Laurent Lecanu

Affiliations: 
McGill University Health Centre 
Area:
Azheimer, drug development, stem cells
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"Laurent Lecanu"
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Publications

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Lecanu L, Papadopoulos V. (2013) Modeling Alzheimer's disease with non-transgenic rat models. Alzheimer's Research & Therapy. 5: 17
Akula N, Midzak A, Lecanu L, et al. (2012) Identification of small-molecule inhibitors of the steroidogenic acute regulatory protein (STARD1) by structure-based design. Bioorganic & Medicinal Chemistry Letters. 22: 4139-43
Lecanu L, Hashim AI, McCourty A, et al. (2012) A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo. Steroids. 77: 224-32
Papadopoulos V, Lecanu L. (2012) Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties. Journal of Neuroendocrinology. 24: 93-101
Rammouz G, Lecanu L, Papadopoulos V. (2011) Oxidative Stress-Mediated Brain Dehydroepiandrosterone (DHEA) Formation in Alzheimer's Disease Diagnosis. Frontiers in Endocrinology. 2: 69
Lecanu L, Hashim AI, McCourty A, et al. (2011) The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo. Neuroscience. 183: 251-64
Rammouz G, Lecanu L, Aisen P, et al. (2011) A lead study on oxidative stress-mediated dehydroepiandrosterone formation in serum: the biochemical basis for a diagnosis of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 24: 5-16
Tillement L, Lecanu L, Papadopoulos V. (2011) Further evidence on mitochondrial targeting of β-amyloid and specificity of β-amyloid-induced mitotoxicity in neurons. Neuro-Degenerative Diseases. 8: 331-44
Midzak A, Akula N, Lecanu L, et al. (2011) Novel androstenetriol interacts with the mitochondrial translocator protein and controls steroidogenesis. The Journal of Biological Chemistry. 286: 9875-87
Tillement L, Lecanu L, Papadopoulos V. (2011) Alzheimer's disease: effects of β-amyloid on mitochondria. Mitochondrion. 11: 13-21
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