Issam Ben-Sahra, PhD
Affiliations: | Department of Biochemistry and Molecular Genetics | Northwestern University Feinberg School of Medicine, Chicago, IL, United States |
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Publications
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| Torrino S, Oldham WM, Tejedor AR, et al. (2023) Mechano-dependent sorbitol accumulation supports biomolecular condensate. Biorxiv : the Preprint Server For Biology |
| Zhao Z, Cao K, Watanabe J, et al. (2023) Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations. The Journal of Clinical Investigation |
| Ali ES, Ben-Sahra I. (2023) Regulation of nucleotide metabolism in cancers and immune disorders. Trends in Cell Biology |
| Jin Q, Gutierrez Diaz B, Pieters T, et al. (2022) Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science Advances. 8: eabq8437 |
| Ali ES, Lipońska A, O'Hara BP, et al. (2022) The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis. Molecular Cell |
| Soflaee MH, Kesavan R, Sahu U, et al. (2022) Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nature Communications. 13: 2698 |
| De Jesus A, Keyhani-Nejad F, Pusec CM, et al. (2022) Hexokinase 1 cellular localization regulates the metabolic fate of glucose. Molecular Cell |
| Byles V, Cormerais Y, Kalafut K, et al. (2021) Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Molecular Metabolism. 101309 |
| Zerhouni M, Martin AR, Furstoss N, et al. (2021) Dual covalent inhibition of PKM and IMPDH targets metabolism in cutaneous metastatic melanoma. Cancer Research |
| Villa E, Sahu U, O'Hara BP, et al. (2021) mTORC1 stimulates cell growth through SAM synthesis and mA mRNA-dependent control of protein synthesis. Molecular Cell |