J David Spafford
Affiliations: | Biology | University of Waterloo, Waterloo, ON, Canada |
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Publications
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Spafford JD. (2023) A governance of ion selectivity based on the occupancy of the "beacon" in one- and four-domain calcium and sodium channels. Channels (Austin, Tex.). 17: 2191773 |
Guan W, Orellana KG, Stephens RF, et al. (2022) A lysine residue from an extracellular turret switches the ion preference in a Cav3 T-Type channel from calcium to sodium ions. The Journal of Biological Chemistry. 102621 |
Segura E, Mehta A, Marsolais M, et al. (2020) An ancestral maguk protein supports the modulation of mammalian voltage-gated Ca channels through a conserved Caβ-like interface. Biochimica Et Biophysica Acta. Biomembranes. 183439 |
Guan W, Stephens RF, Mourad O, et al. (2020) Unique cysteine-enriched, D2L5 and D4L6 extracellular loops in Ca3 T-type channels alter the passage and block of monovalent and divalent ions. Scientific Reports. 10: 12404 |
Segura E, Mehta A, Marsolais M, et al. (2020) Unicellular CaVβ Subunit Modulates Calcium Channels Biophysical Journal. 118: 107a |
Fux JE, Mehta A, Moffat J, et al. (2018) Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations. Frontiers in Physiology. 9: 1406 |
Chemin J, Taiakina V, Monteil A, et al. (2017) Calmodulin regulates Cav3 T-type channels at their gating brake. The Journal of Biological Chemistry |
Stephens RF, Guan W, Zhorov BS, et al. (2015) Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels. Frontiers in Physiology. 6: 153 |
Senatore A, Spafford JD. (2015) Physiology and pathology of voltage-gated t-type calcium channels T-Type Calcium Channels in Basic and Clinical Science. 3-17 |
Boone AN, Senatore A, Chemin J, et al. (2014) Gd3+ and calcium sensitive, sodium leak currents are features of weak membrane-glass seals in patch clamp recordings. Plos One. 9: e98808 |