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Takashi Daniel Yoshida Kozai, PhD

Bioengineering University of Pittsburgh, Pittsburgh, PA, United States 
Neural Engineering
"Takashi Kozai"

I believe that it is possible to seamlessly integrate machine and the human body by understanding biology at the cellular and molecular level. My diverse education and research background provide a unique combination of knowledge for engineering new devices that interface with the human body, particularly for neural interfaces. My B.S. in Biochemistry and Molecular Cellular Developmental Biology provide me with the fundamental building blocks that enable intelligent bio-design. For example, I worked on the development of a single electron transistor through understanding molecular structure, bio-templating, and bio-mimicry. This foundation was the basis of my graduate study in improving implantable neural interfaces. I developed strategies to insert soft polymer probes into the brain using organic functional group surface modifications to appropriately change surface tension. Additionally, I engineered a novel implantable neural probe with sub-cellular features, improved flexibility, bio-mimitic surface modifications, and an improved recording site material. Further, I investigated strategies to reduce insertion damage through examining the blood brain barrier using advanced in vivo multiphoton technology to select preferred insertion positions. By using these strategies, we can tease apart and evaluate the individual contributions of variables that affect chronic electrode functionality so that we can develop better next generation devices. Finally, my experience with Fontis also demonstrates that my foundation and background is not only limited to neural engineering, but its principles can easily be applied to other devices that interface with the human body. My diverse background and unique depth in molecular biochemistry and engineering provides a powerful marriage to generate a unique program to develop research tools and medical devices with more intimate biological interfaces.
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Mean distance: 15.73 (cluster 51)


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Michael H. B. Stowell research assistant 2002-2005 University of Pittsburgh
Daryl Kipke grad student 2005-2011 University of Michigan
 (Towards bio-integrating interfaces in organic neurotechnology development.)
Xinyan Tracy Cui post-doc 2011-2013 University of Pittsburgh
Seong-Gi Kim post-doc 2011-2013 University of Pittsburgh
Alberto  L. Vazquez post-doc 2011-2013 University of Pittsburgh
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Stieger KC, Eles JR, Ludwig KA, et al. (2020) In vivo microstimulation with cathodic and anodic asymmetric waveforms modulates spatiotemporal calcium dynamics in cortical neuropil and pyramidal neurons of male mice. Journal of Neuroscience Research
Yang Q, Wu B, Eles JR, et al. (2020) Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo. Advanced Biosystems. e1900287
Wellman SM, Guzman K, Stieger KC, et al. (2020) Cuprizone-induced oligodendrocyte loss and demyelination impairs recording performance of chronically implanted neural interfaces. Biomaterials. 239: 119842
Eles JR, Kozai TDY. (2020) In vivo imaging of calcium and glutamate responses to intracortical microstimulation reveals distinct temporal responses of the neuropil and somatic compartments in layer II/III neurons. Biomaterials. 234: 119767
Ereifej ES, Shell C, Schofield JS, et al. (2019) Neural engineering: the process, applications, and its role in the future of medicine. Journal of Neural Engineering
Kozai TDY, Purcell EK. (2019) Pipette-integrated microelectrodes. Nature Biomedical Engineering. 3: 682-683
Wellman SM, Li L, Yaxiaer Y, et al. (2019) Revealing Spatial and Temporal Patterns of Cell Death, Glial Proliferation, and Blood-Brain Barrier Dysfunction Around Implanted Intracortical Neural Interfaces. Frontiers in Neuroscience. 13: 493
Eles JR, Vazquez AL, Kozai TDY, et al. (2019) Meningeal inflammatory response and fibrous tissue remodeling around intracortical implants: An in vivo two-photon imaging study. Biomaterials. 195: 111-123
Stocking KC, Vazquez AL, Kozai T. (2019) Intracortical neural stimulation with untethered, ultrasmall carbon fiber electrodes mediated by the photoelectric effect. Ieee Transactions On Bio-Medical Engineering
Salatino JW, Ludwig KA, Kozai TDY, et al. (2018) Publisher Correction: Glial responses to implanted electrodes in the brain. Nature Biomedical Engineering. 2: 52
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