Bruce T. Lamb

Affiliations: 
1985-1991 Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
 1991-1994 Cellular/Molecular Biology Johns Hopkins University, Baltimore, MD 
 1996-2005 Genetics Case Western Reserve University, Cleveland Heights, OH, United States 
 2005-2016 Neurosciences The Cleveland Clinic, Cleveland, OH, United States 
 2016- Stark Neurosciences Research Institute Indiana University School of Medicine, Indianapolis, IN, United States 
Area:
Alzheimer's disease, traumatic brain injury, neurodegeneration, animal models, drug discovery
Website:
https://medicine.iu.edu/faculty/23627/lamb-bruce/
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"Bruce Lamb"
Bio:

Dr. Lamb received his bachelor’s degree from Swarthmore College and his PhD from the University of Pennsylvania prior to a post-doctoral fellowship at Johns Hopkins University. In 1996, Dr. Lamb was recruited to Case Western Reserve University, where he rose from Assistant to Associate Professor. He joined the Cleveland Clinic in 2005 and rose to full Professor in 2011. In 2016, Dr. Lamb joined the Indiana University School of Medicine as Director of the Stark Neurosciences Research Institute. Dr. Lamb’s laboratory works on the basic and translational science of Alzheimer’s disease, with a focus on; animal models of Alzheimer’s disease (including Director of the IU/Jax/Pitt NIH-Funded Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease program, MODEL-AD), discovery of new therapeutic targets (including Co-Director of the NIH-Funded IUSM/Purdue Alzheimer's Disease Drug Discovery Center), the role immune pathways in the development and progression of Alzheimer's disease and the the role of traumatic brain injury as an environmental modifier for the development of Alzheimer’s pathologies. In addition, Dr. Lamb is actively involved in advocacy for increased research funding for the disease. Dr. Lamb has received multiple honors including the National Civic Award and the Zaven Khachaturian Lifetime Achievement Award from the Alzheimer’s Association and was elected as a Fellow of the American Association for the Advancement of Science.
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Vitek MP, Araujo JA, Fossel M, et al. (2020) Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank. Alzheimer's & Dementia (New York, N. Y.). 6: e12114
Oblak AL, Forner S, Territo PR, et al. (2020) Model organism development and evaluation for late-onset Alzheimer's disease: MODEL-AD. Alzheimer's & Dementia (New York, N. Y.). 6: e12110
Preuss C, Pandey R, Piazza E, et al. (2020) A novel systems biology approach to evaluate mouse models of late-onset Alzheimer's disease. Molecular Neurodegeneration. 15: 67
Jadhav VS, Lin PBC, Pennington T, et al. (2020) Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice. Molecular Neurodegeneration. 15: 62
Pillai JA, Maxwell S, Bena J, et al. (2019) Key inflammatory pathway activations in the MCI stage of Alzheimer's disease. Annals of Clinical and Translational Neurology. 6: 1248-1262
Jay TR, von Saucken VE, Muñoz B, et al. (2019) TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment. Glia
Gunner G, Cheadle L, Johnson KM, et al. (2019) Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling. Nature Neuroscience
Mlodzianoski M, Cheng-Hathaway P, Liu S, et al. (2019) Active PSF Shaping and Adaptive Optics Enable Volumetric Single Molecule Super-Resolution Microscopy through Brain Sections Biophysical Journal. 116: 283a-284a
Snyder HM, Carare RO, DeKosky ST, et al. (2018) Military-related risk factors for dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Kinney JW, Bemiller SM, Murtishaw AS, et al. (2018) Inflammation as a central mechanism in Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 4: 575-590
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