Adrian Isaacs
Affiliations: | Neurology | University College London, London, United Kingdom |
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Sign in to add trainee| Lauren M Gittings | grad student | 2014-2018 | University College London (UCL) |
| Jack Humphrey | grad student | 2015-2019 | UCL |
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Publications
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| Rothstein JD, Baskerville V, Rapuri S, et al. (2023) GC targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons. Acta Neuropathologica. 147: 1 |
| Vahsen BF, Nalluru S, Morgan GR, et al. (2023) C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9. Nature Communications. 14: 5898 |
| Fisher EMC, Greensmith L, Malaspina A, et al. (2023) Opinion: more mouse models and more translation needed for ALS. Molecular Neurodegeneration. 18: 30 |
| Licata NV, Cristofani R, Salomonsson S, et al. (2021) C9orf72 ALS/FTD dipeptide repeat protein levels are reduced by small molecules that inhibit PKA or enhance protein degradation. The Embo Journal. e105026 |
| Barton SK, Gregory JM, Selvaraj BT, et al. (2021) Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis. Frontiers in Neuroscience. 15: 705306 |
| Puentes F, Lombardi V, Lu CH, et al. (2021) Humoral response to neurofilaments and dipeptide repeats in ALS progression. Annals of Clinical and Translational Neurology |
| Quaegebeur A, Glaria I, Lashley T, et al. (2020) Soluble and insoluble dipeptide repeat protein measurements in C9orf72-frontotemporal dementia brains show regional differential solubility and correlation of poly-GR with clinical severity. Acta Neuropathologica Communications. 8: 184 |
| Clayton EL, Isaacs AM. (2020) Progranulin and TMEM106B: when two become wan. Embo Reports. e51668 |
| Humphrey J, Birsa N, Milioto C, et al. (2020) FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention. Nucleic Acids Research |
| Morón-Oset J, Supèr T, Esser J, et al. (2019) Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. Acta Neuropathologica Communications. 7: 209 |