Uffe Kristiansen

Medicinal Chemistry Research University of Copenhagen, København, Denmark 
"Uffe Kristiansen"
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Falk-Petersen CB, Tsonkov TM, Nielsen MS, et al. (2020) Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA receptors. Scientific Reports. 10: 10078
von Schoubye NL, Frederiksen K, Kristiansen U, et al. (2017) The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6(+/-) mice. Neuroscience Letters
Simonsen C, Boddum K, von Schoubye NL, et al. (2017) Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ-subunit-containing GABAA receptors in dentate gyrus granule cells. Pharmacology Research & Perspectives. 5
Boddum K, Jensen TP, Magloire V, et al. (2016) Astrocytic GABA transporter activity modulates excitatory neurotransmission. Nature Communications. 7: 13572
Gasiorek A, Trattnig SM, Ahring PK, et al. (2016) Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 receptors. Biochemical Pharmacology. 110: 92-108
Krall J, Balle T, Krogsgaard-Larsen N, et al. (2015) GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology. Advances in Pharmacology (San Diego, Calif.). 72: 201-27
Boddum K, Frølund B, Kristiansen U. (2014) The GABAA antagonist DPP-4-PIOL selectively antagonises tonic over phasic GABAergic currents in dentate gyrus granule cells. Neurochemical Research. 39: 2078-84
Kjaerby C, Broberg BV, Kristiansen U, et al. (2014) Impaired GABAergic inhibition in the prefrontal cortex of early postnatal phencyclidine (PCP)-treated rats. Cerebral Cortex (New York, N.Y. : 1991). 24: 2522-32
Hoestgaard-Jensen K, O'Connor RM, Dalby NO, et al. (2013) The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors. British Journal of Pharmacology. 170: 919-32
Kjaerby C, Bundgaard C, Fejgin K, et al. (2013) Repeated potentiation of the metabotropic glutamate receptor 5 and the alpha 7 nicotinic acetylcholine receptor modulates behavioural and GABAergic deficits induced by early postnatal phencyclidine (PCP) treatment. Neuropharmacology. 72: 157-68
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