James E. Orfila, Ph.D.

Affiliations: 
Anesthesiology  University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Neuronal Injury Program
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"James Orfila"
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Parents

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Joe L. Martinez grad student 2008 UT San Antonio
 (Necessity of protein synthesis in long-term potentiation (LTP) in the CA3 area of the rat hippocampus.)
Laura E. O'Dell post-doc UT El Paso
Paco S. Herson post-doc 2012- University of Colorado, Denver
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Publications

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Burch AM, Garcia JD, O'Leary H, et al. (2024) TRPM2 and CaMKII signaling drives excessive GABAergic synaptic inhibition following ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Oshima K, Siddiqui N, Orfila JE, et al. (2023) A role for decorin in improving motor deficits after traumatic brain injury. Matrix Biology : Journal of the International Society For Matrix Biology
Fine-Raquet B, Manzella FM, Joksimovic SM, et al. (2023) Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum. Experimental Biology and Medicine (Maywood, N.J.). 15353702231177009
Basak JM, Falk M, Mitchell DN, et al. (2023) Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X231159597
Rumian NL, Brown CN, Hendry-Hofer TB, et al. (2023) Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs. The Journal of Biological Chemistry. 104693
Rumian NL, Brown CN, Hendry-Hofer TB, et al. (2023) Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory and is neuroprotective in non-rodents. Biorxiv : the Preprint Server For Biology
Joksimovic SM, Ghodsi SM, Heinsbroek JA, et al. (2022) Ca3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum. Neuropharmacology. 226: 109400
Moreno M, Minjarez C, Vigil J, et al. (2022) Differences in hippocampal plasticity and memory outcomes in anterior versus posterior cerebellar stroke. Neurobiology of Disease. 168: 105701
Dietz RM, Orfila JE, Chalmers N, et al. (2021) Functional Restoration following Global Cerebral Ischemia in Juvenile Mice following Inhibition of Transient Receptor Potential M2 (TRPM2) Ion Channels. Neural Plasticity. 2021: 8774663
Cruz Del Angel Y, Orfila JE, Herson PS, et al. (2021) Down-regulation of AMPA receptors and long-term potentiation during early epileptogenesis. Epilepsy & Behavior : E&B. 124: 108320
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