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Wolfgang Sadee - Publications

Affiliations: 
1983-2002 University of California, San Francisco, San Francisco, CA 
 2008- Pharmacology Ohio State University, Columbus, Columbus, OH 
Website:
https://wexnermedical.osu.edu/neurological-institute/researchers/wolfgang-sadee-dr-rer-nat
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Year Citation  Score
2015 Mascarenhas R, Pietrzak M, Smith RM, Webb A, Wang D, Papp AC, Pinsonneault JK, Seweryn M, Rempala G, Sadee W. Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms. Plos One. 10: e0136798. PMID 26331722 DOI: 10.1371/Journal.Pone.0136798  0.536
2015 Lu R, Smith RM, Seweryn M, Wang D, Hartmann K, Webb A, Sadee W, Rempala GA. Analyzing allele specific RNA expression using mixture models. Bmc Genomics. 16: 566. PMID 26231172 DOI: 10.1186/S12864-015-1749-0  0.547
2015 Handelman SK, Seweryn M, Smith RM, Hartmann K, Wang D, Pietrzak M, Johnson AD, Kloczkowski A, Sadee W. Conditional entropy in variation-adjusted windows detects selection signatures associated with expression quantitative trait loci (eQTLs). Bmc Genomics. 16: S8. PMID 26111110 DOI: 10.1186/1471-2164-16-S8-S8  0.518
2014 Di Giorgio A, Smith RM, Fazio L, D'Ambrosio E, Gelao B, Tomasicchio A, Selvaggi P, Taurisano P, Quarto T, Masellis R, Rampino A, Caforio G, Popolizio T, Blasi G, Sadee W, et al. DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory. Plos One. 9: e95997. PMID 24819610 DOI: 10.1371/Journal.Pone.0095997  0.52
2014 Smith RM, Banks W, Hansen E, Sadee W, Herman GE. Family-based clinical associations and functional characterization of the serotonin 2A receptor gene (HTR2A) in autism spectrum disorder. Autism Research : Official Journal of the International Society For Autism Research. 7: 459-67. PMID 24753316 DOI: 10.1002/Aur.1383  0.55
2013 Grevel J, Thomas J, Richards ML, Sadée W. Radioreceptor assay of narcotic analgesics in serum. Pharmaceutical Research. 1: 209-14. PMID 24277330 DOI: 10.1023/A:1016369229440  0.31
2013 Richards ML, Sadée W. Buprenorphine is an Antagonist at the ϰ Opioid Receptor. Pharmaceutical Research. 2: 178-81. PMID 24272810 DOI: 10.1023/A:1016340106299  0.339
2013 Smith RM, Webb A, Papp AC, Newman LC, Handelman SK, Suhy A, Mascarenhas R, Oberdick J, Sadee W. Whole transcriptome RNA-Seq allelic expression in human brain. Bmc Genomics. 14: 571. PMID 23968248 DOI: 10.1186/1471-2164-14-571  0.53
2013 Smith RM, Papp AC, Webb A, Ruble CL, Munsie LM, Nisenbaum LK, Kleinman JE, Lipska BK, Sadee W. Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex. Biological Psychiatry. 73: 546-54. PMID 23158458 DOI: 10.1016/J.Biopsych.2012.09.028  0.577
2012 Barrie ES, Smith RM, Sanford JC, Sadee W. mRNA transcript diversity creates new opportunities for pharmacological intervention. Molecular Pharmacology. 81: 620-30. PMID 22319206 DOI: 10.1124/Mol.111.076604  0.528
2011 Smith RM, Sadee W. Synaptic signaling and aberrant RNA splicing in autism spectrum disorders. Frontiers in Synaptic Neuroscience. 3: 1. PMID 21423409 DOI: 10.3389/Fnsyn.2011.00001  0.511
2011 Sadee W, Wang D, Papp AC, Pinsonneault JK, Smith RM, Moyer RA, Johnson AD. Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy. Clinical Pharmacology and Therapeutics. 89: 355-65. PMID 21289622 DOI: 10.1038/Clpt.2010.314  0.534
2011 Moyer RA, Wang D, Papp AC, Smith RM, Duque L, Mash DC, Sadee W. Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 753-62. PMID 21150907 DOI: 10.1038/Npp.2010.208  0.528
2011 Smith RM, Alachkar H, Papp AC, Wang D, Mash DC, Wang JC, Bierut LJ, Sadee W. Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms. European Journal of Human Genetics : Ejhg. 19: 76-83. PMID 20700147 DOI: 10.1038/Ejhg.2010.120  0.549
2009 Roe BE, Tilley MR, Gu HH, Beversdorf DQ, Sadee W, Haab TC, Papp AC. Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene. Plos One. 4: e6704. PMID 19693267 DOI: 10.1371/Journal.Pone.0006704  0.516
2008 Johnson AD, Zhang Y, Papp AC, Pinsonneault JK, Lim JE, Saffen D, Dai Z, Wang D, Sadée W. Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues. Pharmacogenetics and Genomics. 18: 781-91. PMID 18698231 DOI: 10.1097/Fpc.0B013E3283050107  0.506
2007 Lim JE, Pinsonneault J, Sadee W, Saffen D. Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. Molecular Psychiatry. 12: 491-501. PMID 17453063 DOI: 10.1038/sj.mp.4001923  0.496
2006 Lim JE, Papp A, Pinsonneault J, Sadée W, Saffen D. Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR. Molecular Psychiatry. 11: 649-62. PMID 16432527 DOI: 10.1038/sj.mp.4001797  0.485
2003 Han G, Quillan JM, Carlson K, Sadée W, Hruby VJ. Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist. Journal of Medicinal Chemistry. 46: 810-9. PMID 12593660 DOI: 10.1021/Jm020355O  0.348
2002 Botka CW, Wittig TW, Graul RC, Nielsen CU, Higaka K, Amidon GL, Sadée W. Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. Aaps Pharmsci. 2: E16. PMID 11741232 DOI: 10.1208/Ps020216  0.301
2001 Lucas JL, DeYoung JA, Sadee W. Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene Aaps Pharmsci [Electronic Resource]. 3: E31. PMID 12049494 DOI: 10.1208/Ps030431  0.352
2001 Sadee W, Hoeg E, Lucas J, Wang D. Genetic variations in human G protein-coupled receptors: implications for drug therapy. Aaps Pharmsci. 3: E22. PMID 11741273 DOI: 10.1208/Ps030322  0.378
2001 Wang D, Quillan JM, Winans K, Lucas JL, Sadée W. Single nucleotide polymorphisms in the human mu opioid receptor gene alter basal G protein coupling and calmodulin binding. The Journal of Biological Chemistry. 276: 34624-30. PMID 11457836 DOI: 10.1074/Jbc.M104083200  0.375
2001 Wang D, Raehal KM, Bilsky EJ, Sadée W. Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. Journal of Neurochemistry. 77: 1590-600. PMID 11413242 DOI: 10.1046/J.1471-4159.2001.00362.X  0.334
2001 Graul RC, Sadee W. Evolutionary relationships among G protein-coupled receptors using a clustered database approach Aaps Pharmsci. 3. DOI: 10.1208/Ps030212  0.32
2000 Wang D, Tolbert LM, Carlson KW, Sadée W. Nuclear Ca2+/calmodulin translocation activated by mu-opioid (OP3) receptor. Journal of Neurochemistry. 74: 1418-25. PMID 10737597 DOI: 10.1046/J.1471-4159.2000.0741418.X  0.342
2000 Wang Z, Sadée W. Tolerance to morphine at the mu-opioid receptor differentially induced by cAMP-dependent protein kinase activation and morphine. European Journal of Pharmacology. 389: 165-71. PMID 10688980 DOI: 10.1016/S0014-2999(99)00881-X  0.338
2000 Choi DS, Wang D, Tolbert L, Sadée W. Basal signaling activity of human dopamine D2L receptor demonstrated with an ecdysone-inducible mammalian expression system Journal of Neuroscience Methods. 94: 217-225. PMID 10661841 DOI: 10.1016/S0165-0270(99)00147-8  0.348
1999 Shockley MS, Tolbert LM, Tobin AB, Nahorski SR, Sadée W, Lameh J. Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain. European Journal of Pharmacology. 377: 137-46. PMID 10448936 DOI: 10.1016/S0014-2999(99)00303-9  0.314
1999 Wang D, Sadée W, Quillan JM. Calmodulin binding to G protein-coupling domain of opioid receptors. The Journal of Biological Chemistry. 274: 22081-8. PMID 10419536 DOI: 10.1074/Jbc.274.31.22081  0.377
1999 Ito K, Haga T, Lameh J, Sadée W. Sequestration of dopamine D2 receptors depends on coexpression of G-protein-coupled receptor kinases 2 or 5. European Journal of Biochemistry. 260: 112-9. PMID 10091590 DOI: 10.1046/J.1432-1327.1999.00125.X  0.344
1998 Quillan JM, Sadée W, Wei ET, Jimenez C, Ji L, Chang JK. A synthetic human Agouti-related protein-(83-132)-NH2 fragment is a potent inhibitor of melanocortin receptor function. Febs Letters. 428: 59-62. PMID 9645475 DOI: 10.1016/S0014-5793(98)00487-6  0.313
1998 Burford NT, Tolbert LM, Sadee W. Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I. European Journal of Pharmacology. 342: 123-6. PMID 9544801 DOI: 10.1016/S0014-2999(97)01556-2  0.328
1998 Tsuga H, Kameyama K, Haga T, Honma T, Lameh J, Sadée W. Internalization and down-regulation of human muscarinic acetylcholine receptor m2 subtypes. Role of third intracellular m2 loop and G protein-coupled receptor kinase 2. The Journal of Biological Chemistry. 273: 5323-30. PMID 9478991 DOI: 10.1074/Jbc.273.9.5323  0.367
1998 Lu YF, Xu H, Liu-Chen LY, Chen C, Partilla JS, Brine GA, Carroll FI, Rice KC, Lai J, Porreca F, Sadee W, Rothman RB. Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor. Synapse (New York, N.Y.). 28: 117-24. PMID 9450512 DOI: 10.1002/(Sici)1098-2396(199802)28:2<117::Aid-Syn2>3.0.Co;2-E  0.369
1997 Shockley MS, Burford NT, Sadée W, Lameh J. Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor. Journal of Neurochemistry. 68: 601-9. PMID 9003046 DOI: 10.1046/J.1471-4159.1997.68020601.X  0.348
1996 Bilsky EJ, Inturrisi CE, Sadée W, Hruby VJ, Porreca F. Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective μ or δ opioid agonists in mice Pain. 68: 229-237. PMID 9121809 DOI: 10.1016/S0304-3959(96)03185-5  0.31
1996 Wang Z, Arden J, Sadée W. Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+-dependent. Febs Letters. 387: 53-7. PMID 8654566 DOI: 10.1016/0014-5793(96)00467-X  0.335
1995 Kameyama K, Haga K, Haga T, Moro O, Sadée W. Activation of a GTP-binding protein and a GTP-binding-protein-coupled receptor kinase (beta-adrenergic-receptor kinase-1) by a muscarinic receptor m2 mutant lacking phosphorylation sites. European Journal of Biochemistry. 226: 267-76. PMID 8001544 DOI: 10.1111/J.1432-1033.1994.Tb20050.X  0.341
1995 Sadée W, Wang Z. Agonist induced constitutive receptor activation as a novel regulatory mechanism. Mu receptor regulation. Advances in Experimental Medicine and Biology. 373: 85-90. PMID 7668164 DOI: 10.1007/978-1-4615-1951-5_12  0.369
1995 Shockley M, Högger P, Lameh J, Sadée W. Identification of residues in the intracellular loops of the human muscarinic cholinergic HM1 receptor involved in G-protein coupling and down-regulation Life Sciences. 56: 1030. DOI: 10.1016/0024-3205(95)93772-7  0.32
1994 Wang Z, Bilsky EJ, Porreca F, Sadee W. Constitutive μ opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence Life Sciences. 54. PMID 7514710 DOI: 10.1016/0024-3205(94)90022-1  0.33
1994 Wang Z, Arden JR, Segredo V, Sadée W. Agonist induced constitutive activation of the μ opioid receptor by phosphorylation Regulatory Peptides. 54: 323-324. DOI: 10.1016/0167-0115(94)90519-3  0.36
1994 Wang Z, Sadée W. Constitutive μ opioid receptor activity in human neuroblastoma SK-N-SH cells Regulatory Peptides. 53: S283-S284. DOI: 10.1016/0167-0115(94)90348-4  0.357
1993 Drübbisch V, Lameh J, Philip M, Sharma YK, Sadée W. Mapping the ligand binding pocket of the human muscarinic cholinergic receptor Hm1: contribution of tyrosine-82. Pharmaceutical Research. 9: 1644-7. PMID 1488411 DOI: 10.1023/A:1015885029612  0.33
1992 Cook JS, Wolsing DH, Lameh J, Olson CA, Correa PE, Sadee W, Blumenthal EM, Rosenbaum JS. Characterization of the RDC1 gene which encodes the canine homolog of a proposed human VIP receptor. Expression does not correlate with an increase in VIP binding sites. Febs Letters. 300: 149-52. PMID 1373390 DOI: 10.1016/0014-5793(92)80184-I  0.352
1992 Lameh J, Eiger S, Sadée W. Interaction among mu-opioid receptors and alpha 2-adrenoceptors on SH-SY5Y human neuroblastoma cells. European Journal of Pharmacology. 227: 19-24. PMID 1358661 DOI: 10.1016/0922-4106(92)90137-K  0.308
1992 Cone RI, Rosenfeld S, Lameh J, Sadée W. 125I-beta-endorphin binding to neuroblastoma X glioma NG108-15 cells: distribution of delta opioid receptors. Life Sciences. 51: PL219-24. PMID 1331640 DOI: 10.1016/0024-3205(92)90306-A  0.312
1991 Cone RI, Lameh J, Sadée W. Rapid agonist-induced loss of 125I-beta-endorphin opioid receptor sites in NG108-15, but not SK-N-SH neuroblastoma cells. Life Sciences. 49: PL147-52. PMID 1658508 DOI: 10.1016/0024-3205(91)90396-S  0.347
1991 Maeda S, Lameh J, Philip M, Sadee W. Functions of the third cytoplasmic loop of human m1 muscarinic cholinergic receptors : Receptor internalization and phosphatidyl inositol turnover Neuroscience Research Supplements. 14: S136. DOI: 10.1016/S0921-8696(06)80397-X  0.33
1990 Maeda S, Lameh J, Mallet WG, Philip M, Ramachandran J, Sadée W. Internalization of the Hm1 muscarinic cholinergic receptor involves the third cytoplasmic loop. Febs Letters. 269: 386-8. PMID 2401364 DOI: 10.1016/0014-5793(90)81199-X  0.344
1990 Lameh J, Cone RI, Maeda S, Philip M, Corbani M, Nádasdi L, Ramachandran J, Smith GM, Sadée W. Structure and function of G protein coupled receptors. Pharmaceutical Research. 7: 1213-21. PMID 1965663 DOI: 10.1023/A:1015969301407  0.319
1990 Yu VC, Eiger S, Duan DS, Lameh J, Sadée W. Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells. Journal of Neurochemistry. 55: 1390-6. PMID 1697894 DOI: 10.1111/J.1471-4159.1990.Tb03151.X  0.346
1988 Hochhaus G, Sadée W. A Biotin–Avidin-Based Enzyme Immunoassay for βh-Endorphin Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 232-235. PMID 2977649 DOI: 10.1023/A:1015993713471  0.504
1988 Hochhaus G, Patthy A, Schwietert R, Santi DV, Sadée W. [Biocytin13]Dynorphin A 1-13 Amide: A Potential Probe for the κ-Opioid Receptor Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 5: 790-794. PMID 2907785 DOI: 10.1023/A:1015944903360  0.573
1988 Sadee W, Yu VC, Hochhaus G. Effects of opioid peptides on human neuroblastoma cells Nida Research Monograph Series. 111-117. PMID 2855093  0.469
1988 Preis PN, Saya H, Nadasdi L, Hochhaus G, Levin V, Sadee W. Neuronal Cell Differentiation of Human Neuroblastoma Cells by Retinoic Acid plus Herbimycin A Cancer Research. 48: 6530-6534. PMID 2846152  0.451
1988 Hochhaus G, Gibson BW, Sadee W. Biotinylated human β-endorphins as probes for the opioid receptor Journal of Biological Chemistry. 263: 92-97. PMID 2826453  0.517
1987 Yu VC, Sadée W. Phosphatidylinositol turnover in neuroblastoma cells: regulation by bradykinin, acetylcholine, but not mu- and delta-opioid receptors. Neuroscience Letters. 71: 219-23. PMID 3024076 DOI: 10.1016/0304-3940(86)90562-8  0.364
1986 Lybrand TP, Kollman PA, Yu VC, Sadée W. Conformation and electrostatic potential surfaces of opiates: Relationship to µ- and λ-site binding. Pharmaceutical Research. 3: 218-24. PMID 24271585 DOI: 10.1023/A:1016338730077  0.324
1986 Richards ML, Sadeé W. In vivo binding of putative delta-selective opioid antagonists to central opiate receptors. European Journal of Pharmacology. 126: 313-6. PMID 3019718 DOI: 10.1016/0014-2999(86)90064-6  0.37
1986 Hochhaus G, Yu VC, Sadée W. Delta opioid receptor in human neuroblastoma cell lines Brain Research. 382: 327-331. PMID 3019481 DOI: 10.1016/0006-8993(86)91341-7  0.557
1986 Hochhaus G, Gibson BW, Sadée W. Development of a biotin-avidin probe for detecting opioid receptors Nida Research Monograph. 75: 33-36. PMID 2828982  0.488
1985 Richards ML, Sadée W. In vivo opiate receptor binding of oripavines to mu, delta and kappa sites in rat brain as determined by an ex vivo labeling method. European Journal of Pharmacology. 114: 343-53. PMID 2998812 DOI: 10.1016/0014-2999(85)90379-6  0.364
1985 Grevel J, Yu V, Sadée W. Characterization of a labile naloxone binding site (lambda site) in rat brain. Journal of Neurochemistry. 44: 1647-56. PMID 2985759 DOI: 10.1111/J.1471-4159.1985.Tb08808.X  0.306
1984 Rosenbaum JS, Holford NH, Sadée W. Opiate receptor binding-effect relationship: sufentanil and etorphine produce analgesia at the mu-site with low fractional receptor occupancy. Brain Research. 291: 317-24. PMID 6320962 DOI: 10.1016/0006-8993(84)91264-2  0.315
1984 Sadée W, Richards ML, Grevel J, Rosenbaum JS. In vivo characterization of four types of opioid binding sites in rat brain. Life Sciences. 187-9. PMID 6141486 DOI: 10.1016/0024-3205(83)90474-5  0.347
1983 Rosenbaum JS, Kurowski M, Aman RA, Sadée W. Partial loss of opiate receptor regulation by GPP(NH)P evident in vitro. Life Sciences. 31: 1667-70. PMID 6296568 DOI: 10.1016/0024-3205(82)90181-3  0.353
1983 Perry DC, Rosenbaum JS, Sadee W. In vivo binding of 3H-etorphine in morphine-dependent rats. Life Sciences. 31: 1405-8. PMID 6292637 DOI: 10.1016/0024-3205(82)90392-7  0.355
1983 Rosenbaum JS, Sadée W. Demonstration of opiate receptor sub-types in vivo. Life Sciences. 31: 1299-301. PMID 6292617 DOI: 10.1016/0024-3205(82)90366-6  0.318
1983 Kurowski M, Rosenbaum JS, Perry DC, Sadée W. [3H]-etorphine and [3H]-diprenorphine receptor binding in vitro and in vivo: differential effect of Na+ and guanylyl imidodiphosphate. Brain Research. 249: 345-52. PMID 6291717 DOI: 10.1016/0006-8993(82)90068-3  0.346
1982 Sadée W, Perry DC, Rosenbaum JS, Herz A. [3H]diprenorphine receptor binding in vivo and in vitro. European Journal of Pharmacology. 81: 431-40. PMID 6288412 DOI: 10.1016/0014-2999(82)90108-X  0.32
1980 Perry DC, Mullis KB, Oie S, Sadée W. Opiate antagonist receptor binding in vivo: evidence for a new receptor binding model. Brain Research. 199: 49-61. PMID 6250676 DOI: 10.1016/0006-8993(80)90229-2  0.365
1973 CASTAGNOLI N, SADEE W. ChemInform Abstract: MECHANISMEN DER RK. EINES 1,4-BENZODIAZEPIN-N-OXIDES MIT ACETANHYDRID Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/chin.197306283  0.409
1972 Castagnoli N, Sadée W. Mechanism of the reaction of a 1,4-benzodiazepine N-oxide with acetic anhydride. Journal of Medicinal Chemistry. 15: 1076-8. PMID 5069778 DOI: 10.1021/Jm00280A024  0.405
1971 Sadèe W, Garland W, Castagnoli N. Microsomal 3-hydroxylation of 1,4-benzodiazepines. Journal of Medicinal Chemistry. 14: 643-5. PMID 5164455  0.435
1971 SADEE W, GARLAND W, CASTAGNOLI N. ChemInform Abstract: MIKROSOMALE 3-HYDROXYLIERUNG VON 1,4-BENZODIAZEPINEN Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/chin.197143360  0.388
Low-probability matches (unlikely to be authored by this person)
1995 Högger P, Shockley MS, Lameh J, Sadée W. Activating and inactivating mutations in N- and C-terminal i3 loop junctions of muscarinic acetylcholine Hm1 receptors. The Journal of Biological Chemistry. 270: 7405-10. PMID 7706286 DOI: 10.1074/Jbc.270.13.7405  0.298
2003 Kassack MU, Höfgen B, Lehmann J, Eckstein N, Quillan JM, Sadée W. Functional screening of G protein-coupled receptors by measuring intracellular calcium with a fluorescence microplate reader. Journal of Biomolecular Screening. 7: 233-46. PMID 12097186 DOI: 10.1177/108705710200700307  0.294
1997 Quillan JM, Sadée W. Dynorphin peptides: antagonists of melanocortin receptors. Pharmaceutical Research. 14: 713-9. PMID 9210186 DOI: 10.1023/A:1012185919153  0.293
2000 Burford NT, Wang D, Sadée W. G-protein coupling of mu-opioid receptors (OP3): elevated basal signalling activity. The Biochemical Journal. 348: 531-7. PMID 10839983 DOI: 10.1042/Bj3480531  0.286
1981 Cohen MB, Maybaum J, Sadée W. Analysis of purine ribonucleotides and deoxyribonucleotides in cell extracts by high-performance liquid chromatography. Journal of Chromatography. 198: 435-41. PMID 7440680 DOI: 10.1016/S0021-9673(00)80512-9  0.285
1982 Sadée W, Pfeiffer A, Herz A. Opiate receptor: multiple effects of metal ions. Journal of Neurochemistry. 39: 659-67. PMID 6284875 DOI: 10.1111/J.1471-4159.1982.Tb07943.X  0.283
1987 Richards ML, Sadee W. Human neuroblastoma cell lines as models of catechol uptake. Brain Research. 384: 132-7. PMID 3790988 DOI: 10.1016/0006-8993(86)91228-X  0.28
1993 Sadée W, Moro O, Lameh J. HM1 receptor internalization induced by carbachol requires a short S/T rich domain of the i3 loop Life Sciences. 52: 559. DOI: 10.1016/0024-3205(93)90335-Z  0.278
2005 Zhang Y, Wang D, Johnson AD, Papp AC, Sadée W. Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. The Journal of Biological Chemistry. 280: 32618-24. PMID 16046395 DOI: 10.1074/jbc.M504942200  0.277
1998 Covitz KM, Amidon GL, Sadée W. Membrane topology of the human dipeptide transporter, hPEPT1, determined by epitope insertions. Biochemistry. 37: 15214-21. PMID 9790685 DOI: 10.1021/Bi981128K  0.274
2001 Urtti A, Johns SJ, Sadee W. Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant Aaps Pharmsci. 3. DOI: 10.1208/Ps030106  0.274
1980 Maybaum J, Klein FK, Sadee W. Determination of pyrimidine ribotide and deoxyribotide pools in cultured cells and mouse liver by high-performance liquid chromatography. Journal of Chromatography. 188: 149-58. PMID 7380929 DOI: 10.1016/S0021-9673(00)88425-3  0.272
1983 Nguyen BT, Cohen MB, Sadée W. Guanine ribonucleotide depletion in mammalian cells - A target of purine antimetabolites Cancer Chemotherapy and Pharmacology. 11: 117-119. PMID 6578881 DOI: 10.1007/Bf00254259  0.271
1995 Arden JR, Segredo V, Wang Z, Lameh J, Sadée W. Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cells. Journal of Neurochemistry. 65: 1636-45. PMID 7561859 DOI: 10.1046/j.1471-4159.1995.65041636.x  0.267
1995 Sadée W, Drübbisch V, Amidon GL. Biology of Membrane Transport Proteins Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 1823-1837. PMID 8786953 DOI: 10.1023/A:1016211015926  0.265
1995 Oh DM, Amidon GL, Sadee W. Functional expressions of endogenous dipeptide transporter and exogenous proton/peptide cotransporter in Xenopus oocytes Archives of Pharmacal Research. 18: 12-17. DOI: 10.1007/Bf02976500  0.265
1990 Duan DS, Farmer D, Rayner AA, Sadee W. Cytotoxicity of lymphokine-activated killer cells against human neuroblastoma cells: Modulation by neuroblast differentiation Medical and Pediatric Oncology. 18: 339-344. PMID 1972538 DOI: 10.1002/Mpo.2950180418  0.263
2002 Mancinelli L, Cronin M, Sadée W. Pharmacogenomics: the promise of personalized medicine. Aaps Pharmsci. 2: E4. PMID 11741220 DOI: 10.1208/Ps020104  0.261
1999 Lin K, Quillan J, Lameh J, Sadée W. Multiphasic calcium currents stimulated by the HM1 receptors Life Sciences. 64: 577. DOI: 10.1016/S0024-3205(99)90510-6  0.256
1989 Muller J, Agoston D, Lolait S, Yu V, Sadee W, Waschek J. Potential autocrine and autoregulatory action of VIP in human neuroblastoma cells Regulatory Peptides. 26: 171. DOI: 10.1016/0167-0115(89)90065-7  0.251
2002 Lin K, Wang D, Sadée W. Serum response factor activation by muscarinic receptors via RhoA. Novel pathway specific to M1 subtype involving calmodulin, calcineurin, and Pyk2. The Journal of Biological Chemistry. 277: 40789-98. PMID 12200418 DOI: 10.1074/Jbc.M202745200  0.247
1984 Yu VC, Jacobson AE, Rice KC, Sadée W. Stereospecificity of 4,5-epoxymorphinan binding to the λ site in rat brain European Journal of Pharmacology. 101: 161-162. PMID 6086361 DOI: 10.1016/0014-2999(84)90045-1  0.243
1990 Duan DS, Nagashima T, Hoshino T, Waldman F, Pawlak K, Sadee W. Mechanisms of 2'-deoxyguanosine toxicity in mouse T-lymphoma cells with purine nucleoside phosphorylase deficiency and resistance to inhibition of ribonucleotide reductase by dGTP. The Biochemical Journal. 268: 725-31. PMID 2114100 DOI: 10.1042/Bj2680725  0.242
1997 Shukur LR, Powers JL, Marques RA, Winter ME, Sadèe W. Measurement of Procainamide and N-Acetylprocainamide in Serum by High-Performance Liquid Chromatography Clinical Chemistry. 23: 636-638. DOI: 10.1093/Clinchem/23.4.636  0.242
1989 Duan DS, Sadee W. Guanine for DNA synthesis. A compulsory route through ribonucleotide reductase. The Biochemical Journal. 255: 1045-8. PMID 3063254 DOI: 10.1042/Bj2551045  0.241
1997 Segredo V, Burford NT, Lameh J, Sadée W. A constitutively internalizing and recycling mutant of the mu-opioid receptor. Journal of Neurochemistry. 68: 2395-404. PMID 9166733 DOI: 10.1046/j.1471-4159.1997.68062395.x  0.241
2006 Anderle P, Nielsen CU, Pinsonneault J, Krog PL, Brodin B, Sadée W. Genetic variants of the human dipeptide transporter PEPT1. The Journal of Pharmacology and Experimental Therapeutics. 316: 636-46. PMID 16258023 DOI: 10.1124/jpet.105.094615  0.238
2007 Wang D, Sun X, Sadee W. Different effects of opioid antagonists on mu-, delta-, and kappa-opioid receptors with and without agonist pretreatment. The Journal of Pharmacology and Experimental Therapeutics. 321: 544-52. PMID 17267582 DOI: 10.1124/jpet.106.118810  0.235
2006 Wang D, Sadée W. Searching for polymorphisms that affect gene expression and mRNA processing: example ABCB1 (MDR1). The Aaps Journal. 8: E515-20. PMID 17025270 DOI: 10.1208/aapsj080361  0.232
1999 Sadée W, Graul RC, Lee AY. Classification of membrane transporters Pharmaceutical Biotechnology. 12: 29-58. PMID 10742971 DOI: 10.1007/0-306-46812-3_2  0.232
2004 Pinsonneault J, Nielsen CU, Sadée W. Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions. The Journal of Pharmacology and Experimental Therapeutics. 311: 1088-96. PMID 15282265 DOI: 10.1124/jpet.104.073098  0.231
1988 Klinz FJ, Yu VC, Sadée W, Costa T. Differential expression of alpha-subunits of G-proteins in human neuroblastoma-derived cell clones. Febs Letters. 224: 43-8. PMID 3119368 DOI: 10.1016/0014-5793(87)80419-2  0.231
1980 Wasserman TH, Phillips TL, Johnson RJ, Gomer CJ, Lawrence GA, Sadee W, Marques RA, Levin VA, VanRaalte G. Initial United States clinical and pharmacologic evaluation of misonidazole (Ro-07-0582), an hypoxic cell radiosensitizer. International Journal of Radiation Oncology, Biology, Physics. 5: 775-86. PMID 227821 DOI: 10.1016/0360-3016(79)90061-0  0.23
1998 Schmidt MC, Rothen-Rutishauser B, Rist B, Beck-Sickinger A, Wunderli-Allenspach H, Rubas W, Sadée W, Merkle HP. Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane. Biochemistry. 37: 16582-90. PMID 9843425 DOI: 10.1021/Bi981219H  0.228
1994 Sadée W, Wang Z, Arden JR, Segredo V. Constitutive Activation of the μ-Opioid Receptor: A Novel Paradigm of Receptor Regulation in Narcotic Analgesia, Tolerance, and Dependence Analgesia. 1: 11-14. DOI: 10.3727/107156994819564474  0.228
2005 Sadée W, Wang D, Bilsky EJ. Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities. Life Sciences. 76: 1427-37. PMID 15680308 DOI: 10.1016/j.lfs.2004.10.024  0.227
2002 Zahn K, Eckstein N, Tränkle C, Sadée W, Mohr K. Allosteric modulation of muscarinic receptor signaling: alcuronium-induced conversion of pilocarpine from an agonist into an antagonist. The Journal of Pharmacology and Experimental Therapeutics. 301: 720-8. PMID 11961078 DOI: 10.1124/jpet.301.2.720  0.227
1999 Pang DC, Amidon GL, Preusch PC, Sadee W. Meeting report. Second AAPS-NIH frontier symposium 1999: Membrane transporters and drug therapy Aaps Pharmsci. 1: XI-XII. DOI: 10.1208/Ps010205  0.226
1978 Friedman MA, Sadée W. The fluoropyrimidines: biochemical mechanisms and design of clinical trials. Cancer Chemotherapy and Pharmacology. 1: 77-82. PMID 373913 DOI: 10.1007/Bf00254040  0.226
1978 Wasserman TH, Phillips TL, Johnson RJ, Sadee W, Gomer C, Lawrence G, Levin V, VanRaalte G. +++Clinical toxicology and pharmacology of misonidazole- an hypoxic cell radiosensitizer International Journal of Radiation Oncology*Biology*Physics. 4: 132. DOI: 10.1016/0360-3016(78)90306-1  0.225
1999 Surendran N, Covitz KM, Han H, Sadee W, Oh DM, Amidon GL, Williamson RM, Bigge CF, Stewart BH. Evidence for overlapping substrate specificity between large neutral amino acid (LNAA) and dipeptide (hPEPT1) transporters for PD 158473, an NMDA antagonist. Pharmaceutical Research. 16: 391-5. PMID 10213369 DOI: 10.1023/A:1018821718340  0.222
2001 Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W. Potential role of pharmacogenomics in reducing adverse drug reactions: A systematic review Journal of the American Medical Association. 286: 2270-2279. PMID 11710893 DOI: 10.1001/Jama.286.18.2270  0.221
2013 Sadée W. Protein drugs: a revolution in therapy? Pharmaceutical Research. 3: 3-6. PMID 24271350 DOI: 10.1023/A:1016360512814  0.22
1997 Graul RC, Sadée W. Sequence alignments of the H(+)-dependent oligopeptide transporter family PTR: inferences on structure and function of the intestinal PET1 transporter. Pharmaceutical Research. 14: 388-400. PMID 9144720 DOI: 10.1023/A:1012070726480  0.219
1981 Day JL, Maybaum J, Sadée W. Determination of 5-fluoro-2'-deoxyuridine[6-3H] as an impurity in 5-fluoro-uracil[6-3H] by high-performance liquid chromatography. Journal of Chromatography. 206: 407-9. PMID 6453879 DOI: 10.1016/S0021-9673(00)82557-1  0.219
2022 Sadee W, McKew JC. Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction. Molecules (Basel, Switzerland). 27. PMID 36144565 DOI: 10.3390/molecules27185826  0.219
2016 Barrie ES, Hartmann K, Lee SH, Frater JT, Seweryn M, Wang D, Sadee W. The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations. Human Mutation. PMID 27758088 DOI: 10.1002/humu.23135  0.217
1986 Day JL, Sadee W. Determination of 5-fluorouridine diphosphate glucose as a metabolite of 5-fluorouracil in mouse T-lymphoma (S-49) cells using high-performance liquid chromatography. Journal of Chromatography. 356: 445-9. PMID 3486874 DOI: 10.1016/S0021-9673(00)91515-2  0.216
2015 Wang D, Sadee W. CYP3A4 intronic SNP rs35599367 (CYP3A4*22) alters RNA splicing. Pharmacogenetics and Genomics. PMID 26488616 DOI: 10.1097/FPC.0000000000000183  0.216
2023 Sadee W. Ligand-Free Signaling of G-Protein-Coupled Receptors: Physiology, Pharmacology, and Genetics. Molecules (Basel, Switzerland). 28. PMID 37687205 DOI: 10.3390/molecules28176375  0.213
2000 Wang D, Surratt CK, Sadée W. Calmodulin regulation of basal and agonist-stimulated G protein coupling by the mu-opioid receptor (OP(3)) in morphine-pretreated cell. Journal of Neurochemistry. 75: 763-71. PMID 10899953 DOI: 10.1046/j.1471-4159.2000.0750763.x  0.212
1998 Graul RC, Sadée W. Evolutionary relationships among proteins probed by an iterative neighborhood cluster analysis (INCA). Alignment of bacteriorhodopsins with the yeast sequence YRO2. Pharmaceutical Research. 14: 1533-41. PMID 9434271 DOI: 10.1023/A:1012166015402  0.212
2005 Johnson AD, Wang D, Sadee W. Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics. Pharmacology & Therapeutics. 106: 19-38. PMID 15781120 DOI: 10.1016/j.pharmthera.2004.11.001  0.212
2011 Wang D, Para MF, Koletar SL, Sadee W. Human N-acetyltransferase 1 *10 and *11 alleles increase protein expression through distinct mechanisms and associate with sulfamethoxazole-induced hypersensitivity. Pharmacogenetics and Genomics. 21: 652-64. PMID 21878835 DOI: 10.1097/FPC.0b013e3283498ee9  0.209
1998 Sadée W. Genomics and drugs: finding the optimal drug for the right patient. Pharmaceutical Research. 15: 959-63. PMID 9688044 DOI: 10.1023/A:1011949221202  0.208
2014 Suhy A, Hartmann K, Newman L, Papp A, Toneff T, Hook V, Sadee W. Genetic variants affecting alternative splicing of human cholesteryl ester transfer protein. Biochemical and Biophysical Research Communications. 443: 1270-4. PMID 24393849 DOI: 10.1016/J.Bbrc.2013.12.127  0.203
1982 El Sayed YM, Sadée W. Metabolic activation of ftorafur [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil]: the microsomal oxidative pathway. Biochemical Pharmacology. 31: 3006-8. PMID 6814451 DOI: 10.1016/0006-2952(82)90279-9  0.202
1994 Wang Z, Bilsky EJ, Porreca F, Sadée W. Accelerated communciation: Constitutive μ opioid receptor activation as a regulatory mechanism underlying narcotic tolerance and dependence Life Sciences. 54. DOI: 10.1016/0024-3205(94)90022-1  0.202
1978 Marques RA, Stafford B, Flynn N, Sadée W. Determination of metronidazole and misonidazole and their metabolites in plasma and urine by high-performance liquid chromatography Journal of Chromatography B: Biomedical Sciences and Applications. 146: 163-166. PMID 670352 DOI: 10.1016/S0378-4347(00)81303-1  0.201
2003 Tammler U, Quillan JM, Lehmann J, Sadée W, Kassack MU. Design, synthesis, and biological evaluation of non-peptidic ligands at the Xenopus laevis skin-melanocortin receptor. European Journal of Medicinal Chemistry. 38: 481-93. PMID 12767598 DOI: 10.1016/S0223-5234(03)00062-X  0.198
2012 Papp AC, Pinsonneault JK, Wang D, Newman LC, Gong Y, Johnson JA, Pepine CJ, Kumari M, Hingorani AD, Talmud PJ, Shah S, Humphries SE, Sadee W. Cholesteryl Ester Transfer Protein (CETP) polymorphisms affect mRNA splicing, HDL levels, and sex-dependent cardiovascular risk. Plos One. 7: e31930. PMID 22403620 DOI: 10.1371/journal.pone.0031930  0.196
2005 Zhang Y, Wang D, Sadée W. Calmodulin interaction with peptides from G-protein coupled receptors measured with S-Tag labeling. Biochemical and Biophysical Research Communications. 333: 390-5. PMID 15950946 DOI: 10.1016/j.bbrc.2005.05.129  0.196
2019 Jabeen S, Pinsonneault JK, Sadee W, Lee SH, Zafar MM, Raja MS, Raja GK. Significant association of DRD2 enhancer variant rs12364283 with heroin addiction in a Pakistani population. Annals of Human Genetics. PMID 31025317 DOI: 10.1111/ahg.12322  0.196
2011 Pinsonneault JK, Han DD, Burdick KE, Kataki M, Bertolino A, Malhotra AK, Gu HH, Sadee W. Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1644-55. PMID 21525861 DOI: 10.1038/Npp.2011.45  0.195
2001 Belcheva MM, Szùcs M, Wang D, Sadee W, Coscia CJ. mu-Opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation. The Journal of Biological Chemistry. 276: 33847-53. PMID 11457825 DOI: 10.1074/jbc.M101535200  0.195
2006 Pinsonneault JK, Papp AC, Sadée W. Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors. Human Molecular Genetics. 15: 2636-49. PMID 16893905 DOI: 10.1093/hmg/ddl192  0.194
2008 Dai Z, Papp AC, Wang D, Hampel H, Sadee W. Genotyping panel for assessing response to cancer chemotherapy. Bmc Medical Genomics. 1: 24. PMID 18547414 DOI: 10.1186/1755-8794-1-24  0.194
2022 Sadee W, Oberdick J. Low-Dose 6β-Naltrexol Prevents Opioid Dependence Without Affecting Antinociception. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 35553999 DOI: 10.1096/fasebj.2022.36.S1.R6225  0.192
2022 Hartmann K, Seweryn M, Sadee W. Interpreting coronary artery disease GWAS results: A functional genomics approach assessing biological significance. Plos One. 17: e0244904. PMID 35192625 DOI: 10.1371/journal.pone.0244904  0.192
2000 Wang Z, Sadee W. Dissociation of morphine-induced cyclic AMP-upregulation and μ-opioid receptor desensitization Proceedings of the Western Pharmacology Society. 43: 9-10. PMID 11056942  0.19
2013 Azad AK, Curtis A, Papp A, Webb A, Knoell D, Sadee W, Schlesinger LS. Allelic mRNA expression imbalance in C-type lectins reveals a frequent regulatory SNP in the human surfactant protein A (SP-A) gene. Genes and Immunity. 14: 99-106. PMID 23328842 DOI: 10.1038/Gene.2012.61  0.189
2014 Wang D, Poi MJ, Sun X, Gaedigk A, Leeder JS, Sadee W. Common CYP2D6 polymorphisms affecting alternative splicing and transcription: long-range haplotypes with two regulatory variants modulate CYP2D6 activity. Human Molecular Genetics. 23: 268-78. PMID 23985325 DOI: 10.1093/Hmg/Ddt417  0.188
2011 Wang D, Guo Y, Wrighton SA, Cooke GE, Sadee W. Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs. The Pharmacogenomics Journal. 11: 274-86. PMID 20386561 DOI: 10.1038/tpj.2010.28  0.187
1999 Lin K, Sadée W, Quillan JM. Rapid measurements of intracellular calcium using a fluorescence plate reader. Biotechniques. 26: 318-22, 324-6. PMID 10023544 DOI: 10.2144/99262rr02  0.186
2013 Webb A, Papp AC, Sanford JC, Huang K, Parvin JD, Sadee W. Expression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver. Pharmacogenetics and Genomics. 23: 269-78. PMID 23492907 DOI: 10.1097/FPC.0b013e32835ff536  0.185
2018 Ray B, Ozcagli E, Sadee W, Wang D. CYP2D6 haplotypes with enhancer single-nucleotide polymorphism rs5758550 and rs16947 (*2 allele): implications for CYP2D6 genotyping panels. Pharmacogenetics and Genomics. PMID 30520769 DOI: 10.1097/FPC.0000000000000363  0.183
2018 Lee SH, Ahn WY, Seweryn M, Sadee W. Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence. Bmc Genomics. 19: 826. PMID 30453884 DOI: 10.1186/S12864-018-5219-3  0.182
1996 Sadée W. Quo vadis, pharmaceutical sciences, and AAPS? Pharmaceutical Research. 12: 1393-4. PMID 8584470 DOI: 10.1023/A:1016202530097  0.181
2017 Pinsonneault JK, Frater JT, Kompa B, Mascarenhas R, Wang D, Sadee W. Intronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traits. Plos One. 12: e0179020. PMID 28617822 DOI: 10.1371/journal.pone.0179020  0.18
2008 Alachkar H, Kataki M, Scharre DW, Papp A, Sadee W. Allelic mRNA expression of sortilin-1 (SORL1) mRNA in Alzheimer's autopsy brain tissues. Neuroscience Letters. 448: 120-4. PMID 18938222 DOI: 10.1016/j.neulet.2008.10.034  0.18
1983 Grevel J, Sadée W. An opiate binding site in the rat brain is highly selective for 4,5-epoxymorphinans. Science (New York, N.Y.). 221: 1198-201. PMID 6310750 DOI: 10.1126/science.6310750  0.177
2014 Sadee W, Hartmann K, Seweryn M, Pietrzak M, Handelman SK, Rempala GA. Missing heritability of common diseases and treatments outside the protein-coding exome. Human Genetics. 133: 1199-215. PMID 25107510 DOI: 10.1007/s00439-014-1476-7  0.176
2001 Sadee W, Hoeg JLE, Wang D. Genetic variations in human G protein-coupled receptors: implications for drug therapy Aaps Journal. 3: XXVI-XXVII. DOI: 10.1208/ps030322  0.176
2015 Webb A, Papp AC, Curtis A, Newman LC, Pietrzak M, Seweryn M, Handelman SK, Rempala GA, Wang D, Graziosa E, Tyndale RF, Lerman C, Kelsoe JR, Mash DC, Sadee W. RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles. Bmc Genomics. 16: 990. PMID 26597164 DOI: 10.1186/S12864-015-2207-8  0.175
2016 Cubells JF, Schroeder JP, Barrie ES, Manvich DF, Sadee W, Berg T, Mercer K, Stowe TA, Liles LC, Squires KE, Mezher A, Curtin P, Perdomo DL, Szot P, Weinshenker D. Human Bacterial Artificial Chromosome (BAC) Transgenesis Fully Rescues Noradrenergic Function in Dopamine β-Hydroxylase Knockout Mice. Plos One. 11: e0154864. PMID 27148966 DOI: 10.1371/Journal.Pone.0154864  0.175
1997 Lin K, Lameh J, Sadée W. Overexpression of β-adrenergic receptor kinase attenuates muscarinic m1 receptor coupling in HEK 293 cells Life Sciences. 60: 1185. DOI: 10.1016/S0024-3205(97)84342-1  0.174
1999 Felder CB, Graul RC, Lee AY, Merkle HP, Sadee W. The venus flytrap of periplasmic binding proteins: An ancient protein module present in multiple drug receptors Aaps Journal. 1: XIII-XIV. DOI: 10.1208/ps010202  0.173
2013 Sanford JC, Guo Y, Sadee W, Wang D. Regulatory polymorphisms in CYP2C19 affecting hepatic expression. Drug Metabolism and Drug Interactions. 28: 23-30. PMID 23412869 DOI: 10.1515/dmdi-2012-0038  0.173
2020 Sadee W, Oberdick J, Wang Z. Biased Opioid Antagonists as Modulators of Opioid Dependence: Opportunities to Improve Pain Therapy and Opioid Use Management. Molecules (Basel, Switzerland). 25. PMID 32932935 DOI: 10.3390/molecules25184163  0.172
2003 Salvi A, Quillan JM, Sadée W. Monitoring intracellular pH changes in response to osmotic stress and membrane transport activity using 5-chloromethylfluorescein. Aaps Pharmsci. 4: E21. PMID 12645993 DOI: 10.1208/ps040421  0.172
1982 Pfeiffer A, Sadee W, Herz A. Differential regulation of the mu-, delta-, and kappa-opiate receptor subtypes by guanyl nucleotides and metal ions The Journal of Neuroscience. 2: 912-917. DOI: 10.1523/JNEUROSCI.02-07-00912.1982  0.17
2008 Wang D, Chen H, Momary KM, Cavallari LH, Johnson JA, Sadée W. Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement. Blood. 112: 1013-21. PMID 18523153 DOI: 10.1182/Blood-2008-03-144899  0.17
2020 Safa A, Lau AR, Aten S, Schilling K, Bales KL, Miller VA, Fitzgerald J, Chen M, Hill K, Dzwigalski K, Obrietan K, Phelps MA, Sadee W, Oberdick J. Pharmacological Prevention of Neonatal Opioid Withdrawal in a Pregnant Guinea Pig Model. Frontiers in Pharmacology. 11: 613328. PMID 33716726 DOI: 10.3389/fphar.2020.613328  0.169
2005 Raehal KM, Lowery JJ, Bhamidipati CM, Paolino RM, Blair JR, Wang D, Sadée W, Bilsky EJ. In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. The Journal of Pharmacology and Experimental Therapeutics. 313: 1150-62. PMID 15716384 DOI: 10.1124/jpet.104.082966  0.168
2012 Azad AK, Sadee W, Schlesinger LS. Innate immune gene polymorphisms in tuberculosis. Infection and Immunity. 80: 3343-59. PMID 22825450 DOI: 10.1128/IAI.00443-12  0.167
2009 Bertolino A, Fazio L, Caforio G, Blasi G, Rampino A, Romano R, Di Giorgio A, Taurisano P, Papp A, Pinsonneault J, Wang D, Nardini M, Popolizio T, Sadee W. Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia. Brain : a Journal of Neurology. 132: 417-25. PMID 18829695 DOI: 10.1093/brain/awn248  0.167
2019 Wang D, Lu R, Rempala G, Sadee W. Ligand-Free Estrogen Receptor Alpha (ESR1) as Master Regulator for the Expression of CYP3A4 and other Cytochrome P450s (CYPs) in Human Liver. Molecular Pharmacology. PMID 31399483 DOI: 10.1124/Mol.119.116897  0.166
2016 Chhibber A, French CE, Yee SW, Gamazon ER, Theusch E, Qin X, Webb A, Papp AC, Wang A, Simmons CQ, Konkashbaev A, Chaudhry AS, Mitchel K, Stryke D, Ferrin TE, ... ... Sadee W, et al. Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines. The Pharmacogenomics Journal. PMID 26856248 DOI: 10.1038/Tpj.2015.93  0.166
2006 Lucas JL, Wang D, Sadée W. Calmodulin binding to peptides derived from the i3 loop of muscarinic receptors. Pharmaceutical Research. 23: 647-53. PMID 16552497 DOI: 10.1007/11095-006-9784-9  0.166
2010 Ni W, Ji J, Dai Z, Papp A, Johnson AJ, Ahn S, Farley KL, Lin TS, Dalton JT, Li X, Jarjoura D, Byrd JC, Sadee W, Grever MR, Phelps MA. Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. Plos One. 5: e13792. PMID 21072184 DOI: 10.1371/Journal.Pone.0013792  0.166
2013 Sullivan D, Pinsonneault JK, Papp AC, Zhu H, Lemeshow S, Mash DC, Sadee W. Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction. Translational Psychiatry. 3: e222. PMID 23340505 DOI: 10.1038/Tp.2012.146  0.165
2009 Johnson AD, Gong Y, Wang D, Langaee TY, Shin J, Cooper-Dehoff RM, Schork NJ, Binkley P, Pepine CJ, Johnson JA, Sadee W. Promoter polymorphisms in ACE (angiotensin I-converting enzyme) associated with clinical outcomes in hypertension. Clinical Pharmacology and Therapeutics. 85: 36-44. PMID 18946466 DOI: 10.1038/Clpt.2008.194  0.165
1986 Perry DC, Sadée W. Autoradiography of lambda binding sites in rat brain. European Journal of Pharmacology. 129: 147-58. PMID 3770072 DOI: 10.1016/0014-2999(86)90346-8  0.164
2012 Wang D, Sadee W. The Making of a CYP3A Biomarker Panel for Guiding Drug Therapy. Journal of Personalized Medicine. 2: 175-91. PMID 24466438 DOI: 10.3390/jpm2040175  0.163
2006 Wang D, Papp AC, Binkley PF, Johnson JA, Sadée W. Highly variable mRNA expression and splicing of L-type voltage-dependent calcium channel alpha subunit 1C in human heart tissues. Pharmacogenetics and Genomics. 16: 735-45. PMID 17001293 DOI: 10.1097/01.Fpc.0000230119.34205.8A  0.163
2010 Bertolino A, Taurisano P, Pisciotta NM, Blasi G, Fazio L, Romano R, Gelao B, Lo Bianco L, Lozupone M, Di Giorgio A, Caforio G, Sambataro F, Niccoli-Asabella A, Papp A, Ursini G, ... ... Sadee W, et al. Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance. Plos One. 5: e9348. PMID 20179754 DOI: 10.1371/journal.pone.0009348  0.162
2005 Bahadduri PM, D'Souza VM, Pinsonneault JK, Sadée W, Bao S, Knoell DL, Swaan PW. Functional characterization of the peptide transporter PEPT2 in primary cultures of human upper airway epithelium. American Journal of Respiratory Cell and Molecular Biology. 32: 319-25. PMID 15626774 DOI: 10.1165/Rcmb.2004-0322Oc  0.156
2023 Sadee W, Cheeseman IH, Papp A, Pietrzak M, Seweryn M, Zhou X, Lin S, Williams AM, Wewers MD, Curry HM, Zhang H, Cai H, Kunsevi-Kilola C, Tshivhula H, Walzl G, et al. Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability. Research Square. PMID 37333188 DOI: 10.21203/rs.3.rs-2986649/v1  0.156
2005 Wang D, Johnson AD, Papp AC, Kroetz DL, Sadée W. Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenetics and Genomics. 15: 693-704. PMID 16141795 DOI: 10.1097/01.Fpc.0000178311.02878.83  0.153
2018 Papp AC, Azad AK, Pietrzak M, Williams A, Handelman SK, Igo RP, Stein CM, Hartmann K, Schlesinger LS, Sadee W. AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection. Plos One. 13: e0198221. PMID 29847580 DOI: 10.1371/journal.pone.0198221  0.152
2016 Pietrzak M, Papp A, Curtis A, Handelman SK, Kataki M, Scharre DW, Rempala G, Sadee W. Gene expression profiling of brain samples from patients with Lewy body dementia. Biochemical and Biophysical Research Communications. PMID 27666482 DOI: 10.1016/J.Bbrc.2016.09.114  0.15
2017 Costa Sá AC, Sadee W, Johnson JA. Whole Transcriptome Profiling: An RNA-Seq Primer and Implications for Pharmacogenomics Research. Clinical and Translational Science. PMID 28945944 DOI: 10.1111/cts.12511  0.15
2013 Pinsonneault JK, Sullivan D, Sadee W, Soares CN, Hampson E, Steiner M. Association study of the estrogen receptor gene ESR1 with postpartum depression--a pilot study. Archives of Women's Mental Health. 16: 499-509. PMID 23917948 DOI: 10.1007/S00737-013-0373-8  0.15
2009 Bertolino A, Fazio L, Di Giorgio A, Blasi G, Romano R, Taurisano P, Caforio G, Sinibaldi L, Ursini G, Popolizio T, Tirotta E, Papp A, Dallapiccola B, Borrelli E, Sadee W. Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1224-34. PMID 19176830 DOI: 10.1523/JNEUROSCI.4858-08.2009  0.149
2011 Yancey-Wrona J, Dallaire B, Bilsky E, Bath B, Burkart J, Webster L, Magiera D, Yang X, Phelps M, Sadee W. 6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study. Pain Medicine (Malden, Mass.). 12: 1727-37. PMID 22123184 DOI: 10.1111/j.1526-4637.2011.01279.x  0.148
2019 Luzum JA, English JD, Ahmad US, Sun JW, Canan BD, Sadee W, Kitzmiller JP, Binkley PF. Association of Genetic Polymorphisms in the Beta-1 Adrenergic Receptor with Recovery of Left Ventricular Ejection Fraction in Patients with Heart Failure. Journal of Cardiovascular Translational Research. PMID 30756358 DOI: 10.1007/S12265-019-09866-5  0.146
2015 Wang D, Sadee W. Response to paper by Kelly et al "The opioid receptor pharmacology of GSK1521498 compared to other ligands with different effects on compulsive reward-related behaviors" published in Psychopharmacology 232, 305-314, 2014. Psychopharmacology. 232: 1493-4. PMID 25740344 DOI: 10.1007/s00213-015-3892-3  0.145
2013 Sadee W. Gene-gene-environment interactions between drugs, transporters, receptors, and metabolizing enzymes: Statins, SLCO1B1, and CYP3A4 as an example. Journal of Pharmaceutical Sciences. 102: 2924-9. PMID 23436703 DOI: 10.1002/jps.23483  0.145
2009 Blasi G, Lo Bianco L, Taurisano P, Gelao B, Romano R, Fazio L, Papazacharias A, Di Giorgio A, Caforio G, Rampino A, Masellis R, Papp A, Ursini G, Sinibaldi L, Popolizio T, ... Sadee W, et al. Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14812-9. PMID 19940176 DOI: 10.1523/JNEUROSCI.3609-09.2009  0.144
2016 Oberdick J, Ling Y, Phelps MA, Yudovich MS, Schilling K, Sadee W. Preferential delivery of an opioid antagonist to the fetal brain in pregnant mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 27189967 DOI: 10.1124/jpet.115.231902  0.144
2021 Chen D, Lu H, Sui W, Li L, Xu J, Yang T, Yang S, Zheng P, Chen Y, Chen J, Xue W, Li Q, Zheng Q, Ye D, Sadee W, et al. Functional CYP3A variants affecting tacrolimus trough blood concentrations in Chinese renal transplant recipients. The Pharmacogenomics Journal. PMID 33649515 DOI: 10.1038/s41397-021-00216-w  0.144
2007 Blower PE, Verducci JS, Lin S, Zhou J, Chung JH, Dai Z, Liu CG, Reinhold W, Lorenzi PL, Kaldjian EP, Croce CM, Weinstein JN, Sadee W. MicroRNA expression profiles for the NCI-60 cancer cell panel. Molecular Cancer Therapeutics. 6: 1483-91. PMID 17483436 DOI: 10.1158/1535-7163.Mct-07-0009  0.144
2007 Liu R, Blower PE, Pham AN, Fang J, Dai Z, Wise C, Green B, Teitel CH, Ning B, Ling W, Lyn-Cook BD, Kadlubar FF, Sadée W, Huang Y. Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. Molecular Pharmacology. 72: 1637-46. PMID 17875604 DOI: 10.1124/Mol.107.039644  0.143
2014 Barrie ES, Weinshenker D, Verma A, Pendergrass SA, Lange LA, Ritchie MD, Wilson JG, Kuivaniemi H, Tromp G, Carey DJ, Gerhard GS, Brilliant MH, Hebbring SJ, Cubells JF, Pinsonneault JK, ... ... Sadee W, et al. Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity. Circulation Research. 115: 1017-25. PMID 25326128 DOI: 10.1161/Circresaha.116.304398  0.143
1997 Quillan JM, Sadée W. Structure-based search for peptide ligands that cross-react with melanocortin receptors. Pharmaceutical Research. 13: 1624-30. PMID 8956325 DOI: 10.1023/A:1016424203457  0.143
2009 Beitelshees AL, Navare H, Wang D, Gong Y, Wessel J, Moss JI, Langaee TY, Cooper-DeHoff RM, Sadee W, Pepine CJ, Schork NJ, Johnson JA. CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response. Circulation. Cardiovascular Genetics. 2: 362-70. PMID 20031608 DOI: 10.1161/CIRCGENETICS.109.857839  0.143
2017 Suhy AM, Webb A, Papp AC, Geier EG, Sadee W. Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 28188910 DOI: 10.1016/J.Ejps.2017.02.010  0.141
2005 Huang Y, Dai Z, Barbacioru C, Sadée W. Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance. Cancer Research. 65: 7446-54. PMID 16103098 DOI: 10.1158/0008-5472.Can-04-4267  0.138
2004 Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z, Reinhold WC, Papp A, Weinstein JN, Sadée W. Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance. Cancer Research. 64: 4294-301. PMID 15205344 DOI: 10.1158/0008-5472.Can-03-3884  0.138
2006 Dai Z, Barbacioru C, Huang Y, Sadée W. Prediction of anticancer drug potency from expression of genes involved in growth factor signaling. Pharmaceutical Research. 23: 336-49. PMID 16425089 DOI: 10.1007/S11095-005-9260-Y  0.137
2004 Landowski CP, Anderle P, Sun D, Sadee W, Amidon GL. Transporter and ion channel gene expression after Caco-2 cell differentiation using 2 different microarray technologies. The Aaps Journal. 6: e21. PMID 15760106 DOI: 10.1208/Aapsj060321  0.137
1992 Arden JR, Nagata O, Shockley MS, Philip M, Lameh J, Sadée W. Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor. Biochemical and Biophysical Research Communications. 188: 1111-5. PMID 1445347 DOI: 10.1016/0006-291X(92)91346-R  0.137
2003 Anderle P, Rakhmanova V, Woodford K, Zerangue N, Sadée W. Messenger RNA expression of transporter and ion channel genes in undifferentiated and differentiated Caco-2 cells compared to human intestines. Pharmaceutical Research. 20: 3-15. PMID 12608530 DOI: 10.1023/A:1022282221530  0.135
2022 Huang H, Zhang S, Wen X, Sadee W, Wang D, Yang S, Li L. Transcription Factors and ncRNAs Associated with Expression in Human Liver and Small Intestine Assessed with Weighted Gene Co-Expression Network Analysis. Biomedicines. 10. PMID 36551817 DOI: 10.3390/biomedicines10123061  0.135
2000 Yan Q, Sadée W. Human membrane transporter database: a Web-accessible relational database for drug transport studies and pharmacogenomics Aaps Pharmsci [Electronic Resource]. 2. PMID 11741236 DOI: 10.1208/ps020320  0.134
1996 Covitz KMY, Amidon GL, Sadée W. Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells Pharmaceutical Research. 13: 1631-1634. PMID 8956326 DOI: 10.1023/A:1016476220296  0.134
2020 Li J, Seligson N, Zhang X, Johnson J, Vangundy Z, Wang D, Phelps M, Hofmeister C, Sadee W, Poi MJ. Association of Polymorphism With Overall Survival in Adult Patients With Hematologic Malignancies After Allogeneic Hematopoietic Stem Cell Transplantation. Anticancer Research. 40: 5707-5713. PMID 32988896 DOI: 10.21873/anticanres.14585  0.134
2014 Gadow KD, Pinsonneault JK, Perlman G, Sadee W. Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder. Research in Developmental Disabilities. 35: 1658-65. PMID 24780147 DOI: 10.1016/J.Ridd.2014.04.007  0.133
2014 Leusink M, Onland-Moret NC, Asselbergs FW, Ding B, Kotti S, van Zuydam NR, Papp AC, Danchin N, Donnelly L, Morris AD, Chasman DI, Doevendans PA, Klungel OH, Ridker PM, van Gilst WH, ... ... Sadee W, et al. Cholesteryl ester transfer protein polymorphisms, statin use, and their impact on cholesterol levels and cardiovascular events. Clinical Pharmacology and Therapeutics. 95: 314-20. PMID 24080640 DOI: 10.1038/clpt.2013.194  0.133
2019 Luzum JA, Ting C, Peterson EL, Gui H, Shugg T, Williams LK, Li L, Sadee W, Wang D, Lanfear DE. Association of Regulatory Genetic Variants for Protein Kinase Cα with Mortality and Drug Efficacy in Patients with Heart Failure. Cardiovascular Drugs and Therapy. PMID 31728800 DOI: 10.1007/s10557-019-06909-6  0.133
2005 Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, Frank MH. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Research. 65: 4320-33. PMID 15899824 DOI: 10.1158/0008-5472.CAN-04-3327  0.132
2016 Sanford JC, Wang X, Shi J, Barrie ES, Wang D, Zhu HJ, Sadee W. Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus. Pharmacogenetics and Genomics. PMID 26871237 DOI: 10.1097/FPC.0000000000000206  0.132
2015 Suhy A, Hartmann K, Papp AC, Wang D, Sadee W. Regulation of cholesteryl ester transfer protein expression by upstream polymorphisms: reduced expression associated with rs247616. Pharmacogenetics and Genomics. 25: 394-401. PMID 26061659 DOI: 10.1097/FPC.0000000000000151  0.132
2010 Sadee W. Regulatory polymorphisms in key candidate genes for disease susceptibility and drug response: a mandate for valid genetic biomarkers. Expert Review of Molecular Diagnostics. 10: 9-11. PMID 20014917 DOI: 10.1586/erm.09.72  0.131
2007 Dai Z, Huang Y, Sadee W, Blower P. Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc-. Journal of Medicinal Chemistry. 50: 1896-906. PMID 17367118 DOI: 10.1021/Jm060960H  0.131
1994 Högger P, Lameh J, Sadee W. P80 effects of point mutations in i3 loop junctions on coupling of the muscarinic HM1 receptor European Journal of Pharmaceutical Sciences. 2: 138. DOI: 10.1016/0928-0987(94)90253-4  0.131
2022 Zafar A, Shafiq M, Ali B, Sadee W, Shakoori AR, Shakoori FR. Association of IRGM promoter region polymorphisms and haplotype with pulmonary tuberculosis in Pakistani (Punjab) population. Tuberculosis (Edinburgh, Scotland). 136: 102233. PMID 35939988 DOI: 10.1016/j.tube.2022.102233  0.13
2009 Sadee W. Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility. Genome Medicine. 1: 116. PMID 20090894 DOI: 10.1186/gm116  0.13
1987 Pawlak K, Lawi-Berger C, Sadée W. Incorporation of nucleotide tracers into nucleic acids in permeabilized cells and cellular homogenates. The Biochemical Journal. 238: 13-21. PMID 2432880 DOI: 10.1042/bj2380013  0.128
2014 Webb A, Albin A, Ye Z, Rastegar-Mojarad M, Huang K, Parvin J, Sadee W, Li L, Lin S, Xiang Y. Mining massive SNP data for identifying associated SNPs and uncovering gene relationships Acm Bcb 2014 - 5th Acm Conference On Bioinformatics, Computational Biology, and Health Informatics. 304-313. DOI: 10.1145/2649387.264939  0.128
2018 Wang D, Hartmann K, Seweryn M, Sadee W. Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7α-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression. Circulation. Genomic and Precision Medicine. 11: e002082. PMID 30354296 DOI: 10.1161/CIRCGEN.118.002082  0.127
2003 Brown S, Chang JL, Sadée W, Babbitt PC. A semiautomated approach to gene discovery through expressed sequence tag data mining: discovery of new human transporter genes. Aaps Pharmsci. 5: E1. PMID 12713273 DOI: 10.1208/Ps050101  0.124
2005 Sadée W, Dai Z. Pharmacogenetics/genomics and personalized medicine. Human Molecular Genetics. 14: R207-14. PMID 16244319 DOI: 10.1093/Hmg/Ddi261  0.124
2002 Quillan JM, Carlson KW, Song C, Wang D, Sadée W. Differential effects of mu-opioid receptor ligands on Ca(2+) signaling. The Journal of Pharmacology and Experimental Therapeutics. 302: 1002-12. PMID 12183657 DOI: 10.1124/jpet.302.3.1002  0.123
2004 Anderle P, Huang Y, Sadée W. Intestinal membrane transport of drugs and nutrients: genomics of membrane transporters using expression microarrays. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 21: 17-24. PMID 14706809 DOI: 10.1016/S0928-0987(03)00169-6  0.121
2018 Locke LW, Crouser ED, White P, Julian MW, Guirado Caceres E, Papp AC, Le VT, Sadee W, Schlesinger LS. IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model. American Journal of Respiratory Cell and Molecular Biology. PMID 30134122 DOI: 10.1165/rcmb.2018-0053OC  0.121
2007 Liu J, Buskirk J, Santangelo J, Deiter RJ, Papp A, Cooke GE, Sadee W, Kamal J. Data mining tools for genotype-phenotype correlation. Amia ... Annual Symposium Proceedings / Amia Symposium. Amia Symposium. 1037. PMID 18694135  0.12
2008 Besecker B, Bao S, Bohacova B, Papp A, Sadee W, Knoell DL. The human zinc transporter SLC39A8 (Zip8) is critical in zinc-mediated cytoprotection in lung epithelia. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L1127-36. PMID 18390834 DOI: 10.1152/Ajplung.00057.2008  0.12
2006 Wang Y, Dai Z, Sadee W, Hancock WS. A pharmacoproteomics study of the cancer cell line EKVX using capillary-LC/MS/MS. Molecular Pharmaceutics. 3: 566-78. PMID 17009856 DOI: 10.1021/Mp060002B  0.119
1991 Farsam H, Eiger S, Lameh J, Rezvani A, Gibson BW, Sadée W. Morphine impurity with opioid activity is identified as 10 alpha-hydroxymorphine. Pharmaceutical Research. 7: 1205-7. PMID 1963495 DOI: 10.1023/A:1015957031449  0.119
2018 Barrie ES, Pinsonneault JK, Sadee W, Hollway JA, Handen BL, Smith T, Arnold LE, Butter E, Hansen-Kiss E, Herman GE, Aman MG. Testing genetic modifiers of behavior and response to atomoxetine in autism spectrum disorder with ADHD. Journal of Developmental and Physical Disabilities. 30: 355-371. PMID 30197492 DOI: 10.1007/S10882-018-9590-4  0.118
2005 Huang Y, Blower PE, Yang C, Barbacioru C, Dai Z, Zhang Y, Xiao JJ, Chan KK, Sadée W. Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1. The Pharmacogenomics Journal. 5: 112-25. PMID 15668728 DOI: 10.1038/Sj.Tpj.6500297  0.118
2015 Higgins GA, Allyn-Feuer A, Handelman S, Sadee W, Athey BD. The epigenome, 4D nucleome and next-generation neuropsychiatric pharmacogenomics. Pharmacogenomics. 16: 1649-69. PMID 26338265 DOI: 10.2217/pgs.15.111  0.118
2014 Chhibber A, Kroetz DL, Tantisira KG, McGeachie M, Cheng C, Plenge R, Stahl E, Sadee W, Ritchie MD, Pendergrass SA. Genomic architecture of pharmacological efficacy and adverse events. Pharmacogenomics. 15: 2025-48. PMID 25521360 DOI: 10.2217/Pgs.14.144  0.117
2006 Krejsa C, Rogge M, Sadee W. Protein therapeutics: new applications for pharmacogenetics. Nature Reviews. Drug Discovery. 5: 507-21. PMID 16763661 DOI: 10.1038/nrd2039  0.117
2023 Sadee W, Wang D, Hartmann K, Toland AE. . Pharmacological Reviews. PMID 36927888 DOI: 10.1124/pharmrev.122.000810  0.114
2003 Brown S, Chang JL, Sadee W, Babbitt PC. A semiautomated approach to gene discovery through expressed sequence tag data mining: Discovery of new human transporter genes Aaps Journal. 5: XI-XII.  0.113
1977 Sadee W, Wong CG. Pharmacokinetics of 5-fluorouracil: inter-relationship with biochemical kinetics in monitoring therapy. Clinical Pharmacokinetics. 2: 437-50. PMID 589882 DOI: 10.2165/00003088-197702060-00004  0.113
2015 Luzum JA, Theusch E, Taylor KD, Wang A, Sadee W, Binkley PF, Krauss RM, Medina MW, Kitzmiller JP. Individual and Combined Associations of Genetic Variants in CYP3A4, CYP3A5, and SLCO1B1 With Simvastatin and Simvastatin Acid Plasma Concentrations. Journal of Cardiovascular Pharmacology. 66: 80-5. PMID 26164721 DOI: 10.1097/Fjc.0000000000000246  0.11
2017 Sá ACC, Webb A, Gong Y, McDonough CW, Datta S, Langaee TY, Turner ST, Beitelshees AL, Chapman AB, Boerwinkle E, Gums JG, Scherer SE, Cooper-DeHoff RM, Sadee W, Johnson JA. Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics. Scientific Reports. 7: 16068. PMID 29167564 DOI: 10.1038/S41598-017-16343-Z  0.11
2011 Sadee W. Pharmacogenomic biomarkers: validation needed for both the molecular genetic mechanism and clinical effect. Pharmacogenomics. 12: 675-80. PMID 21619429 DOI: 10.2217/pgs.11.23  0.109
2018 McDonough CW, Magvanjav O, Sá ACC, El Rouby NM, Dave C, Deitchman AN, Kawaguchi-Suzuki M, Mei W, Shen Y, Singh RSP, Solayman M, Bailey KR, Boerwinkle E, Chapman AB, Gums JG, ... ... Sadee W, et al. Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses). Circulation. Genomic and Precision Medicine. 11: e001854. PMID 29650764 DOI: 10.1161/CIRCGEN.117.001854  0.109
2005 Xiao JJ, Foraker AB, Swaan PW, Liu S, Huang Y, Dai Z, Chen J, Sadée W, Byrd J, Marcucci G, Chan KK. Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1. The Journal of Pharmacology and Experimental Therapeutics. 313: 268-76. PMID 15634944 DOI: 10.1124/Jpet.104.072033  0.109
2013 Kitzmiller JP, Sullivan DM, Phelps MA, Wang D, Sadee W. CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control. Drug Metabolism and Drug Interactions. 28: 59-63. PMID 23314529 DOI: 10.1515/Dmdi-2012-0031  0.105
2021 Agrawal S, Ransom RF, Saraswathi S, Garcia-Gonzalo E, Webb A, Fernandez-Martinez JL, Popovic M, Guess AJ, Kloczkowski A, Benndorf R, Sadee W, Smoyer WE, On Behalf Of The Pediatric Nephrology Research Consortium Pnrc. Sulfatase 2 Is Associated with Steroid Resistance in Childhood Nephrotic Syndrome. Journal of Clinical Medicine. 10. PMID 33540508 DOI: 10.3390/jcm10030523  0.105
2013 Geier EG, Chen EC, Webb A, Papp AC, Yee SW, Sadee W, Giacomini KM. Profiling solute carrier transporters in the human blood-brain barrier. Clinical Pharmacology and Therapeutics. 94: 636-9. PMID 24013810 DOI: 10.1038/Clpt.2013.175  0.104
2018 Barrie ES, Lee SH, Frater JT, Kataki M, Scharre DW, Sadee W. Alpha-synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3'UTR. Molecular Genetics & Genomic Medicine. PMID 29730891 DOI: 10.1002/mgg3.407  0.104
2009 Yancey-Wrona JE, Raymond TJ, Mercer HK, Sadée W, Bilsky EJ. 6beta-naltrexol preferentially antagonizes opioid effects on gastrointestinal transit compared to antinociception in mice. Life Sciences. 85: 413-20. PMID 19583969 DOI: 10.1016/j.lfs.2009.06.016  0.101
2007 Beitelshees AL, Gong Y, Wang D, Schork NJ, Cooper-Dehoff RM, Langaee TY, Shriver MD, Sadee W, Knot HJ, Pepine CJ, Johnson JA. KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST). Pharmacogenetics and Genomics. 17: 719-29. PMID 17700361 DOI: 10.1097/FPC.0b013e32810f2e3c  0.1
2017 Crouser ED, White P, Guirado Caceres E, Julian MW, Papp AC, Locke LW, Sadee W, Schlesinger LS. A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent TB Infection. American Journal of Respiratory Cell and Molecular Biology. PMID 28598206 DOI: 10.1165/rcmb.2016-0321OC  0.1
2017 Li L, Zhang L, Binkley PF, Sadee W, Wang D. Regulatory Variants Modulate Protein Kinase C α (PRKCA) Gene Expression in Human Heart. Pharmaceutical Research. PMID 28120175 DOI: 10.1007/S11095-017-2102-X  0.1
1979 Finn C, Schwandt HJ, Sadée W. Determination of uracil and thymine and their nucleosides and nucleotides in picomole amounts by gas chromatography mass spectrometry selected ion monitoring. Biomedical Mass Spectrometry. 6: 194-9. PMID 476282 DOI: 10.1002/bms.1200060505  0.098
2006 Dai Z, Liu S, Marcucci G, Sadee W. 5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer). Biochemical and Biophysical Research Communications. 351: 455-61. PMID 17064661 DOI: 10.1016/J.Bbrc.2006.10.055  0.097
2015 Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, Wang D, Vinks AA, He Y, Swen JJ, Leeder JS, van Schaik R, Thummel KE, Klein TE, Caudle KE, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. Clinical Pharmacology and Therapeutics. 98: 19-24. PMID 25801146 DOI: 10.1002/Cpt.113  0.096
2015 Handelman SK, Aaronson JM, Seweryn M, Voronkin I, Kwiek JJ, Sadee W, Verducci JS, Janies DA. Cladograms with Path to Event (ClaPTE): a novel algorithm to detect associations between genotypes or phenotypes using phylogenies. Computers in Biology and Medicine. 58: 1-13. PMID 25577610 DOI: 10.1016/J.Compbiomed.2014.12.013  0.096
2016 Hartmann K, Seweryn M, Handleman SK, Rempała GA, Sadee W. Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles. Bmc Genomics. 17: 738. PMID 27640124 DOI: 10.1186/s12864-016-3075-6  0.093
2016 Hartmann K, Seweryn M, Handelman SK, Rempała GA, Sadee W. Erratum to: Non-linear interactions between candidate genes of myocardial infarction revealed in mRNA expression profiles. Bmc Genomics. 17: 988. PMID 27912746 DOI: 10.1186/s12864-016-3349-z  0.092
2017 Lavalett L, Rodriguez H, Ortega H, Sadee W, Schlesinger LS, Barrera LF. Alveolar macrophages from tuberculosis patients display an altered inflammatory gene expression profile. Tuberculosis (Edinburgh, Scotland). 107: 156-167. PMID 29050765 DOI: 10.1016/j.tube.2017.08.012  0.09
1977 Finn AM, Brown R, Sadée W. Tissue distribution of 3H-canrenoate potassium in rabbits. Journal of Pharmaceutical Sciences. 66: 275-7. PMID 839430 DOI: 10.1002/jps.2600660237  0.09
2003 Huang Y, Sadée W. Drug sensitivity and resistance genes in cancer chemotherapy: a chemogenomics approach. Drug Discovery Today. 8: 356-63. PMID 12681939 DOI: 10.1016/S1359-6446(03)02654-0  0.089
2009 Pham AN, Wang J, Fang J, Gao X, Zhang Y, Blower PE, Sadée W, Huang Y. Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins. Pharmaceutical Research. 26: 936-45. PMID 19067123 DOI: 10.1007/s11095-008-9796-8  0.087
2003 Pinsonneault J, Sadée W. Pharmacogenomics of multigenic diseases: sex-specific differences in disease and treatment outcome. Aaps Pharmsci. 5: E29. PMID 15198517 DOI: 10.1208/ps050429  0.087
2010 Wang H, Karikomi M, Naidu S, Rajmohan R, Caserta E, Chen HZ, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Weinstein M, Wang D, Sadee W, La Perle K, Stromberg P, et al. Allele-specific tumor spectrum in pten knockin mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 5142-7. PMID 20194734 DOI: 10.1073/Pnas.0912524107  0.086
1979 Silber B, Sheiner LB, Powers JL, Winter ME, Sadée W. Spironolactone-associated digoxin radioimmunoassay interference. Clinical Chemistry. 25: 48-50. DOI: 10.1093/clinchem/25.1.48  0.085
2005 Xiao JJ, Huang Y, Dai Z, Sadée W, Chen J, Liu S, Marcucci G, Byrd J, Covey JM, Wright J, Grever M, Chan KK. Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines. The Journal of Pharmacology and Experimental Therapeutics. 314: 467-75. PMID 15833893 DOI: 10.1124/Jpet.105.083956  0.085
2004 Dai Z, Huang Y, Sadée W. Growth factor signaling and resistance to cancer chemotherapy. Current Topics in Medicinal Chemistry. 4: 1347-56. PMID 15379649 DOI: 10.2174/1568026043387746  0.084
1976 Cheng SC, Suzuki K, Sadee W, Harding BW. Effects of spironolactone, canrenone and canrenoate-K on cytochrome P450, and 11beta- and 18-hydroxylation in bovine and human adrenal cortical mitochondria. Endocrinology. 99: 1097-106. PMID 976190 DOI: 10.1210/endo-99-4-1097  0.084
2003 Phan DD, Chin-Hong P, Lin ET, Anderle P, Sadee W, Guglielmo BJ. Intra- and interindividual variabilities of valacyclovir oral bioavailability and effect of coadministration of an hPEPT1 inhibitor. Antimicrobial Agents and Chemotherapy. 47: 2351-3. PMID 12821497 DOI: 10.1128/AAC.47.7.2351-2353.2003  0.083
1970 Beyer KH, Sadée W. [Synthesis and analysis of possible nitrazepam-metabolites. 4. Chemistry and analysis of benzodiazepin-derivatives]. Archiv Der Pharmazie Und Berichte Der Deutschen Pharmazeutischen Gesellschaft. 302: 152-7. PMID 5260845 DOI: 10.1002/ardp.19693020211  0.082
2006 Sadée W, Bohn L. How specific are "target-specific" drugs? Celecoxib as a case in point. Molecular Interventions. 6: 196-8. PMID 16960141 DOI: 10.1124/Mi.6.4.5  0.081
2007 Cao X, Fang L, Gibbs S, Huang Y, Dai Z, Wen P, Zheng X, Sadee W, Sun D. Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia. Cancer Chemotherapy and Pharmacology. 59: 495-505. PMID 16906425 DOI: 10.1007/S00280-006-0291-9  0.081
2002 Sadee W. Pharmacogenomics: the implementation phase. Aaps Pharmsci. 4: E5. PMID 12141268  0.08
1975 Sadée W, Finn AM, Schmiedek P, Baethmann A. Aldosterone plasma radioimmunoassay interference by a spirolactone metabolite. Steroids. 25: 301-11. PMID 1145668 DOI: 10.1016/0039-128X(75)90088-4  0.08
2008 Blower PE, Chung JH, Verducci JS, Lin S, Park JK, Dai Z, Liu CG, Schmittgen TD, Reinhold WC, Croce CM, Weinstein JN, Sadee W. MicroRNAs modulate the chemosensitivity of tumor cells. Molecular Cancer Therapeutics. 7: 1-9. PMID 18187804 DOI: 10.1158/1535-7163.Mct-07-0573  0.079
1978 Powers JL, Sadee W. Determination of quinidine by high-performance liquid chromatography. Clinical Chemistry. 24: 299-302. DOI: 10.1093/clinchem/24.2.299  0.078
2011 Kitzmiller JP, Groen DK, Phelps MA, Sadee W. Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others. Cleveland Clinic Journal of Medicine. 78: 243-57. PMID 21460130 DOI: 10.3949/Ccjm.78A.10145  0.078
2011 Sadee W. Genomics and personalized medicine. International Journal of Pharmaceutics. 415: 2-4. PMID 21539903 DOI: 10.1016/j.ijpharm.2011.04.048  0.077
2010 Atkinson EJ, McDonnell SK, Witte JS, Crawford DC, Fan Y, Fridley B, Li D, Li L, Rodin A, Sadee W, Speed T, Weiss ST, Yang J, Yerges L, Schaid DJ. Conference Scene: Lessons learned from the 5th Statistical Analysis Workshop of the Pharmacogenetics Research Network. Pharmacogenomics. 11: 297-303. PMID 20235785 DOI: 10.2217/Pgs.10.5  0.077
1986 Nguyen BT, Sadee W. Compartmentation of guanine nucleotide precursors for DNA synthesis Biochemical Journal. 234: 263-269. PMID 2424429 DOI: 10.1042/bj2340263  0.076
1975 Sadée W, Staroscik J, Finn C, Cohen J. Determination of (plus or minus)-1, 2-bis(3, 5-dioxopiperazinyl) propane plasma levels in rats, rabbits, and humans by GLC and mass fragmentography. Journal of Pharmaceutical Sciences. 64: 998-1001. PMID 1133759 DOI: 10.1002/jps.2600640623  0.076
2007 Huang Y, Blower PE, Liu R, Dai Z, Pham AN, Moon H, Fang J, Sadée W. Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1. Pharmaceutical Research. 24: 1702-12. PMID 17457659 DOI: 10.1007/S11095-007-9300-X  0.075
1990 Farmer D, Duan R, Sadee W, Rayner A. Neuroblastoma: In vitro modeling of combination therapy with retinoic acid & lymphokine activated killer cells Journal of Pediatric Surgery. 25: 257. DOI: 10.1016/0022-3468(90)90433-A  0.073
2005 Becker JB, Arnold AP, Berkley KJ, Blaustein JD, Eckel LA, Hampson E, Herman JP, Marts S, Sadee W, Steiner M, Taylor J, Young E. Strategies and methods for research on sex differences in brain and behavior. Endocrinology. 146: 1650-73. PMID 15618360 DOI: 10.1210/En.2004-1142  0.072
1979 Chan KK, Giannini DD, Staroscik JA, Sadee W. 5-Azacytidine hydrolysis kinetics measured by high-pressure liquid chromatography and 13C-NMR spectroscopy. Journal of Pharmaceutical Sciences. 68: 807-12. PMID 88514 DOI: 10.1002/jps.2600680705  0.072
2013 Trivedi JS, Poi M, McBride A, Roddy J, Poi E, Wang J, Wang D, Zhu H, Marek E, Kolli S, Sadee W, Devine SM, Griffith N, Phelps M. A Prospective, Double-Blinded, Observational Clinical Cohort Study of the Association Between Tacrolimus Exposure and CYP3A4, CYP3A5 Genotypes in Adult Hematopoietic Stem Cell Transplant Recipients Biology of Blood and Marrow Transplantation. 19: S380. DOI: 10.1016/J.Bbmt.2012.11.617  0.067
1974 Cheng S, Sadee W, Suzuki K, Harding B. 253. Effects of spironolactone and its metabolites, canrenone, and canrenonate-K on bovine and human adrenal cytochrome P450's Journal of Steroid Biochemistry. 5: 356. DOI: 10.1016/0022-4731(74)90398-7  0.065
2018 Luzum JA, Ting C, Peterson E, Gui H, Li L, Sadee W, Wang D, Lanfear DE. A Cardiac-Specific Regulatory Genetic Variant for Protein Kinase C α is Significantly Associated with Mortality in Patients with Heart Failure Journal of Cardiac Failure. 24: S2. DOI: 10.1016/j.cardfail.2018.07.013  0.064
1989 Sadée W. Genes and the pharmaceutical sciences. Pharmaceutical Research. 5: 199-200. PMID 3247299 DOI: 10.1023/A:1015981310745  0.063
2017 Pyle CJ, Azad AK, Papp AC, Sadee W, Knoell DL, Schlesinger LS. Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis. International Journal of Molecular Sciences. 18. PMID 29120360 DOI: 10.3390/ijms18112375  0.062
1973 Sadee W, Segal J, Finn C. Diazoxide urine and plasma levels in humans by stable-isotope dilution-mass fragmentography Journal of Pharmacokinetics and Biopharmaceutics. 1: 295-305. DOI: 10.1007/BF01060037  0.062
1980 Sadée W, Beelen GCM. Drug Level Monitoring. Analytical Techniques, Metabollism, and Pharmacokinetics Therapeutic Drug Monitoring. 2: 291-292. DOI: 10.1097/00007691-198007000-00014  0.061
1969 Beyer KH, Sadée W. [Titration of benzodiazepine derivatives in water-free medium. 3. On the chemistry and analysis of benzodiazepine derivatives]. Archiv Der Pharmazie Und Berichte Der Deutschen Pharmazeutischen Gesellschaft. 300: 667-73. PMID 5246916 DOI: 10.1002/ardp.19673000804  0.061
1970 SADEE W. ChemInform Abstract: MASSENSPEKTREN VON 1,4-BENZODIAZEPIN-2-ONEN Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/chin.197033371  0.06
2000 Phillips KA, Veenstra DL, Sadee W. Implications of the genetics revolution for health services research: pharmacogenomics and improvements in drug therapy. Health Services Research. 35: 128-40. PMID 16148957  0.059
2017 Luzum JA, Sweet KM, Binkley PF, Schmidlen TJ, Jarvis JP, Christman MF, Sadee W, Kitzmiller JP. CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure. Pharmaceutical Research. PMID 28181117 DOI: 10.1007/S11095-017-2104-8  0.058
1999 Sadée W. Pharmacogenomics. The Western Journal of Medicine. 171: 328-32. PMID 18751198  0.058
2017 Luzum JA, Pakyz RE, Elsey AR, Haidar CE, Peterson JF, Whirl-Carrillo M, Handelman SK, Palmer K, Pulley JM, Beller M, Schildcrout JS, Field JR, Weitzel KW, Cooper-DeHoff RM, Cavallari LH, ... ... Sadee W, et al. "The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems". Clinical Pharmacology and Therapeutics. PMID 28090649 DOI: 10.1002/Cpt.630  0.058
2020 Azad AK, Lloyd C, Sadee W, Schlesinger LS. Challenges of Immune Response Diversity in the Human Population Concerning New Tuberculosis Diagnostics, Therapies, and Vaccines. Frontiers in Cellular and Infection Microbiology. 10: 139. PMID 32322562 DOI: 10.3389/fcimb.2020.00139  0.057
2012 Kitzmiller JP, Embi PJ, Manickam K, Sweet KM, Phelps MA, Jackson RD, Marsh CB, Sadee W. Program in pharmacogenomics at the Ohio State University Medical Center. Pharmacogenomics. 13: 751-6. PMID 22594506 DOI: 10.2217/Pgs.12.46  0.057
2018 Sá ACC, Webb A, Gong Y, McDonough CW, Shahin MH, Datta S, Langaee TY, Turner ST, Beitelshees AL, Chapman AB, Boerwinkle E, Gums JG, Scherer SE, Cooper-DeHoff RM, Sadee W, et al. Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies. Bmc Medical Genomics. 11: 55. PMID 29925376 DOI: 10.1186/S12920-018-0370-X  0.056
2013 Duan W, Gao L, Zhao W, Leon M, Sadee W, Webb A, Resnick K, Wu X, Ramaswamy B, Cohn DE, Shapiro C, Andreassen PR, Otterson GA, Villalona-Calero MA. Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents. Translational Research : the Journal of Laboratory and Clinical Medicine. 161: 156-64. PMID 23063585 DOI: 10.1016/j.trsl.2012.09.003  0.056
1973 Schmiedek P, Sadée W, Baethmann A. Cerebral uptake of a 3 H-labelled spirolactone compound in the dog. European Journal of Pharmacology. 21: 238-41. PMID 4696105 DOI: 10.1016/0014-2999(73)90232-X  0.055
2012 Sadee W. The relevance of "missing heritability " in pharmacogenomics. Clinical Pharmacology and Therapeutics. 92: 428-30. PMID 22910439 DOI: 10.1038/clpt.2012.116  0.055
1971 Sadée W, Riegelman S, Johnson LF. On the mechanism of steroid fluorescence in sulfuric acid. Part I. The formation of trienones Steroids. 17: 595-606. PMID 5088146 DOI: 10.1016/S0039-128X(71)80160-5  0.055
2008 Xu LH, Zheng H, Sedmak DD, Sadée W. The re-emerging concept of personalized healthcare. Personalized Medicine. 5: 457-469. PMID 29783441 DOI: 10.2217/17410541.5.5.457  0.053
1972 Sadée W, Dagcioglu M, Riegelman S. Fluorometric microassay for spironolactone and its metabolites in biological fluids. Journal of Pharmaceutical Sciences. 61: 1126-9. PMID 5044814 DOI: 10.1002/Jps.2600610719  0.052
1974 Sadée W, Schwandt HJ, Beyer KH. [On the conformation of unsymmetrically substituted 1,4-benzodiazepin-2-ones (author's transl)]. Archiv Der Pharmazie. 306: 751-6. PMID 4773838 DOI: 10.1002/ardp.19733061006  0.052
1985 Sadée W, Nguyen BT. Biological consequences of guanine starvation Basic Life Sciences. 31: 233-240. PMID 3922344 DOI: 10.1007/978-1-4613-2449-2_14  0.051
2018 Wang D, Lu R, Rempala G, Sadee W. Dissecting CYP3A interactome to understand the causes of CYP3A variability Drug Metabolism and Pharmacokinetics. 33: S83-S84. DOI: 10.1016/J.Dmpk.2017.11.275  0.05
2006 Huang Y, Sadée W. Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells. Cancer Letters. 239: 168-82. PMID 16169662 DOI: 10.1016/j.canlet.2005.07.032  0.05
1972 Sadée W, Riegelman S, Jones SC. Disposition of tritium-labeled spirolactones in the dog Journal of Pharmaceutical Sciences. 61: 1132-1135. PMID 5044816 DOI: 10.1002/Jps.2600610721  0.05
1974 Schwandt H, Sadée W, Beyer K. Metabolic Rearrangements of 1,4-Benzodiazepine Derivatives Xenobiotica. 4: 733-741. DOI: 10.3109/00498257409052075  0.05
2007 Dai Z, Sadee W, Blower P. Chemogenomics of sensitivity and resistance to anticancer drugs Current Pharmacogenomics. 5: 11-19. DOI: 10.2174/157016007780077158  0.048
2002 Salvi A, Quillan JM, Sadee W. Monitoring intracellular pH changes in response to osmotic stress and membrane transport activity using 5-chrloromethylfluorescein Aaps Pharmsci. 4.  0.047
2014 Sweet K, Gordon ES, Sturm AC, Schmidlen TJ, Manickam K, Toland AE, Keller MA, Stack CB, García-España JF, Bellafante M, Tayal N, Embi P, Binkley P, Hershberger RE, Sadee W, et al. Design and implementation of a randomized controlled trial of genomic counseling for patients with chronic disease. Journal of Personalized Medicine. 4: 1-19. PMID 24926413 DOI: 10.3390/Jpm4010001  0.043
2008 Sadee W. Drug therapy and personalized health care: pharmacogenomics in perspective. Pharmaceutical Research. 25: 2713-9. PMID 18726676 DOI: 10.1007/s11095-008-9702-4  0.043
2009 Bekaii-Saab T, Markowitz J, Prescott N, Sadee W, Heerema N, Wei L, Dai Z, Papp A, Campbell A, Culler K, Balint C, O'Neil B, Lee RM, Zalupski M, Dancey J, et al. A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 5895-901. PMID 19737952 DOI: 10.1158/1078-0432.Ccr-09-0465  0.042
2002 Phillips K, Veenstra D, Oren E, Lee J, Sadee W. PHP35 ANALYZING THE CLINICAL, ECONOMIC, AND POLICY IMPACT OF INDIVIDUALIZED MEDICINE BASED ON GENETIC INFORMATION (“PHARMACOGENOMICS“) Value in Health. 5: 152. DOI: 10.1016/S1098-3015(10)60895-9  0.042
2007 Pinsonneault J, Sadée W. Sex Differences in Pharmacogenomics as a Tool to Study CNS Disorders Sex Differences in the Brain: From Genes to Behavior. DOI: 10.1093/acprof:oso/9780195311587.003.0005  0.041
2017 Shahin MH, Sá AC, Webb A, Gong Y, Langaee T, McDonough CW, Riva A, Beitleshees AL, Chapman AB, Gums JG, Turner ST, Boerwinkle E, Scherer SE, Sadee W, Cooper-DeHoff RM, et al. Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response. Circulation. Cardiovascular Genetics. 10. PMID 28115488 DOI: 10.1161/Circgenetics.116.001404  0.041
1977 Chan KK, Staroscik JA, Sadée W. Synthesis of 5-azacytidine-6-13C and -6-14C. Journal of Medicinal Chemistry. 20: 598-600. PMID 66316 DOI: 10.1021/jm00214a034  0.038
2020 Crouser ED, Locke LW, Julian MW, Bicer S, Sadee W, White P, Schlesinger LS. Phagosome-regulated mTOR Signalling during Sarcoidosis Granuloma Biogenesis. The European Respiratory Journal. PMID 32943400 DOI: 10.1183/13993003.02695-2020  0.038
1975 Sadée W, Finn AM, Schmiedek P, Baethmann A. Aldosterone plasma radioimmunoassay interference by a spirolactone metabolite Steroids. 25: 301-311. DOI: 10.1016/S0039-128X(75)90271-8  0.037
1970 Sadée W. [NMR-spectroscopic studies on ring inversion of 1,3-dihydro-5-phenyl-1,4-benzodiazepin-2-on-derivatives]. Archiv Der Pharmazie Und Berichte Der Deutschen Pharmazeutischen Gesellschaft. 302: 769-74. PMID 5263067 DOI: 10.1002/ardp.19693021009  0.037
1981 Au JL, Sadée W. The pharmacology of ftorafur (R, S-1-(tetrahydro-2-furanyl)-5-fluorouracil. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer. 76: 100-14. PMID 6785848 DOI: 10.1007/978-3-642-81565-2_9  0.035
1972 Sadée W, Riegelman S, Jones SC. Plasma levels of spirolactones in the dog Journal of Pharmaceutical Sciences. 61: 1129-1132. PMID 5044815 DOI: 10.1002/Jps.2600610720  0.035
2015 Hampson E, Phillips SD, Duff-Canning SJ, Evans KL, Merrill M, Pinsonneault JK, Sadée W, Soares CN, Steiner M. Working memory in pregnant women: Relation to estrogen and antepartum depression. Hormones and Behavior. PMID 26187710 DOI: 10.1016/J.Yhbeh.2015.07.006  0.033
1982 Au JL, Sadée W. Stereoselective metabolism of ftorafur (R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil). Cancer Chemotherapy and Pharmacology. 7: 55-9. PMID 6804104 DOI: 10.1007/BF00258214  0.031
1977 CHAN KK, STAROSCIK JA, SADEE W. ChemInform Abstract: SYNTHESIS OF 5-AZACYTIDINE-6-13C AND -6-14C Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/chin.197736377  0.031
2013 Sadee W. Bridging material and biological sciences: the legacy of Hans Peter Merkle. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 85: 3-4. PMID 23958312 DOI: 10.1016/j.ejpb.2013.06.026  0.029
1971 Sadée W, Van der Kleijn E. Thermolysis of 1,4-benzodiazepines during gas chromatography and mass spectroscopy. Journal of Pharmaceutical Sciences. 60: 135-7. PMID 5548225 DOI: 10.1002/jps.2600600131  0.029
2005 Sadée W. Pharmacogenomics: harbinger for the era of personalized medicine? Molecular Interventions. 5: 140-3. PMID 15994451 DOI: 10.1124/mi.5.3.1  0.027
2017 Sadee W. Personalized Therapeutics and Pharmacogenomics: Integral to Personalized Health Care. Pharmaceutical Research. PMID 28493098 DOI: 10.1007/s11095-017-2170-y  0.019
2008 Buntem R, Kraisingdecha P, Sadee W. Fluoride and antimony-doped tin oxide film by spray pyrolysis Advanced Materials Research. 55: 513-516.  0.017
2013 Shuldiner AR, Relling MV, Peterson JF, Hicks JK, Freimuth RR, Sadee W, Pereira NL, Roden DM, Johnson JA, Klein TE, Shuldiner AR, Vesely M, Robinson SW, Ambulos N, ... ... Sadee W, et al. The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation. Clinical Pharmacology and Therapeutics. 94: 207-10. PMID 23588301 DOI: 10.1038/clpt.2013.59  0.017
2003 Sadee W. AAPS PharmSci: An advanced publication forum has matured Aaps Pharmsci. 5.  0.015
2001 Sadée W. E-Publishing in 2001 Aaps Pharmsci. 3: ed1. DOI: 10.1208/ps0301_editorial  0.015
2000 Sadée W. E-Publishing in 2000 Aaps Pharmsci. 2: ed1. DOI: 10.1208/ps0201_editorial  0.015
2006 Dougherty D, Stahlberg E, Sadee W. Network analysis using transitive closure: New methods for exploring networks Journal of Statistical Computation and Simulation. 76: 539-551. DOI: 10.1080/10629360500107857  0.011
2002 Sadee W. Pharmacogenomics: The implementation phase Aaps Pharmsci. 4.  0.01
1980 Sadée W. Antineoplastic Agents Therapeutic Drug Monitoring. 2: 177-186. DOI: 10.1097/00007691-198004000-00012  0.01
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