: 3807-3814
Canal CE, Morgan D. (2012) Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model. Drug Testing and Analysis. 4: 556-76
Córdova-Sintjago T, Villa N, Canal C, et al. (2012) Human serotonin 5-HT2C G protein-coupled receptor homology model from the β2 adrenoceptor structure: Ligand docking and mutagenesis studies International Journal of Quantum Chemistry. 112: 140-149
Canal CE, Cordova-Sintjago TC, Villa NY, et al. (2011) Drug discovery targeting human 5-HT(2C) receptors: residues S3.36 and Y7.43 impact ligand-binding pocket structure via hydrogen bond formation. European Journal of Pharmacology. 673: 1-12
Sadowski RN, Canal CE, Gold PE. (2011) Lidocaine attenuates anisomycin-induced amnesia and release of norepinephrine in the amygdala. Neurobiology of Learning and Memory. 96: 136-42
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