Dilshan S. Harischandra

University of Pennsylvania, Philadelphia, PA, United States 
Neurodegenerative disease, Protein aggregation, metal neurotoxicity
"Dilshan Harischandra"
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Nikhil Panicker collaborator
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Ghaisas S, Harischandra DS, Palanisamy B, et al. (2021) Chronic Manganese Exposure and the Enteric Nervous System: An and Mouse Study. Environmental Health Perspectives. 129: 87005
Zhu G, Harischandra DS, Ghaisas S, et al. (2020) TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease. Cell Reports. 33: 108418
Sarkar S, Nguyen HM, Malovic E, et al. (2020) Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. The Journal of Clinical Investigation
Harischandra DS, Rokad D, Ghaisas S, et al. (2019) Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson's disease. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165533
Harischandra DS, Ghaisas S, Zenitsky G, et al. (2019) Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation. Frontiers in Neuroscience. 13: 654
Panicker N, Sarkar S, Harischandra DS, et al. (2019) Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. The Journal of Experimental Medicine
Harischandra DS, Rokad D, Neal ML, et al. (2019) Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein. Science Signaling. 12
Sarkar S, Rokad D, Malovic E, et al. (2019) Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells. Science Signaling. 12
Neal M, Luo J, Harischandra DS, et al. (2018) Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes. Glia
Sarkar S, Malovic E, Harischandra DS, et al. (2017) Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes. Neurotoxicology
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