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Gucan Dai, Ph.D.

Affiliations: 
Biochemistry and Molecular Biology Saint Louis University School of Medicine, St. Louis, MO, United States 
Area:
ion channel biophysics
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"Gucan Dai"
Bio:

Assistant Professor, Saint Louis University School of Medicine
Postdoc Fellow, University of Washington School of Medicine
Ph.D. in Neuroscience 2014 Washington State University

Mean distance: 14.31 (cluster 11)
 		SNBCP
Cross-listing: Chemistry Tree

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Parents

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Michael  D. Varnum grad student WSU
 (Structural mechanisms for the phosphoinositide regulation of cone photoreceptor CNG channels.)
Bertil Hille post-doc University of Washington
 (Mechanism of ion channel regulation and signaling)
William N. Zagotta post-doc University of Washington
 (Gating mechanism of voltage-gated KCNH channels and HCN channels)

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Publications

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Chan AN, Handlin LJ, Lessie EN, et al. (2025) Voltage Sensor Conformations Induced by LQTS-associated Mutations in hERG Potassium Channels. Biorxiv : the Preprint Server For Biology
Handlin LJ, Macchi NL, Dumaire NLA, et al. (2024) Membrane lipid nanodomains modulate HCN pacemaker channels in nociceptor DRG neurons. Nature Communications. 15: 9898
Handlin LJ, Dai G. (2023) Direct regulation of the voltage sensor of HCN channels by membrane lipid compartmentalization. Nature Communications. 14: 6595
Dai G. (2023) Signaling by Ion Channels: Pathways, Dynamics and Channelopathies. Missouri Medicine. 120: 367-373
Jensen JB, Falkenburger BH, Dickson EJ, et al. (2022) Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells. The Journal of General Physiology. 154
Dai G. (2022) Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1. The Journal of General Physiology. 154
Dai G. (2022) Symmetry breaking in photoreceptor cyclic nucleotide-gated channels. Nature Structural & Molecular Biology
Dai G, Aman TK, DiMaio F, et al. (2021) Electromechanical coupling mechanism for activation and inactivation of an HCN channel. Nature Communications. 12: 2802
Dai G, Zagotta WN. (2020) Structural Determinants of the Hyperpolarization-Dependent Gating of HCN Channels Biophysical Journal. 118: 331a-332a
Dai G, Aman TK, Dimaio F, et al. (2019) The HCN channel voltage sensor undergoes a large downward motion during hyperpolarization. Nat Struct Mol Biol.
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