Robert Drolet, PhD
Affiliations: | Merck, Semoy, Centre-Val de Loire, France |
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Publications
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| Roecker AJ, Schirripa KM, Loughran HM, et al. (2023) Pyrazole Ureas as Low Dose, CNS Penetrant Glucosylceramide Synthase Inhibitors for the Treatment of Parkinson's Disease. Acs Medicinal Chemistry Letters. 14: 146-155 |
| Cosden M, Jinn S, Yao L, et al. (2021) A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy. Neurobiology of Disease. 105507 |
| Polinski NK, Martinez TN, Gorodinsky A, et al. (2021) Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model. Plos One. 16: e0252325 |
| Rocha EM, De Miranda BR, Castro S, et al. (2019) LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson's disease. Neurobiology of Disease. 104626 |
| Jinn S, Blauwendraat C, Toolan D, et al. (2019) Functionalization of the TMEM175 p.M393T Variant as a risk factor for Parkinson Disease. Human Molecular Genetics |
| Jinn S, Drolet RE, Cramer PE, et al. (2017) TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America |
| Farrell KF, Krishnamachari S, Villanueva E, et al. (2014) Non-motor parkinsonian pathology in aging A53T α-synuclein mice is associated with progressive synucleinopathy and altered enzymatic function. Journal of Neurochemistry. 128: 536-46 |
| Greenamyre JT, Cannon JR, Drolet R, et al. (2010) Lessons from the rotenone model of Parkinson's disease. Trends in Pharmacological Sciences. 31: 141-2; author reply |
| Drolet RE, Cannon JR, Montero L, et al. (2009) Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiology of Disease. 36: 96-102 |
| Cannon JR, Tapias V, Na HM, et al. (2009) A highly reproducible rotenone model of Parkinson's disease. Neurobiology of Disease. 34: 279-90 |