Lawrence A. Loeb, MD, PhD
Affiliations: | Pathology | University of Washington School of Medicine, Seattle, WA, United States |
Area:
mutations and human cancerWebsite:
http://www.pathology.washington.edu/faculty/lloebGoogle:
"Lawrence A. Loeb"Bio:
http://depts.washington.edu/biowww/pages/faculty-Loeb.shtml
http://depts.washington.edu/loeblabs/loebcv.php
Mean distance: 10.74 | S | N | B | C | P |
Parents
Sign in to add mentor| Harry V. Gelboin | research assistant | 1962-1964 | National Cancer Institute | |
| Daniel Mazia | grad student | 1967 | UC Berkeley (Neurotree) | |
| (Nuclear DNA polymerase of sea urchin embryos) | ||||
Children
Sign in to add trainee| Roel M. Schaaper | grad student | 1982 | UW Medical School |
| Premal H. Patel | grad student | 2001 | University of Washington |
| Haiwei H. Guo | grad student | 2004 | University of Washington |
| Jessica L. Sneeden | grad student | 2004 | University of Washington |
| Ern Loh | grad student | 2006 | University of Washington |
| Marc Vermulst | grad student | 2008 | University of Washington |
| Jesse J. Salk | grad student | 2010 | University of Washington |
| Keith C. Cheng | post-doc | 1992 | University of Washington (Neurotree) |
| Manel Camps | post-doc | 2001-2004 | University of Washington |
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Publications
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| Zhang Y, Kohrn BF, Yang M, et al. (2021) PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Beckman RA, Loeb LA. (2020) Rare Mutations in Cancer Drug Resistance and Implications for Therapy. Clinical Pharmacology and Therapeutics |
| Loeb LA, Kohrn BF, Loubet-Senear KJ, et al. (2019) Extensive subclonal mutational diversity in human colorectal cancer and its significance. Proceedings of the National Academy of Sciences of the United States of America |
| Shen JC, Kamath-Loeb AS, Kohrn BF, et al. (2019) A high-resolution landscape of mutations in the super-enhancer in normal human B cells. Proceedings of the National Academy of Sciences of the United States of America |
| Salk JJ, Loubet-Senear K, Maritschnegg E, et al. (2019) Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan. Cell Reports. 28: 132-144.e3 |
| Beckman RA, Kohrn B, Loubet-Senear K, et al. (2019) Abstract 3770: Unexpectedly high subclonal mutational diversity in human colorectal cancer and its significance Cancer Research. 79: 3770-3770 |
| Schmitt MW, Pritchard JR, Leighow SM, et al. (2018) Single-molecule sequencing reveals patterns of pre-existing drug resistance that suggest treatment strategies in Philadelphia-positive leukemias. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research |
| Salk JJ, Schmitt MW, Loeb LA. (2018) Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations. Nature Reviews. Genetics |
| Mabrey FL, Chien SS, Martins TS, et al. (2018) High Throughput Drug Screening of Leukemia Stem Cells Reveals Resistance to Standard Therapies and Sensitivity to Other Agents in Acute Myeloid Leukemia Blood. 132: 180-180 |
| Beckman RA, Loeb LA. (2017) Evolutionary dynamics and significance of multiple subclonal mutations in cancer. Dna Repair |