Johnathan Violin
Affiliations: | Duke University, Durham, NC |
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| Wobblish M, Carr R, Cowan C, et al. (2017) (224) Assessment of Nociceptive Sensitization with TRV9101, a Novel μ Receptor G Protein Pathway Selective Modulator (μ-GPS), versus Fentanyl, Morphine, and Oxycodone The Journal of Pain. 18: S32 |
| Siuda ER, Carr R, Rominger DH, et al. (2016) Biased mu-opioid receptor ligands: a promising new generation of pain therapeutics. Current Opinion in Pharmacology. 32: 77-84 |
| Tarigopula M, Davis RT, Mungai PT, et al. (2015) Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model. Cardiovascular Research. 107: 226-34 |
| Felker GM, Butler J, Collins SP, et al. (2015) Heart failure therapeutics on the basis of a biased ligand of the angiotensin-2 type 1 receptor. Rationale and design of the BLAST-AHF study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure). Jacc. Heart Failure. 3: 193-201 |
| Violin JD, Crombie AL, Soergel DG, et al. (2014) Biased ligands at G-protein-coupled receptors: Promise and progress Trends in Pharmacological Sciences. 35: 308-316 |
| Rominger DH, Cowan CL, Gowen-MacDonald W, et al. (2014) Biased ligands: pathway validation for novel GPCR therapeutics. Current Opinion in Pharmacology. 16: 108-15 |
| Strachan RT, Sun JP, Rominger DH, et al. (2014) Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). The Journal of Biological Chemistry. 289: 14211-24 |
| Violin JD, Crombie AL, Soergel DG, et al. (2014) Biased ligands at G protein-coupled receptors: promise and progress. [Trends in Pharmacological Sciences 35 (2014) 308-316] (DOI:10.1016/j.tips.2014.04.007) Trends in Pharmacological Sciences |
| Chen XT, Pitis P, Liu G, et al. (2013) Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain. Journal of Medicinal Chemistry. 56: 8019-31 |
| Violin JD, Soergel DG, Boerrigter G, et al. (2013) GPCR biased ligands as novel heart failure therapeutics. Trends in Cardiovascular Medicine. 23: 242-9 |