Bruno M.D.C. Godinho
Affiliations: | University Of Massachusetts Med Sch Worcester |
Area:
RNA Therapeutics, siRNA, Oligonucleotide Delivery, CNSGoogle:
"Bruno Godinho"Mean distance: (not calculated yet)
Parents
Sign in to add mentorJohn F. Cryan | grad student | 2009-2014 | University College Cork, Ireland |
Caitriona M. O'Driscoll | grad student | 2009-2014 | University College Cork |
Anastasia Khvorova | post-doc | 2015-2019 | University Of Massachusetts Med Sch Worcester |
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Publications
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Alterman JF, Godinho BMDC, Hassler MR, et al. (2019) A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system. Nature Biotechnology. 37: 884-894 |
Haraszti RA, Miller R, Dubuke ML, et al. (2019) Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition. Iscience. 16: 230-241 |
Osborn MF, Coles AH, Biscans A, et al. (2018) Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways. Nucleic Acids Research |
Turanov AA, Lo A, Hassler MR, et al. (2018) RNAi modulation of placental sFLT1 for the treatment of preeclampsia. Nature Biotechnology |
Godinho BMDC, Henninger N, Bouley J, et al. (2018) Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier. Molecular Therapy : the Journal of the American Society of Gene Therapy |
Hassler MR, Turanov AA, Alterman JF, et al. (2018) Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo. Nucleic Acids Research |
Godinho BMDC, Gilbert JW, Haraszti RA, et al. (2017) Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay. Nucleic Acid Therapeutics |
Haraszti RA, Roux L, Coles AH, et al. (2017) 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo. Nucleic Acids Research |
Nikan M, Osborn MF, Coles AH, et al. (2017) Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable, O-phosphocholine-N-docosahexaenoyl-L-serine siRNA Conjugate in Mouse Brain. Bioconjugate Chemistry |
Coles AH, Osborn MF, Alterman JF, et al. (2015) A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo. Nucleic Acid Therapeutics |