Douglas A. Lappi, Ph.D. - Publications

Affiliations: 
Advanced Targeting Systems 
Area:
Toxins, ribosome-inactivating proteins

29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
1996 Biro S, Shrivastav S, Yu Z, Lappi DA, Baird A, Casscells W. Stimulation of endothelial cells by doses of basic FGF-saporin that are lethal to smooth muscle cells Drug Delivery. 3: 155-163. PMID 26790911 DOI: 10.3109/10717549609029445  0.354
1995 Davol P, Beitz JG, Mohler M, Ying W, Cook J, Lappi DA, Frackelton AR. Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model. Cancer. 76: 79-85. PMID 8630880 DOI: 10.1002/1097-0142(19950701)76:1<79::Aid-Cncr2820760111>3.0.Co;2-G  0.337
1994 Lappi DA, Ying W, Barthelemy I, Martineau D, Prieto I, Benatti L, Soria M, Baird A. Expression and activities of a recombinant basic fibroblast growth factor-saporin fusion protein. The Journal of Biological Chemistry. 269: 12552-8. PMID 8175664  0.303
1994 Gonzalez AM, Logan A, Ying W, Lappi DA, Berry M, Baird A. Fibroblast growth factor in the hypothalamic-pituitary axis: differential expression of fibroblast growth factor-2 and a high affinity receptor. Endocrinology. 134: 2289-97. PMID 8156932 DOI: 10.1210/Endo.134.5.8156932  0.328
1994 Ying W, Martineau D, Beitz J, Lappi DA, Baird A. Anti-B16-F10 melanoma activity of a basic fibroblast growth factor-saporin mitotoxin. Cancer. 74: 848-53. PMID 8039113 DOI: 10.1002/1097-0142(19940801)74:3<848::Aid-Cncr2820740310>3.0.Co;2-J  0.37
1993 Casscells W, Lappi DA, Baird A. Molecular atherectomy for restenosis. Trends in Cardiovascular Medicine. 3: 235-43. PMID 21244914 DOI: 10.1016/1050-1738(93)90045-8  0.383
1993 Lappi DA, Martineau D, Sarmientos P, Garofano L, Aranda AP, Miyajima A, Kitamura T, Baird A. Characterization of a saporin mitotoxin specifically cytotoxic to cells bearing the granulocyte-macrophage colony-stimulating factor receptor. Growth Factors (Chur, Switzerland). 9: 31-9. PMID 8347350 DOI: 10.3109/08977199308991580  0.365
1993 Lappi DA, Matsunami R, Martineau D, Baird A. Reducing the heterogeneity of chemically conjugated targeted toxins: homogeneous basic FGF-saporin. Analytical Biochemistry. 212: 446-51. PMID 8214586 DOI: 10.1006/Abio.1993.1353  0.397
1993 Casscells W, Lappi DA, Baird A. Basic FGF’s role in smooth muscle cell proliferation: A basis for molecular atherectomy Developments in Cardiovascular Medicine. 147: 227-248. DOI: 10.1007/978-1-4615-3098-5_13  0.325
1992 David T, Tassin J, Lappi DA, Baird A, Courtois Y. Biphasic effect of the mitotoxin bFGF-saporin on bovine lens epithelial cell growth: effect of cell density and extracellular matrix. Journal of Cellular Physiology. 153: 483-90. PMID 1447311 DOI: 10.1002/Jcp.1041530307  0.365
1992 Stirpe F, Barbieri L, Battelli MG, Soria M, Lappi DA. Ribosome-inactivating proteins from plants: present status and future prospects. Bio/Technology (Nature Publishing Company). 10: 405-12. PMID 1368484 DOI: 10.1038/Nbt0492-405  0.345
1992 Casscells W, Lappi DA, Olwin BB, Wai C, Siegman M, Speir EH, Sasse J, Baird A. Elimination of smooth muscle cells in experimental restenosis: targeting of fibroblast growth factor receptors. Proceedings of the National Academy of Sciences of the United States of America. 89: 7159-63. PMID 1323129 DOI: 10.1073/Pnas.89.15.7159  0.345
1992 Lappi DA, Martineau D, Maher PA, Florkiewicz RZ, Buscaglia M, Gonzalez AM, Farris J, Hamer M, Fox R, Baird A. Basic fibroblast growth factor in cells derived from Dupuytren's contracture: synthesis, presence, and implications for treatment of the disease. The Journal of Hand Surgery. 17: 324-32. PMID 1314273 DOI: 10.1016/0363-5023(92)90415-L  0.385
1991 Beattie GM, Lappi DA, Baird A, Hayek A. Functional impact of attachment and purification in the short term culture of human pancreatic islets. The Journal of Clinical Endocrinology and Metabolism. 73: 93-8. PMID 2045476 DOI: 10.1210/Jcem-73-1-93  0.304
1991 Martineau D, Lappi DA, Amburn E, Baird A. Basic fibroblast growth factor-saporin mitotoxin. In vitro studies of its cell-killing activity and of substances that alter that activity. Annals of the New York Academy of Sciences. 638: 438-41. PMID 1785818 DOI: 10.1111/J.1749-6632.1991.Tb49063.X  0.373
1991 Prieto I, Lappi DA, Ong M, Matsunami R, Benatti L, Villares R, Soria M, Sarmientos P, Baird A. Expression and characterization of a basic fibroblast growth factor-saporin fusion protein in Escherichia coli. Annals of the New York Academy of Sciences. 638: 434-7. PMID 1785817 DOI: 10.1111/J.1749-6632.1991.Tb49062.X  0.363
1991 Gonzalez AM, Lappi DA, Buscaglia ML, Carman LS, Gage FH, Baird A. Basic FGF-SAP mitotoxin in the hippocampus. Specific lethal effect on cells expressing the basic FGF receptor. Annals of the New York Academy of Sciences. 638: 442-4. PMID 1664696 DOI: 10.1111/J.1749-6632.1991.Tb49064.X  0.335
1991 Lappi DA, Maher PA, Martineau D, Baird A. The basic fibroblast growth factor-saporin mitotoxin acts through the basic fibroblast growth factor receptor. Journal of Cellular Physiology. 147: 17-26. PMID 1645359 DOI: 10.1002/Jcp.1041470104  0.42
1990 Beattie GM, Lappi DA, Baird A, Hayek A. Selective elimination of fibroblasts from pancreatic islet monolayers by basic fibroblast growth factor-saporin mitotoxin. Diabetes. 39: 1002-5. PMID 2165003 DOI: 10.2337/Diab.39.8.1002  0.386
1990 Lappi DA, Baird A. Mitotoxins: growth factor-targeted cytotoxic molecules. Progress in Growth Factor Research. 2: 223-36. PMID 2133290 DOI: 10.1016/0955-2235(90)90020-K  0.406
1989 Barbieri L, Bolognesi A, Cenini P, Falasca AI, Minghetti A, Garofano L, Guicciardi A, Lappi D, Miller SP, Stirpe F. Ribosome-inactivating proteins from plant cells in culture Biochemical Journal. 257: 801-807. PMID 2930487 DOI: 10.1042/Bj2570801  0.328
1989 Lappi DA, Martineau D, Baird A. Biological and chemical characterization of basic FGF-saporin mitotoxin. Biochemical and Biophysical Research Communications. 160: 917-23. PMID 2541718 DOI: 10.1016/0006-291X(89)92522-9  0.418
1989 Bregni M, Siena S, Formosa A, Lappi DA, Martineau D, Malavasi F, Dorken B, Bonadonna G, Gianni AM. B-cell restricted saporin immunotoxins: activity against B-cell lines and chronic lymphocytic leukemia cells. Blood. 73: 753-62. PMID 2465042 DOI: 10.1182/Blood.V73.3.753.753  0.342
1980 Lappi DA, Evans FE, Kaplan NO. Reduced nicotinamide 8-(alkylamino)adenine dinucleotides: enzyme-coenzyme interactions with different adenyl glycosyl bond conformations. Biochemistry. 19: 3841-5. PMID 6773554 DOI: 10.1021/Bi00557A030  0.508
1979 Kapmeyer H, Lappi DA, Kaplan NO. The synthesis of 8-(6-aminohexyl)-amino-GTP and -GDP and their application as ligands in affinity chromatography. Analytical Biochemistry. 99: 189-99. PMID 532959 DOI: 10.1016/0003-2697(79)90062-9  0.519
1978 Lappi DA, Kapmeyer W, Beglau JM, Kaplan NO. The disulfide bond connecting the chains of ricin. Proceedings of the National Academy of Sciences of the United States of America. 75: 1096-100. PMID 274699 DOI: 10.1073/Pnas.75.3.1096  0.481
1977 Everse J, Lappi DA, Beglau JM, Lee CL, Kaplan NO. Investigations into the relationship between structure and function of diphtheria toxin. Proceedings of the National Academy of Sciences of the United States of America. 74: 472-6. PMID 403520 DOI: 10.1073/Pnas.74.2.472  0.525
1976 Lappi DA, Stolzenbach FE, Kaplan NO, Kamen MD. Immobilization of hydrogenase on glass beads. Biochemical and Biophysical Research Communications. 69: 878-84. PMID 819014 DOI: 10.1016/0006-291X(76)90455-1  0.48
1974 Lee CY, Lappi DA, Wermuth B, Everse J, Kaplan NO. 8-(6-Aminohexyl)-amino-adenine nucleotide derivatives for affinity chromatography. Archives of Biochemistry and Biophysics. 163: 561-9. PMID 4370563 DOI: 10.1016/0003-9861(74)90515-3  0.51
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