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Emil Chris Muly, MD, PhD

Affiliations: 
Psychiatry Emory University, Atlanta, GA 
Area:
Electron Microscopy
Website:
http://www.psychiatry.emory.edu/faculty/muly_chris.html
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"chris muly"
Bio:

Dr. Muly has a longstanding interest in schizophrenia and is pursuing research aimed at increasing our understanding of this illness and its treatment. This includes preclinical studies of antipsychotic drug metabolism and binding within the brain, as well as participating in a large, multi-site VA study on the genetics of schizophrenia and bipolar disorder.

Recently, Dr. Muly has been engaging in research to understand how stress produces long lasting changes in behavior by altering the machinery of neural communication. By determining how stress changes the localization of key signaling molecules in a rat model of uncontrollable stress he is seeking to shed light on how stress can induce pathological behavioral states in humans.

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Mean distance: 14.49 (cluster 17)
 		SNBCP
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Parents

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David Fitzpatrick grad student 1986-1990 Duke
Patricia Goldman-Rakic post-doc 1993-1993 Yale School of Medicine

Children

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Jill R. Glausier grad student 2003-2008 Emory University / Yerkes National Primate Center

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Publications

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Muly EC, Votaw JR, Ritchie J, et al. (2012) Relationship between dose, drug levels, and D2 receptor occupancy for the atypical antipsychotics risperidone and paliperidone. The Journal of Pharmacology and Experimental Therapeutics. 341: 81-9
Muly EC, Maddox M, Khan ZU. (2010) Distribution of D1 and D5 dopamine receptors in the primate nucleus accumbens. Neuroscience. 169: 1557-66
Glausier JR, Maddox M, Hemmings HC, et al. (2010) Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex. Neuroscience. 167: 428-38
Muly EC, Senyuz M, Khan ZU, et al. (2009) Distribution of D1 and D5 dopamine receptors in the primate and rat basolateral amygdala. Brain Structure & Function. 213: 375-93
Glausier JR, Khan ZU, Muly EC. (2009) Dopamine D1 and D5 receptors are localized to discrete populations of interneurons in primate prefrontal cortex. Cerebral Cortex (New York, N.Y. : 1991). 19: 1820-34
Muly EC, Nairn AC, Greengard P, et al. (2008) Subcellular distribution of the Rho-GEF Lfc in primate prefrontal cortex: effect of neuronal activation. The Journal of Comparative Neurology. 508: 927-39
Bordelon-Glausier JR, Khan ZU, Muly EC. (2008) Quantification of D1 and D5 dopamine receptor localization in layers I, III, and V of Macaca mulatta prefrontal cortical area 9: coexpression in dendritic spines and axon terminals. The Journal of Comparative Neurology. 508: 893-905
Glausier J, Smith Y, Howell L, et al. (2008) DIFFERENTIAL LOCALIZATION OF PROTEIN PHOSPHATASE-1 (PP1) ISOFORMS AT AXOSPINOUS SYNAPSES: RESPONSE TO HALOPERIDOL AND COCAINE TREATMENT Schizophrenia Research. 102: 63
O'Connor JA, Muly EC, Arnold SE, et al. (2007) AMPA receptor subunit and splice variant expression in the DLPFC of schizophrenic subjects and rhesus monkeys chronically administered antipsychotic drugs. Schizophrenia Research. 90: 28-40
Hemby SE, Tang W, Muly EC, et al. (2005) Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates. Journal of Neurochemistry. 95: 1785-93
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