David M. Hilbert

1983-1987 Immunology Graduate Group University of Pennsylvania Perelman School of Medicine 
 1987-1995 Laboratory of Genetics NIH, NCI 
 1995-2005 Research and Development Human Genome Sciences 
 2010- Founder, VP for research Cellective Therapeutics 
"David Hilbert"
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LaFleur DW, Abramyan D, Kanakaraj P, et al. (2013) Monoclonal antibody therapeutics with up to five specificities: functional enhancement through fusion of target-specific peptides. Mabs. 5: 208-18
Kanakaraj P, Puffer BA, Yao XT, et al. (2012) Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis. Mabs. 4: 600-13
Stohl W, Hilbert DM. (2012) The discovery and development of belimumab: the anti-BLyS-lupus connection. Nature Biotechnology. 30: 69-77
Woodland RT, Fox CJ, Schmidt MR, et al. (2008) Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood. 111: 750-60
Cambridge G, Stohl W, Leandro MJ, et al. (2006) Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse. Arthritis and Rheumatism. 54: 723-32
Collins CE, Gavin AL, Migone TS, et al. (2006) B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels. Arthritis Research & Therapy. 8: R6
Fleming TJ, Sachdeva M, Delic M, et al. (2005) Discovery of high-affinity peptide binders to BLyS by phage display. Journal of Molecular Recognition : Jmr. 18: 94-102
Stohl W, Metyas S, Tan SM, et al. (2003) B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations. Arthritis and Rheumatism. 48: 3475-86
Baker KP, Edwards BM, Main SH, et al. (2003) Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator. Arthritis and Rheumatism. 48: 3253-65
Stewart DM, McAvoy MJ, Hilbert DM, et al. (2003) B lymphocytes from individuals with common variable immunodeficiency respond to B lymphocyte stimulator (BLyS protein) in vitro. Clinical Immunology (Orlando, Fla.). 109: 137-43
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