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Lei Xue, Ph.D.

Affiliations: 
Fudan university, Shanghai, Shanghai Shi, China 
Area:
synaptic transmission
Website:
http://life.fudan.edu.cn/0a/48/c745a2632/page.htm
Google:
"Lei Xue"
Bio:

Dr. Xue received his B.S in Genetics in 2000 and his Ph.D. in Neurobiology in 2005 in Fudan University. From 2005 to 2012, he was first a postdoc and later a research fellow in NINDS, NIH with Dr. Ling-gang Wu, where he studied the kinetics and mechanisms of synaptic transmission at calyx of Held which is a giant synapse mediating auditory processing in the brain stem. Dr. Xue joined the School of Life Sciences in Nov 2011 as a Professor.
We study the mechanisms of synaptic transmission in the central nervous system, mainly focused on the kinetics regulation of exo-endocytosis, synaptic plasticity and the modeling of vesicle recylcing. Projects include: 1. the mechanisms of calcium controlled exo-endocytosis; 2. calcium and exo-endocytosis affected synaptic plasticity; 3. The modeling of neurotransmitter release and vesicle recycling.

Mean distance: 14.74 (cluster 6)
 		SNBCP
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Parents

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Ling-Gang Wu post-doc NINDS

Children

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Zhicheng 'George' Sun research assistant 2013-2014 Fudan university
Pan-tong Yao research assistant 2013-2016 Fudan university
Jiayang Chen research assistant 2014-2017 Fudan university

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Publications

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Wu Y, Liu Q, Guo B, et al. (2020) BDNF activates postsynaptic TrkB receptors to induce endocannabinoid release and inhibit presynaptic calcium influx at a calyx-type synapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Liu QZ, Hao M, Zhou ZY, et al. (2019) Propofol reduces synaptic strength by inhibiting sodium and calcium channels at nerve terminals. Protein & Cell
Guo J, Ge JL, Hao M, et al. (2016) Erratum: A Three-Pool Model Dissecting Readily Releasable Pool Replenishment at the Calyx of Held. Scientific Reports. 6: 31277
Sun ZC, Ge JL, Guo B, et al. (2016) Extremely Low Frequency Electromagnetic Fields Facilitate Vesicle Endocytosis by Increasing Presynaptic Calcium Channel Expression at a Central Synapse. Scientific Reports. 6: 21774
Xue L, Chen XL, Wei-Han Z, et al. (2016) Impact of Perioperative Blood Transfusion on Postoperative Complications and Prognosis of Gastric Adenocarcinoma Patients with Different Preoperative Hemoglobin Value. Gastroenterology Research and Practice. 2016: 6470857
Chen XL, Xue L, Wang W, et al. (2015) Prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study. Oncotarget
Guo J, Sun ZC, Yao PT, et al. (2015) A Monte Carlo simulation dissecting quantal release at the calyx of Held. Frontiers in Bioscience (Landmark Edition). 20: 1079-91
Guo J, Ge JL, Hao M, et al. (2015) A three-pool model dissecting readily releasable pool replenishment at the calyx of held. Scientific Reports. 5: 9517
Xue L, Chen XL, Zhang WH, et al. (2015) Risk factors and prognostic significance of retropancreatic lymph nodes in gastric adenocarcinoma. Gastroenterology Research and Practice. 2015: 367679
Xue L, Sheng J, Wu XS, et al. (2013) Most vesicles in a central nerve terminal participate in recycling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 8820-6
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