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Frederick W. Alt, PhD

Affiliations: 
Genetics Harvard University, Cambridge, MA, United States 
Area:
DNA repair, immunology, lymphoma
Website:
https://www.hms.harvard.edu/dms/bbs/fac/Alt.php
Google:
"Frederick W. Alt"
Bio:

https://genetics.hms.harvard.edu/faculty-staff/frederick-w-alt
https://www.hhmi.org/scientists/frederick-w-alt
http://searchworks.stanford.edu/view/761131

Mean distance: 14.7 (cluster 31)
 		SNBCP
Cross-listing: Chemistry Tree - Cell Biology Tree

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Parents

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Robert T. Schimke grad student 1977 Stanford
 (The molecular mechanism of dihydrofolate reductase overproduction in methotrexate-resistant variants of culture murine cells)
David Baltimore post-doc 1982 MIT (Chemistry Tree)

Children

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George Yancopoulos grad student Columbia University Medical School
Yang Xu grad student 1994 Harvard (Stem Cell Tree)
Darryll D. Dudley grad student 2003 Harvard
Sean E. Rooney grad student 2003 Harvard
David H. Jung grad student 2006 Harvard
Cristian Boboila grad student 2005-2011 Harvard
Tingting Zhang-Kharas grad student 2005-2011 Harvard (Chemistry Tree)
Suprawee Tepsuporn grad student 2013 Harvard
Uttiya Basu post-doc Harvard
Jayanta Chaudhuri post-doc (MathTree)
Huan Chen post-doc Harvard (Cell Biology Tree)
Bjoern Schwer post-doc
Adam Yongxin Ye post-doc 2018- Harvard Medical School (GenetiTree)
Ronald A. DePinho post-doc 1984-1988 Columbia
Angela K. Eggleston post-doc 1999-1999 Harvard Medical School - Boston Children's Hospital (Chemistry Tree)
Shan Zha post-doc 2004-2009 Harvard - Boston Children's Hospital (Chemistry Tree)
Richard L Frock post-doc 2010-2017 Harvard Medical School - Boston Children's Hospital (Cell Biology Tree)

Collaborators

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Publications

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Liang Z, Zhao L, Ye AY, et al. (2023) Contribution of the IGCR1 regulatory element and the 3' CTCF-binding elements to regulation of V(D)J recombination. Proceedings of the National Academy of Sciences of the United States of America. 120: e2306564120
Liang Z, Zhao L, Yongxin Ye A, et al. (2023) Contribution of the IGCR1 regulatory element and the 3 CBEs to Regulation of V(D)J Recombination. Biorxiv : the Preprint Server For Biology
Luo S, Jing C, Ye AY, et al. (2022) Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors. Proceedings of the National Academy of Sciences of the United States of America. 120: e2217883120
Luo S, Zhang J, Kreutzberger AJB, et al. (2022) An Antibody from Single Human V-rearranging Mouse Neutralizes All SARS-CoV-2 Variants Through BA.5 by Inhibiting Membrane Fusion. Science Immunology. eadd5446
Vincendeau E, Wei W, Zhang X, et al. (2022) SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination. Nature Communications. 13: 3707
Zhang Y, Zhang X, Dai HQ, et al. (2022) The role of chromatin loop extrusion in antibody diversification. Nature Reviews. Immunology
Wang Y, Wang M, Djekidel MN, et al. (2021) eccDNAs are apoptotic products with high innate immunostimulatory activity. Nature. 599: 308-314
Cheng YC, Snavely A, Barrett LB, et al. (2021) Topoisomerase I inhibition and peripheral nerve injury induce DNA breaks and ATF3-associated axon regeneration in sensory neurons. Cell Reports. 36: 109666
Liang Z, Kumar V, Le Bouteiller M, et al. (2021) Ku70 suppresses alternative end joining in G1-arrested progenitor B cells. Proceedings of the National Academy of Sciences of the United States of America. 118
Dai HQ, Hu H, Lou J, et al. (2021) Loop extrusion mediates physiological Igh locus contraction for RAG scanning. Nature
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