Alan Roy Fersht
Affiliations: | Chemistry | University of Cambridge, Cambridge, England, United Kingdom |
Area:
protein engineering, protein folding, and enzyme catalysisWebsite:
http://www.ch.cam.ac.uk/person/arf25Google:
"Alan Fersht"Bio:
The Copley Medal 2020 was awarded to Sir Alan Fersht for developing and applying "the methods of protein engineering to provide descriptions of protein folding pathways at atomic resolution, revolutionising our understanding of these processes."
https://royalsociety.org/people/alan-fersht-11430/
http://www.nasonline.org/member-directory/members/64214.html
Mean distance: 9.02
Parents
Sign in to add mentor| Anthony J. Kirby | grad student | 1965-1968 | Cambridge |
| William P. Jencks | post-doc | 1968-1969 | Brandeis |
Children
Sign in to add trainee| Markus A. Seeliger | grad student | (Cell Biology Tree) | |
| Alan J. Russell | grad student | 1987 | Imperial College London (BME Tree) |
| Elizabeth Meiering | grad student | 1992 | Cambridge |
| Paul A Dalby | grad student | 1994-1998 | Cambridge University UK |
| Andreas G Ladurner | grad student | 1994-1998 | University of Cambridge and MRC |
| Javier Sancho | post-doc | Cambridge University UK (Computational Biology Tree) | |
| Robin John Leatherbarrow | post-doc | 1984-1985 | Imperial College London |
| Jesus M Sanz | post-doc | 1992-1994 | |
| Assaf Friedler | post-doc | 2000-2004 | Cambridge |
| Frank M. Boeckler | post-doc | 2006-2008 | |
| Joel L. Kaar | post-doc | 2008-2010 | Cambridge (Neurotree) |
| M. Eugenio Vazquez | research scientist | 1998-1998 | Cambridge |
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Publications
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| Fersht AR, Cohen FE. (2019) Folding & Design: introduction to a new journal. Folding & Design. 1: i |
| Baretić D, Pollard HK, Fisher DI, et al. (2017) Structures of closed and open conformations of dimeric human ATM. Science Advances. 3: e1700933 |
| Bromley D, Bauer MR, Fersht AR, et al. (2016) An in silico algorithm for identifying stabilizing pockets in proteins: test case, the Y220C mutant of the p53 tumor suppressor protein. Protein Engineering, Design & Selection : Peds |
| Bauer MR, Jones RN, Baud MG, et al. (2016) Harnessing fluorine-sulfur contacts and multipolar interactions for the design of p53 mutant Y220C rescue drugs. Acs Chemical Biology |
| Joerger AC, Bauer MR, Wilcken R, et al. (2015) Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53. Structure (London, England : 1993). 23: 2246-55 |
| Wilcken R, Zimmermann MO, Bauer MR, et al. (2015) Experimental and theoretical evaluation of the ethynyl moiety as a halogen bioisostere. Acs Chemical Biology |
| Nasedkin A, Marcellini M, Religa TL, et al. (2015) Deconvoluting Protein (Un)folding Structural Ensembles Using X-Ray Scattering, Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulation. Plos One. 10: e0125662 |
| Brandt T, Kaar JL, Fersht AR, et al. (2012) Stability of p53 Homologs Plos One. 7 |
| Vogel SM, Bauer MR, Joerger AC, et al. (2012) Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2 Proceedings of the National Academy of Sciences of the United States of America. 109: 16906-16910 |
| Wilcken R, Wang G, Boeckler FM, et al. (2012) Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition Proceedings of the National Academy of Sciences of the United States of America. 109: 13584-13589 |