Joseph B. O'Brien
Affiliations: | University of Iowa, Iowa City, IA |
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| Dwyer TS, O'Brien JB, Ptak CP, et al. (2022) Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype. Frontiers in Pharmacology. 13: 977742 |
| Cagle BS, Sturgeon ML, O'Brien JB, et al. (2021) Stable expression of the human dopamine transporter in N27 cells as an in vitro model for dopamine cell trafficking and metabolism. Toxicology in Vitro : An International Journal Published in Association With Bibra. 76: 105210 |
| O'Brien JB, Roman DL. (2021) Novel treatments for chronic pain: moving beyond opioids. Translational Research : the Journal of Laboratory and Clinical Medicine |
| Hayes MP, O'Brien J, Fowler CA, et al. (2021) Fragment-based nuclear magnetic resonance screen against a Regulator of G Protein Signaling identifies a binding "hot spot". Chembiochem : a European Journal of Chemical Biology |
| O'Brien JB, Wilkinson JC, Roman DL. (2019) Regulator of G protein signaling (RGS) proteins as drug targets: Progress and future potentials. The Journal of Biological Chemistry |
| Sieng M, Hayes MP, O'Brien JB, et al. (2019) High-resolution structure of RGS17 suggests a role for Ca2+ in promoting the GTPase activating protein activity by RZ subfamily members. The Journal of Biological Chemistry |
| Bodle CR, Schamp JH, O'Brien JB, et al. (2018) Screen Targeting Lung and Prostate Cancer Oncogene Identifies Novel Inhibitors of RGS17 and Problematic Chemical Substructures. Slas Discovery : Advancing Life Sciences R & D. 2472555217752301 |
| Bodle CR, Hayes MP, O'Brien JB, et al. (2017) "Development of bimolecular luminescence complementation assay for RGS: G protein interactions in cells." Analytical Biochemistry |