Charles Shyng, PhD

Affiliations: 
2010-2016 DBBS Washington University, Saint Louis, St. Louis, MO 
 2016- Gene Therapy Center University of North Carolina, Chapel Hill, Chapel Hill, NC 
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"Charles Shyng"
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Parents

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Mark S. Sands grad student 2010-2016 Washington University
Steven J. Gray post-doc 2016-2018 UNC Chapel Hill
Benjamin D. Philpot post-doc 2017-2018 UNC Chapel Hill
 (Co-mentor)
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Publications

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Judson MC, Shyng C, Simon JM, et al. (2021) Dual-isoform hUBE3A gene transfer improves behavioral and seizure outcomes in Angelman syndrome model mice. Jci Insight. 6
Lykken EA, Shyng C, Edwards RJ, et al. (2018) Recent progress and considerations for AAV gene therapies targeting the central nervous system. Journal of Neurodevelopmental Disorders. 10: 16
Nelvagal HR, Shyng C, Sands MS, et al. (2018) Early gait abnormalities relate to brainstem and spinal cord pathology in CLN1 disease Molecular Genetics and Metabolism. 123: S104
Shyng C, Nelvagal HR, Dearborn JT, et al. (2017) Synergistic effects of treating the spinal cord and brain in CLN1 disease. Proceedings of the National Academy of Sciences of the United States of America
Shyng C, Macauley SL, Dearborn JT, et al. (2017) Widespread Expression of a Membrane-Tethered Version of the Soluble Lysosomal Enzyme Palmitoyl Protein Thioesterase-1. Jimd Reports
Shyng C, Nelvagal HR, Dearborn JT, et al. (2016) 27. Therapeutic Efficacy of Intracranial and Intrathecal AAV2/9-PPT1 in Infantile Batten Disease Molecular Therapy. 24: S12-S13
Dearborn JT, Ramachandran S, Shyng C, et al. (2015) Histochemical localization of palmitoyl protein thioesterase-1 activity. Molecular Genetics and Metabolism
Macauley SL, Wong AM, Shyng C, et al. (2014) An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13077-82
Shyng C, Sands MS. (2014) Astrocytosis in infantile neuronal ceroid lipofuscinosis: friend or foe? Biochemical Society Transactions. 42: 1282-5
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