Sascha R.A. Alles, Ph.D.

Affiliations: 
2019- Department of Anesthesiology and Critical Care Medicine University of New Mexico School of Medicine 
Area:
Chronic pain, nociception, ion channels
Website:
alleslab.com
Google:
"Sascha Alles"
Bio:

Dr. Alles completed his undergraduate degree in Biochemistry at Imperial College London and his PhD in Neuroscience at the University of Alberta with Prof Peter Smith, studying mechanisms of the gabapentinoid drugs for neuropathic pain. He then went on to complete Postdoctoral Fellowships at the University of British Columbia with Professor Terry Snutch and at University College London with Professor John Wood. His work focusses on understanding chronic pain mechanisms and ion channel biology and has facilitated unique insights into novel therapeutics for treating pain, such as those impacting the ion channel NaV1.7.

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Parents

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Peter A. Smith grad student 2011-2016 University of Alberta
Terry P. Snutch post-doc 2016-2017 UBC
John N. Wood post-doc 2017-2019 University College London

Collaborators

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Karin Westlund High collaborator 2019- University of New Mexico School of Medicine
Michael Blake Hoppa collaborator 2020- Dartmouth
Rajesh Khanna collaborator 2020- University of Arizona
Aubin Moutal collaborator 2020- University of Arizona
Ian Winship collaborator 2014-2016 University of Alberta
Glen Baker collaborator 2015-2017 University of Alberta
Brian A. Macvicar collaborator 2016-2017 UBC
Marco Beato collaborator 2018-2019 UCL
BETA: Related publications

Publications

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MacDonald DI, Sikandar S, Weiss J, et al. (2021) A central mechanism of analgesia in mice and humans lacking the sodium channel NaV1.7 Neuron. 109: 1497-1512
Alles SRA, Odem MA, Lu VB, et al. (2021) Chronic BDNF simultaneously inhibits and unmasks superficial dorsal horn neuronal activity. Scientific Reports. 11: 2249
Ehsanian R, Koshkin E, Goins AE, et al. (2021) Pre- and Post-Interventional Changes in Physiological Profiles in a Patient Presenting With Opioid Withdrawal After Intrathecal Drug Delivery System Failure Related to Assumed Catheter Microfracture Cureus. 13: e14835
Montera M, Goins A, Cmarko L, et al. (2020) Trigeminal neuropathic pain is alleviated by inhibition of Ca3.3 T-type calcium channels in mice. Channels (Austin, Tex.)
Alles SRA, Gomez K, Moutal A, et al. (2020) Putative roles of SLC7A5 (LAT1) transporter in pain. Neurobiology of Pain (Cambridge, Mass.). 8: 100050
Alles SRA, Cain SM, Snutch TP. (2020) Pregabalin as a Pain Therapeutic: Beyond Calcium Channels. Frontiers in Cellular Neuroscience. 14: 83
Alles SRA, Nascimento F, Luján R, et al. (2020) Sensory neuron-derived Na1.7 contributes to dorsal horn neuron excitability. Science Advances. 6: eaax4568
Kunamneni A, Montera M, Suri N, et al. (2020) Therapeutic anti‐P2X4 receptor scFv antibody for chronic neuropathic pain The Faseb Journal. 34: 1-1
Alles SRA, Smith PA. (2018) Comparison of ex vivo and in vitro actions of gabapentin in superficial dorsal horn and the role of extra-spinal sites of drug action. Neuroscience Letters. 694: 148-153
Bangash MA, Alles SRA, Santana-Varela S, et al. (2018) Distinct transcriptional responses of mouse sensory neurons in models of human chronic pain conditions. Wellcome Open Research. 3: 78
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