Gwenaelle S.G. Geleoc

Boston Children's Hospital, Harvard Medical School 
Inner ear physiology, hair cells, gene therapy
"Gwenaelle Geleoc"
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Lentz JJ, Pan B, Ponnath A, et al. (2020) Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice. Molecular Therapy : the Journal of the American Society of Gene Therapy
György B, Nist-Lund C, Pan B, et al. (2019) Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss. Nature Medicine
Asai Y, Pan B, Nist-Lund C, et al. (2018) Transgenic Tmc2 expression preserves inner ear hair cells and vestibular function in mice lacking Tmc1. Scientific Reports. 8: 12124
Géléoc GS, Holt JR. (2014) Sound strategies for hearing restoration. Science (New York, N.Y.). 344: 1241062
Kawashima Y, Géléoc GS, Kurima K, et al. (2011) Mechanotransduction in mouse inner ear hair cells requires transmembrane channel-like genes. The Journal of Clinical Investigation. 121: 4796-809
Steigelman KA, Lelli A, Wu X, et al. (2011) Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12241-50
Horwitz GC, Lelli A, Géléoc GS, et al. (2010) HCN channels are not required for mechanotransduction in sensory hair cells of the mouse inner ear. Plos One. 5: e8627
Asai Y, Holt JR, Géléoc GS. (2010) A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea. Journal of the Association For Research in Otolaryngology : Jaro. 11: 27-37
Lelli A, Asai Y, Forge A, et al. (2009) Tonotopic gradient in the developmental acquisition of sensory transduction in outer hair cells of the mouse cochlea. Journal of Neurophysiology. 101: 2961-73
Holt JR, Stauffer EA, Abraham D, et al. (2007) Dominant-negative inhibition of M-like potassium conductances in hair cells of the mouse inner ear. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8940-51
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