Rashmi Kothary, Ph.D

Affiliations: 
Ottawa Hospital Research Institute 
Area:
Muscle and nervous system integrity, pathology of neuromuscular diseases
Website:
http://www.ohri.ca/profiles/kothary.asp
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"Rashmi Kothary"
Bio:

Dr. Kothary is an Associate Director and Senior Scientist at the Ottawa Hospital Research Institute. He was originally fascinated by physics, but his interests shifted towards biology, biochemistry, embryology and ultimately neuromuscular disorders. Dr. Kothary received a Ph.D. in Biochemistry from the University of British Columbia and pursued postdoctoral research in the laboratory of Dr. Janet Rossant at the Mount Sinai Hospital Research Institute in Toronto and in the laboratory of Dr. Azim Surani in Cambridge, U.K. It was during these formative years that Dr. Kothary developed his interests in the use of transgenic mice to model disease pathology. Dr. Kothary returned to Canada to begin his independent research career at the Institut du cancer de Montréal. In 1998, Dr. Kothary joined the OHRI as a Senior Scientist. He holds the University Health Research Chair in Neuromuscular Disorders and is a Professor at the University of Ottawa. Dr. Kothary's laboratory is funded by research grants from the Canadian Institutes of Health Research (CIHR), the Muscular Dystrophy Association (USA), Families of Spinal Muscular Atrophy, and the Multiple Sclerosis Society of Canada. His current research focuses on studying the fundamental role of a cytoskeletal linker protein important for intracellular trafficking, investigating signal transduction pathways important for oligodendrocyte mediated myelination and remyelination of the CNS, and understanding Spinal Muscular Atrophy pathogenesis and identifying novel therapeutics for this devastating children's disease.
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Mean distance: 15.95 (cluster 57)
 
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Publications

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Reilly A, Yaworski R, Beauvais A, et al. (2023) Long term peripheral AAV9-SMN gene therapy promotes survival in a mouse model of spinal muscular atrophy. Human Molecular Genetics
Chehade L, Deguise MO, De Repentigny Y, et al. (2022) Suppression of the necroptotic cell death pathways improves survival in mice. Frontiers in Cellular Neuroscience. 16: 972029
Khayrullina G, Alipio-Gloria ZA, Deguise MO, et al. (2022) Survival motor neuron protein deficiency alters microglia reactivity. Glia
Lynch-Godrei A, De Repentigny Y, Ferrier A, et al. (2020) Dystonin loss-of-function leads to impaired autophagy-endolysosomal pathway dynamics. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Deguise MO, De Repentigny Y, Tierney A, et al. (2020) Motor transmission defects with sex differences in a new mouse model of mild spinal muscular atrophy. Ebiomedicine. 55: 102750
Deguise MO, Beauvais A, Schneider BL, et al. (2020) Blood Flow to the Spleen is Altered in a Mouse Model of Spinal Muscular Atrophy. Journal of Neuromuscular Diseases
Lynch-Godrei A, Kothary R. (2020) HSAN-VI: A spectrum disorder based on dystonin isoform expression. Neurology. Genetics. 6: e389
Lynch-Godrei A, De Repentigny Y, Yaworski RA, et al. (2019) Characterization of gastrointestinal pathologies in the dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. e13773
Alvarez-Saavedra M, Yan K, De Repentigny Y, et al. (2019) Snf2h Drives Chromatin Remodeling to Prime Upper Layer Cortical Neuron Development. Frontiers in Molecular Neuroscience. 12: 243
Deguise MO, Baranello G, Mastella C, et al. (2019) Abnormal fatty acid metabolism is a core component of spinal muscular atrophy. Annals of Clinical and Translational Neurology. 6: 1519-1532
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