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Daniel John Siegwart - Publications

Affiliations: 
2008 Carnegie Mellon University, Pittsburgh, PA 
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wei T, Cheng Q, Farbiak L, Anderson DG, Langer R, Siegwart DJ. Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for CRISPR/Cas-Based Genome Editing. Acs Nano. PMID 32697075 DOI: 10.1021/Acsnano.0C04707  0.303
2020 Xiong H, Liu S, Wei T, Cheng Q, Siegwart DJ. Theranostic dendrimer-based lipid nanoparticles containing PEGylated BODIPY dyes for tumor imaging and systemic mRNA delivery in vivo. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 32629133 DOI: 10.1016/J.Jconrel.2020.06.030  0.352
2020 Wei T, Cheng Q, Min YL, Olson EN, Siegwart DJ. Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing. Nature Communications. 11: 3232. PMID 32591530 DOI: 10.1038/S41467-020-17029-3  0.318
2020 Xue L, Yan Y, Kos P, Chen X, Siegwart DJ. PEI fluorination reduces toxicity and promotes liver-targeted siRNA delivery. Drug Delivery and Translational Research. PMID 32506259 DOI: 10.1007/S13346-020-00790-9  0.411
2020 Zhou K, Johnson LT, Xiong H, Barrios S, Minnig JT, Yan Y, Abram B, Yu X, Siegwart DJ. The hydrophobic domain structure of linear-dendritic poly(ethylene glycol) lipids affects RNA delivery of lipid nanoparticles. Molecular Pharmaceutics. PMID 32267707 DOI: 10.1021/Acs.Molpharmaceut.9B01288  0.355
2020 Cheng Q, Wei T, Farbiak L, Johnson LT, Dilliard SA, Siegwart DJ. Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR-Cas gene editing. Nature Nanotechnology. PMID 32251383 DOI: 10.1038/S41565-020-0669-6  0.319
2020 Yu X, Liu S, Cheng Q, Wei T, Lee S, Zhang D, Siegwart DJ. Lipid-Modified Aminoglycosides for mRNA Delivery to the Liver. Advanced Healthcare Materials. e1901487. PMID 32108440 DOI: 10.1002/Adhm.201901487  0.372
2019 Dong Y, Siegwart DJ, Anderson DG. Strategies, design, and chemistry in siRNA delivery systems. Advanced Drug Delivery Reviews. PMID 31102606 DOI: 10.1016/J.Addr.2019.05.004  0.376
2018 Elkassih SA, Kos P, Xiong H, Siegwart DJ. Degradable redox-responsive disulfide-based nanogel drug carriers via dithiol oxidation polymerization. Biomaterials Science. PMID 30462102 DOI: 10.1039/C8Bm01120F  0.412
2017 Miller JB, Kos P, Tieu V, Zhou K, Siegwart DJ. Development of Cationic Quaternary Ammonium Sulfonamide Amino Lipids (CSALs) for Nucleic Acid Delivery. Acs Applied Materials & Interfaces. PMID 29286232 DOI: 10.1021/Acsami.7B15982  0.344
2017 Yan Y, Xiong H, Zhang X, Cheng Q, Siegwart DJ. Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers. Biomacromolecules. PMID 29141136 DOI: 10.1021/Acs.Biomac.7B01356  0.33
2017 Senevirathne SA, Washington KE, Miller JB, Biewer MC, Oupicky D, Siegwart DJ, Stefan MC. HDAC Inhibitor Conjugated Polymeric Prodrug Micelles for Doxorubicin Delivery. Journal of Materials Chemistry. B, Materials For Biology and Medicine. 5: 2106-2114. PMID 28630710 DOI: 10.1039/C6Tb03038F  0.614
2017 Xiong H, Zuo H, Yan Y, Occhialini G, Zhou K, Wan Y, Siegwart DJ. High-Contrast Fluorescence Detection of Metastatic Breast Cancer Including Bone and Liver Micrometastases via Size-Controlled pH-Activatable Water-Soluble Probes. Advanced Materials (Deerfield Beach, Fla.). PMID 28563903 DOI: 10.1002/Adma.201700131  0.303
2016 Miller JB, Zhang S, Kos P, Xiong H, Zhou K, Perelman SS, Zhu H, Siegwart DJ. Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA. Angewandte Chemie (International Ed. in English). PMID 27981708 DOI: 10.1002/Anie.201610209  0.327
2016 Yan Y, Zhou K, Xiong H, Miller JB, Motea EA, Boothman DA, Liu L, Siegwart DJ. Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors. Biomaterials. 118: 84-93. PMID 27974266 DOI: 10.1016/J.Biomaterials.2016.12.001  0.31
2016 Zhou K, Kos P, Yan Y, Xiong H, Min YL, Kinghorn KA, Minnig JT, Miller JB, Siegwart DJ. Intercalation-mediated nucleic acid nanoparticles for siRNA delivery. Chemical Communications (Cambridge, England). 52: 12155-12158. PMID 27711272 DOI: 10.1039/C6Cc06024B  0.317
2016 Yan Y, Liu L, Xiong H, Miller JB, Zhou K, Kos P, Huffman KE, Elkassih S, Norman JW, Carstens R, Kim J, Minna JD, Siegwart DJ. Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 27621434 DOI: 10.1073/Pnas.1606886113  0.319
2016 Zhou K, Nguyen LH, Miller JB, Yan Y, Kos P, Xiong H, Li L, Hao J, Minnig JT, Zhu H, Siegwart DJ. Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model. Proceedings of the National Academy of Sciences of the United States of America. PMID 26729861 DOI: 10.1073/Pnas.1520756113  0.312
2016 Hao J, Elkassih S, Siegwart DJ. Progress towards the Synthesis of Amino Polyesters via Ring-Opening Polymerization (ROP) of Functional Lactones Synlett. 27: 2285-2292. DOI: 10.1055/S-0035-1562505  0.364
2015 Rainbolt EA, Miller JB, Washington KE, Senevirathne SA, Biewer MC, Siegwart DJ, Stefan MC. Fine-tuning thermoresponsive functional poly(ε-caprolactone)s to enhance micelle stability and drug loading. Journal of Materials Chemistry. B. 3: 1779-1787. PMID 32262251 DOI: 10.1039/C4Tb02016B  0.605
2015 Yan Y, Xue L, Miller JB, Zhou K, Kos P, Elkassih S, Liu L, Nagai A, Xiong H, Siegwart DJ. One-pot Synthesis of Functional Poly(amino ester sulfide)s and Utility in Delivering pDNA and siRNA. Polymer. 72: 271-280. PMID 26726270 DOI: 10.1016/J.Polymer.2015.02.020  0.46
2015 Nagai A, Miller JB, Du J, Kos P, Stefan MC, Siegwart DJ. Correction: Biocompatible organic charge transfer complex nanoparticles based on a semi-crystalline cellulose template. Chemical Communications (Cambridge, England). PMID 26552587 DOI: 10.1039/C5Cc90504D  0.546
2015 Hao J, Kos P, Zhou K, Miller JB, Xue L, Yan Y, Xiong H, Elkassih S, Siegwart DJ. Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery. Journal of the American Chemical Society. PMID 26166403 DOI: 10.1021/Jacs.5B03429  0.449
2015 Nagai A, Miller JB, Du J, Kos P, Stefan MC, Siegwart DJ. Biocompatible organic charge transfer complex nanoparticles based on a semi-crystalline cellulose template. Chemical Communications (Cambridge, England). PMID 26110741 DOI: 10.1039/C5Cc03822G  0.553
2015 Rainbolt EA, Miller JB, Washington KE, Senevirathne SA, Biewer MC, Siegwart DJ, Stefan MC. Fine-tuning thermoresponsive functional poly(ε-caprolactone)s to enhance micelle stability and drug loading Journal of Materials Chemistry B. 3: 1779-1787. DOI: 10.1039/c4tb02016b  0.547
2014 Yan Y, Siegwart DJ. Scalable synthesis and derivation of functional polyesters bearing ene and epoxide side chains Polymer Chemistry. 5: 1362-1371. DOI: 10.1039/C3Py01474F  0.425
2012 Siegwart DJ, Leiendecker M, Langer R, Anderson DG. Automated ARGET ATRP Accelerates Catalyst Optimization for the Synthesis of Thiol-Functionalized Polymers. Macromolecules. 45: 1254-1261. PMID 23599541 DOI: 10.1021/Ma3000219  0.402
2012 Siegwart DJ, Oh JK, Matyjaszewski K. ATRP in the design of functional materials for biomedical applications. Progress in Polymer Science. 37: 18-37. PMID 23525884 DOI: 10.1016/J.Progpolymsci.2011.08.001  0.536
2012 Averick SE, Paredes E, Irastorza A, Shrivats AR, Srinivasan A, Siegwart DJ, Magenau AJ, Cho HY, Hsu E, Averick AA, Kim J, Liu S, Hollinger JO, Das SR, Matyjaszewski K. Preparation of cationic nanogels for nucleic acid delivery. Biomacromolecules. 13: 3445-9. PMID 22967138 DOI: 10.1021/Bm301166S  0.489
2012 Eltoukhy AA, Siegwart DJ, Alabi CA, Rajan JS, Langer R, Anderson DG. Effect of molecular weight of amine end-modified poly(β-amino ester)s on gene delivery efficiency and toxicity. Biomaterials. 33: 3594-603. PMID 22341939 DOI: 10.1016/J.Biomaterials.2012.01.046  0.447
2011 Siegwart DJ, Whitehead KA, Nuhn L, Sahay G, Cheng H, Jiang S, Ma M, Lytton-Jean A, Vegas A, Fenton P, Levins CG, Love KT, Lee H, Cortez C, Collins SP, et al. Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery. Proceedings of the National Academy of Sciences of the United States of America. 108: 12996-3001. PMID 21784981 DOI: 10.1073/Pnas.1106379108  0.403
2011 Ma M, Liu WF, Hill PS, Bratlie KM, Siegwart DJ, Chin J, Park M, Guerreiro J, Anderson DG. Development of cationic polymer coatings to regulate foreign-body responses. Advanced Materials (Deerfield Beach, Fla.). 23: H189-94. PMID 21567481 DOI: 10.1002/Adma.201100513  0.336
2011 Cheng H, Hill PS, Siegwart DJ, Vacanti N, Lytton-Jean AK, Cho SW, Ye A, Langer R, Anderson DG. A novel family of biodegradable poly(ester amide) elastomers. Advanced Materials (Deerfield Beach, Fla.). 23: H95-100. PMID 21394790 DOI: 10.1002/Adma.201003482  0.314
2011 Pritchard CD, O'Shea TM, Siegwart DJ, Calo E, Anderson DG, Reynolds FM, Thomas JA, Slotkin JR, Woodard EJ, Langer R. An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate. Biomaterials. 32: 587-97. PMID 20880573 DOI: 10.1016/J.Biomaterials.2010.08.106  0.373
2010 Cho HY, Gao H, Srinivasan A, Hong J, Bencherif SA, Siegwart DJ, Paik HJ, Hollinger JO, Matyjaszewski K. Rapid cellular internalization of multifunctional star polymers prepared by atom transfer radical polymerization. Biomacromolecules. 11: 2199-203. PMID 20831270 DOI: 10.1021/Bm1006272  0.697
2010 Cheng H, Kastrup CJ, Ramanathan R, Siegwart DJ, Ma M, Bogatyrev SR, Xu Q, Whitehead KA, Langer R, Anderson DG. Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. Acs Nano. 4: 625-31. PMID 20121215 DOI: 10.1021/Nn901319Y  0.324
2009 Bencherif SA, Siegwart DJ, Srinivasan A, Horkay F, Hollinger JO, Washburn NR, Matyjaszewski K. Nanostructured hybrid hydrogels prepared by a combination of atom transfer radical polymerization and free radical polymerization. Biomaterials. 30: 5270-8. PMID 19592087 DOI: 10.1016/J.Biomaterials.2009.06.011  0.537
2009 Siegwart DJ, Srinivasan A, Bencherif SA, Karunanidhi A, Oh JK, Vaidya S, Jin R, Hollinger JO, Matyjaszewski K. Cellular uptake of functional nanogels prepared by inverse miniemulsion ATRP with encapsulated proteins, carbohydrates, and gold nanoparticles. Biomacromolecules. 10: 2300-9. PMID 19572639 DOI: 10.1021/Bm9004904  0.525
2009 Bencherif SA, Gao H, Srinivasan A, Siegwart DJ, Hollinger JO, Washburn NR, Matyjaszewski K. Cell-adhesive star polymers prepared by ATRP. Biomacromolecules. 10: 1795-803. PMID 19518096 DOI: 10.1021/Bm900213U  0.65
2008 Siegwart DJ, Bencherif SA, Srinivasan A, Hollinger JO, Matyjaszewski K. Synthesis, characterization, and in vitro cell culture viability of degradable poly(N-isopropylacrylamide-co-5,6-benzo-2-methylene-1,3-dioxepane)-based polymers and crosslinked gels. Journal of Biomedical Materials Research. Part A. 87: 345-58. PMID 18181103 DOI: 10.1002/Jbm.A.31708  0.536
2008 Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K. The development of microgels/nanogels for drug delivery applications Progress in Polymer Science (Oxford). 33: 448-477. DOI: 10.1016/J.Progpolymsci.2008.01.002  0.523
2008 Siegwart DJ, Oh JK, Gao H, Bencherif SA, Perineau F, Bohaty AK, Hollinger JO, Matyjaszewski K. Biotin-, pyrene-, and GRGDS-functionalized polymers and nanogels via ATRP and end group modification Macromolecular Chemistry and Physics. 209: 2179-2193. DOI: 10.1002/Macp.200800337  0.664
2007 Oh JK, Siegwart DJ, Matyjaszewski K. Synthesis and biodegradation of nanogels as delivery carriers for carbohydrate drugs. Biomacromolecules. 8: 3326-31. PMID 17894465 DOI: 10.1021/Bm070381+  0.502
2007 Oh JK, Siegwart DJ, Lee HI, Sherwood G, Peteanu L, Hollinger JO, Kataoka K, Matyjaszewski K. Biodegradable nanogels prepared by atom transfer radical polymerization as potential drug delivery carriers: synthesis, biodegradation, in vitro release, and bioconjugation. Journal of the American Chemical Society. 129: 5939-45. PMID 17439215 DOI: 10.1021/Ja069150L  0.706
2007 Siegwart DJ, Wu W, Mandalaywala M, Tamir M, Sarbu T, Silverstein MS, Kowalewski T, Hollinger JO, Matyjaszewski K. Solvent induced morphologies of poly(methyl methacrylate-b-ethylene oxide-b-methyl methacrylate) triblock copolymers synthesized by atom transfer radical polymerization Polymer. 48: 7279-7290. DOI: 10.1016/J.Polymer.2007.10.009  0.498
2006 Huang J, Jia S, Siegwart DJ, Kowalewski T, Matyjaszewski K. Cover Picture: Macromol. Chem. Phys. 9/2006 Macromolecular Chemistry and Physics. 207: 793-793. DOI: 10.1002/Macp.200690014  0.543
2006 Hucing J, Jia S, Siegwart DJ, Kowalewski T, Matyjaszewski K. Synthesis and characterization of styrene/butyl acrylate linear and star block copolymers via atom transfer radical polymerization Macromolecular Chemistry and Physics. 207: 801-811. DOI: 10.1002/Macp.200600003  0.459
2005 Gao H, Siegwart DJ, Jahed N, Sarbu T, Matyjaszewski K. Characterization of α,ω-dihydroxypolystyrene by gradient polymer elution chromatography and two-dimensional liquid chromatography Designed Monomers and Polymers. 8: 533-546. DOI: 10.1163/156855505774597713  0.631
2004 Sarbu T, Lin KY, Spanswick J, Gil RR, Siegwart DJ, Matyjaszewski K. Synthesis of hydroxy-telechelic poly(methyl acrylate) and polystyrene by atom transfer radical coupling Macromolecules. 37: 9694-9700. DOI: 10.1021/Ma0484375  0.486
2004 Sarbu T, Lin KY, Ell J, Siegwart DJ, Spanswick J, Matyjaszewski K. Polystyrene with designed molecular weight distribution by atom transfer radical coupling Macromolecules. 37: 3120-3127. DOI: 10.1021/Ma035901H  0.421
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