Tsuyoshi Hirota, PhD

Biology University of California, San Diego, La Jolla, CA 
Circadian Rhythms
"Tsuyoshi Hirota"
Mean distance: 19 (cluster 11)
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Miller S, Aikawa Y, Sugiyama A, et al. (2020) An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chemical Biology
Miller S, Son YL, Aikawa Y, et al. (2020) Isoform-selective regulation of mammalian cryptochromes. Nature Chemical Biology
Mosser EA, Chiu CN, Tamai TK, et al. (2019) Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen. Scientific Reports. 9: 12405
Uehara TN, Mizutani Y, Kuwata K, et al. (2019) Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock. Proceedings of the National Academy of Sciences of the United States of America
Oshima T, Niwa Y, Kuwata K, et al. (2019) Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Science Advances. 5: eaau9060
Lee JW, Hirota T, Ono D, et al. (2019) Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. Journal of Medicinal Chemistry
Qu M, Duffy T, Hirota T, et al. (2018) Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks. Proceedings of the National Academy of Sciences of the United States of America
Zhao X, Hirota T, Han X, et al. (2016) Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. Cell. 165: 1644-57
Lee JW, Hirota T, Kumar A, et al. (2015) Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. Chemmedchem. 10: 1489-97
Oshima T, Yamanaka I, Kumar A, et al. (2015) C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock. Angewandte Chemie (International Ed. in English). 54: 7193-7
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