Michael P. Cancro, Ph.D.
|1978-||Pathology and Laboratory Medicine||University of Pennsylvania Perelman School of Medicine|
Area:Immunology, B cell development. B cell homeostasis, B cell activation, Immune tolerance, autoimmunity,
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Professor Michael P. Cancro obtained his PhD under the tutelage of Dr. Michael Potter at the National Cancer Institute. His doctoral research examined the basis for pristane-induced growth promotion in the murine myeloma model system providing the basis for the widespread use of pristane as a growth promotant in mouse myelomas and hybridomas. His postdoctoral research under Dr. Norman R. Klinman at the University of Pennsylvania was pivotal in developing the influenza hemagglutinin model antigen system, and yielded the first estimate of B cell repertoire diversity to a viral antigen. He subsequently applied this system to understanding developmentally regulated expression of antibody specificities, and was among the first to perform limiting dilution measurements of helper T cell activity.
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|Johnson JL, Rosenthal RL, Knox JJ, et al. (2020) The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans. Immunity|
|Berry CT, Liu X, Myles A, et al. (2020) BCR-Induced Ca Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells. Cell Reports. 31: 107474|
|Cancro MP. (2020) Age-Associated B Cells. Annual Review of Immunology|
|Das S, Sutoh Y, Cancro MP, et al. (2019) Ancient -like Genes Herald B Cell Regulation in Lampreys. Journal of Immunology (Baltimore, Md. : 1950)|
|Awasthi S, Hook LM, Pardi N, et al. (2019) Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes. Science Immunology. 4|
|Johnson JL, Scholz JL, Marshak-Rothstein A, et al. (2019) Molecular pattern recognition in peripheral B cell tolerance: lessons from age-associated B cells. Current Opinion in Immunology. 61: 33-38|
|Moser EK, Roof J, Dybas JM, et al. (2019) The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses. The Journal of Experimental Medicine|
|Wilson RP, McGettigan SE, Dang VD, et al. (2019) IgM plasma cells reside in healthy skin and accumulate with chronic inflammation. The Journal of Investigative Dermatology|
|Knox JJ, Myles A, Cancro MP. (2019) T-bet memory B cells: Generation, function, and fate. Immunological Reviews. 288: 149-160|
|Myles A, Sanz I, Cancro MP. (2019) T-bet B cells: A common denominator in protective and autoreactive antibody responses? Current Opinion in Immunology. 57: 40-45|