Matthew James Smith

Affiliations: 
2015- IRIC, Université de Montréal 
Area:
RAS GTPases
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Parents

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Anthony  J. Pawson grad student 2000-2007 Mt Sinai Hospital
Mitsu Ikura post-doc 2007-2014 University Health Network (Chemistry Tree)
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Publications

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Smith MJ. (2023) Defining bone fide effectors of RAS GTPases. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2300088
Goudreault M, Gagné V, Jo CH, et al. (2022) Afadin couples RAS GTPases to the polarity rheostat Scribble. Nature Communications. 13: 4562
Bernal Astrain G, Nikolova M, Smith MJ. (2022) Functional diversity in the RAS subfamily of small GTPases. Biochemical Society Transactions
Killoran RC, Smith MJ. (2021) NMR Detection Methods for Profiling RAS Nucleotide Cycling. Methods in Molecular Biology (Clifton, N.J.). 2262: 169-182
Singh S, Smith MJ. (2020) RAS GTPase signalling to alternative effector pathways. Biochemical Society Transactions. 48: 2241-2252
Dhanaraman T, Singh S, Killoran RC, et al. (2020) RASSF effectors couple diverse RAS subfamily GTPases to the Hippo pathway. Science Signaling. 13
Pestinger V, Smith M, Sillo T, et al. (2020) Correction to: Use of an Integrated Pan-Cancer Oncology Enrichment Next-Generation Sequencing Assay to Measure Tumour Mutational Burden and Detect Clinically Actionable Variants. Molecular Diagnosis & Therapy
Pestinger V, Smith M, Sillo T, et al. (2020) Use of an Integrated Pan-Cancer Oncology Enrichment Next-Generation Sequencing Assay to Measure Tumour Mutational Burden and Detect Clinically Actionable Variants. Molecular Diagnosis & Therapy
Killoran RC, Smith MJ. (2019) Conformational resolution of nucleotide cycling and effector interactions for multiple small GTPases determined in parallel. The Journal of Biological Chemistry
Spencer-Smith R, Koide A, Zhou Y, et al. (2016) Inhibition of RAS function through targeting an allosteric regulatory site. Nature Chemical Biology
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