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Frances Wiseman, MRes, PhD

2018- UCL Institute of Neurology, Queen Square, London, England, United Kingdom 
Ageing, Neuroscience, Down Syndrome, Alzheimer’s disease, Genetics
"Frances Wiseman"

01-NOV-2018 – 31-OCT-2022, Alzheimer's Research UK Senior Fellow
Academic Background
2007, PhD, Doctor of Philosophy – Biomedical Sciences, University of Edinburgh
2003, MRes, Master of Research – Cell and Molecular Biology, University of Edinburgh
2002, BA, Bachelor of Arts – Biological Sciences, University of Oxford

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Elizabeth Mary Claire Fisher post-doc UCL Institute of Neurology, Queen Square
 (Source: Personal communication (E. M. C. Fisher, 2020))
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Granno S, Nixon-Abell J, Berwick DC, et al. (2019) Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus. Scientific Reports. 9: 7322
Wiseman FK, Pulford LJ, Barkus C, et al. (2018) Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP. Brain : a Journal of Neurology
Tosh JL, Rickman M, Rhymes E, et al. (2017) The integration site of the APP transgene in the J20 mouse model of Alzheimer's disease. Wellcome Open Research. 2: 84
Powell NM, Modat M, Cardoso MJ, et al. (2016) Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome. Plos One. 11: e0162974
Hall JH, Wiseman FK, Fisher EM, et al. (2016) Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory. Neurobiology of Learning and Memory
Wiseman FK, Al-Janabi T, Hardy J, et al. (2015) A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome. Nature Reviews. Neuroscience. 16: 564-74
Gribble SM, Wiseman FK, Clayton S, et al. (2013) Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome. Plos One. 8: e60482
Ahmed MM, Dhanasekaran AR, Tong S, et al. (2013) Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Human Molecular Genetics. 22: 1709-24
Grizenkova J, Akhtar S, Hummerich H, et al. (2012) Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 13722-7
Sheppard O, Wiseman FK, Ruparelia A, et al. (2012) Mouse models of aneuploidy. Thescientificworldjournal. 2012: 214078
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