Lauren M Slosky

Duke University, Durham, NC 
pain, addiction, GPCRs
"Lauren Slosky"
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Singhal SM, Zell V, Faget L, et al. (2023) Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens. Neuropharmacology. 109544
Krumm BE, DiBerto JF, Olsen RHJ, et al. (2023) Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry
Slosky LM, Pires A, Bai Y, et al. (2022) Establishment of multi-stage intravenous self-administration paradigms in mice. Scientific Reports. 12: 21422
Hornburg KJ, Slosky LM, Cofer G, et al. (2022) Prenatal Heroin Exposure Alters Brain Morphology and Connectivity in Adolescent Mice. Nmr in Biomedicine. e4842
Slosky LM, Caron MG, Barak LS. (2021) Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery. Trends in Pharmacological Sciences
Slosky LM, Bai Y, Toth K, et al. (2020) β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. Cell
Toth K, Nagi K, Slosky LM, et al. (2019) Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs. Acs Pharmacology & Translational Science. 2: 230-246
Pinkerton AB, Peddibhotla S, Yamamoto F, et al. (2019) Discovery of b-Arrestin Biased, Orally Bioavailable and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. Journal of Medicinal Chemistry
Toth K, Slosky LM, Pack TF, et al. (2017) Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2. Synapse (New York, N.Y.)
Grenald SA, Doyle TM, Zhang H, et al. (2017) Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation. Pain
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