Michael D. Hambuchen, Ph.D.

Affiliations: 
2013 Pharmacology University of Arkansas for Medical Sciences, United States 
Area:
Pharmacology
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S. Michael Owens grad student 2013 UAMS
 (Combination immunotherapy for early and continuous protection from methamphetamine pharmacological effects.)
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Berquist MD, McGill MR, Mazur A, et al. (2020) Effect of bile duct ligation-induced liver dysfunction on methamphetamine pharmacokinetics in male and female rats. Drug and Alcohol Dependence. 215: 108190
Hay CE, Ewing LE, Hambuchen MD, et al. (2020) The development and characterization of an scFv-Fc fusion based gene therapy to reduce the psychostimulant effects of methamphetamine abuse. The Journal of Pharmacology and Experimental Therapeutics
McClenahan SJ, Kormos CM, Gunnell M, et al. (2019) Design, synthesis and biological evaluation of a bi-specific vaccine against α-pyrrolidinovalerophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats. Vaccine
Hambuchen MD, Berquist MD, Simecka CM, et al. (2019) Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, Societe Canadienne Des Sciences Pharmaceutiques. 22: 301-312
McClenahan SJ, Hambuchen MD, Simecka CM, et al. (2019) Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats. Drug and Alcohol Dependence. 195: 140-147
Hay CE, Gonzalez GA, Ewing LE, et al. (2018) Development and testing of AAV-delivered single-chain variable fragments for the treatment of methamphetamine abuse. Plos One. 13: e0200060
Hambuchen MD, Hendrickson HP, Gunnell MG, et al. (2017) The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats. Drug and Alcohol Dependence. 179: 347-354
Hambuchen MD, Hendrickson HP, Owens SM. (2017) Chiral determination of 3,4-methylenedioxypyrovalerone enantiomers in rat serum. Analytical Methods : Advancing Methods and Applications. 9: 609-617
Hambuchen MD, Rüedi-Bettschen D, Gunnell MG, et al. (2016) Chronic Treatment of (+)-Methamphetamine-Induced Locomotor Effects in Rats Using One or a Combination of Two High Affinity Anti-Methamphetamine Monoclonal Antibodies. Human Vaccines & Immunotherapeutics. 0
Hambuchen MD, Carroll FI, Rüedi-Bettschen D, et al. (2015) Combining Active Immunization with Monoclonal Antibody Therapy To Facilitate Early Initiation of a Long-Acting Anti-Methamphetamine Antibody Response. Journal of Medicinal Chemistry. 58: 4665-77
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