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Year Citation  Score
2018 Danandeh A, Vozella V, Lim J, Oveisi F, Ramirez GL, Mears D, Wynn G, Piomelli D. Effects of fatty acid amide hydrolase inhibitor URB597 in a rat model of trauma-induced long-term anxiety. Psychopharmacology. PMID 30251159 DOI: 10.1007/s00213-018-5020-7  0.44
2018 Spadoni G, Bedini A, Furiassi L, Mari M, Mor M, Scalvini L, Lodola A, Ghidini A, Lucini V, Dugnani S, Scaglione F, Piomelli D, Jung KM, Supuran CT, Lucarini L, et al. Identification of bivalent ligands with melatonin receptor agonist and fatty acid amide hydrolase (FAAH) inhibitory activity that exhibit ocular hypotensive effect in the rabbit. Journal of Medicinal Chemistry. PMID 30126274 DOI: 10.1021/acs.jmedchem.8b00893  0.52
2018 Koethe D, Pahlisch F, Hellmich M, Rohleder C, Mueller JK, Meyer-Lindenberg A, Torrey EF, Piomelli D, Leweke FM. Familial Abnormalities of Endocannabinoid Signaling in Schizophrenia. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1-26. PMID 29521179 DOI: 10.1080/15622975.2018.1449966  0.96
2017 Castellani B, Diamanti E, Pizzirani D, Tardia P, Maccesi M, Realini N, Magotti P, Garau G, Bakkum T, Rivara S, Mor M, Piomelli D. Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD). Chemical Communications (Cambridge, England). PMID 29143042 DOI: 10.1039/c7cc07582k  0.52
2017 Angelini R, Argueta DA, Piomelli D, DiPatrizio NV. Identification of a Widespread Palmitoylethanolamide Contamination in Standard Laboratory Glassware. Cannabis and Cannabinoid Research. 2: 123-132. PMID 28861512 DOI: 10.1089/can.2017.0019  0.88
2017 Rock EM, Moreno-Sanz G, Limebeer CL, Petrie GN, Angelini R, Piomelli D, Parker LA. Suppression of acute and anticipatory nausea by peripherally restricted FAAH inhibitor in animal models: Role of PPARα and CB1 receptors. British Journal of Pharmacology. PMID 28805944 DOI: 10.1111/bph.13980  0.48
2017 Khurana L, Mackie K, Piomelli D, Kendall DA. Modulation of CB1 cannabinoid receptor by allosteric ligands: Pharmacology and therapeutic opportunities. Neuropharmacology. PMID 28527758 DOI: 10.1016/j.neuropharm.2017.05.018  0.8
2017 Wang W, Jia Y, Pham DT, Palmer LC, Jung KM, Cox CD, Rumbaugh G, Piomelli D, Gall CM, Lynch G. Atypical Endocannabinoid Signaling Initiates a New Form of Memory-Related Plasticity at a Cortical Input to Hippocampus. Cerebral Cortex (New York, N.Y. : 1991). 1-14. PMID 28520937 DOI: 10.1093/cercor/bhx126  0.52
2016 Moradi H, Oveisi F, Khanifar E, Moreno-Sanz G, Vaziri ND, Piomelli D. Increased Renal 2-Arachidonoylglycerol Level Is Associated with Improved Renal Function in a Mouse Model of Acute Kidney Injury. Cannabis and Cannabinoid Research. 1: 218-228. PMID 28861493 DOI: 10.1089/can.2016.0013  0.44
2016 den Hoedt S, Janssen CI, Astarita G, Piomelli D, Leijten FP, Crivelli SM, Verhoeven AJ, de Vries HE, Walter J, Martinez-Martinez P, Sijbrands EJ, Kiliaan AJ, Mulder MT. Pleiotropic Effect of Human ApoE4 on Cerebral Ceramide and Saturated Fatty Acid Levels. Journal of Alzheimer's Disease : Jad. PMID 28035926 DOI: 10.3233/JAD-160739  0.52
2016 Igarashi M, Narayanaswami V, Kimonis V, Galassetti PM, Oveisi F, Jung KM, Piomelli D. Dysfunctional oleoylethanolamide signaling in a mouse model of Prader-Willi syndrome. Pharmacological Research. PMID 28007570 DOI: 10.1016/j.phrs.2016.12.024  0.52
2016 Lee SH, Dudok B, Parihar VK, Jung KM, Zöldi M, Kang YJ, Maroso M, Alexander AL, Nelson GA, Piomelli D, Katona I, Limoli CL, Soltesz I. Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission. Brain Structure & Function. PMID 27905022 DOI: 10.1007/s00429-016-1345-3  0.52
2016 Wang W, Trieu BH, Palmer LC, Jia Y, Pham DT, Jung KM, Karsten CA, Merrill CB, Mackie K, Gall CM, Piomelli D, Lynch G. A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation. Eneuro. 3. PMID 27517090 DOI: 10.1523/ENEURO.0160-16.2016  0.8
2016 Scalvini L, Vacondio F, Bassi M, Pala D, Lodola A, Rivara S, Jung KM, Piomelli D, Mor M. Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL. Scientific Reports. 6: 31046. PMID 27499063 DOI: 10.1038/srep31046  1
2016 Migliore M, Pontis S, Fuentes de Arriba AL, Realini N, Torrente E, Armirotti A, Romeo E, Di Martino S, Russo D, Pizzirani D, Summa M, Lanfranco M, Ottonello G, Busquet P, Jung KM, ... ... Piomelli D, et al. Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis. Angewandte Chemie (International Ed. in English). PMID 27404798 DOI: 10.1002/anie.201603746  1
2016 Wang H, Taussig MD, DiPatrizio NV, Bruce K, Piomelli D, Eckel RH. Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition. Metabolism: Clinical and Experimental. 65: 987-97. PMID 27282869 DOI: 10.1016/j.metabol.2016.01.015  0.88
2016 Jung KM, Piomelli D. Assay of Monoacylglycerol Lipase Activity. Methods in Molecular Biology (Clifton, N.J.). 1412: 157-68. PMID 27245902 DOI: 10.1007/978-1-4939-3539-0_17  0.52
2016 Jacome-Sosa M, Vacca C, Mangat R, Diane A, Nelson RC, Reaney MJ, Shen J, Curtis JM, Vine DF, Field CJ, Igarashi M, Piomelli D, Banni S, Proctor SD. Vaccenic acid suppresses intestinal inflammation by increasing the endocannabinoid anandamide and non-cannabinoid signaling molecules in a rat model of the metabolic syndrome. Journal of Lipid Research. PMID 26891736 DOI: 10.1194/jlr.M066308  1
2016 Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, ... ... Piomelli D, et al. Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain. Journal of Medicinal Chemistry. PMID 26888301 DOI: 10.1021/acs.jmedchem.5b01812  1
2016 Wei D, Lee D, Li D, Daglian J, Jung KM, Piomelli D. A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice. Psychopharmacology. PMID 26873082 DOI: 10.1007/s00213-016-4222-0  1
2016 Nuzzi A, Fiasella A, Ortega JA, Pagliuca C, Ponzano S, Pizzirani D, Bertozzi SM, Ottonello G, Tarozzo G, Reggiani A, Bandiera T, Bertozzi F, Piomelli D. Potent α-amino-β-lactam carbamic acid ester as NAAA inhibitors. Synthesis and structure-activity relationship (SAR) studies. European Journal of Medicinal Chemistry. 111: 138-159. PMID 26866968 DOI: 10.1016/j.ejmech.2016.01.046  1
2015 Migliore M, Habrant D, Sasso O, Albani C, Bertozzi SM, Armirotti A, Piomelli D, Scarpelli R. Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies. European Journal of Medicinal Chemistry. 109: 216-237. PMID 26774927 DOI: 10.1016/j.ejmech.2015.12.036  1
2015 Veronesi M, Giacomina F, Romeo E, Castellani B, Ottonello G, Lambruschini C, Garau G, Scarpelli R, Bandiera T, Piomelli D, Dalvit C. Fluorine NMR-based assay in living mammalian cells. Analytical Biochemistry. PMID 26686030 DOI: 10.1016/j.ab.2015.11.015  1
2015 Pontis S, Ribeiro A, Sasso O, Piomelli D. Macrophage-derived lipid agonists of PPAR-α as intrinsic controllers of inflammation. Critical Reviews in Biochemistry and Molecular Biology. 1-8. PMID 26585314 DOI: 10.3109/10409238.2015.1092944  1
2015 Bach A, Pizzirani D, Realini N, Vozella V, Russo D, Penna I, Melzig L, Scarpelli R, Piomelli D. Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies. Journal of Medicinal Chemistry. PMID 26560855 DOI: 10.1021/acs.jmedchem.5b01188  1
2015 Realini N, Palese F, Pizzirani D, Pontis S, Basit A, Bach A, Ganesan A, Piomelli D. Acid Ceramidase in Melanoma: Expression, Localization and Effects of Pharmacological Inhibition. The Journal of Biological Chemistry. PMID 26553872 DOI: 10.1074/jbc.M115.666909  1
2015 Wei D, Lee D, Cox CD, Karsten CA, Peñagarikano O, Geschwind DH, Gall CM, Piomelli D. Endocannabinoid signaling mediates oxytocin-driven social reward. Proceedings of the National Academy of Sciences of the United States of America. PMID 26504214 DOI: 10.1073/pnas.1509795112  1
2015 Scarpelli R, Sasso O, Piomelli D. A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation. Chemmedchem. PMID 26486424 DOI: 10.1002/cmdc.201500395  1
2015 Lim J, Igarashi M, Jung KM, Butini S, Campiani G, Piomelli D. Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26361059 DOI: 10.1038/npp.2015.284  1
2015 DiPatrizio NV, Igarashi M, Narayanaswami V, Murray C, Gancayco J, Russell A, Jung KM, Piomelli D. Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00239.2015. PMID 26290104 DOI: 10.1152/ajpregu.00239.2015  1
2015 Yu T, Taussig MD, DiPatrizio NV, Astarita G, Piomelli D, Bergman BC, Dell'Acqua ML, Eckel RH, Wang H. Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice. Plos One. 10: e0135113. PMID 26263173 DOI: 10.1371/journal.pone.0135113  1
2015 Scalvini L, Piomelli D, Mor M. Monoglyceride lipase: Structure and inhibitors. Chemistry and Physics of Lipids. PMID 26216043 DOI: 10.1016/j.chemphyslip.2015.07.011  0.52
2015 Romeo E, Ponzano S, Armirotti A, Summa M, Bertozzi F, Garau G, Bandiera T, Piomelli D. Activity-Based Probe for N-Acylethanolamine Acid Amidase. Acs Chemical Biology. 10: 2057-64. PMID 26102511 DOI: 10.1021/acschembio.5b00197  1
2015 Bilbao A, Serrano A, Cippitelli A, Pavón FJ, Giuffrida A, Suárez J, García-Marchena N, Baixeras E, Gómez de Heras R, Orio L, Alén F, Ciccocioppo R, Cravatt BF, Parsons LH, Piomelli D, et al. Role of the satiety factor oleoylethanolamide in alcoholism. Addiction Biology. PMID 26037332 DOI: 10.1111/adb.12276  1
2015 Igarashi M, DiPatrizio NV, Narayanaswami V, Piomelli D. Feeding-induced oleoylethanolamide mobilization is disrupted in the gut of diet-induced obese rodents. Biochimica Et Biophysica Acta. 1851: 1218-26. PMID 26024927 DOI: 10.1016/j.bbalip.2015.05.006  0.88
2015 Dotsey EY, Jung KM, Basit A, Wei D, Daglian J, Vacondio F, Armirotti A, Mor M, Piomelli D. Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons. Chemistry & Biology. 22: 619-28. PMID 26000748 DOI: 10.1016/j.chembiol.2015.04.013  1
2015 Sasso O, Wagner K, Morisseau C, Inceoglu B, Hammock BD, Piomelli D. Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 97: 7-15. PMID 25882247 DOI: 10.1016/j.phrs.2015.04.001  1
2015 Ribeiro A, Pontis S, Mengatto L, Armirotti A, Chiurchiù V, Capurro V, Fiasella A, Nuzzi A, Romeo E, Moreno-Sanz G, Maccarrone M, Reggiani A, Tarzia G, Mor M, Bertozzi F, ... ... Piomelli D, et al. A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation. Acs Chemical Biology. PMID 25874594 DOI: 10.1021/acschembio.5b00114  1
2015 Sasso O, Migliore M, Habrant D, Armirotti A, Albani C, Summa M, Moreno-Sanz G, Scarpelli R, Piomelli D. Multitarget fatty acid amide hydrolase/cyclooxygenase blockade suppresses intestinal inflammation and protects against nonsteroidal anti-inflammatory drug-dependent gastrointestinal damage. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2616-27. PMID 25757568 DOI: 10.1096/fj.15-270637  1
2015 Justinova Z, Panlilio LV, Moreno-Sanz G, Redhi GH, Auber A, Secci ME, Mascia P, Bandiera T, Armirotti A, Bertorelli R, Chefer SI, Barnes C, Yasar S, Piomelli D, Goldberg SR. Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2185-97. PMID 25754762 DOI: 10.1038/npp.2015.62  1
2015 Basit A, Piomelli D, Armirotti A. Rapid evaluation of 25 key sphingolipids and phosphosphingolipids in human plasma by LC-MS/MS. Analytical and Bioanalytical Chemistry. 407: 5189-98. PMID 25749796 DOI: 10.1007/s00216-015-8585-6  1
2015 Niki M, Jyotaki M, Yoshida R, Yasumatsu K, Shigemura N, DiPatrizio NV, Piomelli D, Ninomiya Y. Modulation of sweet taste sensitivities by endogenous leptin and endocannabinoids in mice. The Journal of Physiology. 593: 2527-45. PMID 25728242 DOI: 10.1113/JP270295  1
2015 Magotti P, Bauer I, Igarashi M, Babagoli M, Marotta R, Piomelli D, Garau G. Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids. Structure (London, England : 1993). 23: 598-604. PMID 25684574 DOI: 10.1016/j.str.2014.12.018  1
2015 Astarita G, Avanesian A, Grimaldi B, Realini N, Justinova Z, Panlilio LV, Basit A, Goldberg SR, Piomelli D. Methamphetamine accelerates cellular senescence through stimulation of de novo ceramide biosynthesis. Plos One. 10: e0116961. PMID 25671639 DOI: 10.1371/journal.pone.0116961  1
2015 DiPatrizio NV, Piomelli D. Intestinal lipid-derived signals that sense dietary fat. The Journal of Clinical Investigation. 125: 891-8. PMID 25642767 DOI: 10.1172/JCI76302  1
2015 Greco R, Bandiera T, Mangione A, Demartini C, Siani F, Nappi G, Sandrini G, Guijarro A, Armirotti A, Piomelli D, Tassorelli C. Effects of peripheral FAAH blockade on NTG-induced hyperalgesia-evaluation of URB937 in an animal model of migraine. Cephalalgia : An International Journal of Headache. PMID 25608877 DOI: 10.1177/0333102414566862  1
2015 Pizzirani D, Bach A, Realini N, Armirotti A, Mengatto L, Bauer I, Girotto S, Pagliuca C, De Vivo M, Summa M, Ribeiro A, Piomelli D. Benzoxazolone carboxamides: potent and systemically active inhibitors of intracellular acid ceramidase. Angewandte Chemie (International Ed. in English). 54: 485-9. PMID 25395373 DOI: 10.1002/anie.201409042  1
2015 Colombano G, Albani C, Ottonello G, Ribeiro A, Scarpelli R, Tarozzo G, Daglian J, Jung KM, Piomelli D, Bandiera T. O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors. Chemmedchem. 10: 380-95. PMID 25338703 DOI: 10.1002/cmdc.201402374  1
2015 Scalvini L, Piomelli D, Mor M. Monoglyceride lipase: Structure and inhibitors Chemistry and Physics of Lipids. DOI: 10.1016/j.chemphyslip.2015.07.011  1
2015 Igarashi M, DiPatrizio NV, Narayanaswami V, Piomelli D. Feeding-induced oleoylethanolamide mobilization is disrupted in the gut of diet-induced obese rodents Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1851: 1218-1226. DOI: 10.1016/j.bbalip.2015.05.006  1
2014 Piomelli D, Hohmann AG, Seybold V, Hammock BD. A lipid gate for the peripheral control of pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15184-91. PMID 25392487 DOI: 10.1523/JNEUROSCI.3475-14.2014  1
2014 Ponzano S, Berteotti A, Petracca R, Vitale R, Mengatto L, Bandiera T, Cavalli A, Piomelli D, Bertozzi F, Bottegoni G. Synthesis, biological evaluation, and 3D QSAR study of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters as N-acylethanolamine acid amidase (NAAA) inhibitors. Journal of Medicinal Chemistry. 57: 10101-11. PMID 25380517 DOI: 10.1021/jm501455s  1
2014 Moreno-Sanz G, Barrera B, Armirotti A, Bertozzi SM, Scarpelli R, Bandiera T, Prieto JG, Duranti A, Tarzia G, Merino G, Piomelli D. Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 87: 87-93. PMID 24993496 DOI: 10.1016/j.phrs.2014.06.004  1
2014 Piomelli D. A mighty (ochondrial) fight? Molecular Metabolism. 3: 345-6. PMID 24944892 DOI: 10.1016/j.molmet.2014.04.005  1
2014 Fiasella A, Nuzzi A, Summa M, Armirotti A, Tarozzo G, Tarzia G, Mor M, Bertozzi F, Bandiera T, Piomelli D. 3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration. Chemmedchem. 9: 1602-14. PMID 24828120 DOI: 10.1002/cmdc.201300546  1
2014 Pietrzak RH, Huang Y, Corsi-Travali S, Zheng MQ, Lin SF, Henry S, Potenza MN, Piomelli D, Carson RE, Neumeister A. Cannabinoid type 1 receptor availability in the amygdala mediates threat processing in trauma survivors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2519-28. PMID 24820537 DOI: 10.1038/npp.2014.110  1
2014 Bandiera T, Ponzano S, Piomelli D. Advances in the discovery of N-acylethanolamine acid amidase inhibitors. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 86: 11-7. PMID 24798679 DOI: 10.1016/j.phrs.2014.04.011  1
2014 Armirotti A, Basit A, Realini N, Caltagirone C, Bossù P, Spalletta G, Piomelli D. Sample preparation and orthogonal chromatography for broad polarity range plasma metabolomics: application to human subjects with neurodegenerative dementia. Analytical Biochemistry. 455: 48-54. PMID 24708938 DOI: 10.1016/j.ab.2014.03.019  1
2014 De Simone A, Ruda GF, Albani C, Tarozzo G, Bandiera T, Piomelli D, Cavalli A, Bottegoni G. Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase. Chemical Communications (Cambridge, England). 50: 4904-7. PMID 24691497 DOI: 10.1039/c4cc00967c  1
2014 Piomelli D. A discount on cannabinoids. Biological Psychiatry. 75: 432-4. PMID 24560432 DOI: 10.1016/j.biopsych.2014.01.010  1
2014 Piomelli D, Sasso O. Peripheral gating of pain signals by endogenous lipid mediators. Nature Neuroscience. 17: 164-74. PMID 24473264 DOI: 10.1038/nn.3612  1
2014 Sahar S, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, et al. Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1. The Journal of Biological Chemistry. 289: 6091-7. PMID 24425865 DOI: 10.1074/jbc.M113.537191  1
2014 Vitale R, Ottonello G, Petracca R, Bertozzi SM, Ponzano S, Armirotti A, Berteotti A, Dionisi M, Cavalli A, Piomelli D, Bandiera T, Bertozzi F. Synthesis, structure-activity, and structure-stability relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine acid amidase (NAAA) inhibitors. Chemmedchem. 9: 323-36. PMID 24403170 DOI: 10.1002/cmdc.201300416  1
2014 Holman EA, Guijarro A, Lim J, Piomelli D. Effects of acute stress on cardiac endocannabinoids, lipogenesis, and inflammation in rats. Psychosomatic Medicine. 76: 20-8. PMID 24367128 DOI: 10.1097/PSY.0000000000000025  1
2014 Veronesi M, Romeo E, Lambruschini C, Piomelli D, Bandiera T, Scarpelli R, Garau G, Dalvit C. Fluorine NMR-based screening on cell membrane extracts. Chemmedchem. 9: 286-9. PMID 24339446 DOI: 10.1002/cmdc.201300438  1
2014 Iorio M, Sasso O, Maffioli SI, Bertorelli R, Monciardini P, Sosio M, Bonezzi F, Summa M, Brunati C, Bordoni R, Corti G, Tarozzo G, Piomelli D, Reggiani A, Donadio S. A glycosylated, labionin-containing lanthipeptide with marked antinociceptive activity. Acs Chemical Biology. 9: 398-404. PMID 24191663 DOI: 10.1021/cb400692w  1
2014 Llewellyn KJ, Nalbandian A, Jung KM, Nguyen C, Avanesian A, Mozaffar T, Piomelli D, Kimonis VE. Lipid-enriched diet rescues lethality and slows down progression in a murine model of VCP-associated disease. Human Molecular Genetics. 23: 1333-44. PMID 24158850 DOI: 10.1093/hmg/ddt523  1
2014 Piomelli D. More surprises lying ahead. The endocannabinoids keep us guessing. Neuropharmacology. 76: 228-34. PMID 23954677 DOI: 10.1016/j.neuropharm.2013.07.026  1
2014 Rasmussen JM, Entringer S, Nguyen A, Van Erp TGM, Burns J, Guijarro A, Oveisi F, Swanson JM, Piomelli D, Wadhwa PD, Buss C, Potkin SG. Correction: Brown adipose tissue quantification in human neonates using water-fat separated MRI (PLoS ONE (2013) 8, 10 (e77907) DOI: 10.1371/journal.pone.0077907) Plos One. 9. DOI: 10.1371/annotation/f1b2fa68-726c-4f30-b061-d05c8a281eb8  1
2013 Rasmussen JM, Entringer S, Nguyen A, van Erp TG, Burns J, Guijarro A, Oveisi F, Swanson JM, Piomelli D, Wadhwa PD, Buss C, Potkin SG. Brown adipose tissue quantification in human neonates using water-fat separated MRI. Plos One. 8: e77907. PMID 24205024 DOI: 10.1371/journal.pone.0077907  1
2013 Ponzano S, Bertozzi F, Mengatto L, Dionisi M, Armirotti A, Romeo E, Berteotti A, Fiorelli C, Tarozzo G, Reggiani A, Duranti A, Tarzia G, Mor M, Cavalli A, Piomelli D, et al. Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors. Journal of Medicinal Chemistry. 56: 6917-34. PMID 23991897 DOI: 10.1021/jm400739u  1
2013 O'Brien LD, Limebeer CL, Rock EM, Bottegoni G, Piomelli D, Parker LA. Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus). British Journal of Pharmacology. 170: 1130-6. PMID 23991698 DOI: 10.1111/bph.12360  1
2013 Lambruschini C, Veronesi M, Romeo E, Garau G, Bandiera T, Piomelli D, Scarpelli R, Dalvit C. Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH. Chembiochem : a European Journal of Chemical Biology. 14: 1611-9. PMID 23918626 DOI: 10.1002/cbic.201300347  1
2013 Moreno-Sanz G, Duranti A, Melzig L, Fiorelli C, Ruda GF, Colombano G, Mestichelli P, Sanchini S, Tontini A, Mor M, Bandiera T, Scarpelli R, Tarzia G, Piomelli D. Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors. Journal of Medicinal Chemistry. 56: 5917-30. PMID 23822179 DOI: 10.1021/jm4007017  1
2013 Neumeister A, Normandin MD, Pietrzak RH, Piomelli D, Zheng MQ, Gujarro-Anton A, Potenza MN, Bailey CR, Lin SF, Najafzadeh S, Ropchan J, Henry S, Corsi-Travali S, Carson RE, Huang Y. Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study. Molecular Psychiatry. 18: 1034-40. PMID 23670490 DOI: 10.1038/mp.2013.61  1
2013 Pizzirani D, Pagliuca C, Realini N, Branduardi D, Bottegoni G, Mor M, Bertozzi F, Scarpelli R, Piomelli D, Bandiera T. Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). Journal of Medicinal Chemistry. 56: 3518-30. PMID 23614460 DOI: 10.1021/jm301879g  1
2013 Piomelli D. A fatty gut feeling. Trends in Endocrinology and Metabolism: Tem. 24: 332-41. PMID 23567058 DOI: 10.1016/j.tem.2013.03.001  1
2013 Lopes JP, Tarozzo G, Reggiani A, Piomelli D, Cavalli A. Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity. Brain and Behavior. 3: 67-74. PMID 23532860 DOI: 10.1002/brb3.118  1
2013 DiPatrizio NV, Joslin A, Jung KM, Piomelli D. Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2513-20. PMID 23463697 DOI: 10.1096/fj.13-227587  1
2013 Capurro V, Busquet P, Lopes JP, Bertorelli R, Tarozzo G, Bolognesi ML, Piomelli D, Reggiani A, Cavalli A. Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease. Plos One. 8: e56870. PMID 23441223 DOI: 10.1371/journal.pone.0056870  1
2013 Lodola A, Capoferri L, Rivara S, Tarzia G, Piomelli D, Mulholland A, Mor M. Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors. Journal of Medicinal Chemistry. 56: 2500-12. PMID 23425199 DOI: 10.1021/jm301867x  1
2013 Realini N, Solorzano C, Pagliuca C, Pizzirani D, Armirotti A, Luciani R, Costi MP, Bandiera T, Piomelli D. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity. Scientific Reports. 3: 1035. PMID 23301156 DOI: 10.1038/srep01035  1
2013 Bertolacci L, Romeo E, Veronesi M, Magotti P, Albani C, Dionisi M, Lambruschini C, Scarpelli R, Cavalli A, De Vivo M, Piomelli D, Garau G. A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase. Journal of the American Chemical Society. 135: 22-5. PMID 23240907 DOI: 10.1021/ja308733u  1
2013 Sasso O, Moreno-Sanz G, Martucci C, Realini N, Dionisi M, Mengatto L, Duranti A, Tarozzo G, Tarzia G, Mor M, Bertorelli R, Reggiani A, Piomelli D. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain. 154: 350-60. PMID 23218523 DOI: 10.1016/j.pain.2012.10.018  1
2013 Fiorelli C, Scarpelli R, Piomelli D, Bandiera T. Development of a Multigram synthesis of URB937, a peripherally restricted FAAH inhibitor Organic Process Research and Development. 17: 359-367. DOI: 10.1021/op300301u  1
2013 Palermo G, Campomanes P, Neri M, Piomelli D, Cavalli A, Rothlisberger U, De Vivo M. Wagging the tail: Essential role of substrate flexibility in FAAH catalysis Journal of Chemical Theory and Computation. 9: 1202-1213. DOI: 10.1021/ct300611q  1
2012 Armirotti A, Romeo E, Ponzano S, Mengatto L, Dionisi M, Karacsonyi C, Bertozzi F, Garau G, Tarozzo G, Reggiani A, Bandiera T, Tarzia G, Mor M, Piomelli D. β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine. Acs Medicinal Chemistry Letters. 3: 422-6. PMID 24900487 DOI: 10.1021/ml300056y  1
2012 Busquet P, Capurro V, Cavalli A, Piomelli D, Reggiani A, Bertorelli R. Synergistic effects of galantamine and memantine in attenuating scopolamine-induced amnesia in mice. Journal of Pharmacological Sciences. 120: 305-9. PMID 23149577 DOI: DN/JST.JSTAGE/jphs/12166SC  1
2012 Favia AD, Habrant D, Scarpelli R, Migliore M, Albani C, Bertozzi SM, Dionisi M, Tarozzo G, Piomelli D, Cavalli A, De Vivo M. Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. Journal of Medicinal Chemistry. 55: 8807-26. PMID 23043222 DOI: 10.1021/jm3011146  1
2012 Simoni E, Daniele S, Bottegoni G, Pizzirani D, Trincavelli ML, Goldoni L, Tarozzo G, Reggiani A, Martini C, Piomelli D, Melchiorre C, Rosini M, Cavalli A. Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease. Journal of Medicinal Chemistry. 55: 9708-21. PMID 23033965 DOI: 10.1021/jm3009458  1
2012 Jung KM, Sepers M, Henstridge CM, Lassalle O, Neuhofer D, Martin H, Ginger M, Frick A, DiPatrizio NV, Mackie K, Katona I, Piomelli D, Manzoni OJ. Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome. Nature Communications. 3: 1080. PMID 23011134 DOI: 10.1038/ncomms2045  1
2012 Khasabova IA, Xiong Y, Coicou LG, Piomelli D, Seybold V. Peroxisome proliferator-activated receptor α mediates acute effects of palmitoylethanolamide on sensory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 12735-43. PMID 22972997 DOI: 10.1523/JNEUROSCI.0130-12.2012  1
2012 Jumpertz R, Guijarro A, Pratley RE, Mason CC, Piomelli D, Krakoff J. Associations of fatty acids in cerebrospinal fluid with peripheral glucose concentrations and energy metabolism. Plos One. 7: e41503. PMID 22911803 DOI: 10.1371/journal.pone.0041503  1
2012 Leweke FM, Piomelli D, Pahlisch F, Muhl D, Gerth CW, Hoyer C, Klosterkötter J, Hellmich M, Koethe D. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Translational Psychiatry. 2: e94. PMID 22832859 DOI: 10.1038/tp.2012.15  1
2012 Carloni S, Alonso-Alconada D, Girelli S, Duranti A, Tontini A, Piomelli D, Hilario E, Alvarez A, Balduini W. Pretreatment with the monoacylglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. Pediatric Research. 72: 400-6. PMID 22821058 DOI: 10.1038/pr.2012.91  1
2012 Gregg LC, Jung KM, Spradley JM, Nyilas R, Suplita RL, Zimmer A, Watanabe M, Mackie K, Katona I, Piomelli D, Hohmann AG. Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9457-68. PMID 22787031 DOI: 10.1523/JNEUROSCI.0013-12.2012  1
2012 Moreno-Sanz G, Sasso O, Guijarro A, Oluyemi O, Bertorelli R, Reggiani A, Piomelli D. Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier. British Journal of Pharmacology. 167: 1620-8. PMID 22774772 DOI: 10.1111/j.1476-5381.2012.02098.x  1
2012 Vaidyanathan V, Bastarrachea RA, Higgins PB, Voruganti VS, Kamath S, DiPatrizio NV, Piomelli D, Comuzzie AG, Parks EJ. Selective cannabinoid-1 receptor blockade benefits fatty acid and triglyceride metabolism significantly in weight-stable nonhuman primates. American Journal of Physiology. Endocrinology and Metabolism. 303: E624-34. PMID 22761159 DOI: 10.1152/ajpendo.00072.2012  1
2012 DiPatrizio NV, Piomelli D. The thrifty lipids: endocannabinoids and the neural control of energy conservation. Trends in Neurosciences. 35: 403-11. PMID 22622030 DOI: 10.1016/j.tins.2012.04.006  1
2012 Duranti A, Tontini A, Antonietti F, Vacondio F, Fioni A, Silva C, Lodola A, Rivara S, Solorzano C, Piomelli D, Tarzia G, Mor M. N-(2-oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships. Journal of Medicinal Chemistry. 55: 4824-36. PMID 22515328 DOI: 10.1021/jm300349j  1
2012 Sasso O, Bertorelli R, Bandiera T, Scarpelli R, Colombano G, Armirotti A, Moreno-Sanz G, Reggiani A, Piomelli D. Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 65: 553-63. PMID 22420940 DOI: 10.1016/j.phrs.2012.02.012  1
2012 Jung KM, Clapper JR, Fu J, D'Agostino G, Guijarro A, Thongkham D, Avanesian A, Astarita G, DiPatrizio NV, Frontini A, Cinti S, Diano S, Piomelli D. 2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. Cell Metabolism. 15: 299-310. PMID 22405068 DOI: 10.1016/j.cmet.2012.01.021  1
2012 Lodola A, Branduardi D, De Vivo M, Capoferri L, Mor M, Piomelli D, Cavalli A. A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations. Plos One. 7: e32397. PMID 22389698 DOI: 10.1371/journal.pone.0032397  1
2012 Abumrad NA, Piomelli D, Yurko-Mauro K, Merrill A, Clandinin MT, Serhan CN. Moving beyond "good fat, bad fat": the complex roles of dietary lipids in cellular function and health: session abstracts. Advances in Nutrition (Bethesda, Md.). 3: 60-8. PMID 22332103 DOI: 10.3945/an.111.000802  1
2012 Newberry EP, Kennedy SM, Xie Y, Luo J, Crooke RM, Graham MJ, Fu J, Piomelli D, Davidson NO. Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp -/- mice. Journal of Lipid Research. 53: 744-54. PMID 22327204 DOI: 10.1194/jlr.M020966  1
2012 Snigdha S, Astarita G, Piomelli D, Cotman CW. Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain. Neuroscience. 202: 326-33. PMID 22183056 DOI: 10.1016/j.neuroscience.2011.12.002  1
2012 Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A, Lodola A, Armirotti A, Garau G, Bandiera T, Reggiani A, Mor M, Cavalli A, Piomelli D. A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nature Neuroscience. 15: 64-9. PMID 22101642 DOI: 10.1038/nn.2986  1
2012 Piomelli D. A thickening network of lipids. Pain. 153: 3-4. PMID 22019134 DOI: 10.1016/j.pain.2011.09.026  1
2012 Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiology of Aging. 33: 1522-32. PMID 21546126 DOI: 10.1016/j.neurobiolaging.2011.03.012  1
2011 Cippitelli A, Astarita G, Duranti A, Caprioli G, Ubaldi M, Stopponi S, Kallupi M, Sagratini G, Rodrìguez de Fonseca F, Piomelli D, Ciccocioppo R. Endocannabinoid regulation of acute and protracted nicotine withdrawal: effect of FAAH inhibition. Plos One. 6: e28142. PMID 22140525 DOI: 10.1371/journal.pone.0028142  1
2011 Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. Plos One. 6: e24777. PMID 22046234 DOI: 10.1371/journal.pone.0024777  1
2011 Snigdha S, Berchtold N, Astarita G, Saing T, Piomelli D, Cotman CW. Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain. Plos One. 6: e24652. PMID 21931796 DOI: 10.1371/journal.pone.0024652  1
2011 Palermo G, Branduardi D, Masetti M, Lodola A, Mor M, Piomelli D, Cavalli A, De Vivo M. Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas. Journal of Medicinal Chemistry. 54: 6612-23. PMID 21830831 DOI: 10.1021/jm2004283  1
2011 Vacondio F, Silva C, Lodola A, Carmi C, Rivara S, Duranti A, Tontini A, Sanchini S, Clapper JR, Piomelli D, Tarzia G, Mor M. Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability. European Journal of Medicinal Chemistry. 46: 4466-73. PMID 21820769 DOI: 10.1016/j.ejmech.2011.07.021  1
2011 Moreno-Sanz G, Barrera B, Guijarro A, d'Elia I, Otero JA, Alvarez AI, Bandiera T, Merino G, Piomelli D. The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 64: 359-63. PMID 21767647 DOI: 10.1016/j.phrs.2011.07.001  1
2011 Yang R, Fredman G, Krishnamoorthy S, Agrawal N, Irimia D, Piomelli D, Serhan CN. Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. The Journal of Biological Chemistry. 286: 31532-41. PMID 21757729 DOI: 10.1074/jbc.M111.237990  1
2011 DiPatrizio NV, Astarita G, Schwartz G, Li X, Piomelli D. Endocannabinoid signal in the gut controls dietary fat intake. Proceedings of the National Academy of Sciences of the United States of America. 108: 12904-8. PMID 21730161 DOI: 10.1073/pnas.1104675108  1
2011 Ollero M, Guerrera IC, Astarita G, Piomelli D, Edelman A. New lipidomic approaches in cystic fibrosis. Methods in Molecular Biology (Clifton, N.J.). 742: 265-78. PMID 21547738 DOI: 10.1007/978-1-61779-120-8_16  1
2011 Astarita G, Piomelli D. Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 85: 197-203. PMID 21543199 DOI: 10.1016/j.plefa.2011.04.021  1
2011 Jung KM, Astarita G, Thongkham D, Piomelli D. Diacylglycerol lipase-alpha and -beta control neurite outgrowth in neuro-2a cells through distinct molecular mechanisms. Molecular Pharmacology. 80: 60-7. PMID 21493725 DOI: 10.1124/mol.110.070458  1
2011 Fu J, Dipatrizio NV, Guijarro A, Schwartz GJ, Li X, Gaetani S, Astarita G, Piomelli D. Sympathetic activity controls fat-induced oleoylethanolamide signaling in small intestine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 5730-6. PMID 21490214 DOI: 10.1523/JNEUROSCI.5668-10.2011  1
2011 Di Sabatino A, Battista N, Biancheri P, Rapino C, Rovedatti L, Astarita G, Vanoli A, Dainese E, Guerci M, Piomelli D, Pender SL, MacDonald TT, Maccarrone M, Corazza GR. The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease. Mucosal Immunology. 4: 574-83. PMID 21471961 DOI: 10.1038/mi.2011.18  1
2011 Ollero M, Astarita G, Guerrera IC, Sermet-Gaudelus I, Trudel S, Piomelli D, Edelman A. Plasma lipidomics reveals potential prognostic signatures within a cohort of cystic fibrosis patients. Journal of Lipid Research. 52: 1011-22. PMID 21335323 DOI: 10.1194/jlr.P013722  1
2011 Lodola A, Capoferri L, Rivara S, Chudyk E, Sirirak J, Dyguda-Kazimierowicz E, Andrzej Sokalski W, Mileni M, Tarzia G, Piomelli D, Mor M, Mulholland AJ. Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling. Chemical Communications (Cambridge, England). 47: 2517-9. PMID 21240393 DOI: 10.1039/c0cc04937a  1
2011 Zhu C, Solorzano C, Sahar S, Realini N, Fung E, Sassone-Corsi P, Piomelli D. Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages. Molecular Pharmacology. 79: 786-92. PMID 21233218 DOI: 10.1124/mol.110.070201  1
2011 Guindon J, Guijarro A, Piomelli D, Hohmann AG. Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. British Journal of Pharmacology. 163: 1464-78. PMID 21198549 DOI: 10.1111/j.1476-5381.2010.01192.x  1
2011 Wang H, Astarita G, Taussig MD, Bharadwaj KG, DiPatrizio NV, Nave KA, Piomelli D, Goldberg IJ, Eckel RH. Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity. Cell Metabolism. 13: 105-13. PMID 21195353 DOI: 10.1016/j.cmet.2010.12.006  1
2011 Jumpertz R, Guijarro A, Pratley RE, Piomelli D, Krakoff J. Central and peripheral endocannabinoids and cognate acylethanolamides in humans: association with race, adiposity, and energy expenditure. The Journal of Clinical Endocrinology and Metabolism. 96: 787-91. PMID 21177788 DOI: 10.1210/jc.2010-2028  1
2011 Cassano T, Gaetani S, Macheda T, Laconca L, Romano A, Morgese MG, Cimmino CS, Chiarotti F, Bambico FR, Gobbi G, Cuomo V, Piomelli D. Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice. Psychopharmacology. 214: 465-76. PMID 21042794 DOI: 10.1007/s00213-010-2051-0  1
2011 Ludányi A, Hu SS, Yamazaki M, Tanimura A, Piomelli D, Watanabe M, Kano M, Sakimura K, Maglóczky Z, Mackie K, Freund TF, Katona I. Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. Neuroscience. 174: 50-63. PMID 21035522 DOI: 10.1016/j.neuroscience.2010.10.062  1
2011 Mascia P, Pistis M, Justinova Z, Panlilio LV, Luchicchi A, Lecca S, Scherma M, Fratta W, Fadda P, Barnes C, Redhi GH, Yasar S, Le Foll B, Tanda G, Piomelli D, et al. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biological Psychiatry. 69: 633-41. PMID 20801430 DOI: 10.1016/j.biopsych.2010.07.009  1
2011 Astarita G, Piomelli D. Lipidomics of Alzheimer's disease: A liver peroxisomal dysfunction in the metabolism of omega-3 fatty acids Ocl - Oleagineux Corps Gras Lipides. 18: 218-223. DOI: 10.1684/ocl.2011.0387  1
2011 Piomelli D. Corrigendum to "The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew)" [Physiology & Behavior. Volume (97) 121-124] Physiology and Behavior. 104: 1082. DOI: 10.1016/j.physbeh.2011.05.016  1
2011 Ludányi A, Hu SSJ, Yamazaki M, Tanimura A, Piomelli D, Watanabe M, Kano M, Sakimura K, Maglóczky Z, Mackie K, Freund TF, Katona I. Corrigendum to "Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus". [Neuroscience 174 (2011) 50-63]. Neuroscience. 186: 220. DOI: 10.1016/j.neuroscience.2011.04.072  1
2011 Astarita G, Piomelli D. Corrigendum to "Lipidomic analysis of endocannabinoid metabolism in biological samples" [J. Chromatogr. B 877 (2009) 2755] Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 879: 1844. DOI: 10.1016/j.jchromb.2011.05.001  1
2011 Jumpertz R, Guijarro A, Pratley RE, Piomelli D, Krakoff J. Central and peripheral endocannabinoids and cognate acylethanolamides in humans: Association with race, adiposity, and energy expenditure (Journal of Clinical Endocrinology and Metabolism (2011) 96, (787-791)) Journal of Clinical Endocrinology and Metabolism. 96: 1908.  1
2011 Piomelli D. Role of endocannabinoids and their analogues in obesity and eating disorders (Eating and Weight Disorders (2008) 13, 3 (e42-e48)) Eating and Weight Disorders. 16: e72.  1
2010 Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH, Granneman JG, Piomelli D, Leff T, Sassone-Corsi P. PER2 controls lipid metabolism by direct regulation of PPARγ. Cell Metabolism. 12: 509-20. PMID 21035761 DOI: 10.1016/j.cmet.2010.10.005  1
2010 Luo L, Rodriguez E, Jerbi K, Lachaux JP, Martinerie J, Corbetta M, Shulman GL, Piomelli D, Turrigiano GG, Nelson SB, Joëls M, de Kloet ER, Holsboer F, Amodio DM, Frith CD, et al. Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nature Reviews. Neuroscience. 11: 718-26. PMID 20852655 DOI: 10.1038/nrn2912  1
2010 Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, Duranti A, Tontini A, Sanchini S, Sciolino NR, Spradley JM, Hohmann AG, Calignano A, Mor M, Tarzia G, Piomelli D. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nature Neuroscience. 13: 1265-70. PMID 20852626 DOI: 10.1038/nn.2632  1
2010 Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E. Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. Journal of Alzheimer's Disease : Jad. 22: 135-50. PMID 20847439 DOI: 10.3233/JAD-2010-100639  1
2010 Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. Plos One. 5: e12538. PMID 20838618 DOI: 10.1371/journal.pone.0012538  1
2010 Solorzano C, Antonietti F, Duranti A, Tontini A, Rivara S, Lodola A, Vacondio F, Tarzia G, Piomelli D, Mor M. Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. Journal of Medicinal Chemistry. 53: 5770-81. PMID 20604568 DOI: 10.1021/jm100582w  1
2010 Bambico FR, Cassano T, Dominguez-Lopez S, Katz N, Walker CD, Piomelli D, Gobbi G. Genetic deletion of fatty acid amide hydrolase alters emotional behavior and serotonergic transmission in the dorsal raphe, prefrontal cortex, and hippocampus. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 2083-100. PMID 20571484 DOI: 10.1038/npp.2010.80  1
2010 Gaetani S, Fu J, Cassano T, Dipasquale P, Romano A, Righetti L, Cianci S, Laconca L, Giannini E, Scaccianoce S, Mairesse J, Cuomo V, Piomelli D. The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8096-101. PMID 20554860 DOI: 10.1523/JNEUROSCI.0036-10.2010  1
2010 Alkaitis MS, Solorzano C, Landry RP, Piomelli D, DeLeo JA, Romero-Sandoval EA. Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain. Plos One. 5: e10891. PMID 20531936 DOI: 10.1371/journal.pone.0010891  1
2010 Oddi S, Fezza F, Catanzaro G, De Simone C, Pucci M, Piomelli D, Finazzi-Agrò A, Maccarrone M. Pitfalls and solutions in assaying anandamide transport in cells. Journal of Lipid Research. 51: 2435-44. PMID 20447929 DOI: 10.1194/jlr.D004176  1
2010 Sciolino NR, Bortolato M, Eisenstein SA, Fu J, Oveisi F, Hohmann AG, Piomelli D. Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats. Neuroscience. 168: 371-86. PMID 20394803 DOI: 10.1016/j.neuroscience.2010.04.007  1
2010 Eisenstein SA, Clapper JR, Holmes PV, Piomelli D, Hohmann AG. A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 61: 419-29. PMID 20044005 DOI: 10.1016/j.phrs.2009.12.013  1
2010 Touriño C, Oveisi F, Lockney J, Piomelli D, Maldonado R. FAAH deficiency promotes energy storage and enhances the motivation for food. International Journal of Obesity (2005). 34: 557-68. PMID 20029375 DOI: 10.1038/ijo.2009.262  1
2010 Guijarro A, Fu J, Astarita G, Piomelli D. CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 61: 27-33. PMID 19778614 DOI: 10.1016/j.phrs.2009.09.003  1
2009 Solorzano C, Zhu C, Battista N, Astarita G, Lodola A, Rivara S, Mor M, Russo R, Maccarrone M, Antonietti F, Duranti A, Tontini A, Cuzzocrea S, Tarzia G, Piomelli D. Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. Proceedings of the National Academy of Sciences of the United States of America. 106: 20966-71. PMID 19926854 DOI: 10.1073/pnas.0907417106  1
2009 Guerrera IC, Astarita G, Jais JP, Sands D, Nowakowska A, Colas J, Sermet-Gaudelus I, Schuerenberg M, Piomelli D, Edelman A, Ollero M. A novel lipidomic strategy reveals plasma phospholipid signatures associated with respiratory disease severity in cystic fibrosis patients. Plos One. 4: e7735. PMID 19893743 DOI: 10.1371/journal.pone.0007735  1
2009 King AR, Dotsey EY, Lodola A, Jung KM, Ghomian A, Qiu Y, Fu J, Mor M, Piomelli D. Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chemistry & Biology. 16: 1045-52. PMID 19875078 DOI: 10.1016/j.chembiol.2009.09.012  1
2009 Astarita G, Ahmed F, Piomelli D. Lipidomic analysis of biological samples by liquid chromatography coupled to mass spectrometry. Methods in Molecular Biology (Clifton, N.J.). 579: 201-19. PMID 19763477 DOI: 10.1007/978-1-60761-322-0_10  1
2009 Clapper JR, Vacondio F, King AR, Duranti A, Tontini A, Silva C, Sanchini S, Tarzia G, Mor M, Piomelli D. A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo. Chemmedchem. 4: 1505-13. PMID 19637155 DOI: 10.1002/cmdc.200900210  1
2009 Gaetani S, Dipasquale P, Romano A, Righetti L, Cassano T, Piomelli D, Cuomo V. The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs. International Review of Neurobiology. 85: 57-72. PMID 19607961 DOI: 10.1016/S0074-7742(09)85005-8  1
2009 Astarita G, Geaga J, Ahmed F, Piomelli D. Targeted lipidomics as a tool to investigate endocannabinoid function. International Review of Neurobiology. 85: 35-55. PMID 19607960 DOI: 10.1016/S0074-7742(09)85004-6  1
2009 Vacondio F, Silva C, Lodola A, Fioni A, Rivara S, Duranti A, Tontini A, Sanchini S, Clapper JR, Piomelli D, Mor M, Tarzia G. Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability. Chemmedchem. 4: 1495-504. PMID 19554599 DOI: 10.1002/cmdc.200900120  1
2009 King AR, Lodola A, Carmi C, Fu J, Mor M, Piomelli D. A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors. British Journal of Pharmacology. 157: 974-83. PMID 19486005 DOI: 10.1111/j.1476-5381.2009.00276.x  1
2009 Campolongo P, Roozendaal B, Trezza V, Cuomo V, Astarita G, Fu J, McGaugh JL, Piomelli D. Fat-induced satiety factor oleoylethanolamide enhances memory consolidation. Proceedings of the National Academy of Sciences of the United States of America. 106: 8027-31. PMID 19416833 DOI: 10.1073/pnas.0903038106  1
2009 D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Mattace Raso G, Cuzzocrea S, Loverme J, Piomelli D, Meli R, Calignano A. Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia. European Journal of Pharmacology. 613: 54-9. PMID 19386271 DOI: 10.1016/j.ejphar.2009.04.022  1
2009 Mangieri RA, Hong KI, Piomelli D, Sinha R. An endocannabinoid signal associated with desire for alcohol is suppressed in recently abstinent alcoholics. Psychopharmacology. 205: 63-72. PMID 19343330 DOI: 10.1007/s00213-009-1518-3  1
2009 Koethe D, Giuffrida A, Schreiber D, Hellmich M, Schultze-Lutter F, Ruhrmann S, Klosterkötter J, Piomelli D, Leweke FM. Anandamide elevation in cerebrospinal fluid in initial prodromal states of psychosis. The British Journal of Psychiatry : the Journal of Mental Science. 194: 371-2. PMID 19336792 DOI: 10.1192/bjp.bp.108.053843  1
2009 Parker LA, Limebeer CL, Rock EM, Litt DL, Kwiatkowska M, Piomelli D. The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew). Physiology & Behavior. 97: 121-4. PMID 19239915 DOI: 10.1016/j.physbeh.2009.02.014  1
2009 Astarita G, Piomelli D. Lipidomic analysis of endocannabinoid metabolism in biological samples. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 877: 2755-67. PMID 19171504 DOI: 10.1016/j.jchromb.2009.01.008  1
2009 Piomelli D. Responses to stress: from the periphery to the brain. Current Opinion in Pharmacology. 9: 1-2. PMID 19162545 DOI: 10.1016/j.coph.2008.12.013  1
2009 Fehrenbacher JC, Loverme J, Clarke W, Hargreaves KM, Piomelli D, Taylor BK. Rapid pain modulation with nuclear receptor ligands. Brain Research Reviews. 60: 114-24. PMID 19162071 DOI: 10.1016/j.brainresrev.2008.12.019  1
2009 Cluny NL, Keenan CM, Lutz B, Piomelli D, Sharkey KA. The identification of peroxisome proliferator-activated receptor alpha-independent effects of oleoylethanolamide on intestinal transit in mice. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 21: 420-9. PMID 19140957 DOI: 10.1111/j.1365-2982.2008.01248.x  1
2009 Koethe D, Schreiber D, Giuffrida A, Mauss C, Faulhaber J, Heydenreich B, Hellmich M, Graf R, Klosterkötter J, Piomelli D, Leweke FM. Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid. Journal of Neural Transmission (Vienna, Austria : 1996). 116: 301-5. PMID 19137236 DOI: 10.1007/s00702-008-0169-6  1
2009 LoVerme J, Duranti A, Tontini A, Spadoni G, Mor M, Rivara S, Stella N, Xu C, Tarzia G, Piomelli D. Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorganic & Medicinal Chemistry Letters. 19: 639-43. PMID 19128970 DOI: 10.1016/j.bmcl.2008.12.059  1
2009 Valitutti G, Duranti A, Mor M, Piersanti G, Piomelli D, Rivara S, Tontini A, Tarzia G, Traldi P. The collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with biological activity. Journal of Mass Spectrometry : Jms. 44: 561-5. PMID 19034887 DOI: 10.1002/jms.1524  1
2009 Clapper JR, Mangieri RA, Piomelli D. The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology. 56: 235-43. PMID 18691603 DOI: 10.1016/j.neuropharm.2008.07.018  1
2008 Gaetani S, Kaye WH, Cuomo V, Piomelli D. Role of endocannabinoids and their analogues in obesity and eating disorders. Eating and Weight Disorders : Ewd. 13: e42-8. PMID 19011363  1
2008 Duncan M, Thomas AD, Cluny NL, Patel A, Patel KD, Lutz B, Piomelli D, Alexander SP, Sharkey KA. Distribution and function of monoacylglycerol lipase in the gastrointestinal tract. American Journal of Physiology. Gastrointestinal and Liver Physiology. 295: G1255-65. PMID 18948437 DOI: 10.1152/ajpgi.90500.2008  1
2008 Schwartz GJ, Fu J, Astarita G, Li X, Gaetani S, Campolongo P, Cuomo V, Piomelli D. The lipid messenger OEA links dietary fat intake to satiety. Cell Metabolism. 8: 281-8. PMID 18840358 DOI: 10.1016/j.cmet.2008.08.005  1
2008 Justinova Z, Mangieri RA, Bortolato M, Chefer SI, Mukhin AG, Clapper JR, King AR, Redhi GH, Yasar S, Piomelli D, Goldberg SR. Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates. Biological Psychiatry. 64: 930-7. PMID 18814866 DOI: 10.1016/j.biopsych.2008.08.008  1
2008 Scherma M, Panlilio LV, Fadda P, Fattore L, Gamaleddin I, Le Foll B, Justinová Z, Mikics E, Haller J, Medalie J, Stroik J, Barnes C, Yasar S, Tanda G, Piomelli D, et al. Inhibition of anandamide hydrolysis by cyclohexyl carbamic acid 3'-carbamoyl-3-yl ester (URB597) reverses abuse-related behavioral and neurochemical effects of nicotine in rats. The Journal of Pharmacology and Experimental Therapeutics. 327: 482-90. PMID 18725543 DOI: 10.1124/jpet.108.142224  1
2008 Piomelli D. The element of surprise. Nature Medicine. 14: 720-1. PMID 18607371 DOI: 10.1038/nm0708-720  1
2008 Moise AM, Eisenstein SA, Astarita G, Piomelli D, Hohmann AG. An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters. Psychopharmacology. 200: 333-46. PMID 18545985 DOI: 10.1007/s00213-008-1209-5  1
2008 Mor M, Lodola A, Rivara S, Vacondio F, Duranti A, Tontini A, Sanchini S, Piersanti G, Clapper JR, King AR, Tarzia G, Piomelli D. Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. Journal of Medicinal Chemistry. 51: 3487-98. PMID 18507372 DOI: 10.1021/jm701631z  1
2008 Koethe D, Bortolato M, Piomelli D, Leweke FM. Improvement of general symptoms in a chronic psychotic patient treated with finasteride: case report. Pharmacopsychiatry. 41: 115-6. PMID 18484553 DOI: 10.1055/s-2008-1058110  1
2008 Cippitelli A, Cannella N, Braconi S, Duranti A, Tontini A, Bilbao A, Defonseca FR, Piomelli D, Ciccocioppo R. Increase of brain endocannabinoid anandamide levels by FAAH inhibition and alcohol abuse behaviours in the rat. Psychopharmacology. 198: 449-60. PMID 18446329 DOI: 10.1007/s00213-008-1104-0  1
2008 Fu J, Kim J, Oveisi F, Astarita G, Piomelli D. Targeted enhancement of oleoylethanolamide production in proximal small intestine induces across-meal satiety in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 295: R45-50. PMID 18434444 DOI: 10.1152/ajpregu.00126.2008  1
2008 Solinas M, Goldberg SR, Piomelli D. The endocannabinoid system in brain reward processes. British Journal of Pharmacology. 154: 369-83. PMID 18414385 DOI: 10.1038/bjp.2008.130  1
2008 Genovese T, Esposito E, Mazzon E, Di Paola R, Meli R, Bramanti P, Piomelli D, Calignano A, Cuzzocrea S. Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury. The Journal of Pharmacology and Experimental Therapeutics. 326: 12-23. PMID 18367664 DOI: 10.1124/jpet.108.136903  1
2008 Potvin S, Kouassi E, Lipp O, Bouchard RH, Roy MA, Demers MF, Gendron A, Astarita G, Piomelli D, Stip E. Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. Journal of Psychopharmacology (Oxford, England). 22: 262-9. PMID 18308802 DOI: 10.1177/0269881107083816  1
2008 La Rana G, Russo R, D'Agostino G, Sasso O, Raso GM, Iacono A, Meli R, Piomelli D, Calignano A. AM404, an anandamide transport inhibitor, reduces plasma extravasation in a model of neuropathic pain in rat: role for cannabinoid receptors. Neuropharmacology. 54: 521-9. PMID 18093621 DOI: 10.1016/j.neuropharm.2007.10.021  1
2008 Lodola A, Mor M, Rivara S, Christov C, Tarzia G, Piomelli D, Mulholland AJ. Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling. Chemical Communications (Cambridge, England). 214-6. PMID 18092091 DOI: 10.1039/b714136j  1
2008 Rock EM, Limebeer CL, Mechoulam R, Piomelli D, Parker LA. The effect of cannabidiol and URB597 on conditioned gaping (a model of nausea) elicited by a lithium-paired context in the rat. Psychopharmacology. 196: 389-95. PMID 17992520 DOI: 10.1007/s00213-007-0970-1  1
2008 Astarita G, Ahmed F, Piomelli D. Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. Journal of Lipid Research. 49: 48-57. PMID 17957091 DOI: 10.1194/jlr.M700354-JLR200  1
2008 Scherma M, Medalie J, Fratta W, Vadivel SK, Makriyannis A, Piomelli D, Mikics E, Haller J, Yasar S, Tanda G, Goldberg SR. The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition. Neuropharmacology. 54: 129-40. PMID 17904589 DOI: 10.1016/j.neuropharm.2007.08.011  1
2008 Bortolato M, Piomelli D. Chapter 4.5 The endocannabinoid system and anxiety responses Handbook of Behavioral Neuroscience. 17: 303-324. DOI: 10.1016/S1569-7339(07)00014-8  1
2007 King AR, Duranti A, Tontini A, Rivara S, Rosengarth A, Clapper JR, Astarita G, Geaga JA, Luecke H, Mor M, Tarzia G, Piomelli D. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices. Chemistry & Biology. 14: 1357-65. PMID 18096504 DOI: 10.1016/j.chembiol.2007.10.017  1
2007 Valitutti G, Duranti A, Lodola A, Mor M, Piersanti G, Piomelli D, Rivara S, Tontini A, Tarzia G, Traldi P. Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors. Journal of Mass Spectrometry : Jms. 42: 1624-7. PMID 18085570 DOI: 10.1002/jms.1346  1
2007 Tarzia G, Antonietti F, Duranti A, Tontini A, Mor M, Rivara S, Traldi P, Astarita G, King A, Clapper JR, Piomelli D. Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754). Annali Di Chimica. 97: 887-94. PMID 17970304 DOI: 10.1002/adic.200790073  1
2007 Mangieri RA, Piomelli D. Enhancement of endocannabinoid signaling and the pharmacotherapy of depression. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 56: 360-6. PMID 17945507 DOI: 10.1016/j.phrs.2007.09.003  1
2007 Piomelli D, Astarita G, Rapaka R. A neuroscientist's guide to lipidomics. Nature Reviews. Neuroscience. 8: 743-54. PMID 17882252 DOI: 10.1038/nrn2233  1
2007 Cippitelli A, Bilbao A, Gorriti MA, Navarro M, Massi M, Piomelli D, Ciccocioppo R, Rodríguez de Fonseca F. The anandamide transport inhibitor AM404 reduces ethanol self-administration. The European Journal of Neuroscience. 26: 476-86. PMID 17650118 DOI: 10.1111/j.1460-9568.2007.05665.x  1
2007 Vila A, Rosengarth A, Piomelli D, Cravatt B, Marnett LJ. Hydrolysis of prostaglandin glycerol esters by the endocannabinoid-hydrolyzing enzymes, monoacylglycerol lipase and fatty acid amide hydrolase. Biochemistry. 46: 9578-85. PMID 17649977 DOI: 10.1021/bi7005898  1
2007 Jung KM, Astarita G, Zhu C, Wallace M, Mackie K, Piomelli D. A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Molecular Pharmacology. 72: 612-21. PMID 17584991 DOI: 10.1124/mol.107.037796  1
2007 Leweke FM, Giuffrida A, Koethe D, Schreiber D, Nolden BM, Kranaster L, Neatby MA, Schneider M, Gerth CW, Hellmich M, Klosterkötter J, Piomelli D. Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use. Schizophrenia Research. 94: 29-36. PMID 17566707 DOI: 10.1016/j.schres.2007.04.025  1
2007 D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Raso GM, Cuzzocrea S, Lo Verme J, Piomelli D, Meli R, Calignano A. Acute intracerebroventricular administration of palmitoylethanolamide, an endogenous peroxisome proliferator-activated receptor-alpha agonist, modulates carrageenan-induced paw edema in mice. The Journal of Pharmacology and Experimental Therapeutics. 322: 1137-43. PMID 17565008 DOI: 10.1124/jpet.107.123265  1
2007 Guindon J, LoVerme J, Piomelli D, Beaulieu P. The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors. Anesthesia and Analgesia. 104: 1563-9, table of con. PMID 17513659 DOI: 10.1213/01.ane.0000263278.05423.a3  1
2007 Bortolato M, Mangieri RA, Fu J, Kim JH, Arguello O, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biological Psychiatry. 62: 1103-10. PMID 17511970 DOI: 10.1016/j.biopsych.2006.12.001  1
2007 Russo R, LoVerme J, La Rana G, D'Agostino G, Sasso O, Calignano A, Piomelli D. Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. European Journal of Pharmacology. 566: 117-9. PMID 17434479 DOI: 10.1016/j.ejphar.2007.03.007  1
2007 Russo R, Loverme J, La Rana G, Compton TR, Parrott J, Duranti A, Tontini A, Mor M, Tarzia G, Calignano A, Piomelli D. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. The Journal of Pharmacology and Experimental Therapeutics. 322: 236-42. PMID 17412883 DOI: 10.1124/jpet.107.119941  1
2007 Ferrer B, Bermúdez-Silva FJ, Bilbao A, Alvarez-Jaimes L, Sanchez-Vera I, Giuffrida A, Serrano A, Baixeras E, Khaturia S, Navarro M, Parsons LH, Piomelli D, Rodríguez de Fonseca F. Regulation of brain anandamide by acute administration of ethanol. The Biochemical Journal. 404: 97-104. PMID 17302558 DOI: 10.1042/BJ20061898  1
2007 Solinas M, Tanda G, Justinova Z, Wertheim CE, Yasar S, Piomelli D, Vadivel SK, Makriyannis A, Goldberg SR. The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport. The Journal of Pharmacology and Experimental Therapeutics. 321: 370-80. PMID 17210800 DOI: 10.1124/jpet.106.114124  1
2007 Schreiber D, Harlfinger S, Nolden BM, Gerth CW, Jaehde U, Schömig E, Klosterkötter J, Giuffrida A, Astarita G, Piomelli D, Markus Leweke F. Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometry. Analytical Biochemistry. 361: 162-8. PMID 17196922 DOI: 10.1016/j.ab.2006.11.027  1
2007 Fu J, Astarita G, Gaetani S, Kim J, Cravatt BF, Mackie K, Piomelli D. Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. The Journal of Biological Chemistry. 282: 1518-28. PMID 17121838 DOI: 10.1074/jbc.M607809200  1
2007 Lodola A, Mor M, Zurek J, Tarzia G, Piomelli D, Harvey JN, Mulholland AJ. Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase. Biophysical Journal. 92: L20-2. PMID 17098788 DOI: 10.1529/biophysj.106.098434  1
2006 Guindon J, LoVerme J, De Léan A, Piomelli D, Beaulieu P. Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides? European Journal of Pharmacology. 550: 68-77. PMID 17027744 DOI: 10.1016/j.ejphar.2006.08.045  1
2006 LoVerme J, Russo R, La Rana G, Fu J, Farthing J, Mattace-Raso G, Meli R, Hohmann A, Calignano A, Piomelli D. Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha. The Journal of Pharmacology and Experimental Therapeutics. 319: 1051-61. PMID 16997973 DOI: 10.1124/jpet.106.111385  1
2006 Clapper JR, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 54: 341-4. PMID 16935521 DOI: 10.1016/j.phrs.2006.06.008  1
2006 Pintor A, Tebano MT, Martire A, Grieco R, Galluzzo M, Scattoni ML, Pèzzola A, Coccurello R, Felici F, Cuomo V, Piomelli D, Calamandrei G, Popoli P. The cannabinoid receptor agonist WIN 55,212-2 attenuates the effects induced by quinolinic acid in the rat striatum. Neuropharmacology. 51: 1004-12. PMID 16895732 DOI: 10.1016/j.neuropharm.2006.06.013  0.32
2006 Tarzia G, Duranti A, Gatti G, Piersanti G, Tontini A, Rivara S, Lodola A, Plazzi PV, Mor M, Kathuria S, Piomelli D. Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring. Chemmedchem. 1: 130-9. PMID 16892344 DOI: 10.1002/cmdc.200500017  1
2006 Piomelli D, Tarzia G, Duranti A, Tontini A, Mor M, Compton TR, Dasse O, Monaghan EP, Parrott JA, Putman D. Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597). Cns Drug Reviews. 12: 21-38. PMID 16834756 DOI: 10.1111/j.1527-3458.2006.00021.x  1
2006 LoVerme J, Guzmán M, Gaetani S, Piomelli D. Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue. The Journal of Biological Chemistry. 281: 22815-8. PMID 16785227 DOI: 10.1074/jbc.M604751200  0.52
2006 Katona I, Urbán GM, Wallace M, Ledent C, Jung KM, Piomelli D, Mackie K, Freund TF. Molecular composition of the endocannabinoid system at glutamatergic synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5628-37. PMID 16723519 DOI: 10.1523/JNEUROSCI.0309-06.2006  1
2006 Astarita G, Di Giacomo B, Gaetani S, Oveisi F, Compton TR, Rivara S, Tarzia G, Mor M, Piomelli D. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. The Journal of Pharmacology and Experimental Therapeutics. 318: 563-70. PMID 16702440 DOI: 10.1124/jpet.106.105221  1
2006 Bortolato M, Campolongo P, Mangieri RA, Scattoni ML, Frau R, Trezza V, La Rana G, Russo R, Calignano A, Gessa GL, Cuomo V, Piomelli D. Anxiolytic-like properties of the anandamide transport inhibitor AM404. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2652-9. PMID 16541083 DOI: 10.1038/sj.npp.1301061  1
2006 La Rana G, Russo R, Campolongo P, Bortolato M, Mangieri RA, Cuomo V, Iacono A, Raso GM, Meli R, Piomelli D, Calignano A. Modulation of neuropathic and inflammatory pain by the endocannabinoid transport inhibitor AM404 [N-(4-hydroxyphenyl)-eicosa-5,8,11,14-tetraenamide]. The Journal of Pharmacology and Experimental Therapeutics. 317: 1365-71. PMID 16510698 DOI: 10.1124/jpet.105.100792  1
2006 Connell K, Bolton N, Olsen D, Piomelli D, Hohmann AG. Role of the basolateral nucleus of the amygdala in endocannabinoid-mediated stress-induced analgesia. Neuroscience Letters. 397: 180-4. PMID 16378681 DOI: 10.1016/j.neulet.2005.12.008  1
2006 Astarita G, Rourke BC, Andersen JB, Fu J, Kim JH, Bennett AF, Hicks JW, Piomelli D. Postprandial increase of oleoylethanolamide mobilization in small intestine of the Burmese python (Python molurus). American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 290: R1407-12. PMID 16373434 DOI: 10.1152/ajpregu.00664.2005  1
2006 Suplita RL, Gutierrez T, Fegley D, Piomelli D, Hohmann AG. Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. Neuropharmacology. 50: 372-9. PMID 16316669 DOI: 10.1016/j.neuropharm.2005.10.007  1
2006 Su HF, Samsamshariat A, Fu J, Shan YX, Chen YH, Piomelli D, Wang PH. Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure. Endocrinology. 147: 827-34. PMID 16269455 DOI: 10.1210/en.2005-1098  0.52
2005 Gobbi G, Bambico FR, Mangieri R, Bortolato M, Campolongo P, Solinas M, Cassano T, Morgese MG, Debonnel G, Duranti A, Tontini A, Tarzia G, Mor M, Trezza V, Goldberg SR, ... ... Piomelli D, et al. Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. 102: 18620-5. PMID 16352709 DOI: 10.1073/pnas.0509591102  1
2005 Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N, Makriyannis A, Piomelli D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD, Sharkey KA. Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science (New York, N.Y.). 310: 329-32. PMID 16224028 DOI: 10.1126/science.1115740  1
2005 Lodola A, Mor M, Hermann JC, Tarzia G, Piomelli D, Mulholland AJ. QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation. Chemical Communications (Cambridge, England). 4399-401. PMID 16136230 DOI: 10.1039/b503887a  1
2005 Makara JK, Mor M, Fegley D, Szabó SI, Kathuria S, Astarita G, Duranti A, Tontini A, Tarzia G, Rivara S, Freund TF, Piomelli D. Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nature Neuroscience. 8: 1139-41. PMID 16116451 DOI: 10.1038/nn1521  1
2005 Rapaka RS, Piomelli D, Spiegel S, Bazan N, Dennis EA. Targeted lipidomics: signaling lipids and drugs of abuse. Prostaglandins & Other Lipid Mediators. 77: 223-34. PMID 16099407 DOI: 10.1016/j.prostaglandins.2005.06.005  1
2005 Jung KM, Mangieri R, Stapleton C, Kim J, Fegley D, Wallace M, Mackie K, Piomelli D. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. Molecular Pharmacology. 68: 1196-202. PMID 16051747 DOI: 10.1124/mol.105.013961  1
2005 Solbrig MV, Adrian R, Baratta J, Piomelli D, Giuffrida A. A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena. Experimental Neurology. 194: 355-62. PMID 16022863 DOI: 10.1016/j.expneurol.2005.02.017  1
2005 Hohmann AG, Suplita RL, Bolton NM, Neely MH, Fegley D, Mangieri R, Krey JF, Walker JM, Holmes PV, Crystal JD, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. An endocannabinoid mechanism for stress-induced analgesia. Nature. 435: 1108-12. PMID 15973410 DOI: 10.1038/nature03658  1
2005 LoVerme J, La Rana G, Russo R, Calignano A, Piomelli D. The search for the palmitoylethanolamide receptor. Life Sciences. 77: 1685-98. PMID 15963531 DOI: 10.1016/j.lfs.2005.05.012  0.8
2005 Fu J, Oveisi F, Gaetani S, Lin E, Piomelli D. Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology. 48: 1147-53. PMID 15910890 DOI: 10.1016/j.neuropharm.2005.02.013  0.52
2005 Makriyannis A, Mechoulam R, Piomelli D. Therapeutic opportunities through modulation of the endocannabinoid system. Neuropharmacology. 48: 1068-71. PMID 15885714 DOI: 10.1016/j.neuropharm.2005.03.012  1
2005 Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D. Regulation of food intake by oleoylethanolamide. Cellular and Molecular Life Sciences : Cmls. 62: 708-16. PMID 15770421 DOI: 10.1007/s00018-004-4494-0  0.52
2005 Fegley D, Gaetani S, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. The Journal of Pharmacology and Experimental Therapeutics. 313: 352-8. PMID 15579492 DOI: 10.1124/jpet.104.078980  1
2005 Lo Verme J, Fu J, Astarita G, La Rana G, Russo R, Calignano A, Piomelli D. The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Molecular Pharmacology. 67: 15-9. PMID 15465922 DOI: 10.1124/mol.104.006353  1
2004 Basso E, Duranti A, Mor M, Piomelli D, Tontini A, Tarzia G, Traldi P. Tandem mass spectrometric data-FAAH inhibitory activity relationships of some carbamic acid O-aryl esters. Journal of Mass Spectrometry : Jms. 39: 1450-5. PMID 15578755 DOI: 10.1002/jms.729  1
2004 Mor M, Rivara S, Lodola A, Plazzi PV, Tarzia G, Duranti A, Tontini A, Piersanti G, Kathuria S, Piomelli D. Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies. Journal of Medicinal Chemistry. 47: 4998-5008. PMID 15456244 DOI: 10.1021/jm031140x  1
2004 Giuffrida A, Leweke FM, Gerth CW, Schreiber D, Koethe D, Faulhaber J, Klosterkötter J, Piomelli D. Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 2108-14. PMID 15354183 DOI: 10.1038/sj.npp.1300558  1
2004 Dinh TP, Kathuria S, Piomelli D. RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. Molecular Pharmacology. 66: 1260-4. PMID 15272052 DOI: 10.1124/mol.104.002071  1
2004 Gulyas AI, Cravatt BF, Bracey MH, Dinh TP, Piomelli D, Boscia F, Freund TF. Segregation of two endocannabinoid-hydrolyzing enzymes into pre- and postsynaptic compartments in the rat hippocampus, cerebellum and amygdala. The European Journal of Neuroscience. 20: 441-58. PMID 15233753 DOI: 10.1111/j.1460-9568.2004.03428.x  1
2004 Hájos N, Kathuria S, Dinh T, Piomelli D, Freund TF. Endocannabinoid transport tightly controls 2-arachidonoyl glycerol actions in the hippocampus: effects of low temperature and the transport inhibitor AM404. The European Journal of Neuroscience. 19: 2991-6. PMID 15182306 DOI: 10.1111/j.0953-816X.2004.03433.x  1
2004 Fegley D, Kathuria S, Mercier R, Li C, Goutopoulos A, Makriyannis A, Piomelli D. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proceedings of the National Academy of Sciences of the United States of America. 101: 8756-61. PMID 15138300 DOI: 10.1073/pnas.0400997101  1
2004 Guzmán M, Lo Verme J, Fu J, Oveisi F, Blázquez C, Piomelli D. Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha). The Journal of Biological Chemistry. 279: 27849-54. PMID 15123613 DOI: 10.1074/jbc.M404087200  0.52
2004 Oveisi F, Gaetani S, Eng KT, Piomelli D. Oleoylethanolamide inhibits food intake in free-feeding rats after oral administration. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 49: 461-6. PMID 14998556 DOI: 10.1016/j.phrs.2003.12.006  0.52
2003 Murillo-Rodriguez E, Blanco-Centurion C, Sanchez C, Piomelli D, Shiromani PJ. Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study. Sleep. 26: 943-7. PMID 14746372  1
2003 Sparling PB, Giuffrida A, Piomelli D, Rosskopf L, Dietrich A. Exercise activates the endocannabinoid system. Neuroreport. 14: 2209-11. PMID 14625449 DOI: 10.1097/01.wnr.0000097048.56589.47  1
2003 Gaetani S, Cuomo V, Piomelli D. Anandamide hydrolysis: a new target for anti-anxiety drugs? Trends in Molecular Medicine. 9: 474-8. PMID 14604824  0.52
2003 Ferrer B, Asbrock N, Kathuria S, Piomelli D, Giuffrida A. Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias. The European Journal of Neuroscience. 18: 1607-14. PMID 14511339 DOI: 10.1046/j.1460-9568.2003.02896.x  1
2003 Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodríguez De Fonseca F, Rosengarth A, Luecke H, Di Giacomo B, Tarzia G, Piomelli D. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature. 425: 90-3. PMID 12955147 DOI: 10.1038/nature01921  1
2003 Tarzia G, Duranti A, Tontini A, Spadoni G, Mor M, Rivara S, Vincenzo Plazzi P, Kathuria S, Piomelli D. Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists. Bioorganic & Medicinal Chemistry. 11: 3965-73. PMID 12927857 DOI: 10.1016/S0968-0896(03)00413-9  1
2003 Chen K, Ratzliff A, Hilgenberg L, Gulyás A, Freund TF, Smith M, Dinh TP, Piomelli D, Mackie K, Soltesz I. Long-term plasticity of endocannabinoid signaling induced by developmental febrile seizures. Neuron. 39: 599-611. PMID 12925275 DOI: 10.1016/S0896-6273(03)00499-9  1
2003 Freund TF, Katona I, Piomelli D. Role of endogenous cannabinoids in synaptic signaling. Physiological Reviews. 83: 1017-66. PMID 12843414 DOI: 10.1152/physrev.00004.2003  1
2003 Tarzia G, Duranti A, Tontini A, Piersanti G, Mor M, Rivara S, Plazzi PV, Park C, Kathuria S, Piomelli D. Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors. Journal of Medicinal Chemistry. 46: 2352-60. PMID 12773040 DOI: 10.1021/jm021119g  1
2003 Gaetani S, Oveisi F, Piomelli D. Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1311-6. PMID 12700681 DOI: 10.1038/sj.npp.1300166  0.52
2003 Kathuria S, Gaetani S, Fegley D, Valiño F, Duranti A, Tontini A, Mor M, Tarzia G, La Rana G, Calignano A, Giustino A, Tattoli M, Palmery M, Cuomo V, Piomelli D. Modulation of anxiety through blockade of anandamide hydrolysis. Nature Medicine. 9: 76-81. PMID 12461523 DOI: 10.1038/nm803  1
2002 Schuel H, Burkman LJ, Lippes J, Crickard K, Forester E, Piomelli D, Giuffrida A. N-Acylethanolamines in human reproductive fluids. Chemistry and Physics of Lipids. 121: 211-27. PMID 12505702 DOI: 10.1016/S0009-3084(02)00158-5  1
2002 Dinh TP, Freund TF, Piomelli D. A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation. Chemistry and Physics of Lipids. 121: 149-58. PMID 12505697 DOI: 10.1016/S0009-3084(02)00150-0  1
2002 Gómez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, Del Arco I, Cippitelli A, Nava F, Piomelli D, Rodríguez de Fonseca F. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9612-7. PMID 12417686  0.48
2002 Del Arco I, Navarro M, Bilbao A, Ferrer B, Piomelli D, Rodríguez De Fonseca F. Attenuation of spontaneous opiate withdrawal in mice by the anandamide transport inhibitor AM404. European Journal of Pharmacology. 454: 103-4. PMID 12409011  0.32
2002 Schäbitz WR, Giuffrida A, Berger C, Aschoff A, Schwaninger M, Schwab S, Piomelli D. Release of fatty acid amides in a patient with hemispheric stroke: a microdialysis study. Stroke; a Journal of Cerebral Circulation. 33: 2112-4. PMID 12154273 DOI: 10.1161/01.STR.0000023491.63693.18  1
2002 Dinh TP, Carpenter D, Leslie FM, Freund TF, Katona I, Sensi SL, Kathuria S, Piomelli D. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proceedings of the National Academy of Sciences of the United States of America. 99: 10819-24. PMID 12136125 DOI: 10.1073/pnas.152334899  1
2001 Rodríguez de Fonseca F, Navarro M, Gómez R, Escuredo L, Nava F, Fu J, Murillo-Rodríguez E, Giuffrida A, LoVerme J, Gaetani S, Kathuria S, Gall C, Piomelli D. An anorexic lipid mediator regulated by feeding. Nature. 414: 209-12. PMID 11700558 DOI: 10.1038/35102582  1
2001 Stella N, Piomelli D. Receptor-dependent formation of endogenous cannabinoids in cortical neurons. European Journal of Pharmacology. 425: 189-96. PMID 11513837 DOI: 10.1016/S0014-2999(01)01182-7  1
2001 Calignano A, La Rana G, Piomelli D. Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. European Journal of Pharmacology. 419: 191-8. PMID 11426841  0.8
2001 Giuffrida A, Beltramo M, Piomelli D. Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology. The Journal of Pharmacology and Experimental Therapeutics. 298: 7-14. PMID 11408519  1
2000 Giuffrida A, Piomelli D. The endocannabinoid system: a physiological perspective on its role in psychomotor control. Chemistry and Physics of Lipids. 108: 151-8. PMID 11106788 DOI: 10.1016/S0009-3084(00)00193-6  1
2000 Calignano A, La Rana G, Loubet-Lescoulié P, Piomelli D. A role for the endogenous cannabinoid system in the peripheral control of pain initiation. Progress in Brain Research. 129: 471-82. PMID 11098711  0.8
2000 Calignano A, Kátona I, Désarnaud F, Giuffrida A, La Rana G, Mackie K, Freund TF, Piomelli D. Bidirectional control of airway responsiveness by endogenous cannabinoids. Nature. 408: 96-101. PMID 11081515 DOI: 10.1038/35040576  1
2000 Giuffrida A, Rodriguez de Fonseca F, Nava F, Loubet-Lescoulié P, Piomelli D. Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404. European Journal of Pharmacology. 408: 161-8. PMID 11080522 DOI: 10.1016/S0014-2999(00)00786-X  1
2000 Piomelli D, Giuffrida A, Calignano A, Rodríguez de Fonseca F. The endocannabinoid system as a target for therapeutic drugs. Trends in Pharmacological Sciences. 21: 218-24. PMID 10838609 DOI: 10.1016/S0165-6147(00)01482-6  1
2000 Beltramo M, Piomelli D. Carrier-mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2-arachidonylglycerol. Neuroreport. 11: 1231-5. PMID 10817598  0.6
2000 Giuffrida A, Rodríguez de Fonseca F, Piomelli D. Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry. Analytical Biochemistry. 280: 87-93. PMID 10805525 DOI: 10.1006/abio.2000.4509  1
2000 Giuffrida A, Désarnaud F, Piomelli D. Endogenous cannabinoid signaling and psychomotor disorders. Prostaglandins & Other Lipid Mediators. 61: 63-70. PMID 10785542 DOI: 10.1016/S0090-6980(00)00055-1  1
2000 Beltramo M, de Fonseca FR, Navarro M, Calignano A, Gorriti MA, Grammatikopoulos G, Sadile AG, Giuffrida A, Piomelli D. Reversal of dopamine D(2) receptor responses by an anandamide transport inhibitor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3401-7. PMID 10777802  1
1999 Straiker A, Stella N, Piomelli D, Mackie K, Karten HJ, Maguire G. Cannabinoid CB1 receptors and ligands in vertebrate retina: localization and function of an endogenous signaling system. Proceedings of the National Academy of Sciences of the United States of America. 96: 14565-70. PMID 10588745 DOI: 10.1073/pnas.96.25.14565  1
1999 Leweke FM, Giuffrida A, Wurster U, Emrich HM, Piomelli D. Elevated endogenous cannabinoids in schizophrenia. Neuroreport. 10: 1665-9. PMID 10501554  1
1999 Piomelli D, Beltramo M, Glasnapp S, Lin SY, Goutopoulos A, Xie XQ, Makriyannis A. Structural determinants for recognition and translocation by the anandamide transporter. Proceedings of the National Academy of Sciences of the United States of America. 96: 5802-7. PMID 10318965 DOI: 10.1073/pnas.96.10.5802  1
1999 Giuffrida A, Parsons LH, Kerr TM, Rodríguez de Fonseca F, Navarro M, Piomelli D. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum. Nature Neuroscience. 2: 358-63. PMID 10204543 DOI: 10.1038/7268  1
1999 Beltramo M, Piomelli D. Anandamide transport inhibition by the vanilloid agonist olvanil. European Journal of Pharmacology. 364: 75-8. PMID 9920187  0.6
1998 Piomelli D, Beltramo M, Giuffrida A, Stella N. Endogenous cannabinoid signaling. Neurobiology of Disease. 5: 462-73. PMID 9974178 DOI: 10.1006/nbdi.1998.0221  1
1998 Calignano A, La Rana G, Giuffrida A, Piomelli D. Control of pain initiation by endogenous cannabinoids. Nature. 394: 277-81. PMID 9685157 DOI: 10.1038/28393  1
1998 Giuffrida A, Piomelli D. Isotope dilution GC/MS determination of anandamide and other fatty acylethanolamides in rat blood plasma. Febs Letters. 422: 373-6. PMID 9498819 DOI: 10.1016/S0014-5793(98)00046-5  1
1997 Calignano A, La Rana G, Makriyannis A, Lin SY, Beltramo M, Piomelli D. Inhibition of intestinal motility by anandamide, an endogenous cannabinoid. European Journal of Pharmacology. 340: R7-8. PMID 9537804  0.8
1997 Calignano A, La Rana G, Beltramo M, Makriyannis A, Piomelli D. Potentiation of anandamide hypotension by the transport inhibitor, AM404. European Journal of Pharmacology. 337: R1-2. PMID 9389389  0.8
1997 Di Tomaso E, Cadas H, Gaillet S, Beltramo M, Desarnaud F, Venance L, Piomelli D. Endogenous lipids that activate cannabinoid receptors. Formation and inactivation. Advances in Experimental Medicine and Biology. 407: 335-40. PMID 9321973  0.92
1997 Stella N, Schweitzer P, Piomelli D. A second endogenous cannabinoid that modulates long-term potentiation. Nature. 388: 773-8. PMID 9285589 DOI: 10.1038/42015  1
1997 Beltramo M, Stella N, Calignano A, Lin SY, Makriyannis A, Piomelli D. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science (New York, N.Y.). 277: 1094-7. PMID 9262477 DOI: 10.1126/science.277.5329.1094  1
1997 Stella N, Estellés A, Siciliano J, Tencé M, Desagher S, Piomelli D, Glowinski J, Prémont J. Interleukin-1 enhances the ATP-evoked release of arachidonic acid from mouse astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2939-46. PMID 9096130  1
1997 Beltramo M, di Tomaso E, Piomelli D. Inhibition of anandamide hydrolysis in rat brain tissue by (E)-6-(bromomethylene) tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one. Febs Letters. 403: 263-7. PMID 9091314  0.6
1996 di Tomaso E, Beltramo M, Piomelli D. Brain cannabinoids in chocolate. Nature. 382: 677-8. PMID 8751435 DOI: 10.1038/382677a0  0.6
1996 Cadas H, Gaillet S, Beltramo M, Venance L, Piomelli D. Biosynthesis of an endogenous cannabinoid precursor in neurons and its control by calcium and cAMP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 3934-42. PMID 8656287  0.92
1996 Lammers CH, Schweitzer P, Facchinetti P, Arrang JM, Madamba SG, Siggins GR, Piomelli D. Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling. Journal of Neurochemistry. 66: 147-52. PMID 8522947  1
1995 Venance L, Piomelli D, Glowinski J, Giaume C. Inhibition by anandamide of gap junctions and intercellular calcium signalling in striatal astrocytes. Nature. 376: 590-4. PMID 7637807 DOI: 10.1038/376590a0  0.92
1993 Sihra TS, Piomelli D, Nichols RA. Barium evokes glutamate release from rat brain synaptosomes by membrane depolarization: involvement of K+, Na+, and Ca2+ channels. Journal of Neurochemistry. 61: 1220-30. PMID 7690845  1
1992 Ruat M, Traiffort E, Leurs R, Arrang JM, Kouyoumdjian G, Tardivel-Lacombe J, Piomelli D, Diaz G, Schwartz JC. Molecular biology and pharmacology of histamine receptor subtypes. Clinical Neuropharmacology. 15: 149A-150A. PMID 1498787  1
1992 Traiffort E, Ruat M, Arrang JM, Leurs R, Piomelli D, Schwartz JC. Expression of a cloned rat histamine H2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation. Proceedings of the National Academy of Sciences of the United States of America. 89: 2649-53. PMID 1313563  1
1991 Piomelli D, Pilon C, Giros B, Sokoloff P, Martres MP, Schwartz JC. Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism. Nature. 353: 164-7. PMID 1909771 DOI: 10.1038/353164a0  1
1991 Piomelli D, Greengard P. Bidirectional control of phospholipase A2 activity by Ca2+/calmodulin-dependent protein kinase II, cAMP-dependent protein kinase, and casein kinase II. Proceedings of the National Academy of Sciences of the United States of America. 88: 6770-4. PMID 1650481  1
1991 Calignano A, Piomelli D, Sacktor TC, Schwartz JH. A phospholipase A2-stimulating protein regulated by protein kinase C in Aplysia neurons. Brain Research. Molecular Brain Research. 9: 347-51. PMID 1645437 DOI: 10.1016/0169-328X(91)90083-A  1
1990 Piomelli D, Greengard P. Lipoxygenase metabolites of arachidonic acid in neuronal transmembrane signalling. Trends in Pharmacological Sciences. 11: 367-73. PMID 2122564 DOI: 10.1016/0165-6147(90)90182-8  1
1989 Piomelli D, Feinmark SJ, Shapiro E, Schwartz JH. 12-keto-eicosatetraenoic acid. A biologically active eicosanoid in the nervous system of Aplysia. Annals of the New York Academy of Sciences. 559: 208-18. PMID 2774398  1
1989 Piomelli D, Wang JK, Sihra TS, Nairn AC, Czernik AJ, Greengard P. Inhibition of Ca2+/calmodulin-dependent protein kinase II by arachidonic acid and its metabolites. Proceedings of the National Academy of Sciences of the United States of America. 86: 8550-4. PMID 2554319  1
1989 Feinmark SJ, Piomelli D, Shapiro E, Schwartz JH. Biologically active metabolites of the 12-lipoxygenase pathway are formed by Aplysia nervous tissue. Annals of the New York Academy of Sciences. 559: 121-30. PMID 2505651  1
1989 Piomelli D, Shapiro E, Zipkin R, Schwartz JH, Feinmark SJ. Formation and action of 8-hydroxy-11,12-epoxy-5,9,14-icosatrienoic acid in Aplysia: a possible second messenger in neurons. Proceedings of the National Academy of Sciences of the United States of America. 86: 1721-5. PMID 2493649  1
1988 Piomelli D, Feinmark SJ, Shapiro E, Schwartz JH. Formation and biological activity of 12-ketoeicosatetraenoic acid in the nervous system of Aplysia. The Journal of Biological Chemistry. 263: 16591-6. PMID 3182804  1
1988 Shapiro E, Piomelli D, Feinmark S, Vogel S, Chin G, Schwartz JH. The role of arachidonic acid metabolites in signal transduction in an identified neural network mediating presynaptic inhibition in Aplysia. Cold Spring Harbor Symposia On Quantitative Biology. 53: 425-33. PMID 3151176  1
1987 Piomelli D, Feinmark SJ, Cannon PJ. Leukotriene biosynthesis by canine and human coronary arteries. The Journal of Pharmacology and Experimental Therapeutics. 241: 763-70. PMID 3598901  0.52
1987 Piomelli D, Shapiro E, Feinmark SJ, Schwartz JH. Metabolites of arachidonic acid in the nervous system of Aplysia: possible mediators of synaptic modulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 3675-86. PMID 3119791  1
1987 Piomelli D, Volterra A, Dale N, Siegelbaum SA, Kandel ER, Schwartz JH, Belardetti F. Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature. 328: 38-43. PMID 2439918 DOI: 10.1038/328038a0  1
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