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Mala L. Radhakrishnan - Publications

Affiliations: 
2007 Chemistry Wellesley College, Wellesley, MA, United States 
Area:
computational biophysical chemistry, analysis/design of drugs and other biological molecules, and creatively teaching chemistry
Website:
http://www.wellesley.edu/chemistry/facultystaff/radhakrishnan
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20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kim R, Radhakrishnan ML. Macromolecular crowding effects on electrostatic binding affinity: Fundamental insights from theoretical, idealized models. The Journal of Chemical Physics. 154: 225101. PMID 34241219 DOI: 10.1063/5.0042082  0.31
2019 Perez CP, Elmore DE, Radhakrishnan ML. Computationally Modeling Electrostatic Binding Energetics in a Crowded, Dynamic Environment: Physical Insights from a Peptide-DNA System. The Journal of Physical Chemistry. B. PMID 31751509 DOI: 10.1021/Acs.Jpcb.9B09478  0.412
2017 Sim S, Wang P, Beyer BN, Cutrona KJ, Radhakrishnan ML, Elmore DE. Investigating the Nucleic Acid Interactions of Histone-Derived Antimicrobial Peptides. Febs Letters. PMID 28130840 DOI: 10.1002/1873-3468.12574  0.357
2016 Sim S, Cutrona KJ, Beyer B, Wang P, Radhakrishnan ML, Elmore DE. Characterization of Nucleic Acid Binding by the Histone-Derived Antimicrobial Peptides Buforin II and DesHDAP1 Biophysical Journal. 110: 560a-561a. DOI: 10.1016/J.Bpj.2015.11.2997  0.361
2015 Shen Y, Radhakrishnan ML, Tidor B. Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: lessons learned from HIV-1 protease inhibition. Proteins. 83: 351-72. PMID 25410041 DOI: 10.1002/Prot.24730  0.604
2015 Sim S, Wang P, Beyer B, Radhakrishnan ML, Elmore DE. Effects of Cationic Residues and Base Sequence in Nucleic Acid Binding of Histone-Derived Antimicrobial Peptides Biophysical Journal. 108: 74a. DOI: 10.1016/J.Bpj.2014.11.437  0.357
2015 Akamandisa M, Kedaigle AJ, Radhakrishnan ML, Peterman TK, Elmore DE. Investigating Sec14 Domain Lipid Binding using Structural Modeling Biophysical Journal. 108: 252a. DOI: 10.1016/J.Bpj.2014.11.1396  0.341
2015 Shen Y, Radhakrishnan ML, Tidor B. Molecular mechanisms and design principles for promiscuous inhibitors to avoid drug resistance: Lessons learned from HIV-1 protease inhibition Proteins: Structure, Function and Bioinformatics. 83: 351-372. DOI: 10.1002/prot.24730  0.49
2014 Qi HW, Nakka P, Chen C, Radhakrishnan ML. The effect of macromolecular crowding on the electrostatic component of barnase-barstar binding: a computational, implicit solvent-based study. Plos One. 9: e98618. PMID 24915485 DOI: 10.1371/Journal.Pone.0098618  0.367
2012 Minkara MS, Davis PH, Radhakrishnan ML. Multiple drugs and multiple targets: an analysis of the electrostatic determinants of binding between non-nucleoside HIV-1 reverse transcriptase inhibitors and variants of HIV-1 RT. Proteins. 80: 573-90. PMID 22095671 DOI: 10.1002/Prot.23221  0.403
2012 Radhakrishnan ML. Designing electrostatic interactions in biological systems via charge optimization or combinatorial approaches: Insights and challenges with a continuum electrostatic framework Theoretical Chemistry Accounts. 131: 1-24. DOI: 10.1007/S00214-012-1252-5  0.369
2010 Radhakrishnan ML, Tidor B. Cellular level models as tools for cytokine design Biotechnology Progress. 26: 919-937. PMID 20568274 DOI: 10.1002/Btpr.387  0.549
2009 Zhang YL, Radhakrishnan ML, Lu X, Gross AW, Tidor B, Lodish HF. Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex. Molecular Cell. 33: 266-74. PMID 19187767 DOI: 10.1016/J.Molcel.2008.11.026  0.506
2009 Johnston AP, Radhakrishnan ML. Simultaneously Targeting Multiple Drug-Resistant Variants with Optimally Small Drug Cocktails: Application and Analysis of Novel Methods Biophysical Journal. 96: 86a. DOI: 10.1016/J.Bpj.2008.12.347  0.383
2009 Minkara M, Radhakrishnan ML. Analyzing Electrostatic Determinants of Affinity and Promiscuity in the HIV-1 Reverse Transcriptase System Using Charge Optimization Biophysical Journal. 96: 596a. DOI: 10.1016/J.Bpj.2008.12.3118  0.414
2008 Radhakrishnan ML, Tidor B. Optimal drug cocktail design: methods for targeting molecular ensembles and insights from theoretical model systems. Journal of Chemical Information and Modeling. 48: 1055-73. PMID 18505239 DOI: 10.1021/Ci700452R  0.574
2008 Radhakrishnan ML, Tidor B. Optimal drug cocktail design: Methods for targeting molecular ensembles and insights from theoretical model systems Journal of Chemical Information and Modeling. 48: 1055-1073. DOI: 10.1021/ci700452r  0.508
2007 Radhakrishnan ML, Tidor B. Specificity in molecular design: a physical framework for probing the determinants of binding specificity and promiscuity in a biological environment. The Journal of Physical Chemistry. B. 111: 13419-35. PMID 17979267 DOI: 10.1021/Jp074285E  0.603
2007 Radhakrishnan ML, Tidor B. Specificity in molecular design: A physical framework for probing the determinants of binding specificity and promiscuity in a biological environment Journal of Physical Chemistry B. 111: 13419-13435. DOI: 10.1021/jp074285e  0.528
2005 Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS. Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chemistry & Biology. 12: 811-23. PMID 16039528 DOI: 10.1016/J.Chembiol.2005.05.011  0.6
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