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Abigail S. Hackam - Publications

Affiliations: 
Ophthalmology University of Miami Medical School Bascom Palmer Eye Institute, Miami, FL, United States 
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Patel AK, Davis A, Rodriguez ME, Agron S, Hackam AS. Protective effects of a grape-supplemented diet in a mouse model of retinal degeneration. Nutrition (Burbank, Los Angeles County, Calif.). PMID 26732835 DOI: 10.1016/j.nut.2015.09.017  0.64
2015 Seigel GM, Sharma S, Hackam AS, Shah DK. HER2/ERBB2 immunoreactivity in human retinoblastoma. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. PMID 26614428 DOI: 10.1007/s13277-015-4475-y  0.64
2015 Patel AK, Akinsoji E, Hackam AS. Defining the Relationships Among Retinal Function, Layer Thickness and Visual Behavior During Oxidative Stress-Induced Retinal Degeneration. Current Eye Research. 1-10. PMID 26554945 DOI: 10.3109/02713683.2015.1083588  0.64
2015 Chhadva P, Lee T, Sarantopoulos CD, Hackam AS, McClellan AL, Felix ER, Levitt RC, Galor A. Human Tear Serotonin Levels Correlate with Symptoms and Signs of Dry Eye. Ophthalmology. 122: 1675-80. PMID 25983214 DOI: 10.1016/j.ophtha.2015.04.010  0.64
2015 Syeda S, Patel AK, Lee T, Hackam AS. Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88. Experimental Neurology. 267: 1-12. PMID 25725353 DOI: 10.1016/j.expneurol.2015.02.027  0.64
2015 Patel AK, Surapaneni K, Yi H, Nakamura RE, Karli SZ, Syeda S, Lee T, Hackam AS. Activation of Wnt/β-catenin signaling in Muller glia protects photoreceptors in a mouse model of inherited retinal degeneration. Neuropharmacology. 91: 1-12. PMID 25486619 DOI: 10.1016/j.neuropharm.2014.11.015  0.64
2014 Patel AK, Hackam AS. A novel protective role for the innate immunity Toll-Like Receptor 3 (TLR3) in the retina via Stat3. Molecular and Cellular Neurosciences. 63: 38-48. PMID 25264029 DOI: 10.1016/j.mcn.2014.09.004  0.64
2013 Patel AK, Hackam AS. Toll-like receptor 3 (TLR3) protects retinal pigmented epithelium (RPE) cells from oxidative stress through a STAT3-dependent mechanism. Molecular Immunology. 54: 122-31. PMID 23267850 DOI: 10.1016/j.molimm.2012.11.005  0.64
2012 Fragoso MA, Patel AK, Nakamura RE, Yi H, Surapaneni K, Hackam AS. The Wnt/β-catenin pathway cross-talks with STAT3 signaling to regulate survival of retinal pigment epithelium cells. Plos One. 7: e46892. PMID 23056515 DOI: 10.1371/journal.pone.0046892  0.64
2012 Yi H, Patel AK, Sodhi CP, Hackam DJ, Hackam AS. Novel role for the innate immune receptor Toll-like receptor 4 (TLR4) in the regulation of the Wnt signaling pathway and photoreceptor apoptosis. Plos One. 7: e36560. PMID 22615780 DOI: 10.1371/journal.pone.0036560  0.64
2012 Yi H, Hu J, Qian J, Hackam AS. Expression of brain-derived neurotrophic factor is regulated by the Wnt signaling pathway. Neuroreport. 23: 189-94. PMID 22198686 DOI: 10.1097/WNR.0b013e32834fab06  0.64
2011 Fragoso MA, Yi H, Nakamura RE, Hackam AS. The Wnt signaling pathway protects retinal ganglion cell 5 (RGC-5) cells from elevated pressure. Cellular and Molecular Neurobiology. 31: 163-73. PMID 21061158 DOI: 10.1007/s10571-010-9603-z  0.64
2010 Nakamura RE, Hackam AS. Analysis of Dickkopf3 interactions with Wnt signaling receptors. Growth Factors (Chur, Switzerland). 28: 232-42. PMID 20370576 DOI: 10.3109/08977191003738832  0.64
2010 Silva AK, Yi H, Hayes SH, Seigel GM, Hackam AS. Lithium chloride regulates the proliferation of stem-like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway. Molecular Vision. 16: 36-45. PMID 20069066  0.64
2008 Cebulla CM, Jockovich ME, Piña Y, Boutrid H, Alegret A, Kulak A, Hackam AS, Bhattacharya SK, Feuer WJ, Murray TG. Basic fibroblast growth factor impact on retinoblastoma progression and survival. Investigative Ophthalmology & Visual Science. 49: 5215-21. PMID 18614803 DOI: 10.1167/iovs.07-1668  0.64
2008 Hackam DG, Hackam AS. Translation of genetic discoveries into clinical therapies. Annals of Internal Medicine. 148: 246-7. PMID 18252690  0.64
2008 Hackam AS. Regulation of neurotrophin expression and activity in the retina. Advances in Experimental Medicine and Biology. 613: 343-9. PMID 18188963 DOI: 10.1007/978-0-387-74904-4_40  0.64
2007 Nakamura RE, Hunter DD, Yi H, Brunken WJ, Hackam AS. Identification of two novel activities of the Wnt signaling regulator Dickkopf 3 and characterization of its expression in the mouse retina. Bmc Cell Biology. 8: 52. PMID 18093317 DOI: 10.1186/1471-2121-8-52  0.64
2007 Yi H, Nakamura RE, Mohamed O, Dufort D, Hackam AS. Characterization of Wnt signaling during photoreceptor degeneration. Investigative Ophthalmology & Visual Science. 48: 5733-41. PMID 18055826 DOI: 10.1167/iovs.07-0097  0.64
2007 Seigel GM, Hackam AS, Ganguly A, Mandell LM, Gonzalez-Fernandez F. Human embryonic and neuronal stem cell markers in retinoblastoma. Molecular Vision. 13: 823-32. PMID 17615543  0.64
2007 Ruggeri M, Wehbe H, Jiao S, Gregori G, Jockovich ME, Hackam A, Duan Y, Puliafito CA. In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography. Investigative Ophthalmology & Visual Science. 48: 1808-14. PMID 17389515 DOI: 10.1167/iovs.06-0815  0.64
2007 Ruggeri M, Wehbe H, Jiao S, Gregori G, Jockovich ME, Hackam A, Duan Y, Puliafito CA. Spectral domain optical coherence tomography for in-vivo three dimensional retinal imaging of small animals Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6429. DOI: 10.1117/12.700437  0.64
2007 Shuliang J, Ruggeri M, Wehbe H, Gregory G, Jockovich ME, Hackam A, Puliafito CA. Imaging of eye tumor in the mouse model of retinoblastoma with spectral-domain optical coherence tomography Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6426. DOI: 10.1117/12.700338  0.64
2006 Tell S, Yi H, Jockovich ME, Murray TG, Hackam AS. The Wnt signaling pathway has tumor suppressor properties in retinoblastoma. Biochemical and Biophysical Research Communications. 349: 261-9. PMID 16930536 DOI: 10.1016/j.bbrc.2006.08.044  0.64
2005 Hackam AS. The Wnt signaling pathway in retinal degenerations. Iubmb Life. 57: 381-8. PMID 16012046 DOI: 10.1080/15216540500137586  0.64
2004 Hackam AS, Qian J, Liu D, Gunatilaka T, Farkas RH, Chowers I, Kageyama M, Parmigiani G, Zack DJ. Comparative gene expression analysis of murine retina and brain. Molecular Vision. 10: 637-49. PMID 15359217  0.64
2004 Hackam AS, Strom R, Liu D, Qian J, Wang C, Otteson D, Gunatilaka T, Farkas RH, Chowers I, Kageyama M, Leveillard T, Sahel JA, Campochiaro PA, Parmigiani G, Zack DJ. Identification of gene expression changes associated with the progression of retinal degeneration in the rd1 mouse. Investigative Ophthalmology & Visual Science. 45: 2929-42. PMID 15326104 DOI: 10.1167/iovs.03-1184  0.64
2004 Chowers I, Kim Y, Farkas RH, Gunatilaka TL, Hackam AS, Campochiaro PA, Finnemann SC, Zack DJ. Changes in retinal pigment epithelial gene expression induced by rod outer segment uptake. Investigative Ophthalmology & Visual Science. 45: 2098-106. PMID 15223782 DOI: 10.1167/iovs.03-0863  0.64
2004 Farkas RH, Chowers I, Hackam AS, Kageyama M, Nickells RW, Otteson DC, Duh EJ, Wang C, Valenta DF, Gunatilaka TL, Pease ME, Quigley HA, Zack DJ. Increased expression of iron-regulating genes in monkey and human glaucoma. Investigative Ophthalmology & Visual Science. 45: 1410-7. PMID 15111596 DOI: 10.1167/iovs.03-0872  0.64
2004 Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death and Differentiation. 11: 424-38. PMID 14713958 DOI: 10.1038/sj.cdd.4401358  0.64
2003 Chowers I, Liu D, Farkas RH, Gunatilaka TL, Hackam AS, Bernstein SL, Campochiaro PA, Parmigiani G, Zack DJ. Gene expression variation in the adult human retina. Human Molecular Genetics. 12: 2881-93. PMID 14519682 DOI: 10.1093/hmg/ddg326  0.64
2003 Chowers I, Gunatilaka TL, Farkas RH, Qian J, Hackam AS, Duh E, Kageyama M, Wang C, Vora A, Campochiaro PA, Zack DJ. Identification of novel genes preferentially expressed in the retina using a custom human retina cDNA microarray. Investigative Ophthalmology & Visual Science. 44: 3732-41. PMID 12939286 DOI: 10.1167/iovs.02-1080  0.64
2003 Hackam AS, Bradford RL, Bakhru RN, Shah RM, Farkas R, Zack DJ, Adler R. Gene discovery in the embryonic chick retina. Molecular Vision. 9: 262-76. PMID 12819621  0.64
2002 Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancourt JP, Houtzager V, Rasper DM, Roy S, Hayden MR, Nicholson DW. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nature Cell Biology. 4: 95-105. PMID 11788820 DOI: 10.1038/ncb735  0.64
2002 Hackam AS. Keeping an eye on splicing Clinical Genetics. 61: 169-170. DOI: 10.1034/j.1399-0004.2002.610301.x  0.64
2002 Hackam AS. Schizophrenia genetics Clinical Genetics. 62: 434-436.  0.64
2002 Hackam AS. Down with mutant GATA1 Clinical Genetics. 62: 433-434.  0.64
2002 Hackam AS. Man and mouse: A comparison between two genomes Clinical Genetics. 62: 436-437.  0.64
2002 Hackam AS. A FOX speaks Clinical Genetics. 61: 170-173.  0.64
2002 Hackam AS. An aneuploidy surprise Clinical Genetics. 61: 173-175.  0.64
2001 Hackam AS. HotSpots Clinical Genetics. 59: 150-155. DOI: 10.1034/j.1399-0004.2001.590302.x  0.64
2000 Hackam AS, Yassa AS, Singaraja R, Metzler M, Gutekunst CA, Gan L, Warby S, Wellington CL, Vaillancourt J, Chen N, Gervais FG, Raymond L, Nicholson DW, Hayden MR. Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain. The Journal of Biological Chemistry. 275: 41299-308. PMID 11007801 DOI: 10.1074/jbc.M008408200  0.64
2000 Rigamonti D, Bauer JH, De-Fraja C, Conti L, Sipione S, Sciorati C, Clementi E, Hackam A, Hayden MR, Li Y, Cooper JK, Ross CA, Govoni S, Vincenz C, Cattaneo E. Wild-type huntingtin protects from apoptosis upstream of caspase-3. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3705-13. PMID 10804212  0.64
2000 Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B, Cattaneo E, Hackam A, Sharp A, Thornberry N, Nicholson DW, Bredesen DE, Hayden MR. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. The Journal of Biological Chemistry. 275: 19831-8. PMID 10770929 DOI: 10.1074/jbc.M001475200  0.64
1999 Hackam AS, Hodgson JG, Singaraja R, Zhang T, Gan L, Gutekunst CA, Hersch SM, Hayden MR. Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 1047-55. PMID 10434304 DOI: 10.1098/rstb.1999.0457  0.64
1999 Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. The Journal of Biological Chemistry. 274: 8730-6. PMID 10085113 DOI: 10.1074/jbc.274.13.8730  0.64
1999 Hackam AS, Singaraja R, Zhang T, Gan L, Hayden MR. In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease. Human Molecular Genetics. 8: 25-33. PMID 9887328 DOI: 10.1093/hmg/8.1.25  0.64
1999 Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. Journal of Neurochemistry. 72: 185-95. PMID 9886069 DOI: 10.1046/j.1471-4159.1999.0720185.x  0.64
1998 Hackam AS, Wellington CL, Hayden MR. The fatal attraction of polyglutamine-containing proteins. Clinical Genetics. 53: 233-42. PMID 9650759  0.64
1998 Hackam AS, Singaraja R, Wellington CL, Metzler M, McCutcheon K, Zhang T, Kalchman M, Hayden MR. The influence of huntingtin protein size on nuclear localization and cellular toxicity. The Journal of Cell Biology. 141: 1097-105. PMID 9606203 DOI: 10.1083/jcb.141.5.1097  0.64
1998 Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, et al. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. The Journal of Biological Chemistry. 273: 9158-67. PMID 9535906 DOI: 10.1074/jbc.273.15.9158  0.64
1998 Martindale D, Hackam A, Wieczorek A, Ellerby L, Wellington C, McCutcheon K, Singaraja R, Kazemi-Esfarjani P, Devon R, Kim SU, Bredesen DE, Tufaro F, Hayden MR. Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates Nature Genetics. 18: 150-154. PMID 9462744 DOI: 10.1038/ng0298-150  0.64
1998 Hackam AS, Wang TL, Guggino WB, Cutting GR. Sequences in the amino termini of GABA rho and GABA(A) subunits specify their selective interaction in vitro. Journal of Neurochemistry. 70: 40-6. PMID 9422345  0.64
1997 Qian H, Hyatt G, Schanzer A, Hazra R, Hackam AS, Cutting GR, Dowling JE. A comparison of GABAC and rho subunit receptors from the white perch retina. Visual Neuroscience. 14: 843-51. PMID 9364723  0.64
1997 Hackam AS, Wang TL, Guggino WB, Cutting GR. A 100 amino acid region in the GABA rho 1 subunit confers robust homo-oligomeric expression. Neuroreport. 8: 1425-30. PMID 9172147  0.64
1997 Hackam AS, Wang TL, Guggino WB, Cutting GR. The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction. The Journal of Biological Chemistry. 272: 13750-7. PMID 9153229 DOI: 10.1074/jbc.272.21.13750  0.64
1997 Hackam AS, Wang TL, Guggino WB, Cutting GR. The amino termini of GABAP and GABAA subunits contain sequences for their selective interaction Investigative Ophthalmology and Visual Science. 38: S588.  0.64
1996 Hackam AS, Wang TL, Guggino WB, Cutting GR. The N-terminal domain of GABA receptor subunit ρ1 contains regions required for subunit assembly Investigative Ophthalmology and Visual Science. 37: S138.  0.64
1996 Cutting GR, Mickle J, Blaschak CJ, Hackam AS. Stable expression of human GABAC receptor ρ1 subunit in a human embryonic kidney cell line Investigative Ophthalmology and Visual Science. 37: S138.  0.64
1995 Wang TL, Hackam AS, Guggino WB, Cutting GR. A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition. Proceedings of the National Academy of Sciences of the United States of America. 92: 11751-5. PMID 8524842 DOI: 10.1073/pnas.92.25.11751  0.64
1995 Wang TL, Hackam A, Guggino WB, Cutting GR. A single histidine residue is essential for zinc inhibition of GABA ρ1 receptors Journal of Neuroscience. 15: 7684-7691. PMID 7472519  0.64
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