Gucan Dai, Ph.D.

Physiology and Biophysics University of Washington, Seattle, Seattle, WA 
ion channel biophysics
"Gucan Dai"

B.S. 2008 Nanjing University, China
Ph.D. 2014 Washington State University

Mean distance: 14.31 (cluster 11)
Cross-listing: Chemistry Tree


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Michael  D. Varnum grad student 2008-2014 WSU
 (Structural mechanisms for the phosphoinositide regulation of cone photoreceptor CNG channels.)
Bertil Hille post-doc 2014- University of Washington
 (Mechanism of ion channel regulation and signaling)
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Dai G, Aman TK, Dimaio F, et al. (2019) The HCN channel voltage sensor undergoes a large downward motion during hyperpolarization. Nat Struct Mol Biol.
Dai G, James ZM, Zagotta WN. (2018) Dynamic rearrangement of the intrinsic ligand regulates KCNH potassium channels. The Journal of General Physiology
Dai G, Zagotta WN. (2017) Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels. Elife
Traynor-Kaplan A, Kruse M, Dickson EJ, et al. (2017) Fatty-acyl chain profiles of cellular phosphoinositides. Biochimica Et Biophysica Acta
Dai G, Yu H, Kruse M, et al. (2016) Osmoregulatory inositol transporter SMIT1 modulates electrical activity by adjusting PI(4,5)P2 levels. Proceedings of the National Academy of Sciences of the United States of America
Dai G, Sherpa T, Varnum MD. (2014) Alternative splicing governs cone cyclic nucleotide-gated (CNG) channel sensitivity to regulation by phosphoinositides. The Journal of Biological Chemistry. 289: 13680-90
Dai G, Varnum MD. (2013) CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactions. American Journal of Physiology. Cell Physiology. 305: C147-59
Dai G, Peng C, Liu C, et al. (2013) Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides. The Journal of General Physiology. 141: 413-30
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