Douglas M. Cerasoli - Publications

Affiliations: 
2004- Physiology and Immunology U.S. Army Medical Research Institute of Chemical Defense 

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cerasoli DM, Armstrong SJ, Reeves TE, Hodgins SM, Kasten SA, Lee-Stubbs RB, Linn Cadieux C, Otto TC, Capacio BR, Lenz DE. Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication. Biochemical Pharmacology. 113670. PMID 31628910 DOI: 10.1016/j.bcp.2019.113670  1
2019 Zhang P, Liu EJ, Tsao C, Kasten SA, Boeri MV, Dao TL, DeBus SJ, Cadieux CL, Baker CA, Otto TC, Cerasoli DM, Chen Y, Jain P, Sun F, Li W, et al. Nanoscavenger provides long-term prophylactic protection against nerve agents in rodents. Science Translational Medicine. 11. PMID 30602537 DOI: 10.1126/scitranslmed.aau7091  0.72
2018 Dunn EN, Ferrara-Bowens TM, Chachich ME, Honnold CL, Rothwell CC, Hoard-Fruchey HM, Lesyna CA, Johnson EA, Cerasoli DM, McDonough JH, Cadieux CL. Evaluating Mice lacking Serum Carboxylesterase as a Behavioral Model for Nerve Agent Intoxication. Toxicology Mechanisms and Methods. 1-31. PMID 29768075 DOI: 10.1080/15376516.2018.1476637  0.6
2018 Corbin JM, Kailemia MJ, Cadieux CL, Alkanaimsh S, Karuppanan K, Rodriguez RL, Lebrilla CB, Cerasoli DM, McDonald KA, Nandi S. Purification, Characterization, and N-glycosylation of Recombinant Butyrylcholinesterase from Transgenic Rice Cell Suspension Cultures. Biotechnology and Bioengineering. PMID 29411865 DOI: 10.1002/bit.26557  0.6
2017 Matson LM, McCarren HS, Cadieux CL, Cerasoli DM, McDonough JH. The Role of Genetic Background in Susceptibility to Chemical Warfare Nerve Agents Across Rodent and Non-Human Primate Models. Toxicology. PMID 29113833 DOI: 10.1016/j.tox.2017.11.003  0.6
2016 McCranor BJ, Hofstetter CA, Olert MA, Moorad-Doctor D, Cerasoli DM, Garcia GE. Targeting of organophosphorus compound bioscavengers to the surface of red blood cells. Chemico-Biological Interactions. PMID 27163849 DOI: 10.1016/j.cbi.2016.05.007  1
2015 Kirby SD, Norris J, Sweeney R, Bahnson BJ, Cerasoli DM. A rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman. Biochimica Et Biophysica Acta. 1854: 1809-15. PMID 26343853 DOI: 10.1016/j.bbapap.2015.09.001  1
2015 Rezk PE, Zdenka P, Sabnekar P, Kajih T, Mata DG, Wrobel C, Cerasoli DM, Chilukuri N. An in vitro and in vivo evaluation of the efficacy of recombinant human liver prolidase as a catalytic bioscavenger of chemical warfare nerve agents. Drug and Chemical Toxicology. 38: 37-43. PMID 24641262 DOI: 10.3109/01480545.2014.900071  1
2014 Kasten SA, Zulli S, Jones JL, Dephillipo T, Cerasoli DM. Chiral separation of G-type chemical warfare nerve agents via analytical supercritical fluid chromatography. Chirality. 26: 817-24. PMID 25298066 DOI: 10.1002/chir.22368  1
2014 Mata DG, Rezk PE, Sabnekar P, Cerasoli DM, Chilukuri N. Investigation of evolved paraoxonase-1 variants for prevention of organophosphorous pesticide compound intoxication. The Journal of Pharmacology and Experimental Therapeutics. 349: 549-58. PMID 24706983 DOI: 10.1124/jpet.114.213645  1
2013 Kirby SD, Norris JR, Richard Smith J, Bahnson BJ, Cerasoli DM. Human paraoxonase double mutants hydrolyze V and G class organophosphorus nerve agents. Chemico-Biological Interactions. 203: 181-5. PMID 23159884 DOI: 10.1016/j.cbi.2012.10.023  1
2013 Hodgins SM, Kasten SA, Harrison J, Otto TC, Oliver ZP, Rezk P, Reeves TE, Chilukuri N, Cerasoli DM. Assessing protection against OP pesticides and nerve agents provided by wild-type HuPON1 purified from Trichoplusia ni larvae or induced via adenoviral infection. Chemico-Biological Interactions. 203: 177-80. PMID 23123254 DOI: 10.1016/j.cbi.2012.10.015  1
2013 Otto TC, Scott JR, Kauffman MA, Hodgins SM, Ditargiani RC, Hughes JH, Sarricks EP, Saturday GA, Hamilton TA, Cerasoli DM. Identification and characterization of novel catalytic bioscavengers of organophosphorus nerve agents. Chemico-Biological Interactions. 203: 186-90. PMID 23041042 DOI: 10.1016/j.cbi.2012.09.009  1
2012 Sarkar M, Harsch CK, Matic GT, Hoffman K, Norris JR, Otto TC, Lenz DE, Cerasoli DM, Magliery TJ. Solubilization and humanization of paraoxonase-1. Journal of Lipids. 2012: 610937. PMID 22720164 DOI: 10.1155/2012/610937  1
2012 Greenblatt HM, Otto TC, Kirkpatrick MG, Kovaleva E, Brown S, Buchman G, Cerasoli DM, Sussman JL. Structure of recombinant human carboxylesterase 1 isolated from whole cabbage looper larvae. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 68: 269-72. PMID 22442219 DOI: 10.1107/S1744309112003326  1
2012 Pizarro JM, Chang WE, Bah MJ, Wright LK, Saviolakis GA, Alagappan A, Robison CL, Shah JD, Meyerhoff JL, Cerasoli DM, Midboe EG, Lumley LA. Repeated exposure to sublethal doses of the organophosphorus compound VX activates BDNF expression in mouse brain. Toxicological Sciences : An Official Journal of the Society of Toxicology. 126: 497-505. PMID 22240983 DOI: 10.1093/toxsci/kfr353  1
2011 Duysen EG, Koentgen F, Williams GR, Timperley CM, Schopfer LM, Cerasoli DM, Lockridge O. Production of ES1 plasma carboxylesterase knockout mice for toxicity studies. Chemical Research in Toxicology. 24: 1891-8. PMID 21875074 DOI: 10.1021/tx200237a  1
2011 Peterson MW, Fairchild SZ, Otto TC, Mohtashemi M, Cerasoli DM, Chang WE. VX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results. Plos One. 6: e20335. PMID 21655255 DOI: 10.1371/journal.pone.0020335  1
2011 Mumford H, E Price M, Lenz DE, Cerasoli DM. Post-exposure therapy with human butyrylcholinesterase following percutaneous VX challenge in guinea pigs. Clinical Toxicology (Philadelphia, Pa.). 49: 287-97. PMID 21563904 DOI: 10.3109/15563650.2011.568944  1
2011 Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Lewis SL, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, et al. Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. Plos One. 6: e17441. PMID 21445272 DOI: 10.1371/journal.pone.0017441  1
2011 Fairchild SZ, Peterson MW, Hamza A, Zhan CG, Cerasoli DM, Chang WE. Computational characterization of how the VX nerve agent binds human serum paraoxonase 1. Journal of Molecular Modeling. 17: 97-109. PMID 20379755 DOI: 10.1007/s00894-010-0693-9  1
2010 Sanan TT, Muthukrishnan S, Beck JM, Tao P, Hayes CJ, Otto TC, Cerasoli DM, Lenz DE, Hadad CM. Computational Modeling of Human Paraoxonase 1: Preparation of Protein Models, Binding Studies, and Mechanistic Insights. Journal of Physical Organic Chemistry. 23: 357-369. PMID 24077808 DOI: 10.1002/poc.1678  1
2010 Geyer BC, Kannan L, Garnaud PE, Broomfield CA, Cadieux CL, Cherni I, Hodgins SM, Kasten SA, Kelley K, Kilbourne J, Oliver ZP, Otto TC, Puffenberger I, Reeves TE, Robbins N, ... ... Cerasoli DM, et al. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Proceedings of the National Academy of Sciences of the United States of America. 107: 20251-6. PMID 21059932 DOI: 10.1073/pnas.1009021107  1
2010 Tsai PC, Bigley A, Li Y, Ghanem E, Cadieux CL, Kasten SA, Reeves TE, Cerasoli DM, Raushel FM. Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase. Biochemistry. 49: 7978-87. PMID 20701311 DOI: 10.1021/bi101056m  1
2010 Lenz DE, Clarkson ED, Schulz SM, Cerasoli DM. Butyrylcholinesterase as a therapeutic drug for protection against percutaneous VX. Chemico-Biological Interactions. 187: 249-52. PMID 20513442 DOI: 10.1016/j.cbi.2010.05.014  1
2010 Cadieux CL, Broomfield CA, Kirkpatrick MG, Kazanski ME, Lenz DE, Cerasoli DM. Comparison of human and guinea pig acetylcholinesterase sequences and rates of oxime-assisted reactivation. Chemico-Biological Interactions. 187: 229-33. PMID 20433814 DOI: 10.1016/j.cbi.2010.04.020  1
2010 Suzuki SM, Stevens RC, Richter RJ, Cole TB, Park S, Otto TC, Cerasoli DM, Lenz DE, Furlong CE. Engineering human PON1 in an E. coli expression system. Advances in Experimental Medicine and Biology. 660: 37-45. PMID 20221869 DOI: 10.1007/978-1-60761-350-3_5  1
2010 Mumford H, Price ME, Cerasoli DM, Teschner W, Ehrlich H, Schwarz HP, Lenz DE. Efficacy and physiological effects of human butyrylcholinesterase as a post-exposure therapy against percutaneous poisoning by VX in the guinea-pig. Chemico-Biological Interactions. 187: 304-8. PMID 20176007 DOI: 10.1016/j.cbi.2010.02.020  1
2010 Otto TC, Kasten SA, Kovaleva E, Liu Z, Buchman G, Tolosa M, Davis D, Smith JR, Balcerzak R, Lenz DE, Cerasoli DM. Purification and characterization of functional human paraoxonase-1 expressed in Trichoplusia ni larvae. Chemico-Biological Interactions. 187: 388-92. PMID 20176005 DOI: 10.1016/j.cbi.2010.02.022  1
2010 Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR. Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin. Molecular Pharmacology. 77: 508-16. PMID 20051531 DOI: 10.1124/mol.109.062356  1
2010 Bharate SB, Guo L, Reeves TE, Cerasoli DM, Thompson CM. Bisquaternary pyridinium oximes: Comparison of in vitro reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase. Bioorganic & Medicinal Chemistry. 18: 787-94. PMID 20005727 DOI: 10.1016/j.bmc.2009.11.052  1
2009 Otto TC, Harsch CK, Yeung DT, Magliery TJ, Cerasoli DM, Lenz DE. Dramatic differences in organophosphorus hydrolase activity between human and chimeric recombinant mammalian paraoxonase-1 enzymes. Biochemistry. 48: 10416-22. PMID 19764813 DOI: 10.1021/bi901161b  1
2009 Bharate SB, Guo L, Reeves TE, Cerasoli DM, Thompson CM. New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 19: 5101-4. PMID 19640713 DOI: 10.1016/j.bmcl.2009.07.035  1
2009 Samanta U, Kirby SD, Srinivasan P, Cerasoli DM, Bahnson BJ. Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes. Biochemical Pharmacology. 78: 420-9. PMID 19394314 DOI: 10.1016/j.bcp.2009.04.018  1
2009 Epstein TM, Samanta U, Kirby SD, Cerasoli DM, Bahnson BJ. Crystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin. Biochemistry. 48: 3425-35. PMID 19271773 DOI: 10.1021/bi8023527  1
2009 Bruno JG, Carrillo MP, Cadieux CL, Lenz DE, Cerasoli DM, Phillips T. DNA aptamers developed against a soman derivative cross-react with the methylphosphonic acid core but not with flanking hydrophobic groups. Journal of Molecular Recognition : Jmr. 22: 197-204. PMID 19051203 DOI: 10.1002/jmr.932  1
2009 Hu X, Jiang X, Lenz DE, Cerasoli DM, Wallqvist A. In silico analyses of substrate interactions with human serum paraoxonase 1. Proteins. 75: 486-98. PMID 18951406 DOI: 10.1002/prot.22264  1
2008 Huang YJ, Lundy PM, Lazaris A, Huang Y, Baldassarre H, Wang B, Turcotte C, Côté M, Bellemare A, Bilodeau AS, Brouillard S, Touati M, Herskovits P, Bégin I, Neveu N, ... ... Cerasoli DM, et al. Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin. Bmc Biotechnology. 8: 50. PMID 18485214 DOI: 10.1186/1472-6750-8-50  1
2008 Reeves TE, Wales ME, Grimsley JK, Li P, Cerasoli DM, Wild JR. Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities. Protein Engineering, Design & Selection : Peds. 21: 405-12. PMID 18434422 DOI: 10.1093/protein/gzn019  1
2008 Yeung DT, Smith JR, Sweeney RE, Lenz DE, Cerasoli DM. A gas chromatographic-mass spectrometric approach to examining stereoselective interaction of human plasma proteins with soman. Journal of Analytical Toxicology. 32: 86-91. PMID 18269799  1
2007 Huang YJ, Huang Y, Baldassarre H, Wang B, Lazaris A, Leduc M, Bilodeau AS, Bellemare A, Côté M, Herskovits P, Touati M, Turcotte C, Valeanu L, Lemée N, Wilgus H, ... ... Cerasoli DM, et al. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proceedings of the National Academy of Sciences of the United States of America. 104: 13603-8. PMID 17660298 DOI: 10.1073/pnas.0702756104  1
2007 Fleming CD, Edwards CC, Kirby SD, Maxwell DM, Potter PM, Cerasoli DM, Redinbo MR. Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun. Biochemistry. 46: 5063-71. PMID 17407327 DOI: 10.1021/bi700246n  1
2007 Yeung DT, Smith JR, Sweeney RE, Lenz DE, Cerasoli DM. Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase. The Febs Journal. 274: 1183-91. PMID 17286579 DOI: 10.1111/j.1742-4658.2006.05650.x  1
2007 Lenz DE, Yeung D, Smith JR, Sweeney RE, Lumley LA, Cerasoli DM. Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review. Toxicology. 233: 31-9. PMID 17188793 DOI: 10.1016/j.tox.2006.11.066  1
2005 Cerasoli DM, Griffiths EM, Doctor BP, Saxena A, Fedorko JM, Greig NH, Yu QS, Huang Y, Wilgus H, Karatzas CN, Koplovitz I, Lenz DE. In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chemico-Biological Interactions. 157: 363-5. PMID 16429486  1
2005 Lenz DE, Maxwell DM, Koplovitz I, Clark CR, Capacio BR, Cerasoli DM, Federko JM, Luo C, Saxena A, Doctor BP, Olson C. Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys. Chemico-Biological Interactions. 157: 205-10. PMID 16289064 DOI: 10.1016/j.cbi.2005.10.025  1
2005 Yeung DT, Lenz DE, Cerasoli DM. Analysis of active-site amino-acid residues of human serum paraoxonase using competitive substrates. The Febs Journal. 272: 2225-30. PMID 15853807 DOI: 10.1111/j.1742-4658.2005.04646.x  1
2005 Johnson JK, Cerasoli DM, Lenz DE. Role of immunogen design in induction of soman-specific monoclonal antibodies. Immunology Letters. 96: 121-7. PMID 15585315 DOI: 10.1016/j.imlet.2004.08.003  1
2005 Cerasoli DM, Griffiths EM, Doctor BP, Saxena A, Fedorko JM, Greig NH, Yu QS, Huang Y, Wilgus H, Karatzas CN, Koplovitz I, Lenz DE. (07) in vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia™) as a potential nerve agent bioscavenger Chemico-Biological Interactions. 157: 362-365. DOI: 10.1016/j.cbi.2005.10.052  1
2004 Yeung DT, Josse D, Nicholson JD, Khanal A, McAndrew CW, Bahnson BJ, Lenz DE, Cerasoli DM. Structure/function analyses of human serum paraoxonase (HuPON1) mutants designed from a DFPase-like homology model. Biochimica Et Biophysica Acta. 1702: 67-77. PMID 15450851 DOI: 10.1016/j.bbapap.2004.08.002  1
2003 Barberini F, Bucciarelli-Ducci C, Zani A, Cerasoli D. Unusual extended fibular origin of the human soleus muscle: possible morpho-physiologic significance based on comparative anatomy. Clinical Anatomy (New York, N.Y.). 16: 383-8. PMID 12903059 DOI: 10.1002/ca.10171  1
2002 Cerasoli DM, Lenz DE. Nerve Agent Bioscavengers: Protection with Reduced Behavioral Effects Military Psychology. 14: 121-143.  1
2001 Riley MP, Shih FF, Jordan MS, Petrone AL, Cerasoli DM, Scott P, Caton AJ. CD4+ T cells that evade deletion by a self peptide display Th1-biased differentiation. European Journal of Immunology. 31: 311-9. PMID 11265648 DOI: 10.1002/1521-4141(200101)31:1<311::AID-IMMU311>3.0.CO;2-G  0.44
2001 Riley MP, Shih FF, Jordan MS, Petrone AL, Cerasoli DM, Scott P, Caton AJ. Identification of NKp80, a novel triggering molecule expressed by human NK cells European Journal of Immunology. 31: 233-242. PMID 11265639 DOI: 10.1002/1521-4141(200101)31:1<233::AID-IMMU233>3.0.CO;2-4  1
2001 Cerasoli DM, Kelsoe G, Sarzotti M. CD4+Thy1- thymocytes with a Th-type 2 cytokine response. International Immunology. 13: 75-83. PMID 11133836  1
2000 Riley MP, Cerasoli DM, Jordan MS, Petrone AL, Shih FF, Caton AJ. Graded deletion and virus-induced activation of autoreactive CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 165: 4870-6. PMID 11046011  1
1999 Takahashi Y, Cerasoli DM, Dal Porto JM, Shimoda M, Freund R, Fang W, Telander DG, Malvey EN, Mueller DL, Behrens TW, Kelsoe G. Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. The Journal of Experimental Medicine. 190: 399-410. PMID 10430628 DOI: 10.1084/jem.190.3.399  1
1998 Takahashi Y, Dutta PR, Cerasoli DM, Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. The Journal of Experimental Medicine. 187: 885-95. PMID 9500791 DOI: 10.1084/jem.187.6.885  1
1998 Caton AJ, Cerasoli DM, Shih FF. Immune recognition of influenza hemagglutinin as a viral and a neo-self-antigen. Immunologic Research. 17: 23-32. PMID 9479564 DOI: 10.1007/BF02786427  1
1997 Shih FF, Cerasoli DM, Caton AJ. A major T cell determinant from the influenza virus hemagglutinin (HA) can be a cryptic self peptide in HA transgenic mice. International Immunology. 9: 249-61. PMID 9040007 DOI: 10.1093/intimm/9.2.249  1
1995 Caton AJ, Stark SE, Shih FF, Cerasoli DM. Transgenic mice that express different forms of the influenza virus hemagglutinin as a neo-self-antigen. Journal of Clinical Immunology. 15: 106S-112S. PMID 8613482 DOI: 10.1007/BF01540900  1
1995 Cerasoli DM, Riley MP, Shih FF, Caton AJ. Genetic basis for T cell recognition of a major histocompatibility complex class II-restricted neo-self peptide. The Journal of Experimental Medicine. 182: 1327-36. PMID 7595203 DOI: 10.1084/jem.182.5.1327  1
1995 Cerasoli DM, McGrath J, Carding SR, Shih FF, Knowles BB, Caton AJ. Low avidity recognition of a class II-restricted neo-self peptide by virus-specific T cells. International Immunology. 7: 935-45. PMID 7577802  1
1995 Sutherland RM, Pan ZK, Caton AJ, Tang XX, Cerasoli DM, Paterson Y. T cells from unprimed mice respond to the self antigen heme, in a class II restricted manner, at a frequency similar to alloresponses. International Immunology. 7: 771-83. PMID 7547704 DOI: 10.1093/intimm/7.5.771  1
1992 Mayne L, Paterson Y, Cerasoli D, Englander SW. Effect of antibody binding on protein motions studied by hydrogen-exchange labeling and two-dimensional NMR. Biochemistry. 31: 10678-85. PMID 1384698 DOI: 10.1021/bi00159a006  1
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