Dorothy A. Schafer, Ph.D.

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Cells assemble a spectrum of interdependent F-actin networks that, together, move cells and organelles, establish polarity, confer mechanical properties and organize cells in tissues. Our research investigates the mechanisms by which cellular actin filaments assemble types of distinct networks that function in a coordinated manner. Two well-characterized actin networks are: 1) sheet-like, dendritic networks that power propulsive events as cells extend membrane and migrate and 2) contractile actomyosin networks that generate tension and pulling forces. Dendritic actin networks and actomyosin networks are often situated in close proximity in cells, yet, how these two very different networks form and function in a coordinated manner to maintain a dynamic, but coherent, global cytoskeleton is unknown.

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