Jeffrey Milbrandt, MD, PhD

Genetics Washington University School of Medicine, St. Louis, MO, United States 
Axonal degeneration, peripheral neuropathy, Myelination, Schwann cell metabolism
"Jeffrey Milbrandt"

Present: James S. McDonnell Professor and Chair, Department of Genetics, Washington University School of Medicine
MD, Washington University, St. Louis
PhD, biochemistry, University of Virginia,
Resident, pathology, University of Virginia

Mean distance: 16.15 (cluster 11)
Cross-listing: GenetiTree - Chemistry Tree

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Krus KL, Strickland A, Yamada Y, et al. (2022) Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy. Cell Reports. 39: 111001
Weagley JS, Zaydman M, Venkatesh S, et al. (2022) Products of gut microbial Toll/interleukin-1 receptor domain NADase activities in gnotobiotic mice and Bangladeshi children with malnutrition. Cell Reports. 39: 110738
Bloom AJ, Mao X, Strickland A, et al. (2022) Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients. Molecular Neurodegeneration. 17: 1
Li Y, Pazyra-Murphy MF, Avizonis D, et al. (2022) Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. The Journal of Cell Biology. 221
Ko KW, Devault L, Sasaki Y, et al. (2021) Live imaging reveals the cellular events downstream of SARM1 activation. Elife. 10
Wu T, Zhu J, Strickland A, et al. (2021) Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss. Cell Reports. 37: 109872
Eastman S, Smith T, Zaydman MA, et al. (2021) A phytobacterial TIR domain effector manipulates NAD to promote virulence. The New Phytologist
DiAntonio A, Milbrandt J, Figley MD. (2021) The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems. Frontiers in Immunology. 12: 752898
Sasaki Y, Zhu J, Shi Y, et al. (2021) Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Experimental Neurology. 113842
Figley MD, Gu W, Nanson JD, et al. (2021) SARM1 is a metabolic sensor activated by an increased NMN/NAD ratio to trigger axon degeneration. Neuron
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