Adrian Isaacs
Affiliations: | Neurology | University College London, London, United Kingdom |
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Children
Sign in to add trainee| Lauren M Gittings | grad student | 2014-2018 | University College London (UCL) |
| Jack Humphrey | grad student | 2015-2019 | UCL |
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Publications
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| Mizielinska S, Hautbergue GM, Gendron TF, et al. (2025) Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics. The Lancet. Neurology. 24: 261-274 |
| Kempthorne L, Vaizoglu D, Cammack AJ, et al. (2025) Dual-targeting CRISPR-CasRx reduces C9orf72 ALS/FTD sense and antisense repeat RNAs in vitro and in vivo. Nature Communications. 16: 459 |
| van der Geest AT, Jakobs CE, Ljubikj T, et al. (2024) Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids. Acta Neuropathologica Communications. 12: 152 |
| Hutten S, Chen JX, Isaacs AM, et al. (2024) Poly-GR Impairs PRMT1-Mediated Arginine Methylation of Disease-Linked RNA-Binding Proteins by Acting as a Substrate Sink. Biochemistry |
| Feringa FM, Koppes-den Hertog SJ, Wang L, et al. (2024) The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4. Biorxiv : the Preprint Server For Biology |
| Scaber J, Thomas-Wright I, Clark AJ, et al. (2024) Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons. Stem Cell Reports |
| Milioto C, Carcolé M, Giblin A, et al. (2024) PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons. Nature Neuroscience |
| Rothstein JD, Baskerville V, Rapuri S, et al. (2023) GC targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons. Acta Neuropathologica. 147: 1 |
| Vahsen BF, Nalluru S, Morgan GR, et al. (2023) C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9. Nature Communications. 14: 5898 |
| Fisher EMC, Greensmith L, Malaspina A, et al. (2023) Opinion: more mouse models and more translation needed for ALS. Molecular Neurodegeneration. 18: 30 |