Hilal A. Lashuel, Ph. D.

Affiliations: 
Molecular and Chemical Biology École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 
Area:
Neurodegeneration
Website:
http://lashuel-lab.epfl.ch/page-18616-en.html
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"Hilal Lashuel"
Mean distance: 8.73
 
SNBCP

Parents

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Jeffery W. Kelly grad student 1994-1999 Texas A & M
 (Biophysical studies on the acid denaturation of transthyretin: Understanding the mechanism of fibril formation in human amyloid disease.)
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Publications

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Balana AT, Mahul-Mellier AL, Nguyen BA, et al. (2024) O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature Chemical Biology
Yang L, Jasiqi Y, Lashuel H. (2023) Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro. Acs Chemical Neuroscience. 15: 193-204
Yang L, Jasiqi Y, Zettor A, et al. (2023) Effective Inhibition of TDP-43 Aggregation by Native State Stabilization. Angewandte Chemie (International Ed. in English). 63: e202314587
Limorenko G, Tatli M, Kolla R, et al. (2023) Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates. Nature Communications. 14: 3939
Kumar ST, Nazarov S, Porta S, et al. (2023) Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage. Nature Neuroscience
Balana AT, Mahul-Mellier AL, Nguyen BA, et al. (2023) O-GlcNAc modification forces the formation of an α-Synuclein amyloid-strain with notably diminished seeding activity and pathology. Biorxiv : the Preprint Server For Biology
Altay MF, Liu AKL, Holton JL, et al. (2022) Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders. Acta Neuropathologica Communications. 10: 163
Lashuel HA, Mahul-Mellier AL, Novello S, et al. (2022) Revisiting the specificity and ability of phospho-S129 antibodies to capture alpha-synuclein biochemical and pathological diversity. Npj Parkinson's Disease. 8: 136
Teixidor J, Novello S, Ortiz D, et al. (2022) On-Demand Nanoliter Sampling Probe for the Collection of Brain Fluid. Analytical Chemistry
Nazarov S, Chiki A, Boudeffa D, et al. (2022) Structural Basis of Huntingtin Fibril Polymorphism Revealed by Cryogenic Electron Microscopy of Exon 1 HTT Fibrils. Journal of the American Chemical Society. 144: 10723-10735
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