Stefan H. Heinemann - Publications

Affiliations: 
FSU Jena, Jena, Thüringen, Germany 
Area:
voltage-gated ion channels

198 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kuldyushev N, Schönherr R, Coburger I, Ahmed M, Hussein RA, Wiesel E, Godbole A, Pfirrmann T, Hoshi T, Heinemann SH. A GFP-based ratiometric sensor for cellular methionine oxidation. Talanta. 243: 123332. PMID 35276500 DOI: 10.1016/j.talanta.2022.123332  0.423
2021 Rühl P, Langner JM, Reidel J, Schönherr R, Hoshi T, Heinemann SH. Monitoring of compound resting membrane potentials of cell cultures with ratiometric genetically encoded voltage indicators. Communications Biology. 4: 1164. PMID 34620975 DOI: 10.1038/s42003-021-02675-0  0.489
2021 Lu Y, Zhang W, Zhang B, Heinemann SH, Hoshi T, Hou S, Zhang G. Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway. Oxidative Medicine and Cellular Longevity. 2021: 8869908. PMID 34373769 DOI: 10.1155/2021/8869908  0.423
2020 Gessner G, Rühl P, Westerhausen M, Hoshi T, Heinemann SH. Fe-Mediated Activation of BK Channels by Rapid Photolysis of CORM-S1 Releasing CO and Fe. Acs Chemical Biology. PMID 32667185 DOI: 10.1021/acschembio.0c00282  0.543
2020 Coburger I, Yang K, Bernert A, Wiesel E, Sahoo N, Swain SM, Hoshi T, Schönherr R, Heinemann SH. Impact of intracellular hemin on N-type inactivation of voltage-gated K channels. Pflugers Archiv : European Journal of Physiology. PMID 32388729 DOI: 10.1007/S00424-020-02386-1  0.832
2019 Ojha NK, Jin J, Arifin JC, Rühl P, Heinemann SH. Membrane potential manipulation with visible flash lamp illumination of targeted microbeads. Biochemical and Biophysical Research Communications. PMID 31353087 DOI: 10.1016/j.bbrc.2019.07.080  0.746
2019 Paul George AA, Heimer P, Leipold E, Schmitz T, Kaufmann D, Tietze D, Heinemann SH, Imhof D. Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers. Marine Drugs. 17. PMID 31269696 DOI: 10.3390/Md17070390  0.369
2019 Tian Y, Heinemann SH, Hoshi T. Large-conductance Ca- and voltage-gated K channels form and break interactions with membrane lipids during each gating cycle. Proceedings of the National Academy of Sciences of the United States of America. PMID 30967508 DOI: 10.1073/pnas.1901381116  0.634
2019 Sahoo N, Coburger I, Yang K, Swain SM, Gessner G, Kappl R, Imhof D, Hoshi T, Schoenherr R, Heinemann SH. Modulation of KV10.1 Potassium Channel Function by Intracellular Heme Biophysical Journal. 116: 15a. DOI: 10.1016/J.Bpj.2018.11.124  0.836
2018 Peigneur S, Cheneval O, Maiti M, Leipold E, Heinemann SH, Lescrinier E, Herdewijn P, De Lima ME, Craik DJ, Schroeder CI, Tytgat J. Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801909R. PMID 30509130 DOI: 10.1096/Fj.201801909R  0.416
2018 Yang K, Coburger I, Langner JM, Peter N, Hoshi T, Schönherr R, Heinemann SH. Modulation of K channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides. Pflugers Archiv : European Journal of Physiology. PMID 30415410 DOI: 10.1007/s00424-018-2233-x  0.628
2018 Wissuwa B, Heinemann SH, Bauer M, Coldewey SM. Studies into Slo1 K channels and their ligand docosahexaenoic acid in murine sepsis to delineate off-target effects of immunonutrition. Life Sciences. PMID 29684444 DOI: 10.1016/j.lfs.2018.04.031  0.352
2017 Gessner G, Sahoo N, Swain SM, Hirth G, Schönherr R, Mede R, Westerhausen M, Brewitz HH, Heimer P, Imhof D, Hoshi T, Heinemann SH. CO-independent modification of K(+) channels by tricarbonyldichlororuthenium(II) dimer (CORM-2). European Journal of Pharmacology. PMID 28987271 DOI: 10.1016/J.Ejphar.2017.10.006  0.839
2017 Seidel RA, Claudel T, Schleser FA, Ojha NK, Westerhausen M, Nietzsche S, Sponholz C, Cuperus F, Coldewey SM, Heinemann SH, Pohnert G, Trauner M, Bauer M. Impact of higher-order heme degradation products on hepatic function and hemodynamics. Journal of Hepatology. PMID 28412296 DOI: 10.1016/J.Jhep.2017.03.037  0.733
2017 Ojha NK, Leipold E, Schönherr R, Hoshi T, Heinemann SH. Non-photonic sensing of membrane-delimited reactive species with a Na(+) channel protein containing selenocysteine. Scientific Reports. 7: 46003. PMID 28378799 DOI: 10.1038/srep46003  0.799
2017 Yusifov T, Savalli N, Pantazis A, Heinemann SH, Hoshi T, Olcese R. Carbon Monoxide May Regulate BK slo1 Channel Activity by Partially Disrupting Heme Coordination Biophysical Journal. 112: 112a. DOI: 10.1016/J.Bpj.2016.11.631  0.605
2016 Leipold E, Ullrich F, Thiele M, Tietze AA, Terlau H, Imhof D, Heinemann SH. Subtype-specific block of voltage-gated K(+) channels by μ-conopeptides. Biochemical and Biophysical Research Communications. PMID 27916464 DOI: 10.1016/J.Bbrc.2016.11.170  0.722
2016 Tian Y, Aursnes M, Hansen TV, Tungen JE, Galpin JD, Leisle L, Ahern CA, Xu R, Heinemann SH, Hoshi T. Atomic determinants of BK channel activation by polyunsaturated fatty acids. Proceedings of the National Academy of Sciences of the United States of America. PMID 27849612 DOI: 10.1073/Pnas.1615562113  0.626
2016 Marques-Carvalho MJ, Oppermann J, Muñoz E, Fernandes AS, Gabant G, Cadene M, Heinemann SH, Schönherr R, Morais-Cabral JH. Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel. Structure (London, England : 1993). PMID 27618660 DOI: 10.1016/J.Str.2016.07.020  0.508
2016 Tietze D, Leipold E, Heimer P, Böhm M, Winschel W, Imhof D, Heinemann SH, Tietze AA. Molecular interaction of δ-conopeptide EVIA with voltage-gated Na(+) channels. Biochimica Et Biophysica Acta. PMID 27316322 DOI: 10.1016/J.Bbagen.2016.06.013  0.468
2016 Hoshi T, Heinemann SH. Modulation of BK Channels by Small Endogenous Molecules and Pharmaceutical Channel Openers. International Review of Neurobiology. 128: 193-237. PMID 27238265 DOI: 10.1016/bs.irn.2016.03.020  0.678
2016 Han B, He K, Cai C, Tang Y, Yang L, Heinemann SH, Hoshi T, Hou S. Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations. Scientific Reports. 6: 23417. PMID 27005320 DOI: 10.1038/srep23417  0.681
2016 Gessner G, Hoshi T, Heinemann SH. Functional Impact of P320 in hSlo1 BK Channel Gating Biophysical Journal. 110: 280a. DOI: 10.1016/J.BPJ.2015.11.1516  0.631
2015 Leipold E, Hanson-Kahn A, Frick M, Gong P, Bernstein JA, Voigt M, Katona I, Oliver Goral R, Altmüller J, Nürnberg P, Weis J, Hübner CA, Heinemann SH, Kurth I. Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant. Nature Communications. 6: 10049. PMID 26645915 DOI: 10.1038/Ncomms10049  0.354
2015 Swain SM, Sahoo N, Dennhardt S, Schönherr R, Heinemann SH. Ca(2+)/calmodulin regulates Kvβ1.1-mediated inactivation of voltage-gated K(+) channels. Scientific Reports. 5: 15509. PMID 26487174 DOI: 10.1038/Srep15509  0.83
2015 Schink M, Leipold E, Schirmeyer J, Schönherr R, Hoshi T, Heinemann SH. Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglion neurons. Pflugers Archiv : European Journal of Physiology. PMID 26383867 DOI: 10.1007/s00424-015-1735-z  0.59
2015 Goral RO, Leipold E, Nematian-Ardestani E, Heinemann SH. Heterologous expression of NaV1.9 chimeras in various cell systems. Pflugers Archiv : European Journal of Physiology. PMID 25916202 DOI: 10.1007/s00424-015-1709-1  0.528
2015 Tian Y, Ullrich F, Xu R, Heinemann SH, Hou S, Hoshi T. Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels. The Journal of General Physiology. 145: 331-43. PMID 25825171 DOI: 10.1085/jgp.201511363  0.766
2015 Goradia N, Wiedemann C, Herbst C, Görlach M, Heinemann SH, Ohlenschläger O, Ramachandran R. An approach to NMR assignment of intrinsically disordered proteins. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 16: 739-46. PMID 25639453 DOI: 10.1002/cphc.201402872  0.335
2015 Yusifov T, Savalli N, Heinemann SH, Hoshi T, Olcese R. The Heme-Bound Human BK Channel Gating Ring is a Co Sensor Biophysical Journal. 108: 122a. DOI: 10.1016/J.Bpj.2014.11.682  0.645
2014 Heimer P, Tietze AA, Böhm M, Giernoth R, Kuchenbuch A, Stark A, Leipold E, Heinemann SH, Kandt C, Imhof D. Application of room-temperature aprotic and protic ionic liquids for oxidative folding of cysteine-rich peptides. Chembiochem : a European Journal of Chemical Biology. 15: 2754-65. PMID 25376613 DOI: 10.1002/Cbic.201402356  0.301
2014 Mancini M, Soldovieri MV, Gessner G, Wissuwa B, Barrese V, Boscia F, Secondo A, Miceli F, Franco C, Ambrosino P, Canzoniero LM, Bauer M, Hoshi T, Heinemann SH, Taglialatela M. Critical role of large-conductance calcium- and voltage-activated potassium channels in leptin-induced neuroprotection of N-methyl-d-aspartate-exposed cortical neurons. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 87: 80-6. PMID 24973659 DOI: 10.1016/j.phrs.2014.06.010  0.593
2014 Schirmeyer J, Szafranski K, Leipold E, Mawrin C, Platzer M, Heinemann SH. Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia. Channels (Austin, Tex.). 8: 210-5. PMID 24763188 DOI: 10.4161/chan.28146  0.455
2014 Heinemann SH, Hoshi T, Westerhausen M, Schiller A. Carbon monoxide--physiology, detection and controlled release. Chemical Communications (Cambridge, England). 50: 3644-60. PMID 24556640 DOI: 10.1039/c3cc49196j  0.49
2014 Ojha NK, Nematian-Ardestani E, Neugebauer S, Borowski B, El-Hussein A, Hoshi T, Leipold E, Heinemann SH. Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species. Biochimica Et Biophysica Acta. 1838: 1412-9. PMID 24513256 DOI: 10.1016/j.bbamem.2014.01.031  0.787
2014 Sahoo N, Hoshi T, Heinemann SH. Oxidative modulation of voltage-gated potassium channels. Antioxidants & Redox Signaling. 21: 933-52. PMID 24040918 DOI: 10.1089/ars.2013.5614  0.663
2014 Hoshi T, Xu R, Hou S, Heinemann SH, Tian Y. A Point Mutation that Impairs the Omega-3 Fatty Acid Sensitivity of Human Slo1 BK Channels Biophysical Journal. 106: 749a. DOI: 10.1016/j.bpj.2013.11.4125  0.612
2014 Gessner G, Held K, Hoshi T, Heinemann SH. Whole-Cell Gating-Charge Measurements for Analysis of Allosteric Domain Coupling in Hslo1 BK Channels Biophysical Journal. 106: 744a. DOI: 10.1016/j.bpj.2013.11.4096  0.633
2014 Leipold E, Goral RO, Heinemann SH, Hübner CA, Kurth I. Increased Activity of Nav1.9 Sodium Channels Causes Loss of Pain Perception Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.1887  0.491
2013 Hoshi T, Xu R, Hou S, Heinemann SH, Tian Y. A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. The Journal of General Physiology. 142: 507-22. PMID 24127525 DOI: 10.1085/jgp.201311061  0.652
2013 Sahoo N, Goradia N, Ohlenschläger O, Schönherr R, Friedrich M, Plass W, Kappl R, Hoshi T, Heinemann SH. Heme impairs the ball-and-chain inactivation of potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 110: E4036-44. PMID 24082096 DOI: 10.1073/pnas.1313247110  0.648
2013 Leipold E, Liebmann L, Korenke GC, Heinrich T, Giesselmann S, Baets J, Ebbinghaus M, Goral RO, Stödberg T, Hennings JC, Bergmann M, Altmüller J, Thiele H, Wetzel A, Nürnberg P, ... ... Heinemann SH, et al. A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Nature Genetics. 45: 1399-404. PMID 24036948 DOI: 10.1038/Ng.2767  0.342
2013 Hoshi T, Wissuwa B, Tian Y, Tajima N, Xu R, Bauer M, Heinemann SH, Hou S. Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. Proceedings of the National Academy of Sciences of the United States of America. 110: E2260. PMID 23940844 DOI: 10.1073/pnas.1305790110  0.512
2013 Hoshi T, Tian Y, Xu R, Heinemann SH, Hou S. Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. Proceedings of the National Academy of Sciences of the United States of America. 110: 4822-7. PMID 23487786 DOI: 10.1073/pnas.1222003110  0.647
2013 Hoshi T, Wissuwa B, Tian Y, Tajima N, Xu R, Bauer M, Heinemann SH, Hou S. Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels. Proceedings of the National Academy of Sciences of the United States of America. 110: 4816-21. PMID 23487785 DOI: 10.1073/pnas.1221997110  0.623
2013 Gessner G, Hoshi T, Heinemann SH. Modulation of Hslo1 BK Channels by Aminoglycoside Antibiotics Biophysical Journal. 104: 473a. DOI: 10.1016/j.bpj.2012.11.2611  0.678
2013 Tian Y, Ullrich F, Xu R, Heinemann SH, Hou S, Hoshi T. Differential Effects of PIP2 on Slo1 BK Channels with Different β Subunits Biophysical Journal. 104: 472a. DOI: 10.1016/j.bpj.2012.11.2609  0.612
2013 Hoshi T, Wissuwa B, Tian Y, Tajima N, Xu R, Bauer M, Heinemann SH, Hou S. Omega-3 Fatty Acids Activate Slo1 BK Channels and Lower Blood Pressure Biophysical Journal. 104: 471a. DOI: 10.1016/j.bpj.2012.11.2604  0.622
2012 Stengel R, Rivera-Milla E, Sahoo N, Ebert C, Bollig F, Heinemann SH, Schönherr R, Englert C. Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. The Journal of Biological Chemistry. 287: 35565-75. PMID 22927438 DOI: 10.1074/jbc.M112.363978  0.449
2012 Heinemann SH. Visualizing individual sodium channels on the move. Chemistry & Biology. 19: 790-1. PMID 22840766 DOI: 10.1016/j.chembiol.2012.07.002  0.482
2012 Markgraf R, Leipold E, Schirmeyer J, Paolini-Bertrand M, Hartley O, Heinemann SH. Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. British Journal of Pharmacology. 167: 576-86. PMID 22537004 DOI: 10.1111/j.1476-5381.2012.02004.x  0.537
2012 Leipold E, Borges A, Heinemann SH. Scorpion β-toxin interference with NaV channel voltage sensor gives rise to excitatory and depressant modes. The Journal of General Physiology. 139: 305-19. PMID 22450487 DOI: 10.1085/jgp.201110720  0.486
2012 Tietze AA, Tietze D, Ohlenschläger O, Leipold E, Ullrich F, Kühl T, Mischo A, Buntkowsky G, Görlach M, Heinemann SH, Imhof D. Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV 1.4. Angewandte Chemie (International Ed. in English). 51: 4058-61. PMID 22407516 DOI: 10.1002/Anie.201107011  0.665
2012 Gessner G, Cui YM, Otani Y, Ohwada T, Soom M, Hoshi T, Heinemann SH. Molecular mechanism of pharmacological activation of BK channels. Proceedings of the National Academy of Sciences of the United States of America. 109: 3552-7. PMID 22331907 DOI: 10.1073/pnas.1114321109  0.682
2012 Sahoo N, Schönherr R, Hoshi T, Heinemann SH. Cysteines control the N- and C-linker-dependent gating of KCNH1 potassium channels. Biochimica Et Biophysica Acta. 1818: 1187-95. PMID 22310694 DOI: 10.1016/j.bbamem.2012.01.021  0.655
2012 Favreau P, Benoit E, Hocking HG, Carlier L, D' hoedt D, Leipold E, Markgraf R, Schlumberger S, Córdova MA, Gaertner H, Paolini-Bertrand M, Hartley O, Tytgat J, Heinemann SH, Bertrand D, et al. A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors. British Journal of Pharmacology. 166: 1654-68. PMID 22229737 DOI: 10.1111/J.1476-5381.2012.01837.X  0.431
2012 Yusifov T, Javaherian AD, Heinemann SH, Hoshi T, Olcese R. Evidence for Lipid-Induced Structural Rearrangements in the Human BK (Slo1) Channel Gating Ring Biophysical Journal. 102: 688a. DOI: 10.1016/J.Bpj.2011.11.3738  0.623
2012 Yusifov T, Javaherian AD, Heinemann SH, Hoshi T, Olcese R. Calcium and Heme Induce Distinct Conformational States of the Human BK (Slo1) Channel Gating Ring Biophysical Journal. 102: 687a-688a. DOI: 10.1016/J.Bpj.2011.11.3737  0.536
2011 Seidel KN, Derst C, Salzmann M, Höltje M, Priller J, Markgraf R, Heinemann SH, Heilmann H, Skatchkov SN, Eaton MJ, Veh RW, Prüss H. Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKβ1 and BKβ4 in rodent astrocytes. Glia. 59: 893-902. PMID 21438011 DOI: 10.1002/glia.21160  0.49
2011 Leipold E, Markgraf R, Miloslavina A, Kijas M, Schirmeyer J, Imhof D, Heinemann SH. Molecular determinants for the subtype specificity of μ-conotoxin SIIIA targeting neuronal voltage-gated sodium channels. Neuropharmacology. 61: 105-11. PMID 21419143 DOI: 10.1016/J.Neuropharm.2011.03.008  0.518
2011 Hou S, Xu R, Clark JF, Wurster WL, Heinemann SH, Hoshi T. Bilirubin oxidation end products directly alter K+ channels important in the regulation of vascular tone. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 102-12. PMID 20424637 DOI: 10.1038/jcbfm.2010.54  0.678
2011 Gessner G, Hoshi T, Heinemann SH. Influence of Hydrophobic Residues on BK Channel Gating Biophysical Journal. 100: 582a. DOI: 10.1016/j.bpj.2010.12.3363  0.642
2010 Sahoo N, Tröger J, Heinemann SH, Schönherr R. Current inhibition of human EAG1 potassium channels by the Ca2+ binding protein S100B. Febs Letters. 584: 3896-900. PMID 20708613 DOI: 10.1016/j.febslet.2010.07.063  0.528
2010 Kolbe K, Schönherr R, Gessner G, Sahoo N, Hoshi T, Heinemann SH. Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels. The Journal of Physiology. 588: 2999-3009. PMID 20547678 DOI: 10.1113/jphysiol.2010.192468  0.675
2010 Gessner G, Macianskiene R, Starkus JG, Schönherr R, Heinemann SH. The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism. European Journal of Pharmacology. 632: 52-9. PMID 20097192 DOI: 10.1016/j.ejphar.2010.01.010  0.526
2010 Hou S, Vigeland LE, Zhang G, Xu R, Li M, Heinemann SH, Hoshi T. Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain. The Journal of Biological Chemistry. 285: 6434-42. PMID 20037152 DOI: 10.1074/jbc.M109.069211  0.653
2010 Schirmeyer J, Szafranski K, Leipold E, Mawrin C, Platzer M, Heinemann SH. A subtle alternative splicing event of the Na(V)1.8 voltage-gated sodium channel is conserved in human, rat, and mouse. Journal of Molecular Neuroscience : Mn. 41: 310-4. PMID 19953341 DOI: 10.1007/s12031-009-9315-3  0.396
2010 Yusifov T, Javaherian A, Gandhi C, Hou S, Heinemann S, Hoshi T, Olcese R. Heme-Driven Conformational Changes in the Human Slo1 BKCa Channel Gating Ring Biophysical Journal. 98: 126a. DOI: 10.1016/J.Bpj.2009.12.684  0.601
2010 Stengel R, Sahoo N, Englert C, Heinemann SH, Schoenherr R. Ether ℵ go-go Potassium Channels KCNH1 and KCNH5 Have Four Functional Orthologs in Danio Rerio Biophysical Journal. 98: 1-2. DOI: 10.1016/J.Bpj.2009.12.663  0.527
2010 Stengel R, Sahoo N, Ebert C, Bollig F, Englert C, Heinemann SH, Schönherr R. Functional KCNH1 Potassium Channels in Danio Rerio are Essential for Early Development Biophysical Journal. 98: 118. DOI: 10.1016/J.Bpj.2009.12.645  0.531
2010 Bode SG, Affolter H, Heinemann CN, Heinemann SH. Automated Two-Electrode Voltage-Clamp Recording with Additional Compensation Electrode Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.4203  0.341
2010 Gessner G, Cui Y, Otani Y, Ohwada T, Hoshi T, Heinemann SH. Molecular Determinants For hSlo1 Bk Channel Activation by Dihydroabietic Acid Derivatives Biophysical Journal. 98: 316a. DOI: 10.1016/j.bpj.2009.12.1717  0.657
2010 Hou S, Vigeland LE, Zhang G, Xu R, Li M, Heinemann SH, Hoshi T. Zn2+ Activates Human Large-Conductance Ca2+-Activated K+ Channel Biophysical Journal. 98: 316a. DOI: 10.1016/j.bpj.2009.12.1716  0.659
2010 Schirmeyer J, Leipold E, Heinemann SH. Properties of the Domain-II Voltage Sensor Determining the Function of Nav1.8 (SCN10A) Channels Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.1693  0.461
2009 Wicher D, Schäfer R, Bauernfeind R, Stensmyr MC, Heller R, Heinemann SH, Hansson BS. dOr83b--receptor or ion channel? Annals of the New York Academy of Sciences. 1170: 164-7. PMID 19686130 DOI: 10.1111/J.1749-6632.2009.04101.X  0.36
2009 Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin, Tex.). 3: 249-58. PMID 19617704 DOI: 10.4161/chan.3.4.9253  0.808
2009 Hou S, Heinemann SH, Hoshi T. Modulation of BKCa channel gating by endogenous signaling molecules. Physiology (Bethesda, Md.). 24: 26-35. PMID 19196649 DOI: 10.1152/physiol.00032.2008  0.65
2009 Hou S, Horrigan FT, Heinemann SH, Hoshi T. Comparative Mechanisms Of Activation Of The Slo1 BK Channel By Ca2+ And H+ Mediated By The RCK1 Domain Biophysical Journal. 96: 473a-474a. DOI: 10.1016/j.bpj.2008.12.2451  0.791
2009 Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+-and voltage-gated slo1 K+ channels Channels. 3.  0.772
2008 Haenold R, Wassef R, Brot N, Neugebauer S, Leipold E, Heinemann SH, Hoshi T. Protection of vascular smooth muscle cells by over-expressed methionine sulphoxide reductase A: role of intracellular localization and substrate availability. Free Radical Research. 42: 978-88. PMID 19085252 DOI: 10.1080/10715760802566541  0.495
2008 Decher N, Gonzalez T, Streit AK, Sachse FB, Renigunta V, Soom M, Heinemann SH, Daut J, Sanguinetti MC. Structural determinants of Kvbeta1.3-induced channel inactivation: a hairpin modulated by PIP2. The Embo Journal. 27: 3164-74. PMID 18987637 DOI: 10.1038/Emboj.2008.231  0.526
2008 Soom M, Gessner G, Heuer H, Hoshi T, Heinemann SH. A mutually exclusive alternative exon of slo1 codes for a neuronal BK channel with altered function. Channels (Austin, Tex.). 2: 278-82. PMID 18719396 DOI: 10.4161/chan.2.4.6571  0.642
2008 Wicher D, Schäfer R, Bauernfeind R, Stensmyr MC, Heller R, Heinemann SH, Hansson BS. Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels. Nature. 452: 1007-11. PMID 18408711 DOI: 10.1038/Nature06861  0.373
2008 Kassmann M, Hansel A, Leipold E, Birkenbeil J, Lu SQ, Hoshi T, Heinemann SH. Oxidation of multiple methionine residues impairs rapid sodium channel inactivation. Pflã¼Gers Archiv : European Journal of Physiology. 456: 1085-95. PMID 18369661 DOI: 10.1007/s00424-008-0477-6  0.623
2008 Hou S, Xu R, Heinemann SH, Hoshi T. Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain. Nature Structural & Molecular Biology. 15: 403-10. PMID 18345016 DOI: 10.1038/nsmb.1398  0.642
2008 Hou S, Xu R, Heinemann SH, Hoshi T. The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels. Proceedings of the National Academy of Sciences of the United States of America. 105: 4039-43. PMID 18316727 DOI: 10.1073/pnas.0800304105  0.676
2007 Wicher D, Derst C, Gautier H, Lapied B, Heinemann SH, Agricola HJ. The satiety signaling neuropeptide perisulfakinin inhibits the activity of central neurons promoting general activity. Frontiers in Cellular Neuroscience. 1: 3. PMID 18946521 DOI: 10.3389/Neuro.03.003.2007  0.351
2007 Leipold E, DeBie H, Zorn S, Borges A, Olivera BM, Terlau H, Heinemann SH. muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2. Channels (Austin, Tex.). 1: 253-62. PMID 18698149 DOI: 10.4161/Chan.4847  0.524
2007 Wassef R, Haenold R, Hansel A, Brot N, Heinemann SH, Hoshi T. Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12808-16. PMID 18032652 DOI: 10.1523/JNEUROSCI.0322-07.2007  0.462
2007 Haenold R, Wassef R, Hansel A, Heinemann SH, Hoshi T. Identification of a new functional splice variant of the enzyme methionine sulphoxide reductase A (MSRA) expressed in rat vascular smooth muscle cells. Free Radical Research. 41: 1233-45. PMID 17907003 DOI: 10.1080/10715760701642096  0.477
2007 Su Z, Limberis J, Martin RL, Xu R, Kolbe K, Heinemann SH, Hoshi T, Cox BF, Gintant GA. Functional consequences of methionine oxidation of hERG potassium channels. Biochemical Pharmacology. 74: 702-11. PMID 17624316 DOI: 10.1016/j.bcp.2007.06.002  0.673
2007 Decher N, Renigunta V, Zuzarte M, Soom M, Heinemann SH, Timothy KW, Keating MT, Daut J, Sanguinetti MC, Splawski I. Impaired interaction between the slide helix and the C-terminus of Kir2.1: a novel mechanism of Andersen syndrome. Cardiovascular Research. 75: 748-57. PMID 17568571 DOI: 10.1016/J.Cardiores.2007.05.010  0.453
2007 Heinemann SH, Leipold E. Conotoxins of the O-superfamily affecting voltage-gated sodium channels. Cellular and Molecular Life Sciences : Cmls. 64: 1329-40. PMID 17385074 DOI: 10.1007/s00018-007-6565-5  0.545
2007 Karbat I, Kahn R, Cohen L, Ilan N, Gilles N, Corzo G, Froy O, Gur M, Albrecht G, Heinemann SH, Gordon D, Gurevitz M. The unique pharmacology of the scorpion alpha-like toxin Lqh3 is associated with its flexible C-tail. The Febs Journal. 274: 1918-31. PMID 17355257 DOI: 10.1111/j.1742-4658.2007.05737.x  0.336
2007 Gessner G, Heller R, Hoshi T, Heinemann SH. The amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015) opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle. European Journal of Pharmacology. 555: 185-93. PMID 17134694 DOI: 10.1016/j.ejphar.2006.10.053  0.62
2007 Gavrilova-Ruch O, Schönherr R, Heinemann SH. Activation of hEAG1 potassium channels by arachidonic acid. Pflã¼Gers Archiv : European Journal of Physiology. 453: 891-903. PMID 17120019 DOI: 10.1007/s00424-006-0173-3  0.498
2007 Xu M, Gessner G, Groth I, Lange C, Christner A, Bruhn T, Deng Z, Li X, Heinemann SH, Grabley S, Bringmann G, Sattler I, Lin W. Shearinines D-K, new indole triterpenoids from an endophytic Penicillium sp. (strain HKI0459) with blocking activity on large-conductance calcium-activated potassium channels Tetrahedron. 63: 435-444. DOI: 10.1016/J.Tet.2006.10.050  0.38
2006 Hou S, Reynolds MF, Horrigan FT, Heinemann SH, Hoshi T. Reversible binding of heme to proteins in cellular signal transduction. Accounts of Chemical Research. 39: 918-24. PMID 17176030 DOI: 10.1021/ar040020w  0.758
2006 Heinemann SH, Hoshi T. Multifunctional potassium channels: electrical switches and redox enzymes, all in one. Science's Stke : Signal Transduction Knowledge Environment. 2006: pe33. PMID 16940439 DOI: 10.1126/stke.3502006pe33  0.639
2006 Leipold E, Hansel A, Borges A, Heinemann SH. Subtype specificity of scorpion beta-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3. Molecular Pharmacology. 70: 340-7. PMID 16638971 DOI: 10.1124/mol.106.024034  0.527
2006 Zhang G, Xu R, Heinemann SH, Hoshi T. Cysteine oxidation and rundown of large-conductance Ca2+-dependent K+ channels. Biochemical and Biophysical Research Communications. 342: 1389-95. PMID 16516848 DOI: 10.1016/j.bbrc.2006.02.079  0.672
2006 Ziechner U, Schönherr R, Born AK, Gavrilova-Ruch O, Glaser RW, Malesevic M, Küllertz G, Heinemann SH. Inhibition of human ether à go-go potassium channels by Ca2+/calmodulin binding to the cytosolic N- and C-termini. The Febs Journal. 273: 1074-86. PMID 16478480 DOI: 10.1111/j.1742-4658.2006.05134.x  0.427
2006 Zorn S, Leipold E, Hansel A, Bulaj G, Olivera BM, Terlau H, Heinemann SH. The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3. Febs Letters. 580: 1360-4. PMID 16458302 DOI: 10.1016/J.Febslet.2006.01.057  0.525
2006 Tajima N, Schönherr K, Niedling S, Kaatz M, Kanno H, Schönherr R, Heinemann SH. Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1alpha and the von Hippel-Lindau protein. The Journal of Physiology. 571: 349-59. PMID 16396931 DOI: 10.1113/jphysiol.2005.096818  0.473
2006 Santarelli LC, Wassef R, Heinemann SH, Hoshi T. Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels. The Journal of Physiology. 571: 329-48. PMID 16396928 DOI: 10.1113/jphysiol.2005.101089  0.578
2006 Derst C, Walther C, Veh RW, Wicher D, Heinemann SH. Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE. Biochemical and Biophysical Research Communications. 339: 939-48. PMID 16325765 DOI: 10.1016/j.bbrc.2005.11.096  0.517
2006 Wicher D, Agricola HJ, Schönherr R, Heinemann SH, Derst C. TRPgamma channels are inhibited by cAMP and contribute to pacemaking in neurosecretory insect neurons. The Journal of Biological Chemistry. 281: 3227-36. PMID 16319060 DOI: 10.1074/jbc.M511741200  0.473
2006 Barbier J, Lamthanh H, Gall FL, Favreau P, Benoit E, Chen H, Gilles N, Ilan N, Heinemann SH, Gordon D, Ménez A, Molgó J. delta-Conopeptide EVIA isolated from Conus ermineus is a new pharmacological tool for discriminating sodium channel subtypes Journal of Physiology-Paris. 99: 247. DOI: 10.1016/J.Jphysparis.2005.12.020  0.455
2005 Haenold R, Wassef DM, Heinemann SH, Hoshi T. Oxidative damage, aging and anti-aging strategies. Age (Dordrecht, Netherlands). 27: 183-99. PMID 23598652 DOI: 10.1007/s11357-005-2915-0  0.473
2005 Gessner G, Schönherr K, Soom M, Hansel A, Asim M, Baniahmad A, Derst C, Hoshi T, Heinemann SH. BKCa channels activating at resting potential without calcium in LNCaP prostate cancer cells. The Journal of Membrane Biology. 208: 229-40. PMID 16604468 DOI: 10.1007/s00232-005-0830-z  0.629
2005 Kim SW, Yang SD, Ahn BJ, Park JH, Lee DS, Gessner G, Heinemann SH, Herdering W, Yu KH. In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium. Experimental & Molecular Medicine. 37: 269-75. PMID 16155403 DOI: 10.1038/emm.2005.36  0.495
2005 Leipold E, Hansel A, Olivera BM, Terlau H, Heinemann SH. Molecular interaction of delta-conotoxins with voltage-gated sodium channels. Febs Letters. 579: 3881-4. PMID 15990094 DOI: 10.1016/j.febslet.2005.05.077  0.524
2005 Horrigan FT, Heinemann SH, Hoshi T. Heme regulates allosteric activation of the Slo1 BK channel. The Journal of General Physiology. 126: 7-21. PMID 15955873 DOI: 10.1085/jgp.200509262  0.824
2005 Hansel A, Heinemann SH, Hoshi T. Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation. Biochimica Et Biophysica Acta. 1703: 239-47. PMID 15680232 DOI: 10.1016/j.bbapap.2004.09.010  0.539
2004 Santarelli LC, Chen J, Heinemann SH, Hoshi T. The beta1 subunit enhances oxidative regulation of large-conductance calcium-activated K+ channels. The Journal of General Physiology. 124: 357-70. PMID 15452197 DOI: 10.1085/jgp.200409144  0.597
2004 Patt S, Preussat K, Beetz C, Kraft R, Schrey M, Kalff R, Schönherr K, Heinemann SH. Expression of ether à go-go potassium channels in human gliomas. Neuroscience Letters. 368: 249-53. PMID 15364405 DOI: 10.1016/j.neulet.2004.07.001  0.447
2004 Borges A, Alfonzo MJ, García CC, Winand NJ, Leipold E, Heinemann SH. Isolation, molecular cloning and functional characterization of a novel beta-toxin from the Venezuelan scorpion, Tityus zulianus. Toxicon : Official Journal of the International Society On Toxinology. 43: 671-84. PMID 15109888 DOI: 10.1016/j.toxicon.2004.02.022  0.326
2004 Gessner G, Zacharias M, Bechstedt S, Schönherr R, Heinemann SH. Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents. Molecular Pharmacology. 65: 1120-9. PMID 15102940 DOI: 10.1124/mol.65.5.1120  0.502
2004 Leipold E, Lu S, Gordon D, Hansel A, Heinemann SH. Combinatorial interaction of scorpion toxins Lqh-2, Lqh-3, and LqhalphaIT with sodium channel receptor sites-3. Molecular Pharmacology. 65: 685-91. PMID 14978247 DOI: 10.1124/mol.65.3.685  0.51
2004 Tang XD, Santarelli LC, Heinemann SH, Hoshi T. Metabolic regulation of potassium channels. Annual Review of Physiology. 66: 131-59. PMID 14977399 DOI: 10.1146/annurev.physiol.66.041002.142720  0.593
2004 Tang XD, Garcia ML, Heinemann SH, Hoshi T. Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing. Nature Structural & Molecular Biology. 11: 171-8. PMID 14745441 DOI: 10.1038/nsmb725  0.599
2004 Yermolaieva O, Xu R, Schinstock C, Brot N, Weissbach H, Heinemann SH, Hoshi T. Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation. Proceedings of the National Academy of Sciences of the United States of America. 101: 1159-64. PMID 14745014 DOI: 10.1073/Pnas.0308215100  0.487
2004 Barbier J, Lamthanh H, Le Gall F, Favreau P, Benoit E, Chen H, Gilles N, Ilan N, Heinemann SH, Gordon D, Ménez A, Molgó J. A delta-conotoxin from Conus ermineus venom inhibits inactivation in vertebrate neuronal Na+ channels but not in skeletal and cardiac muscles. The Journal of Biological Chemistry. 279: 4680-5. PMID 14615484 DOI: 10.1074/Jbc.M309576200  0.482
2003 Hansel A, Jung S, Hoshi T, Heinemann SH. A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1. Redox Report : Communications in Free Radical Research. 8: 384-8. PMID 14980072 DOI: 10.1179/135100003225003429  0.462
2003 Tang XD, Xu R, Reynolds MF, Garcia ML, Heinemann SH, Hoshi T. Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature. 425: 531-5. PMID 14523450 DOI: 10.1038/nature02003  0.673
2003 Starkus JG, Varga Z, Schönherr R, Heinemann SH. Mechanisms of the inhibition of Shaker potassium channels by protons. Pflã¼Gers Archiv : European Journal of Physiology. 447: 44-54. PMID 12920598 DOI: 10.1007/s00424-003-1121-0  0.522
2003 Derst C, Messutat S, Walther C, Eckert M, Heinemann SH, Wicher D. The large conductance Ca2+-activated potassium channel (pSlo) of the cockroach Periplaneta americana: structure, localization in neurons and electrophysiology. The European Journal of Neuroscience. 17: 1197-212. PMID 12670308 DOI: 10.1046/j.1460-9568.2003.02550.x  0.484
2003 Gessner G, Heinemann SH. Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. British Journal of Pharmacology. 138: 161-71. PMID 12522086 DOI: 10.1038/sj.bjp.0705025  0.543
2002 Schönherr R, Mannuzzu LM, Isacoff EY, Heinemann SH. Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Neuron. 35: 935-49. PMID 12372287 DOI: 10.1016/S0896-6273(02)00869-3  0.396
2002 Chen H, Lu S, Leipold E, Gordon D, Hansel A, Heinemann SH. Differential sensitivity of sodium channels from the central and peripheral nervous system to the scorpion toxins Lqh-2 and Lqh-3. The European Journal of Neuroscience. 16: 767-70. PMID 12270053 DOI: 10.1046/j.1460-9568.2002.02142.x  0.52
2002 Jung S, Hansel A, Kasperczyk H, Hoshi T, Heinemann SH. Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1. Febs Letters. 527: 91-4. PMID 12220640 DOI: 10.1016/S0014-5793(02)03171-X  0.51
2002 Gavrilova-Ruch O, Schönherr K, Gessner G, Schönherr R, Klapperstück T, Wohlrab W, Heinemann SH. Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells. The Journal of Membrane Biology. 188: 137-49. PMID 12172639 DOI: 10.1007/s00232-001-0181-3  0.532
2002 Hansel A, Kuschel L, Hehl S, Lemke C, Agricola HJ, Hoshi T, Heinemann SH. Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 911-3. PMID 12039877 DOI: 10.1096/fj.01-0737fje  0.477
2002 Schönherr R, Gessner G, Löber K, Heinemann SH. Functional distinction of human EAG1 and EAG2 potassium channels. Febs Letters. 514: 204-8. PMID 11943152 DOI: 10.1016/S0014-5793(02)02365-7  0.554
2002 Chen J, Daggett H, De Waard M, Heinemann SH, Hoshi T. Nitric oxide augments voltage-gated P/Q-type Ca(2+) channels constituting a putative positive feedback loop. Free Radical Biology & Medicine. 32: 638-49. PMID 11909698 DOI: 10.1016/S0891-5849(02)00748-7  0.575
2002 Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T, Chen ML, Joiner MA, Heinemann SH. High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proceedings of the National Academy of Sciences of the United States of America. 99: 2748-53. PMID 11867705 DOI: 10.1073/pnas.032671199  0.474
2002 Weissbach H, Etienne F, Hoshi T, Heinemann SH, Lowther WT, Matthews B, St John G, Nathan C, Brot N. Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function. Archives of Biochemistry and Biophysics. 397: 172-8. PMID 11795868 DOI: 10.1006/Abbi.2001.2664  0.485
2001 Gilles N, Leipold E, Chen H, Heinemann SH, Gordon D. Effect of depolarization on binding kinetics of scorpion alpha-toxin highlights conformational changes of rat brain sodium channels. Biochemistry. 40: 14576-84. PMID 11724571 DOI: 10.1021/bi010973r  0.457
2001 Zehelein J, Zhang W, Koenen M, Graf M, Heinemann SH, Katus HA. Molecular cloning and expression of cERG, the ether à go-go-related gene from canine myocardium. Pflã¼Gers Archiv : European Journal of Physiology. 442: 188-91. PMID 11417212 DOI: 10.1007/s004240100524  0.45
2001 Chen H, Heinemann SH. Interaction of scorpion alpha-toxins with cardiac sodium channels: binding properties and enhancement of slow inactivation. The Journal of General Physiology. 117: 505-18. PMID 11382802 DOI: 10.1085/jgp.117.6.505  0.515
2001 Tang XD, Daggett H, Hanner M, Garcia ML, McManus OB, Brot N, Weissbach H, Heinemann SH, Hoshi T. Oxidative regulation of large conductance calcium-activated potassium channels. The Journal of General Physiology. 117: 253-74. PMID 11222629 DOI: 10.1085/Jgp.117.3.253  0.662
2001 Hoshi T, Heinemann S. Regulation of cell function by methionine oxidation and reduction. The Journal of Physiology. 531: 1-11. PMID 11179387 DOI: 10.1111/j.1469-7793.2001.0001j.x  0.538
2001 Soom M, Schönherr R, Kubo Y, Kirsch C, Klinger R, Heinemann SH. Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels. Febs Letters. 490: 49-53. PMID 11172809 DOI: 10.1016/S0014-5793(01)02136-6  0.487
2000 Gilles N, Chen H, Wilson H, Le Gall F, Montoya G, Molgo J, Schönherr R, Nicholson G, Heinemann SH, Gordon D. Scorpion alpha and alpha-like toxins differentially interact with sodium channels in mammalian CNS and periphery. The European Journal of Neuroscience. 12: 2823-32. PMID 10971624 DOI: 10.1046/j.1460-9568.2000.00168.x  0.336
2000 Schönherr R, Löber K, Heinemann SH. Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin. The Embo Journal. 19: 3263-71. PMID 10880439 DOI: 10.1093/emboj/19.13.3263  0.527
2000 Chen H, Gordon D, Heinemann SH. Modulation of cloned skeletal muscle sodium channels by the scorpion toxins Lqh II, Lqh III, and Lqh alphaIT. Pflã¼Gers Archiv : European Journal of Physiology. 439: 423-32. PMID 10678738 DOI: 10.1007/s004240050959  0.457
2000 Starkus JG, Heinemann SH, Rayner MD. Voltage dependence of slow inactivation in Shaker potassium channels results from changes in relative K(+) and Na(+) permeabilities. The Journal of General Physiology. 115: 107-22. PMID 10653891 DOI: 10.1085/jgp.115.2.107  0.413
2000 Chen J, Avdonin V, Ciorba MA, Heinemann SH, Hoshi T. Acceleration of P/C-type inactivation in voltage-gated K(+) channels by methionine oxidation. Biophysical Journal. 78: 174-87. PMID 10620284 DOI: 10.1016/S0006-3495(00)76583-0  0.631
2000 Yermolaieva O, Brot N, Weissbach H, Heinemann SH, Hoshi T. Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling. Proceedings of the National Academy of Sciences of the United States of America. 97: 448-53. PMID 10618438 DOI: 10.1073/Pnas.97.1.448  0.503
1999 Meyer R, Schönherr R, Gavrilova-Ruch O, Wohlrab W, Heinemann SH. Identification of ether à go-go and calcium-activated potassium channels in human melanoma cells. The Journal of Membrane Biology. 171: 107-15. PMID 10489423 DOI: 10.1007/s002329900563  0.552
1999 Kuschel L, Hansel A, Schönherr R, Weissbach H, Brot N, Hoshi T, Heinemann SH. Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA). Febs Letters. 456: 17-21. PMID 10452521 DOI: 10.1016/S0014-5793(99)00917-5  0.544
1999 Höllerer-Beitz G, Schönherr R, Koenen M, Heinemann SH. N-Terminal deletions of rKv1.4 channels affect the voltage dependence of channel availability. Pflã¼Gers Archiv : European Journal of Physiology. 438: 141-6. PMID 10370099 DOI: 10.1007/s004240050891  0.541
1999 Schönherr R, Rosati B, Hehl S, Rao VG, Arcangeli A, Olivotto M, Heinemann SH, Wanke E. Functional role of the slow activation property of ERG K+ channels. The European Journal of Neuroscience. 11: 753-60. PMID 10103069 DOI: 10.1046/J.1460-9568.1999.00493.X  0.548
1999 Schönherr R, Hehl S, Terlau H, Baumann A, Heinemann SH. Individual subunits contribute independently to slow gating of bovine EAG potassium channels. The Journal of Biological Chemistry. 274: 5362-9. PMID 10026145 DOI: 10.1074/jbc.274.9.5362  0.443
1999 Ciorba MA, Heinemann SH, Weissbach H, Brot N, Hoshi T. Regulation of voltage-dependent K+ channels by methionine oxidation: effect of nitric oxide and vitamin C. Febs Letters. 442: 48-52. PMID 9923602 DOI: 10.1016/S0014-5793(98)01616-0  0.632
1998 Kubo Y, Yoshimichi M, Heinemann SH. Probing pore topology and conformational changes of Kir2.1 potassium channels by cysteine scanning mutagenesis. Febs Letters. 435: 69-73. PMID 9755861 DOI: 10.1016/S0014-5793(98)01038-2  0.528
1998 Li A, Ségui J, Heinemann SH, Hoshi T. Oxidation regulates cloned neuronal voltage-dependent Ca2+ channels expressed in Xenopus oocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 6740-7. PMID 9712645 DOI: 10.1523/Jneurosci.18-17-06740.1998  0.602
1998 Steffan R, Hennesthal C, Heinemann SH. Voltage-dependent ion channels: analysis of nonideal macroscopic current data. Methods in Enzymology. 293: 391-419. PMID 9711621 DOI: 10.1016/S0076-6879(98)93026-9  0.35
1998 Schmalwasser H, Neef A, Elliott AA, Heinemann SH. Two-electrode voltage clamp of Xenopus oocytes under high hydrostatic pressure. Journal of Neuroscience Methods. 81: 1-7. PMID 9696303 DOI: 10.1016/S0165-0270(98)00030-2  0.359
1998 Starkus JG, Kuschel L, Rayner MD, Heinemann SH. Macroscopic Na+ currents in the "Nonconducting" Shaker potassium channel mutant W434F. The Journal of General Physiology. 112: 85-93. PMID 9649585 DOI: 10.1085/jgp.112.1.85  0.431
1998 Höllerer-Beitz G, Heinemann SH. Influence of detergents on the function of cloned potassium channels. Receptors & Channels. 5: 61-78. PMID 9606711  0.458
1998 Chen H, Kubo Y, Hoshi T, Heinemann SH. Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes. Febs Letters. 422: 307-10. PMID 9498805 DOI: 10.1016/S0014-5793(98)00028-3  0.634
1998 Meyer R, Heinemann SH. Characterization of an eag-like potassium channel in human neuroblastoma cells. The Journal of Physiology. 508: 49-56. PMID 9490815  0.434
1997 Steffan R, Heinemann SH. Error estimates for results of nonstationary noise analysis derived with linear least squares methods. Journal of Neuroscience Methods. 78: 51-63. PMID 9497001 DOI: 10.1016/S0165-0270(97)00139-8  0.332
1997 Starkus JG, Kuschel L, Rayner MD, Heinemann SH. Ion conduction through C-type inactivated Shaker channels. The Journal of General Physiology. 110: 539-50. PMID 9348326 DOI: 10.1085/jgp.110.5.539  0.374
1997 Suessbrich H, Schönherr R, Heinemann SH, Lang F, Busch AE. Specific block of cloned Herg channels by clofilium and its tertiary analog LY97241. Febs Letters. 414: 435-8. PMID 9315735 DOI: 10.1016/S0014-5793(97)01030-2  0.542
1997 Gòmez-Hernandez JM, Lorra C, Pardo LA, Stühmer W, Pongs O, Heinemann SH, Elliott AA. Molecular basis for different pore properties of potassium channels from the rat brain Kv1 gene family. Pflã¼Gers Archiv : European Journal of Physiology. 434: 661-8. PMID 9305996 DOI: 10.1007/S004240050449  0.52
1997 Terlau H, Heinemann SH, Stühmer W, Pongs O, Ludwig J. Amino terminal-dependent gating of the potassium channel rat eag is compensated by a mutation in the S4 segment. The Journal of Physiology. 502: 537-43. PMID 9279806 DOI: 10.1111/J.1469-7793.1997.537Bj.X  0.545
1997 Ciorba MA, Heinemann SH, Weissbach H, Brot N, Hoshi T. Modulation of potassium channel function by methionine oxidation and reduction. Proceedings of the National Academy of Sciences of the United States of America. 94: 9932-7. PMID 9275229 DOI: 10.1073/Pnas.94.18.9932  0.563
1997 Suessbrich H, Schönherr R, Heinemann SH, Attali B, Lang F, Busch AE. The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes. British Journal of Pharmacology. 120: 968-74. PMID 9138706 DOI: 10.1038/Sj.Bjp.0700989  0.546
1996 Schlief T, Schönherr R, Imoto K, Heinemann SH. Pore properties of rat brain II sodium channels mutated in the selectivity filter domain. European Biophysics Journal : Ebj. 25: 75-91. PMID 9035373 DOI: 10.1007/s002490050020  0.446
1996 Schönherr R, Heinemann SH. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel. The Journal of Physiology. 493: 635-42. PMID 8799887 DOI: 10.1113/Jphysiol.1996.Sp021410  0.572
1996 Heinemann SH, Rettig J, Graack HR, Pongs O. Functional characterization of Kv channel beta-subunits from rat brain. The Journal of Physiology. 493: 625-33. PMID 8799886 DOI: 10.1113/jphysiol.1996.sp021409  0.403
1996 Terlau H, Ludwig J, Steffan R, Pongs O, Stühmer W, Heinemann SH. Extracellular Mg2+ regulates activation of rat eag potassium channel. Pflã¼Gers Archiv : European Journal of Physiology. 432: 301-12. PMID 8662307 DOI: 10.1007/S004240050137  0.438
1996 Schlief T, Schönherr R, Heinemann SH. Modification of C-type inactivating Shaker potassium channels by chloramine-T. Pflã¼Gers Archiv : European Journal of Physiology. 431: 483-93. PMID 8596690 DOI: 10.1007/s004240050026  0.432
1995 Ogielska EM, Zagotta WN, Hoshi T, Heinemann SH, Haab J, Aldrich RW. Cooperative subunit interactions in C-type inactivation of K channels. Biophysical Journal. 69: 2449-57. PMID 8599651 DOI: 10.1016/S0006-3495(95)80114-1  0.818
1995 Heinemann SH, Rettig J, Wunder F, Pongs O. Molecular and functional characterization of a rat brain Kv beta 3 potassium channel subunit. Febs Letters. 377: 383-9. PMID 8549760 DOI: 10.1016/0014-5793(95)01377-6  0.336
1995 Starkus JG, Schlief T, Rayner MD, Heinemann SH. Unilateral exposure of Shaker B potassium channels to hyperosmolar solutions. Biophysical Journal. 69: 860-72. PMID 8519986 DOI: 10.1016/S0006-3495(95)79960-X  0.379
1994 McCormack K, Joiner WJ, Heinemann SH. A characterization of the activating structural rearrangements in voltage-dependent Shaker K+ channels. Neuron. 12: 301-15. PMID 8110460 DOI: 10.1016/0896-6273(94)90273-9  0.45
1994 Heinemann SH, Schlief T, Mori Y, Imoto K. Molecular pore structure of voltage-gated sodium and calcium channels. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Mã©Dicas E Biolã³Gicas / Sociedade Brasileira De Biofã­Sica ... [Et Al.]. 27: 2781-802. PMID 7550000  0.444
1994 Eismann E, Müller F, Heinemann SH, Kaupp UB. A single negative charge within the pore region of a cGMP-gated channel controls rectification, Ca2+ blockage, and ionic selectivity. Proceedings of the National Academy of Sciences of the United States of America. 91: 1109-13. PMID 7508120 DOI: 10.1073/PNAS.91.3.1109  0.343
1993 Ludewig U, Lorra C, Pongs O, Heinemann SH. A site accessible to extracellular TEA+ and K+ influences intracellular Mg2+ block of cloned potassium channels. European Biophysics Journal : Ebj. 22: 237-47. PMID 8253052 DOI: 10.1007/Bf00180258  0.444
1993 López-Barneo J, Hoshi T, Heinemann SH, Aldrich RW. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors & Channels. 1: 61-71. PMID 8081712  0.704
1992 Pardo LA, Heinemann SH, Terlau H, Ludewig U, Lorra C, Pongs O, Stühmer W. Extracellular K+ specifically modulates a rat brain K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 89: 2466-70. PMID 1549610 DOI: 10.1073/Pnas.89.6.2466  0.459
1992 Heinemann SH, Conti F, Stühmer W. Recording of gating currents from Xenopus oocytes and gating noise analysis. Methods in Enzymology. 207: 353-68. PMID 1382191 DOI: 10.1016/0076-6879(92)07024-I  0.418
1992 Heinemann SH, Terlau H, Imoto K. Molecular basis for pharmacological differences between brain and cardiac sodium channels. Pflã¼Gers Archiv : European Journal of Physiology. 422: 90-2. PMID 1331981 DOI: 10.1007/BF00381519  0.417
1992 Heinemann SH, Terlau H, Stühmer W, Imoto K, Numa S. Calcium channel characteristics conferred on the sodium channel by single mutations. Nature. 356: 441-3. PMID 1313551 DOI: 10.1038/356441A0  0.518
1991 Ruppersberg JP, Stocker M, Pongs O, Heinemann SH, Frank R, Koenen M. Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation. Nature. 352: 711-4. PMID 1908562 DOI: 10.1038/352711A0  0.416
1991 Stühmer W, Conti F, Stocker M, Pongs O, Heinemann SH. Gating currents of inactivating and non-inactivating potassium channels expressed in Xenopus oocytes. Pflã¼Gers Archiv : European Journal of Physiology. 418: 423-9. PMID 1876487 DOI: 10.1007/Bf00550881  0.444
1991 Stankovic CJ, Heinemann SH, Schreiber SL. Photo-modulated ion channels based on covalently linked gramicidins. Biochimica Et Biophysica Acta. 1061: 163-70. PMID 1705439 DOI: 10.1016/0005-2736(91)90281-C  0.414
1991 Stocker M, Pongs O, Hoth M, Heinemann SH, Stühmer W, Schröter KH, Ruppersberg JP. Swapping of functional domains in voltage-gated K+ channels. Proceedings. Biological Sciences / the Royal Society. 245: 101-7. PMID 1682932 DOI: 10.1098/Rspb.1991.0094  0.455
1991 Terlau H, Heinemann SH, Stühmer W, Pusch M, Conti F, Imoto K, Numa S. Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. Febs Letters. 293: 93-6. PMID 1660007 DOI: 10.1016/0014-5793(91)81159-6  0.369
1990 Heinemann SH, Sigworth FJ. Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels. Biophysical Journal. 57: 499-514. PMID 1689592 DOI: 10.1016/S0006-3495(90)82566-2  0.302
1990 Stankovic CJ, Heinemann SH, Schreiber SL. Immobilizing the gate of a tartaric acid-gramicidin a hybrid channel molecule by rational design Journal of the American Chemical Society. 112: 3702-3704.  0.337
1989 Heinemann SH, Sigworth FJ. Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents. Biochimica Et Biophysica Acta. 987: 8-14. PMID 2480817 DOI: 10.1016/0005-2736(89)90448-3  0.38
1989 Stankovic CJ, Heinemann SH, Delfino JM, Sigworth FJ, Schreiber SL. Transmembrane channels based on tartaric acid-gramicidin A hybrids. Science (New York, N.Y.). 244: 813-7. PMID 2471263 DOI: 10.1126/Science.2471263  0.423
1988 Heinemann SH, Sigworth FJ. Open channel noise. IV. Estimation of rapid kinetics of formamide block in gramicidin A channels. Biophysical Journal. 54: 757-64. PMID 2465033 DOI: 10.1016/S0006-3495(88)83013-3  0.416
1987 Heinemann SH, Stühmer W, Conti F. Single acetylcholine receptor channel currents recorded at high hydrostatic pressures. Proceedings of the National Academy of Sciences of the United States of America. 84: 3229-33. PMID 2437577 DOI: 10.1073/Pnas.84.10.3229  0.396
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