J David Spafford

Affiliations: 
Biology University of Waterloo, Waterloo, ON, Canada 
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"J Spafford"
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Publications

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Spafford JD. (2023) A governance of ion selectivity based on the occupancy of the "beacon" in one- and four-domain calcium and sodium channels. Channels (Austin, Tex.). 17: 2191773
Guan W, Orellana KG, Stephens RF, et al. (2022) A lysine residue from an extracellular turret switches the ion preference in a Cav3 T-Type channel from calcium to sodium ions. The Journal of Biological Chemistry. 102621
Segura E, Mehta A, Marsolais M, et al. (2020) An ancestral maguk protein supports the modulation of mammalian voltage-gated Ca channels through a conserved Caβ-like interface. Biochimica Et Biophysica Acta. Biomembranes. 183439
Guan W, Stephens RF, Mourad O, et al. (2020) Unique cysteine-enriched, D2L5 and D4L6 extracellular loops in Ca3 T-type channels alter the passage and block of monovalent and divalent ions. Scientific Reports. 10: 12404
Segura E, Mehta A, Marsolais M, et al. (2020) Unicellular CaVβ Subunit Modulates Calcium Channels Biophysical Journal. 118: 107a
Fux JE, Mehta A, Moffat J, et al. (2018) Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations. Frontiers in Physiology. 9: 1406
Chemin J, Taiakina V, Monteil A, et al. (2017) Calmodulin regulates Cav3 T-type channels at their gating brake. The Journal of Biological Chemistry
Stephens RF, Guan W, Zhorov BS, et al. (2015) Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels. Frontiers in Physiology. 6: 153
Senatore A, Spafford JD. (2015) Physiology and pathology of voltage-gated t-type calcium channels T-Type Calcium Channels in Basic and Clinical Science. 3-17
Boone AN, Senatore A, Chemin J, et al. (2014) Gd3+ and calcium sensitive, sodium leak currents are features of weak membrane-glass seals in patch clamp recordings. Plos One. 9: e98808
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