David Luke Fischer, M.D., Ph.D.

Affiliations: 
2006-2010 Radiology, Neurology Michigan State University, East Lansing, MI 
 2010-2018 Translational Science and Molecular Medicine Michigan State University, East Lansing, MI 
 2018-2022 Neurology University of Alabama, Birmingham, Birmingham, AL, United States 
 2022- Neurology University of California, San Francisco, San Francisco, CA 
Area:
Alpha-Synuclein, Parkinson's disease, deep brain stimulation, brain-derived neurotrophic factor
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"D. Luke Fischer"
Bio:

D. Luke Fischer is a neurologist-neuroscientist specializing in cognition in the neuronal synucleinopathies. He graduated Phi Beta Kappa from Michigan State University with degrees in Philosophy and Biochemistry & Molecular Biology, and he remained there to complete his PhD in Neuroscience in the laboratory of Dr. Caryl E. Sortwell as part of a dual-MD/PhD program. As a trainee in the NINDS Morris K. Udall Center of Excellence for Parkinson's Disease Research at Michigan State University, his focus was on the use of deep brain stimulation in rodent models of Parkinson's disease to investigate its potential as a neuroprotective therapy. He remained in her laboratory as a postdoctoral fellow to examine the impact of common genetic variants on clinical outcomes for developing precision medicine approaches for treating patients with Parkinson's disease. He completed his neurology residency at the University of Alabama at Birmingham where he was elected to AOA and served as Chief Resident. As a NINDS R25 resident trainee in the laboratory of Dr. Laura Volpicelli-Daley, he applied confocal and expansion microscopy techniques to human postmortem brain samples to examine co-pathology. Luke is currently a Fellow in the Behavioral Neurology Training Program at the University of California San Francisco.
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Mean distance: 18.69 (cluster 19)
 
SNBCP

Parents

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Kevin L. Berger research assistant 2007-2010 Michigan State
Andrea Cathryn Bozoki research assistant 2007-2010 Michigan State
Caryl E. Sortwell grad student 2010-2015 Michigan State
 (Dissertation: "The Neuroprotective Potential of STN DBS and the Role of BDNF")
Lea Tenenholz Grinberg post-doc 2024- UCSF
 (Neuropathology Research Fellowship Mentor)
William W. Seeley post-doc 2024- UCSF
 (Neuropathology Research Fellowship Co-Mentor)
Caryl E. Sortwell post-doc 2015-2016 Michigan State
David G. Standaert post-doc 2020-2022 UAB
 (Co-Mentor with Dr. Volpicelli-Daley)
Laura A. Volpicelli-Daley post-doc 2020-2022 UAB
Bruce L. Miller post-doc 2022-2024 UCSF
 (Behavioral Neurology Clinical Fellowship Co-Director)
Howard Rosen post-doc 2022-2024 UCSF
 (Behavioral Neurology Clinical Fellowship Director)

Collaborators

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Lawren Vandevrede collaborator 2023- UCSF
Timothy  J. Collier collaborator 2010-2018 Michigan State
Jack W. Lipton collaborator 2011-2018 Michigan State
Fredric P. Manfredsson collaborator 2012-2018 Michigan State
Erik Roberson collaborator 2020-2022 UAB
BETA: Related publications

Publications

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Ellens NR, Fischer DL, Meldau JE, et al. (2020) External Ventricular Drain Placement Accuracy and Safety When Done by Midlevel Practitioners. Neurosurgery. 84: 235-241
Fischer DL, Sortwell CE. (2018) BDNF provides many routes toward STN DBS-mediated disease modification. Movement Disorders : Official Journal of the Movement Disorder Society
Duffy MF, Collier TJ, Patterson JR, et al. (2018) Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of Neuroinflammation. 15: 169
Fischer DL, Auinger P, Goudreau JL, et al. (2018) Bdnf variant is associated with milder motor symptom severity in early-stage Parkinson's disease. Parkinsonism & Related Disorders
Fischer DL, Manfredsson FP, Kemp CJ, et al. (2017) Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression. Scientific Reports. 7: 16356
Fischer DL, Manfredsson FP, Sortwell CE. (2017) Can STN DBS protect both nigral somata and innervation of the striatum? Annals of Neurology
Fischer DL, Kemp CJ, Cole-Strauss A, et al. (2017) Subthalamic Nucleus Deep Brain Stimulation Employs TrkB Signaling for Neuroprotection and Functional Restoration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Su X, Fischer DL, Li X, et al. (2017) Alpha-Synuclein mRNA Is Not Increased. Molecular Therapy : the Journal of the American Society of Gene Therapy
Polinski NK, Manfredsson FP, Benskey MJ, et al. (2016) Impact of age and vector construct on striatal and nigral transgene expression. Molecular Therapy. Methods & Clinical Development. 3: 16082
Fischer DL, Gombash SE, Kemp CJ, et al. (2016) Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease. Methods in Molecular Biology (Clifton, N.J.). 1382: 367-82
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