Janet Rossant, Ph.D.

Sick Kids 
Stem cell research, Molecular genetics, Developmental biology
"Janet Rossant"

Dr. Janet Rossant is a Senior Scientist in the Developmental & Stem Cell Biology Program and Chief of Research at The Hospital for Sick Children, Toronto. She is also a University Professor, University of Toronto, and Professor in the Departments of Molecular Genetics, Obstetrics/Gynaecology and Paediatrics, University of Toronto. Her research interests centre on understanding the genetic control of normal and abnormal development in the early mouse embryo using both cellular and genetic manipulation techniques. Her interests in the early embryo have led to the discovery of a novel placental stem cell type, the trophoblast stem cell. She is Deputy Scientific Director of the Canadian Stem Cell Network and directs the Centre for Modelling Human Disease in Toronto, which is undertaking genome-wide mutagenesis in mice to develop new mouse models of human disease.

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Mean distance: 17.41 (cluster 57)
Cross-listing: DevTree - Chemistry Tree - GenetiTree

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Rossant J, Tam PPL. (2022) Early human embryonic development: Blastocyst formation to gastrulation. Developmental Cell. 57: 152-165
Posfai E, Schell JP, Janiszewski A, et al. (2021) Evaluating totipotency using criteria of increasing stringency. Nature Cell Biology. 23: 49-60
Hyun I, Munsie M, Pera MF, et al. (2020) Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells. Stem Cell Reports
Gu B, Posfai E, Gertsenstein M, et al. (2020) Efficient Generation of Large-Fragment Knock-In Mouse Models Using 2-Cell (2C)-Homologous Recombination (HR)-CRISPR. Current Protocols in Mouse Biology. 10: e67
Okamura E, Tam OH, Posfai E, et al. (2019) Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos. Developmental Biology
Lee CQ, Bailey A, Lopez-Tello J, et al. (2019) Inhibition of Phosphoinositide-3-kinase signaling promotes the stem cell state of trophoblast. Stem Cells (Dayton, Ohio)
Wong AP, Shojaie S, Liang Q, et al. (2019) Conversion of human and mouse fibroblasts into lung-like epithelial cells. Scientific Reports. 9: 9027
Ocana SC, Wong A, Aushev M, et al. (2019) How can gene-editing of human pluripotent stem cells help cystic fibrosis? European Respiratory Journal
Rivron N, Pera M, Rossant J, et al. (2018) Debate ethics of embryo models from stem cells. Nature. 564: 183-185
Rossant J. (2018) Genetic Control of Early Cell Lineages in the Mammalian Embryo. Annual Review of Genetics
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