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Alessandro Fraldi

Affiliations: 
Telethon Institute of Genetics and Medicine, Italy 
Area:
Lysosomal storage disease, autophagy, lysosome, gene therapy, molecular therapy
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"Alessandro Fraldi"
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Fraldi A, Annunziata F, Lombardi A, et al. (2022) Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders. The Embo Journal. e112402
Monaco A, Fraldi A. (2021) Protein aggregation and autophagy dysfunction: new lessons from mucopolysaccharidoses. Autophagy. 1-2
De Risi M, Tufano M, Alvino FG, et al. (2021) Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders. Nature Communications. 12: 3495
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, et al. (2021) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382
Monaco A, Fraldi A. (2020) Protein Aggregation and Dysfunction of Autophagy-Lysosomal Pathway: A Vicious Cycle in Lysosomal Storage Diseases. Frontiers in Molecular Neuroscience. 13: 37
Intartaglia D, Giamundo G, Marrocco E, et al. (2020) Retinal Degeneration in MPS-IIIA Mouse Model. Frontiers in Cell and Developmental Biology. 8: 132
Monaco A, Maffia V, Sorrentino NC, et al. (2020) The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease. Molecular Therapy : the Journal of the American Society of Gene Therapy
Sorrentino NC, Cacace V, De Risi M, et al. (2019) Enhancing the Therapeutic Potential of Sulfamidase for the Treatment of Mucopolysaccharidosis IIIA. Molecular Therapy. Methods & Clinical Development. 15: 333-342
Fraldi A, Serafini M, Sorrentino NC, et al. (2018) Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches. Italian Journal of Pediatrics. 44: 130
Zito E, Fraldi A, Pepe S, et al. (2016) Sulfatase activities are regulated by the interaction of the sulfatase-modifying factor 1 with SUMF2. Embo Reports. 17: 1901
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