George Perry, AA, BA, PhD, HonD
|Biology||University of Texas at San Antonio, San Antonio, TX, United States|
Area:Alzheimer's disease, oxidative stress, cytoskeleton
Ph.D., Marine Biology, Scripps Institution of Oceanography, University of California
at San Diego
Postdoctoral Fellow, Department of Cell Biology, Baylor College of Medicine, Houston, Texas
Dr. Perry joined the UTSA faculty in 2006 from Case Western Reserve University where he was Professor of Pathology and Neurosciences and Chair of the Department of Pathology. Perry is distinguished as one of the top twenty Alzheimer’s disease researchers with over 900 publications. He served as Secretary-Treasurer and President for the American Association of Neuropathologists(2009). He also serves as editor for several journals including Journal of Biomedicine and Biotechnology and Microscopy Research and Technique, is on the editorial board of many journals including American Journal of Pathology and Journal of Biological Chemistry, and is Editor-in-Chief of Journal of Alzheimer’s Disease.
Our studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimer disease. We have shown that oxidative damage is the initial cytopathology in Alzheimer disease. We are working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. Our current studies focus on (i) the mechanism for RNA-based redox metal binding; (ii) the consequences of RNA oxidation on protein synthesis rate and fidelity; (iii) the role of redox active metals in mediating prooxidant and antioxidant properties; (iv) the signal transduction pathways altered in Alzheimer disease that allow neurons to evade apoptosis; and (v) mechanism of phosphorylation control of oxidative damage to neurofilament proteins.
Mean distance: 14.84 (cluster 28)
Cross-listing: Alzheimer's Tree - BCM Tree - Chemistry Tree - Neuropathology Tree
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|Kelley AR, Colley ME, Dyer S, et al. (2020) Ethanol-fixed, paraffin-embedded tissue imaging: implications for Alzheimer's disease research. Journal of the American Society For Mass Spectrometry|
|Plascencia-Villa G, Perry G. (2020) Status and future directions of clinical trials in Alzheimer's disease. International Review of Neurobiology. 154: 3-50|
|Reyes-Pablo AE, Campa-Córdoba BB, Luna-Viramontes NI, et al. (2020) National Dementia BioBank: A Strategy for the Diagnosis and Study of Neurodegenerative Diseases in México. Journal of Alzheimer's Disease : Jad|
|Veurink G, Perry G, Singh SK. (2020) Role of antioxidants and a nutrient rich diet in Alzheimer's disease. Open Biology. 10: 200084|
|Hernandes-Alejandro M, Montaño S, Harrington CR, et al. (2020) Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad|
|Plascencia-Villa G, Perry G. (2020) Preventive and therapeutic strategies in Alzheimer's disease: focus on oxidative stress, redox metals and ferroptosis. Antioxidants & Redox Signaling|
|Wang W, Zhao F, Ma X, et al. (2020) Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances. Molecular Neurodegeneration. 15: 30|
|Reddy VP, Aryal P, Robinson S, et al. (2020) Polyphenols in Alzheimer's Disease and in the Gut-Brain Axis. Microorganisms. 8|
|Gao J, Wang L, Gao C, et al. (2019) TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165580|
|Iverson GL, Gardner AJ, Shultz SR, et al. (2019) Chronic traumatic encephalopathy neuropathology might not be inexorably progressive or unique to repetitive neurotrauma. Brain : a Journal of Neurology|