Bruno M.D.C. Godinho

Affiliations: 
University Of Massachusetts Med Sch Worcester 
Area:
RNA Therapeutics, siRNA, Oligonucleotide Delivery, CNS
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"Bruno Godinho"
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Publications

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Alterman JF, Godinho BMDC, Hassler MR, et al. (2019) A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system. Nature Biotechnology. 37: 884-894
Haraszti RA, Miller R, Dubuke ML, et al. (2019) Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition. Iscience. 16: 230-241
Osborn MF, Coles AH, Biscans A, et al. (2018) Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways. Nucleic Acids Research
Turanov AA, Lo A, Hassler MR, et al. (2018) RNAi modulation of placental sFLT1 for the treatment of preeclampsia. Nature Biotechnology
Godinho BMDC, Henninger N, Bouley J, et al. (2018) Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier. Molecular Therapy : the Journal of the American Society of Gene Therapy
Hassler MR, Turanov AA, Alterman JF, et al. (2018) Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo. Nucleic Acids Research
Godinho BMDC, Gilbert JW, Haraszti RA, et al. (2017) Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay. Nucleic Acid Therapeutics
Haraszti RA, Roux L, Coles AH, et al. (2017) 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo. Nucleic Acids Research
Nikan M, Osborn MF, Coles AH, et al. (2017) Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable, O-phosphocholine-N-docosahexaenoyl-L-serine siRNA Conjugate in Mouse Brain. Bioconjugate Chemistry
Coles AH, Osborn MF, Alterman JF, et al. (2015) A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo. Nucleic Acid Therapeutics
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