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Erminio Costa - Publications

Affiliations: 
National Institute of Mental Health, Bethesda, MD, United States 
Area:
Neuropharmacology
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Year Citation  Score
2011 Kadriu B, Guidotti A, Costa E, Davis JM, Auta J. Acute imidazenil treatment after the onset of DFP-induced seizure is more effective and longer lasting than midazolam at preventing seizure activity and brain neuropathology. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: 136-45. PMID 21097996 DOI: 10.1093/toxsci/kfq356  0.655
2011 Tueting P, Costa E, Guidotti A. Epigenetic animal models of GABAergic deficit in mental disorders Neuromethods. 59: 243-260. DOI: 10.1007/978-1-61779-157-4_11  0.602
2010 Tueting P, Davis JM, Veldic M, Pibiri F, Kadriu B, Guidotti A, Costa E. L-methionine decreases dendritic spine density in mouse frontal cortex. Neuroreport. 21: 543-8. PMID 20442623 DOI: 10.1097/WNR.0b013e3283373126  0.639
2010 Smith RC, Zhubi A, Maloku E, Sershen H, Lajtha A, Davis JM, Costa E, Guidotti A. Varenicline treatment decreases DNMT1 mRNA expression in lymphocytes of schizophrenic patients who are cigarette smokers. Schizophrenia Research. 119: 269-70. PMID 20335008 DOI: 10.1016/j.schres.2010.02.1064  0.606
2010 Auta J, Kadriu B, Giusti P, Costa E, Guidotti A. Anticonvulsant, anxiolytic, and non-sedating actions of imidazenil and other imidazo-benzodiazepine carboxamide derivatives. Pharmacology, Biochemistry, and Behavior. 95: 383-9. PMID 20227434 DOI: 10.1016/j.pbb.2010.02.016  0.668
2010 Maloku E, Covelo IR, Hanbauer I, Guidotti A, Kadriu B, Hu Q, Davis JM, Costa E. Lower number of cerebellar Purkinje neurons in psychosis is associated with reduced reelin expression. Proceedings of the National Academy of Sciences of the United States of America. 107: 4407-11. PMID 20150511 DOI: 10.1073/pnas.0914483107  0.662
2009 Dong E, Grayson DR, Guidotti A, Costa E. Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation. Epigenomics. 1: 201-11. PMID 22122643 DOI: 10.2217/Epi.09.2  0.745
2009 Zhubi A, Veldic M, Puri NV, Kadriu B, Caruncho H, Loza I, Sershen H, Lajtha A, Smith RC, Guidotti A, Davis JM, Costa E. An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes. Schizophrenia Research. 111: 115-22. PMID 19386473 DOI: 10.1016/J.Schres.2009.03.020  0.741
2009 Pinna G, Costa E, Guidotti A. SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake. Current Opinion in Pharmacology. 9: 24-30. PMID 19157982 DOI: 10.1016/j.coph.2008.12.006  0.667
2009 Kadriu B, Guidotti A, Costa E, Auta J. Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. Toxicology. 256: 164-74. PMID 19111886 DOI: 10.1016/j.tox.2008.11.021  0.656
2009 Guidotti A, Dong E, Kundakovic M, Satta R, Grayson DR, Costa E. Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling. Trends in Pharmacological Sciences. 30: 55-60. PMID 19110320 DOI: 10.1016/J.Tips.2008.10.010  0.804
2009 Costa E, Chen Y, Dong E, Grayson DR, Kundakovic M, Maloku E, Ruzicka W, Satta R, Veldic M, Zhubi A, Guidotti A. GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability. Expert Review of Neurotherapeutics. 9: 87-98. PMID 19102671 DOI: 10.1586/14737175.9.1.87  0.787
2008 Satta R, Maloku E, Zhubi A, Pibiri F, Hajos M, Costa E, Guidotti A. Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proceedings of the National Academy of Sciences of the United States of America. 105: 16356-61. PMID 18852456 DOI: 10.1073/Pnas.0808699105  0.667
2008 Pibiri F, Kozikowski AP, Pinna G, Auta J, Kadriu B, Costa E, Guidotti A. The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 14169-74. PMID 18784370 DOI: 10.1073/pnas.0807172105  0.677
2008 Dong E, Nelson M, Grayson DR, Costa E, Guidotti A. Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation. Proceedings of the National Academy of Sciences of the United States of America. 105: 13614-9. PMID 18757738 DOI: 10.1073/Pnas.0805493105  0.722
2008 Auta J, Impagnatiello F, Kadriu B, Guidotti A, Costa E. Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem. Neuropharmacology. 55: 148-53. PMID 18555494 DOI: 10.1016/j.neuropharm.2008.05.002  0.679
2008 Pinna G, Agis-Balboa RC, Pibiri F, Nelson M, Guidotti A, Costa E. Neurosteroid biosynthesis regulates sexually dimorphic fear and aggressive behavior in mice. Neurochemical Research. 33: 1990-2007. PMID 18473173 DOI: 10.1007/s11064-008-9718-5  0.688
2008 Pibiri F, Nelson M, Guidotti A, Costa E, Pinna G. Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder. Proceedings of the National Academy of Sciences of the United States of America. 105: 5567-72. PMID 18391192 DOI: 10.1073/pnas.0801853105  0.64
2008 Maloku E, Rivero-Covelo I, Hanbauer I, Guidotti A, Costa E. Aging in C57B/6 mice is accompanied by a decrease of Purkinje cells and changes in open field motor activity European Psychiatry. 23. DOI: 10.1016/J.Eurpsy.2008.01.1332  0.602
2008 Costa E, Chen Y, Dong E, Grayson DR, Guidotti A, Veldic M. Reelin downregulation as a prospective treatment target for GABAergic dysfunction in schizophrenia Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. 341-363. DOI: 10.1007/978-0-387-76761-1_23  0.703
2007 Agís-Balboa RC, Pinna G, Pibiri F, Kadriu B, Costa E, Guidotti A. Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 18736-41. PMID 18003893 DOI: 10.1073/pnas.0709419104  0.672
2007 Costa E, Dong E, Grayson DR, Guidotti A, Ruzicka W, Veldic M. Reviewing the role of DNA (cytosine-5) methyltransferase overexpression in the cortical GABAergic dysfunction associated with psychosis vulnerability. Epigenetics : Official Journal of the Dna Methylation Society. 2: 29-36. PMID 17965595 DOI: 10.4161/Epi.2.1.4063  0.745
2007 Dong E, Guidotti A, Grayson DR, Costa E. Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters. Proceedings of the National Academy of Sciences of the United States of America. 104: 4676-81. PMID 17360583 DOI: 10.1073/pnas.0700529104  0.732
2007 Veldic M, Kadriu B, Maloku E, Agis-Balboa RC, Guidotti A, Davis JM, Costa E. Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder. Schizophrenia Research. 91: 51-61. PMID 17270400 DOI: 10.1016/j.schres.2006.11.029  0.672
2007 Ruzicka WB, Zhubi A, Veldic M, Grayson DR, Costa E, Guidotti A. Selective epigenetic alteration of layer I GABAergic neurons isolated from prefrontal cortex of schizophrenia patients using laser-assisted microdissection. Molecular Psychiatry. 12: 385-97. PMID 17264840 DOI: 10.1038/Sj.Mp.4001954  0.736
2007 Guidotti A, Ruzicka W, Grayson DR, Veldic M, Pinna G, Davis JM, Costa E. S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis. Neuroreport. 18: 57-60. PMID 17259861 DOI: 10.1097/Wnr.0B013E32800Fefd7  0.729
2007 Kundakovic M, Chen Y, Costa E, Grayson DR. DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Molecular Pharmacology. 71: 644-53. PMID 17065238 DOI: 10.1124/Mol.106.030635  0.75
2007 Maloku E, Satta R, Zhubi A, Veldic M, Kadriu B, Guidotti A, Costa E. Nicotinic cholinergic mechanisms in the regulation of brain DNA-methyltransferase 1 (DNMT1) expression European Psychiatry. 22: S88. DOI: 10.1016/J.Eurpsy.2007.01.1199  0.627
2006 Costa E, Dong E, Grayson DR, Ruzicka WB, Simonini MV, Veldic M, Guidotti A. Epigenetic targets in GABAergic neurons to treat schizophrenia. Advances in Pharmacology (San Diego, Calif.). 54: 95-117. PMID 17175812 DOI: 10.1016/S1054-3589(06)54005-0  0.74
2006 Sharma RP, Rosen C, Kartan S, Guidotti A, Costa E, Grayson DR, Chase K. Valproic acid and chromatin remodeling in schizophrenia and bipolar disorder: preliminary results from a clinical population. Schizophrenia Research. 88: 227-31. PMID 16996718 DOI: 10.1016/J.Schres.2006.07.015  0.723
2006 Agís-Balboa RC, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, Guidotti A. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 103: 14602-7. PMID 16984997 DOI: 10.1073/pnas.0606544103  0.679
2006 Tueting P, Doueiri MS, Guidotti A, Davis JM, Costa E. Reelin down-regulation in mice and psychosis endophenotypes. Neuroscience and Biobehavioral Reviews. 30: 1065-77. PMID 16769115 DOI: 10.1016/j.neubiorev.2006.04.001  0.671
2006 Grayson DR, Chen Y, Costa E, Dong E, Guidotti A, Kundakovic M, Sharma RP. The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia. Pharmacology & Therapeutics. 111: 272-86. PMID 16574235 DOI: 10.1016/J.Pharmthera.2005.01.007  0.799
2006 Pinna G, Agis-Balboa RC, Zhubi A, Matsumoto K, Grayson DR, Costa E, Guidotti A. Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation. Proceedings of the National Academy of Sciences of the United States of America. 103: 4275-80. PMID 16537521 DOI: 10.1073/Pnas.0600329103  0.735
2006 Pinna G, Costa E, Guidotti A. Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake. Psychopharmacology. 186: 362-72. PMID 16432684 DOI: 10.1007/s00213-005-0213-2  0.654
2006 Simonini MV, Camargo LM, Dong E, Maloku E, Veldic M, Costa E, Guidotti A. The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases. Proceedings of the National Academy of Sciences of the United States of America. 103: 1587-92. PMID 16432198 DOI: 10.1073/pnas.0510341103  0.637
2006 Matsumoto K, Pinna G, Guidotti A, Costa E. Neuroendocrine consequences of social isolation Frontiers in Neuroendocrinology. 27: 134. DOI: 10.1016/J.Yfrne.2006.03.281  0.583
2005 Matsumoto K, Guidotti A, Costa E. [Stress and sleep/emotional disorder: possible involvement of neurosteroid allopregnanolone]. Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica. 126: 107-12. PMID 16205012 DOI: JST.JSTAGE/fpj/126.107  0.581
2005 Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A. Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 102: 12578-83. PMID 16113080 DOI: 10.1073/Pnas.0505394102  0.75
2005 Sharma RP, Grayson DR, Guidotti A, Costa E. Chromatin, DNA methylation and neuron gene regulation--the purpose of the package. Journal of Psychiatry & Neuroscience : Jpn. 30: 257-63. PMID 16049569  0.721
2005 Matsumoto K, Pinna G, Puia G, Guidotti A, Costa E. Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis. Stress (Amsterdam, Netherlands). 8: 85-93. PMID 16019600 DOI: 10.1080/10253890500159022  0.66
2005 Auta J, Costa E, Davis JM, Guidotti A. Imidazenil: an antagonist of the sedative but not the anticonvulsant action of diazepam. Neuropharmacology. 49: 425-9. PMID 15964602 DOI: 10.1016/j.neuropharm.2005.04.005  0.673
2005 Grayson DR, Jia X, Chen Y, Sharma RP, Mitchell CP, Guidotti A, Costa E. Reelin promoter hypermethylation in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 102: 9341-6. PMID 15961543 DOI: 10.1073/Pnas.0503736102  0.738
2005 Guidotti A, Auta J, Davis JM, Dong E, Grayson DR, Veldic M, Zhang X, Costa E. GABAergic dysfunction in schizophrenia: new treatment strategies on the horizon. Psychopharmacology. 180: 191-205. PMID 15864560 DOI: 10.1007/S00213-005-2212-8  0.771
2005 Mitchell CP, Chen Y, Kundakovic M, Costa E, Grayson DR. Histone deacetylase inhibitors decrease reelin promoter methylation in vitro. Journal of Neurochemistry. 93: 483-92. PMID 15816871 DOI: 10.1111/J.1471-4159.2005.03040.X  0.724
2005 Tremolizzo L, Doueiri MS, Dong E, Grayson DR, Davis J, Pinna G, Tueting P, Rodriguez-Menendez V, Costa E, Guidotti A. Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biological Psychiatry. 57: 500-9. PMID 15737665 DOI: 10.1016/J.Biopsych.2004.11.046  0.759
2005 Veldic M, Guidotti A, Maloku E, Davis JM, Costa E. In psychosis, cortical interneurons overexpress DNA-methyltransferase 1. Proceedings of the National Academy of Sciences of the United States of America. 102: 2152-7. PMID 15684088 DOI: 10.1073/pnas.0409665102  0.678
2005 Pinna G, Costa E, Guidotti A. Changes in brain testosterone and allopregnanolone biosynthesis elicit aggressive behavior. Proceedings of the National Academy of Sciences of the United States of America. 102: 2135-40. PMID 15677716 DOI: 10.1073/pnas.0409643102  0.642
2005 Noh JS, Sharma RP, Veldic M, Salvacion AA, Jia X, Chen Y, Costa E, Guidotti A, Grayson DR. DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures. Proceedings of the National Academy of Sciences of the United States of America. 102: 1749-54. PMID 15671176 DOI: 10.1073/Pnas.0409648102  0.746
2005 Costa E, Guidotti A, Veldić M. Should allosteric positive modulators of GABA(A) receptors be tested in the treatment of schizophrenia? Schizophrenia Research. 73: 367-8. PMID 15653283 DOI: 10.1016/j.schres.2004.08.005  0.661
2004 Pinna G, Agis-Balboa RC, Doueiri MS, Guidotti A, Costa E. Brain neurosteroids in gender-related aggression induced by social isolation. Critical Reviews in Neurobiology. 16: 75-82. PMID 15581402 DOI: 10.1615/CritRevNeurobiol.v16.i12.80  0.621
2004 Costa E, Davis JM, Dong E, Grayson DR, Guidotti A, Tremolizzo L, Veldic M. A GABAergic cortical deficit dominates schizophrenia pathophysiology. Critical Reviews in Neurobiology. 16: 1-23. PMID 15581395 DOI: 10.1615/Critrevneurobiol.V16.I12.10  0.761
2004 Carboni G, Tueting P, Tremolizzo L, Sugaya I, Davis J, Costa E, Guidotti A. Enhanced dizocilpine efficacy in heterozygous reeler mice relates to GABA turnover downregulation. Neuropharmacology. 46: 1070-81. PMID 15111013 DOI: 10.1016/J.Neuropharm.2004.02.001  0.677
2004 Pinna G, Costa E, Guidotti A. Fluoxetine and norfluoxetine stereospecifically facilitate pentobarbital sedation by increasing neurosteroids. Proceedings of the National Academy of Sciences of the United States of America. 101: 6222-5. PMID 15069199 DOI: 10.1073/pnas.0401479101  0.651
2004 Costa E, Grayson DR, Veldic M, Guidotti A. Neurochemical basis for an epigenetic vision of synaptic organization. International Review of Neurobiology. 59: 73-91. PMID 15006485 DOI: 10.1016/S0074-7742(04)59004-9  0.699
2004 Auta J, Costa E, Davis J, Guidotti A. Imidazenil: a potent and safe protective agent against diisopropyl fluorophosphate toxicity. Neuropharmacology. 46: 397-403. PMID 14975695 DOI: 10.1016/J.Neuropharm.2003.09.010  0.647
2004 Veldic M, Caruncho HJ, Liu WS, Davis J, Satta R, Grayson DR, Guidotti A, Costa E. DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains. Proceedings of the National Academy of Sciences of the United States of America. 101: 348-53. PMID 14684836 DOI: 10.1073/Pnas.2637013100  0.813
2003 Costa E, Grayson DR, Guidotti A. Epigenetic downregulation of GABAergic function in schizophrenia: potential for pharmacological intervention? Molecular Interventions. 3: 220-9. PMID 14993449 DOI: 10.1124/Mi.3.4.220  0.706
2003 Costa E, Grayson DR, Mitchell CP, Tremolizzo L, Veldic M, Guidotti A. GABAergic cortical neuron chromatin as a putative target to treat schizophrenia vulnerability. Critical Reviews in Neurobiology. 15: 121-42. PMID 14977367 DOI: 10.1615/Critrevneurobiol.V15.I2.20  0.748
2003 Dong E, Caruncho H, Liu WS, Smalheiser NR, Grayson DR, Costa E, Guidotti A. A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes. Proceedings of the National Academy of Sciences of the United States of America. 100: 5479-84. PMID 12707415 DOI: 10.1073/Pnas.1031602100  0.81
2003 Larson J, Hoffman JS, Guidotti A, Costa E. Olfactory discrimination learning deficit in heterozygous reeler mice. Brain Research. 971: 40-6. PMID 12691835 DOI: 10.1016/S0006-8993(03)02353-9  0.612
2003 Pinna G, Dong E, Matsumoto K, Costa E, Guidotti A. In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine. Proceedings of the National Academy of Sciences of the United States of America. 100: 2035-40. PMID 12571361 DOI: 10.1073/pnas.0337642100  0.629
2003 Hankiewicz J, Brint SU, Guidotti A, Costa E, Fiat D. In vivo natural-abundance17O/1H MRI of rhesus monkey body in a whole-body scanner Applied Magnetic Resonance. 24: 423-427. DOI: 10.1007/Bf03166945  0.578
2002 Costa E, Chen Y, Davis J, Dong E, Noh JS, Tremolizzo L, Veldic M, Grayson DR, Guidotti A. REELIN and schizophrenia: a disease at the interface of the genome and the epigenome. Molecular Interventions. 2: 47-57. PMID 14993361 DOI: 10.1124/Mi.2.1.47  0.754
2002 Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting P, Sharma R, Grayson DR, Costa E, Guidotti A. An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 99: 17095-100. PMID 12481028 DOI: 10.1073/Pnas.262658999  0.741
2002 Costa E, Auta J, Grayson DR, Matsumoto K, Pappas GD, Zhang X, Guidotti A. GABAA receptors and benzodiazepines: a role for dendritic resident subunit mRNAs. Neuropharmacology. 43: 925-37. PMID 12423662 DOI: 10.1016/S0028-3908(02)00199-5  0.752
2002 Rodriguez MA, Caruncho HJ, Costa E, Pesold C, Liu WS, Guidotti A. In Patas monkey, glutamic acid decarboxylase-67 and reelin mRNA coexpression varies in a manner dependent on layers and cortical areas. The Journal of Comparative Neurology. 451: 279-88. PMID 12210139 DOI: 10.1002/cne.10341  0.742
2002 Chen Y, Sharma RP, Costa RH, Costa E, Grayson DR. On the epigenetic regulation of the human reelin promoter. Nucleic Acids Research. 30: 2930-9. PMID 12087179 DOI: 10.1093/Nar/Gkf401  0.54
2002 Kim HM, Qu T, Kriho V, Lacor P, Smalheiser N, Pappas GD, Guidotti A, Costa E, Sugaya K. Reelin function in neural stem cell biology. Proceedings of the National Academy of Sciences of the United States of America. 99: 4020-5. PMID 11891343 DOI: 10.1073/Pnas.062698299  0.64
2002 Costa E, Davis J, Pesold C, Tueting P, Guidotti A. The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics. Current Opinion in Pharmacology. 2: 56-62. PMID 11786309 DOI: 10.1016/S1471-4892(01)00121-7  0.677
2001 Guidotti A, Dong E, Matsumoto K, Pinna G, Rasmusson AM, Costa E. The socially-isolated mouse: a model to study the putative role of allopregnanolone and 5alpha-dihydroprogesterone in psychiatric disorders. Brain Research. Brain Research Reviews. 37: 110-5. PMID 11744079 DOI: 10.1016/S0165-0173(01)00129-1  0.643
2001 Costa E, Davis J, Grayson DR, Guidotti A, Pappas GD, Pesold C. Dendritic spine hypoplasticity and downregulation of reelin and GABAergic tone in schizophrenia vulnerability. Neurobiology of Disease. 8: 723-42. PMID 11592844 DOI: 10.1006/Nbdi.2001.0436  0.747
2001 Smalheiser NR, Manev H, Costa E. RNAi and brain function: was McConnell on the right track? Trends in Neurosciences. 24: 216-8. PMID 11250005 DOI: 10.1016/S0166-2236(00)01739-2  0.456
2001 Izzo E, Auta J, Impagnatiello F, Pesold C, Guidotti A, Costa E. Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines. Proceedings of the National Academy of Sciences of the United States of America. 98: 3483-8. PMID 11248104 DOI: 10.1073/pnas.051628698  0.7
2001 Liu WS, Pesold C, Rodriguez MA, Carboni G, Auta J, Lacor P, Larson J, Condie BG, Guidotti A, Costa E. Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse. Proceedings of the National Academy of Sciences of the United States of America. 98: 3477-82. PMID 11248103 DOI: 10.1073/Pnas.051614698  0.664
2001 Dong E, Matsumoto K, Uzunova V, Sugaya I, Takahata H, Nomura H, Watanabe H, Costa E, Guidotti A. Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Proceedings of the National Academy of Sciences of the United States of America. 98: 2849-54. PMID 11226329 DOI: 10.1073/pnas.051628598  0.664
2000 Guidotti A, Auta J, Davis JM, Di-Giorgi-Gerevini V, Dwivedi Y, Grayson DR, Impagnatiello F, Pandey G, Pesold C, Sharma R, Uzunov D, Costa E, DiGiorgi Gerevini V. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study. Archives of General Psychiatry. 57: 1061-9. PMID 11074872 DOI: 10.1001/Archpsyc.57.11.1061  0.752
2000 Guidotti A, Pesold C, Costa E. New neurochemical markers for psychosis: a working hypothesis of their operation. Neurochemical Research. 25: 1207-18. PMID 11059795 DOI: 10.1023/A:1007635927069  0.683
2000 Auta J, Lecca D, Nelson M, Guidotti A, Overstreet DH, Costa E, Javaid JI. Expression and function of striatal nAChRs differ in the flinders sensitive (FSL) and resistant (FRL) rat lines. Neuropharmacology. 39: 2624-31. PMID 11044732 DOI: 10.1016/S0028-3908(00)00082-4  0.635
2000 Rodriguez MA, Pesold C, Liu WS, Kriho V, Guidotti A, Pappas GD, Costa E. Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex. Proceedings of the National Academy of Sciences of the United States of America. 97: 3550-5. PMID 10725376 DOI: 10.1073/pnas.050589797  0.686
2000 Lacor PN, Grayson DR, Auta J, Sugaya I, Costa E, Guidotti A. Reelin secretion from glutamatergic neurons in culture is independent from neurotransmitter regulation. Proceedings of the National Academy of Sciences of the United States of America. 97: 3556-61. PMID 10725375 DOI: 10.1073/Pnas.050589597  0.755
2000 Auta J, Guidotti A, Costa E. Imidazenil prevention of alprazolam-induced acquisition deficit in patas monkeys is devoid of tolerance. Proceedings of the National Academy of Sciences of the United States of America. 97: 2314-9. PMID 10696114 DOI: 10.1073/pnas.97.5.2314  0.671
2000 Smalheiser NR, Costa E, Guidotti A, Impagnatiello F, Auta J, Lacor P, Kriho V, Pappas GD. Expression of reelin in adult mammalian blood, liver, pituitary pars intermedia, and adrenal chromaffin cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 1281-6. PMID 10655522 DOI: 10.1073/pnas.97.3.1281  0.632
2000 Smalheiser NR, Costa E, Guidotti A, Impagnatiello F, Auta J, Lacor P, Kriho V, Pappas GD. 474. Reelin, a protein regulating neural development, is expressed in the blood in adult mammals Biological Psychiatry. 47. DOI: 10.1016/S0006-3223(00)00744-7  0.603
2000 Guidotti A, Uzunova V, Uzunov DP, Matsumoto K, Mienville JM, Puia G, Costa E. 408. Putative role of allopregnanolone in psychiatric disorders Biological Psychiatry. 47. DOI: 10.1016/S0006-3223(00)00678-8  0.628
2000 Costa E, Pesold C, Auta J, Caruncho H, Davis J, Davidkova G, Dwivedi Y, Grayson D, Rodriguez M, Uzunov D, Guidotti A. 223. Reelin and GAD67 downregulation and psychosis vulnerability Biological Psychiatry. 47: S68. DOI: 10.1016/S0006-3223(00)00487-X  0.764
2000 Grayson DR, Uzunov DP, Chen Y, Siyanova E, Raca G, Sharma RP, Mirkin S, Costa E. 138. Studies of molecular mechanisms regulating reelin gene expression Biological Psychiatry. 47. DOI: 10.1016/S0006-3223(00)00400-5  0.466
2000 Tueting P, Carboni G, Costa E, Guidotti A, Sugaya I. 83. Pharmacology of psychotic-like abnormalities expressed by reeler heterozygous mouse Biological Psychiatry. 47. DOI: 10.1016/S0006-3223(00)00345-0  0.624
1999 Auta J, Longone P, Guidotti A, Costa E. The regulation of hippocampal nicotinic acetylcholine receptors (nAChRs) after a protracted treatment with selective or nonselective nAChR agonists. Journal of Molecular Neuroscience : Mn. 13: 31-45. PMID 10691290 DOI: 10.1385/JMN:13:1-2:31  0.654
1999 Matsumoto K, Uzunova V, Pinna G, Taki K, Uzunov DP, Watanabe H, Mienville JM, Guidotti A, Costa E. Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss. Neuropharmacology. 38: 955-63. PMID 10428414 DOI: 10.1016/S0028-3908(99)00018-0  0.68
1999 Tueting P, Costa E, Dwivedi Y, Guidotti A, Impagnatiello F, Manev R, Pesold C. The phenotypic characteristics of heterozygous reeler mouse. Neuroreport. 10: 1329-34. PMID 10363948  0.633
1999 Pesold C, Liu WS, Guidotti A, Costa E, Caruncho HJ. Cortical bitufted, horizontal, and Martinotti cells preferentially express and secrete reelin into perineuronal nets, nonsynaptically modulating gene expression. Proceedings of the National Academy of Sciences of the United States of America. 96: 3217-22. PMID 10077664 DOI: 10.1073/pnas.96.6.3217  0.765
1998 Liao Y, Kozikowski AP, Guidotti A, Costa E. Synthesis and pharmacological evaluation of benzofuran-acetamides as "antineophobic" mitochondrial DBI receptor complex ligands. Bioorganic & Medicinal Chemistry Letters. 8: 2099-102. PMID 9873493 DOI: 10.1016/S0960-894X(98)00374-6  0.651
1998 Impagnatiello F, Guidotti AR, Pesold C, Dwivedi Y, Caruncho H, Pisu MG, Uzunov DP, Smalheiser NR, Davis JM, Pandey GN, Pappas GD, Tueting P, Sharma RP, Costa E. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 95: 15718-23. PMID 9861036 DOI: 10.1073/Pnas.95.26.15718  0.773
1998 Longone P, Impagnatiello F, Mienville JM, Costa E, Guidotti A. Changes in AMPA receptor-spliced variant expression and shift in AMPA receptor spontaneous desensitization pharmacology during cerebellar granule cell maturation in vitro. Journal of Molecular Neuroscience : Mn. 11: 23-41. PMID 9826784 DOI: 10.1385/JMN:11:1:23  0.657
1998 Guidotti A, Costa E. Can the antidysphoric and anxiolytic profiles of selective serotonin reuptake inhibitors be related to their ability to increase brain 3 alpha, 5 alpha-tetrahydroprogesterone (allopregnanolone) availability? Biological Psychiatry. 44: 865-73. PMID 9807641 DOI: 10.1016/S0006-3223(98)00070-5  0.689
1998 Costa E. From GABA(A) receptor diversity emerges a unified vision of GABAergic inhibition Annual Review of Pharmacology and Toxicology. 38: 321-350. PMID 9597158 DOI: 10.1146/ANNUREV.PHARMTOX.38.1.321  0.318
1998 Uzunova V, Sheline Y, Davis JM, Rasmusson A, Uzunov DP, Costa E, Guidotti A. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proceedings of the National Academy of Sciences of the United States of America. 95: 3239-44. PMID 9501247 DOI: 10.1073/Pnas.95.6.3239  0.657
1998 Pesold C, Impagnatiello F, Pisu MG, Uzunov DP, Costa E, Guidotti A, Caruncho HJ. Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats. Proceedings of the National Academy of Sciences of the United States of America. 95: 3221-6. PMID 9501244 DOI: 10.1073/pnas.95.6.3221  0.766
1997 Pesold C, Caruncho HJ, Impagnatiello F, Berg MJ, Fritschy JM, Guidotti A, Costa E. Tolerance to diazepam and changes in GABA(A) receptor subunit expression in rat neocortical areas. Neuroscience. 79: 477-87. PMID 9200730 DOI: 10.1016/S0306-4522(96)00609-4  0.771
1997 Impagnatiello F, Oberto A, Longone P, Costa E, Guidotti A. 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide: a partial modulator of AMPA receptor desensitization devoid of neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 94: 7053-8. PMID 9192690 DOI: 10.1073/pnas.94.13.7053  0.693
1997 Caruncho HJ, Guidotti A, Lindstrom J, Costa E, Pesold C. Subcellular localization of the alpha 7 nicotinic receptor in rat cerebellar granule cell layer. Neuroreport. 8: 1431-3. PMID 9172148 DOI: 10.1097/00001756-199704140-00021  0.752
1996 Longone P, Impagnatiello F, Guidotti A, Costa E. Reversible modification of GABAA receptor subunit mRNA expression during tolerance to diazepam-induced cognition dysfunction. Neuropharmacology. 35: 1465-73. PMID 9014162 DOI: 10.1016/S0028-3908(96)00071-8  0.678
1996 Arai A, Guidotti A, Costa E, Lynch G. Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices. Neuroreport. 7: 2211-5. PMID 8930991 DOI: 10.1097/00001756-199609020-00031  0.659
1996 Uzunov DP, Cooper TB, Costa E, Guidotti A. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography. Proceedings of the National Academy of Sciences of the United States of America. 93: 12599-604. PMID 8901628  0.632
1996 Costa E, Guidotti A. Benzodiazepines on trial: a research strategy for their rehabilitation. Trends in Pharmacological Sciences. 17: 192-200. PMID 8669126  0.667
1996 Costa E, Auta J, Thompson JM, Guidotti A. Positive allosteric modulation of AMPA or GABAAreceptors antagonizes alprazolam induced learning impairment in monkeys European Neuropsychopharmacology. 6: 152. DOI: 10.1016/0924-977X(96)88008-4  0.64
1996 Guidotti A, Uzunov DP, Costa E. Fluoxetine treatment selectively causes brain accumulation of allopregnanolone (allo) Biological Psychiatry. 39: 592-593. DOI: 10.1016/0006-3223(96)84262-4  0.645
1995 Auta J, Faust WB, Lambert P, Guidotti A, Costa E, Moerschbaecher JM. Comparison of the effects of full and partial allosteric modulators of GABA(A) receptors on complex behavioral processes in monkeys. Behavioural Pharmacology. 6: 323-332. PMID 11224341  0.634
1995 Cheney DL, Uzunov D, Costa E, Guidotti A. Gas chromatographic-mass fragmentographic quantitation of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 4641-50. PMID 7790929  0.644
1995 Harris BT, Costa E, Grayson DR. Exposure of neuronal cultures to K+ depolarization or to N-methyl-D-aspartate increases the transcription of genes encoding the alpha 1 and alpha 5 GABAA receptor subunits. Brain Research. Molecular Brain Research. 28: 338-42. PMID 7723631 DOI: 10.1016/0169-328X(94)00240-F  0.565
1995 Caruncho HJ, Puia G, Mohler H, Costa E. The density and distribution of six GABAA receptor subunits in primary cultures of rat cerebellar granule cells. Neuroscience. 67: 583-93. PMID 7675188 DOI: 10.1016/0306-4522(95)00065-Q  0.631
1995 Thompson DM, Guidotti A, DiBella M, Costa E. 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys. Proceedings of the National Academy of Sciences of the United States of America. 92: 7667-71. PMID 7644474 DOI: 10.1073/pnas.92.17.7667  0.645
1995 Uzunov DP, Zivkovich I, Pirkle WH, Costa E, Guidotti A. Enantiomeric resolution with a new chiral stationary phase of 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide, a cognition-enhancing benzothiadiazine derivative. Journal of Pharmaceutical Sciences. 84: 937-42. PMID 7500277 DOI: 10.1002/jps.2600840807  0.611
1995 Costa E, Thompson DM, Auta J, Guidotti A. Imidazenil: A Potent Benzodiazepine Partial Positive Modulator of GABAergic Transmission Virtually Devoid of Tolerance Liability Cns Drug Reviews. 1: 168-189. DOI: 10.1111/J.1527-3458.1995.TB00282.X  0.631
1994 Puia G, Costa E, Vicini S. Functional diversity of GABA-activated Cl- currents in Purkinje versus granule neurons in rat cerebellar slices. Neuron. 12: 117-26. PMID 8292357 DOI: 10.1016/0896-6273(94)90157-0  0.572
1994 Costa E, Auta J, Guidotti A, Korneyev A, Romeo E. The pharmacology of neurosteroidogenesis. The Journal of Steroid Biochemistry and Molecular Biology. 49: 385-9. PMID 8043504 DOI: 10.1016/0960-0760(94)90284-4  0.702
1994 Costa E, Armstrong DM, Guidotti A, Kharlamov A, Kiedrowski L, Manev H, Polo A, Wroblewski JT. Gangliosides in the protection against glutamate excitotoxicity. Progress in Brain Research. 101: 357-73. PMID 8029464 DOI: 10.1016/S0079-6123(08)61962-7  0.791
1994 Kharlamov A, Zivkovic I, Polo A, Armstrong DM, Costa E, Guidotti A. LIGA20, a lyso derivative of ganglioside GM1, given orally after cortical thrombosis reduces infarct size and associated cognition deficit. Proceedings of the National Academy of Sciences of the United States of America. 91: 6303-7. PMID 8022776 DOI: 10.1073/pnas.91.14.6303  0.663
1994 Zheng TM, Zhu WJ, Puia G, Vicini S, Grayson DR, Costa E, Caruncho HJ. Changes in gamma-aminobutyrate type A receptor subunit mRNAs, translation product expression, and receptor function during neuronal maturation in vitro. Proceedings of the National Academy of Sciences of the United States of America. 91: 10952-6. PMID 7971990 DOI: 10.1073/Pnas.91.23.10952  0.788
1994 Perillo MA, Guidotti A, Costa E, Yu RK, Maggio B. Modulation of phospholipases A2 and C activities against dilauroylphosphorylcholine in mixed monolayers with semisynthetic derivatives of ganglioside and sphingosine. Molecular Membrane Biology. 11: 119-26. PMID 7920864 DOI: 10.3109/09687689409162229  0.607
1994 Polo A, Kirschner G, Guidotti A, Costa E. Brain content of glycosphingolipids after oral administration of monosialogangliosides GM1 and LIGA20 to rats. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 21: 41-53. PMID 7910019 DOI: 10.1007/Bf03160083  0.686
1994 Rius RA, Guidotti A, Costa E. Pituitary adenylate cyclase activating polypeptide (PACAP) potently enhances tyrosine hydroxylase (TH) expression in adrenal chromaffin cells. Life Sciences. 54: 1735-43. PMID 7909910 DOI: 10.1016/0024-3205(94)00614-8  0.669
1994 Kiedrowski L, Brooker G, Costa E, Wroblewski JT. Glutamate impairs neuronal calcium extrusion while reducing sodium gradient. Neuron. 12: 295-300. PMID 7906528 DOI: 10.1016/0896-6273(94)90272-0  0.61
1994 van Kammen DP, Guidotti A, Neylan T, Guarneri P, Kelley ME, Gurklis J, Gilbertson MW, Peters JL, Costa E. CSF levels of diazepam-binding inhibitor correlate with REM latency in schizophrenia, a pilot study. European Archives of Psychiatry and Clinical Neuroscience. 244: 216-22. PMID 7888420 DOI: 10.1007/Bf02190401  0.628
1994 Costa E, Cheney DL, Grayson DR, Korneyev A, Longone P, Pani L, Romeo E, Zivkovich E, Guidotti A. Pharmacology of neurosteroid biosynthesis. Role of the mitochondrial DBI receptor (MDR) complex. Annals of the New York Academy of Sciences. 746: 223-42. PMID 7825880  0.712
1993 Sun FY, Costa E, Mocchetti I. Adrenal steroids mediate the increase of hippocampal nerve growth factor biosynthesis following bicuculline convulsions. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 8: 219-25. PMID 8507349 DOI: 10.1038/Npp.1993.24  0.301
1993 Kozikowski AP, Ma D, Brewer J, Sun S, Costa E, Romeo E, Guidotti A. Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands. Journal of Medicinal Chemistry. 36: 2908-20. PMID 8411007 DOI: 10.1021/Jm00072A010  0.685
1993 Korneyev A, Pan BS, Polo A, Romeo E, Guidotti A, Costa E. Stimulation of brain pregnenolone synthesis by mitochondrial diazepam binding inhibitor receptor ligands in vivo. Journal of Neurochemistry. 61: 1515-24. PMID 8397297 DOI: 10.1111/J.1471-4159.1993.Tb13647.X  0.69
1993 Cavallaro S, Pani L, Guidotti A, Costa E. ACTH-induced mitochondrial DBI receptor (MDR) and diazepam binding inhibitor (DBI) expression in adrenals of hypophysectomized rats is not cause-effect related to its immediate steroidogenic action. Life Sciences. 53: 1137-47. PMID 8396705 DOI: 10.1016/0024-3205(93)90550-M  0.682
1993 Korneyev AY, Costa E, Guidotti A. During anesthetic-induced activation of hypothalamic pituitary adrenal axis, blood-borne steroids fail to contribute to the anesthetic effect. Neuroendocrinology. 57: 559-65. PMID 8391666 DOI: 10.1159/000126405  0.673
1993 Caruncho HJ, Puia G, Slobodyansky E, da Silva PP, Costa E. Freeze-fracture immunocytochemical study of the expression of native and recombinant GABAA receptors. Brain Research. 603: 234-42. PMID 8384919 DOI: 10.1016/0006-8993(93)91242-K  0.636
1993 Ducić I, Puia G, Vicini S, Costa E. Triazolam is more efficacious than diazepam in a broad spectrum of recombinant GABAA receptors. European Journal of Pharmacology. 244: 29-35. PMID 8380558 DOI: 10.1016/0922-4106(93)90056-F  0.567
1993 van Kammen DP, Guidotti A, Kelley ME, Gurklis J, Guarneri P, Gilbertson MW, Yao JK, Peters J, Costa E. CSF diazepam binding inhibitor and schizophrenia: clinical and biochemical relationships. Biological Psychiatry. 34: 515-22. PMID 8274578 DOI: 10.1016/0006-3223(93)90193-H  0.687
1993 Perillo MA, Polo A, Guidotti A, Costa E, Maggio B. Molecular parameters of semisynthetic derivatives of gangliosides and sphingosine in monolayers at the air-water interface. Chemistry and Physics of Lipids. 65: 225-38. PMID 8269552 DOI: 10.1016/0009-3084(93)90020-4  0.636
1993 Korneyev A, Guidotti A, Costa E. Regional and interspecies differences in brain progesterone metabolism. Journal of Neurochemistry. 61: 2041-7. PMID 8245959 DOI: 10.1111/J.1471-4159.1993.Tb07440.X  0.66
1993 Costa E, Armstrong D, Guidotti A, Kharlamov A, Kiedrowski L, Wroblewski JT. Ganglioside GM1 and its semisynthetic lysogangliosides reduce glutamate neurotoxicity by a novel mechanism. Advances in Experimental Medicine and Biology. 341: 129-41. PMID 7906915 DOI: 10.1007/978-1-4615-2484-7_12  0.782
1993 Livsey CT, Costa E, Vicini S. Glutamate-activated currents in outside-out patches from spiny versus aspiny hilar neurons of rat hippocampal slices. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 5324-33. PMID 7902866  0.531
1993 Kolmer M, Alho H, Costa E, Pani L. Cloning and tissue-specific functional characterization of the promoter of the rat diazepam binding inhibitor, a peptide with multiple biological actions Proceedings of the National Academy of Sciences of the United States of America. 90: 8439-8443. PMID 7690962 DOI: 10.1073/Pnas.90.18.8439  0.313
1993 Livsey CT, Costa E, Vicini S. Glutamate-activated currents in outside-out patches from spiny versus aspiny hilar neurons of rat hippocampal slices The Journal of Neuroscience. 13: 5324-5333. DOI: 10.1523/Jneurosci.13-12-05324.1993  0.582
1993 Kharlamov A, Guidotti A, Costa E, Hayes R, Armstrong D. Semisynthetic sphingolipids prevent protein kinase C translocation and neuronal damage in the perifocal area following a photochemically induced thrombotic brain cortical lesion The Journal of Neuroscience. 13: 2483-2494. DOI: 10.1523/Jneurosci.13-06-02483.1993  0.679
1993 Berkovich A, Ferrarese C, Cavaletti G, Alho H, Marzorati C, Bianchi G, Guidotti A, Costa E. Topology of two DBI receptors in human lymphocytes. Life Sciences. 52: 1265-1277. DOI: 10.1016/S0024-3205(05)80016-5  0.664
1992 Bovolin P, Santi MR, Puia G, Costa E, Grayson D. Expression patterns of gamma-aminobutyric acid type A receptor subunit mRNAs in primary cultures of granule neurons and astrocytes from neonatal rat cerebella. Proceedings of the National Academy of Sciences of the United States of America. 89: 9344-8. PMID 1384051 DOI: 10.1073/Pnas.89.19.9344  0.381
1992 Puia G, Ducic I, Vicini S, Costa E. Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor. Proceedings of the National Academy of Sciences of the United States of America. 89: 3620-4. PMID 1373505 DOI: 10.1073/Pnas.89.8.3620  0.604
1992 Kiedrowski L, Costa E, Wroblewski JT. In vitro interaction between cerebellar astrocytes and granule cells: a putative role for nitric oxide. Neuroscience Letters. 135: 59-61. PMID 1371859 DOI: 10.1016/0304-3940(92)90135-T  0.644
1992 Kiedrowski L, Costa E, Wroblewski JT. Glutamate receptor agonists stimulate nitric oxide synthase in primary cultures of cerebellar granule cells. Journal of Neurochemistry. 58: 335-41. PMID 1370078 DOI: 10.1111/J.1471-4159.1992.Tb09315.X  0.638
1992 Costa E. Partial allosteric modulation of GABAA receptor: molecular mechanisms and clinical implications Clinical Neuropharmacology. 15. PMID 1354045 DOI: 10.1097/00002826-199201001-00210  0.303
1992 Costa E. Building a bridge between neurobiology and mental illness Journal of Psychiatric Research. 26: 449-460. PMID 1337107 DOI: 10.1016/0022-3956(92)90045-P  0.422
1992 Rothstein JD, Guidotti A, Costa E. Release of endogenous benzodiazepine receptor ligands (endozepines) from cultured neurons. Neuroscience Letters. 143: 210-4. PMID 1331901 DOI: 10.1016/0304-3940(92)90267-B  0.692
1992 Bovolin P, Santi MR, Memo M, Costa E, Grayson DR. Distinct developmental patterns of expression of rat alpha 1, alpha 5, gamma 2S, and gamma 2L gamma-aminobutyric acidA receptor subunit mRNAs in vivo and in vitro. Journal of Neurochemistry. 59: 62-72. PMID 1319473 DOI: 10.1111/J.1471-4159.1992.Tb08876.X  0.589
1992 Papadopoulos V, Guarneri P, Kreuger KE, Guidotti A, Costa E. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. Proceedings of the National Academy of Sciences of the United States of America. 89: 5113-7. PMID 1317581 DOI: 10.1073/Pnas.89.11.5113  0.678
1992 Rothstein JD, Garland W, Puia G, Guidotti A, Weber RJ, Costa E. Purification and characterization of naturally occurring benzodiazepine receptor ligands in rat and human brain. Journal of Neurochemistry. 58: 2102-15. PMID 1315376 DOI: 10.1111/J.1471-4159.1992.Tb10952.X  0.714
1992 Apud JA, Grayson DR, De Erausquin E, Costa E. Pharmacological characterization of regulation of phosphoinositide metabolism by recombinant 5-HT2 receptors of the rat. Neuropharmacology. 31: 1-8. PMID 1311807 DOI: 10.1016/0028-3908(92)90153-G  0.541
1992 Cavallaro S, Korneyev A, Guidotti A, Costa E. Diazepam-binding inhibitor (DBI)-processing products, acting at the mitochondrial DBI receptor, mediate adrenocorticotropic hormone-induced steroidogenesis in rat adrenal gland. Proceedings of the National Academy of Sciences of the United States of America. 89: 10598-602. PMID 1279686 DOI: 10.1073/Pnas.89.22.10598  0.68
1992 Peters JL, Kammen DPv, Guidotti A, Neylan T, Mouton A, Kelley ME, Gilbertson M, Gurklis J, Costa E. CSF levels of diazepam binding-inhibitor correlate with rem latency and slow wave sleep in schizophrenia Schizophrenia Research. 6: 126. DOI: 10.1016/0920-9964(92)90171-Z  0.622
1991 Yakovlev AG, De Bernardi MA, Fabrazzo M, Brooker G, Costa E, Mocchetti I. Regulation of nerve growth factor receptor mRNA content by dexamethasone: in vitro and in vivo studies. Neuroscience Letters. 116: 216-20. PMID 2175403 DOI: 10.1016/0304-3940(90)90413-4  0.332
1991 Ferrarese C, Guidotti A, Costa E, Miletich RS, Rice KC, de Costa BR, Fulham MJ, Di Chiro G. In vivo study of NMDA-sensitive glutamate receptor by fluorothienylcyclohexylpiperidine [correction of fluorothienylcycloexylpiperidine], a possible ligand for positron emission tomography. Neuropharmacology. 30: 899-905. PMID 1685770 DOI: 10.1016/0028-3908(91)90125-U  0.689
1991 Kiedrowski L, Manev H, Costa E, Wroblewski JT. Inhibition of glutamate-induced cell death by sodium nitroprusside is not mediated by nitric oxide. Neuropharmacology. 30: 1241-3. PMID 1685560 DOI: 10.1016/0028-3908(91)90171-7  0.699
1991 Manev H, Favaron M, Siman R, Guidotti A, Costa E. Glutamate neurotoxicity is independent of calpain I inhibition in primary cultures of cerebellar granule cells. Journal of Neurochemistry. 57: 1288-95. PMID 1680162 DOI: 10.1111/J.1471-4159.1991.Tb08292.X  0.753
1991 Mereu G, Costa E, Armstrong DM, Vicini S. Glutamate receptor subtypes mediate excitatory synaptic currents of dopamine neurons in midbrain slices. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 1359-66. PMID 1674003  0.534
1991 Papadopoulos V, Berkovich A, Krueger KE, Costa E, Guidotti A. Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology. 129: 1481-8. PMID 1651852 DOI: 10.1210/Endo-129-3-1481  0.674
1991 Costa E, Guidotti A. Diazepam binding inhibitor (DBI): a peptide with multiple biological actions. Life Sciences. 49: 325-44. PMID 1649940 DOI: 10.1016/0024-3205(91)90440-M  0.707
1991 Massotti M, Slobodyansky E, Konkel D, Costa E, Guidotti A. Regulation of diazepam binding inhibitor in rat adrenal gland by adrenocorticotropin. Endocrinology. 129: 591-6. PMID 1649741 DOI: 10.1210/endo-129-2-591  0.677
1991 Mereu G, Costa E, Armstrong D, Vicini S. Glutamate receptor subtypes mediate excitatory synaptic currents of dopamine neurons in midbrain slices. The Journal of Neuroscience. 11: 1359-1366. DOI: 10.1523/Jneurosci.11-05-01359.1991  0.585
1991 Guidotti A, Manev H, Costa E. Neuroprotective effects of glycosphingolipids in in-vitro and in-vivo models of neurotoxicity European Neuropsychopharmacology. 1: 248. DOI: 10.1016/0924-977X(91)90506-P  0.509
1991 Guidotti A, Manev H, Costa E. Neuroprotective effects of glycosphingolipids in in-vitro and in-vivo models of neurotoxicity European Neuropsychopharmacology. 1: 248.  0.691
1990 Guarneri P, Berkovich A, Guidotti A, Costa E. A study of diazepam binding inhibitor (DBI) processing products in human cerebrospinal fluid and in postmortem human brain. Neuropharmacology. 29: 419-28. PMID 2356001 DOI: 10.1016/0028-3908(90)90162-K  0.668
1990 de Erausquin GA, Manev H, Guidotti A, Costa E, Brooker G. Gangliosides normalize distorted single-cell intracellular free Ca2+ dynamics after toxic doses of glutamate in cerebellar granule cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 8017-21. PMID 2236016 DOI: 10.1073/Pnas.87.20.8017  0.735
1990 Manev H, Favaron M, De Erausquin G, Guidotti A, Brooker G, Costa E. Destabilization of ionized Ca2+ homeostasis in excitatory amino acid neurotoxicity: antagonism by glycosphingolipids. Cell Biology International Reports. 14: 3-14. PMID 2185894 DOI: 10.1016/0309-1651(90)90066-8  0.721
1990 Olasmaa M, Rothstein JD, Guidotti A, Weber RJ, Paul SM, Spector S, Zeneroli ML, Baraldi M, Costa E. Endogenous benzodiazepine receptor ligands in human and animal hepatic encephalopathy. Journal of Neurochemistry. 55: 2015-23. PMID 2172467 DOI: 10.1111/J.1471-4159.1990.Tb05790.X  0.671
1990 Lazarewicz JW, Wroblewski JT, Costa E. N-methyl-D-aspartate-sensitive glutamate receptors induce calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells. Journal of Neurochemistry. 55: 1875-81. PMID 2172463 DOI: 10.1111/J.1471-4159.1990.Tb05771.X  0.66
1990 Manev H, Costa E, Wroblewski JT, Guidotti A. Abusive stimulation of excitatory amino acid receptors: a strategy to limit neurotoxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 2789-97. PMID 2165013 DOI: 10.1096/Fasebj.4.10.2165013  0.811
1990 Puia G, Santi MR, Vicini S, Pritchett DB, Purdy RH, Paul SM, Seeburg PH, Costa E. Neurosteroids act on recombinant human GABAA receptors. Neuron. 4: 759-65. PMID 2160838 DOI: 10.1016/0896-6273(90)90202-Q  0.559
1990 Danysz W, Fadda E, Wroblewski JT, Costa E. [3H]D-serine labels strychnine-insensitive glycine recognition sites of rat central nervous system. Life Sciences. 46: 155-64. PMID 2154648 DOI: 10.1016/0024-3205(90)90100-6  0.632
1990 Schramm M, Eimerl S, Costa E. Serum and depolarizing agents cause acute neurotoxicity in cultured cerebellar granule cells: role of the glutamate receptor responsive to N-methyl-D-aspartate. Proceedings of the National Academy of Sciences of the United States of America. 87: 1193-1197. PMID 2153974 DOI: 10.1073/Pnas.87.3.1193  0.361
1990 Ulivi M, Costa E, Wojcik WJ. Kainate receptor activation stimulate release of glutamate, alanine and glycine. Pharmacological Research. 22: 33-34. PMID 1982967 DOI: 10.1016/S1043-6618(09)80014-5  0.324
1990 Guidotti A, Manev H, Favaron M, Brooker G, Costa E. Protection by natural and semisynthetic gangliosides from Ca2(+)-dependent neurotoxicity caused by excitatory amino acid (EAA) neurotransmitters. Advances in Experimental Medicine and Biology. 268: 135-44. PMID 1981639 DOI: 10.1007/978-1-4684-5769-8_16  0.726
1990 Favaron M, Manev H, Siman R, Bertolino M, Szekely AM, DeErausquin G, Guidotti A, Costa E. Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death. Proceedings of the National Academy of Sciences of the United States of America. 87: 1983-7. PMID 1689850 DOI: 10.1073/Pnas.87.5.1983  0.758
1990 Guidotti A, Berkovich A, Muhkin A, Costa E. Diazepam-binding inhibitor: response to Knudsen & Nielsen Biochemical Journal. 265: 928-929. DOI: 10.1042/Bj2650928  0.64
1990 Vicini S, Costa E, Mereu G. Allosteric modulators of the nmda receptor affect excitatory postsynaptic currents in the rat hippocampus Pharmacological Research. 22: 492. DOI: 10.1016/S1043-6618(09)80492-1  0.566
1990 Zeneroli M, Baraldi M, Olusmaa M, Rothstein J, Guidotti A, Costa E. Endogenous benzodiazepines in a rat model of hepatic encephalopathy Journal of Hepatology. 11: S66. DOI: 10.1016/0168-8278(90)91599-R  0.607
1990 Giusti P, Guidotti A, Danysz W, Auta J, Costa E. Neuropharmacological evidence for an interaction between the GABA uptake inhibitor Cl‐966 and anxiolytic benzodiazepines Drug Development Research. 21: 217-225. DOI: 10.1002/Ddr.430210307  0.711
1989 Roy A, Pickar D, Gold P, Barbaccia M, Guidotti A, Costa E, Linnoila M. Diazepam-binding inhibitor and corticotropin-releasing hormone in cerebrospinal fluid. Acta Psychiatrica Scandinavica. 80: 287-91. PMID 2816471 DOI: 10.1111/j.1600-0447.1989.tb01339.x  0.647
1989 Slobodyansky E, Guidotti A, Wambebe C, Berkovich A, Costa E. Isolation and characterization of a rat brain triakontatetraneuropeptide, a posttranslational product of diazepam binding inhibitor: specific action at the Ro 5-4864 recognition site. Journal of Neurochemistry. 53: 1276-84. PMID 2769267 DOI: 10.1111/J.1471-4159.1989.Tb07425.X  0.714
1989 Hynie S, Wroblewski JT, Costa E. Profile of phosphatidylinositol metabolism stimulated by carbachol and glutamate in primary cultures of rat cerebellar neurons. Neuropharmacology. 28: 1309-15. PMID 2615914 DOI: 10.1016/0028-3908(89)90004-X  0.63
1989 Mukhin AG, Papadopoulos V, Costa E, Krueger KE. Mitochondrial benzodiazepine receptors regulate steroid biosynthesis Proceedings of the National Academy of Sciences of the United States of America. 86: 9813-9816. PMID 2574864 DOI: 10.1073/Pnas.86.24.9813  0.33
1989 Danysz W, Fadda E, Wroblewski JT, Costa E. Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the N-methyl-D-aspartate-sensitive glutamate receptor domain. Neuroscience Letters. 96: 340-4. PMID 2566140 DOI: 10.1016/0304-3940(89)90402-3  0.65
1989 Olasmaa M, Guidotti A, Costa E, Rothstein JD, Goldman ME, Weber RJ, Paul SM. Endogenous benzodiazepines in hepatic encephalopathy. Lancet. 1: 491-2. PMID 2563854 DOI: 10.1016/S0140-6736(89)91384-6  0.622
1989 Rothstein JD, McKhann G, Guarneri P, Barbaccia ML, Guidotti A, Costa E. Cerebrospinal fluid content of diazepam binding inhibitor in chronic hepatic encephalopathy. Annals of Neurology. 26: 57-62. PMID 2549847 DOI: 10.1002/Ana.410260109  0.648
1989 Wojcik WJ, Ulivi M, Paez X, Costa E. Islet-Activating Protein Inhibits the β-Adrenergic Receptor Facilitation Elicited by γ-Aminobutyric AcidB Receptors Journal of Neurochemistry. 53: 753-758. PMID 2547900 DOI: 10.1111/J.1471-4159.1989.Tb11769.X  0.348
1989 Wroblewski JT, Fadda E, Mazzetta J, Lazarewicz JW, Costa E. Glycine and D-serine act as positive modulators of signal transduction at N-methyl-D-aspartate sensitive glutamate receptors in cultured cerebellar granule cells. Neuropharmacology. 28: 447-52. PMID 2542835 DOI: 10.1016/0028-3908(89)90077-4  0.646
1989 Danysz W, Wroblewski JT, Brooker G, Costa E. Modulation of glutamate receptors by phencyclidine and glycine in the rat cerebellum: cGMP increase in vivo. Brain Research. 479: 270-6. PMID 2538209 DOI: 10.1016/0006-8993(89)91628-4  0.651
1989 Costa E. Allosteric modulatory centers of transmitter amino acid receptors Neuropsychopharmacology. 2: 167-174. PMID 2477004 DOI: 10.1016/0893-133X(89)90020-1  0.396
1989 Puia G, Santi MR, Vicini S, Pritchett DB, Seeburg PH, Costa E. Differences in the negative allosteric modulation of gamma-aminobutyric acid receptors elicited by 4'-chlorodiazepam and by a beta-carboline-3-carboxylate ester: a study with natural and reconstituted receptors. Proceedings of the National Academy of Sciences of the United States of America. 86: 7275-9. PMID 2476816 DOI: 10.1073/Pnas.86.18.7275  0.596
1989 Bertolino M, Vicini S, Costa E. Kynurenic acid inhibits the activation of kainic and N-methyl-D-aspartic acid-sensitive ionotropic receptors by a different mechanism. Neuropharmacology. 28: 453-7. PMID 2471112 DOI: 10.1016/0028-3908(89)90078-6  0.567
1988 Alho H, Fremeau RT, Tiedge H, Wilcox J, Bovolin P, Brosius J, Roberts JL, Costa E. Diazepam binding inhibitor gene expression: location in brain and peripheral tissues of rat. Proceedings of the National Academy of Sciences of the United States of America. 85: 7018-22. PMID 3413133 DOI: 10.1073/Pnas.85.18.7018  0.353
1988 Barbaccia ML, Costa E, Guidotti A. Endogenous ligands for high-affinity recognition sites of psychotropic drugs. Annual Review of Pharmacology and Toxicology. 28: 451-76. PMID 3289493 DOI: 10.1146/annurev.pa.28.040188.002315  0.673
1988 Favaron M, Manev H, Alho H, Bertolino M, Ferret B, Guidotti A, Costa E. Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex. Proceedings of the National Academy of Sciences of the United States of America. 85: 7351-5. PMID 2902628 DOI: 10.1073/Pnas.85.19.7351  0.754
1988 Danysz W, Wroblewski JT, Costa E. Learning impairment in rats by N-methyl-D-aspartate receptor antagonists. Neuropharmacology. 27: 653-6. PMID 2901678 DOI: 10.1016/0028-3908(88)90189-X  0.62
1988 Fadda E, Danysz W, Wroblewski JT, Costa E. Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes. Neuropharmacology. 27: 1183-5. PMID 2849731 DOI: 10.1016/0028-3908(88)90015-9  0.651
1988 Lazarewicz JW, Wroblewski JT, Palmer ME, Costa E. Activation of N-methyl-D-aspartate-sensitive glutamate receptors stimulates arachidonic acid release in primary cultures of cerebellar granule cells. Neuropharmacology. 27: 765-9. PMID 2843786 DOI: 10.1016/0028-3908(88)90088-3  0.666
1988 Nicoletti F, Wroblewski JT, Fadda E, Costa E. Pertussis toxin inhibits signal transduction at a specific metabolotropic glutamate receptor in primary cultures of cerebellar granule cells. Neuropharmacology. 27: 551-6. PMID 2843781 DOI: 10.1016/0028-3908(88)90174-8  0.657
1988 Bertolino M, Vicini S, Mazzetta J, Costa E. Phencyclidine and glycine modulate NMDA-activated high conductance cationic channels by acting at different sites. Neuroscience Letters. 84: 351-5. PMID 2451195 DOI: 10.1016/0304-3940(88)90534-4  0.542
1987 Ferrarese C, Vaccarino F, Alho H, Mellstrom B, Costa E, Guidotti A. Subcellular location and neuronal release of diazepam binding inhibitor. Journal of Neurochemistry. 48: 1093-102. PMID 3819722  0.681
1987 Costa E, Berkovich A, Guidotti A. The regulation of GABAergic receptors by a novel family of endogenous neuropeptides. Life Sciences. 41: 799-803. PMID 3039273 DOI: 10.1016/0024-3205(87)90166-4  0.669
1987 Wroblewski JT, Nicoletti F, Fadda E, Costa E. Phencyclidine is a negative allosteric modulator of signal transduction at two subclasses of excitatory amino acid receptors. Proceedings of the National Academy of Sciences of the United States of America. 84: 5068-72. PMID 3037532 DOI: 10.1073/Pnas.84.14.5068  0.667
1987 Miyata M, Mocchetti I, Ferrarese C, Guidotti A, Costa E. Protracted treatment with diazepam increases the turnover of putative endogenous ligands for the benzodiazepine/beta-carboline recognition site. Proceedings of the National Academy of Sciences of the United States of America. 84: 1444-8. PMID 3029781 DOI: 10.1073/Pnas.84.5.1444  0.674
1987 Nicoletti F, Wroblewski JT, Alho H, Eva C, Fadda E, Costa E. Lesions of putative glutamatergic pathways potentiate the increase of inositol phospholipid hydrolysis elicited by excitatory amino acids. Brain Research. 436: 103-12. PMID 2891413 DOI: 10.1016/0006-8993(87)91561-7  0.646
1987 Nicoletti F, Wroblewski JT, Costa E. Magnesium ions inhibit the stimulation of inositol phospholipid hydrolysis by endogenous excitatory amino acids in primary cultures of cerebellar granule cells. Journal of Neurochemistry. 48: 967-73. PMID 2879893 DOI: 10.1111/J.1471-4159.1987.Tb05611.X  0.646
1987 Vaccarino F, Guidotti A, Costa E. Ganglioside inhibition of glutamate-mediated protein kinase C translocation in primary cultures of cerebellar neurons. Proceedings of the National Academy of Sciences of the United States of America. 84: 8707-11. PMID 2825205 DOI: 10.1073/Pnas.84.23.8707  0.696
1987 Mocchetti I, Costa E. In vivo studies of the regulation of neuropeptide stores in structures of the rat brain Neuropharmacology. 26: 855-862. PMID 2821428 DOI: 10.1016/0028-3908(87)90062-1  0.342
1987 Ferrarese C, Alho H, Guidotti A, Costa E. Co-localization and co-release of GABA and putative allosteric modulators of GABA receptor. Neuropharmacology. 26: 1011-8. PMID 2821427  0.684
1987 Szekely AM, Barbaccia ML, Costa E. Activation of specific glutamate receptor subtypes increases C-fos proto-oncogene expression in primary cultures of neonatal rat cerebellar granule cells. Neuropharmacology. 26: 1779-1782. PMID 2449626 DOI: 10.1016/0028-3908(87)90132-8  0.394
1987 Novelli A, Nicoletti F, Wroblewski J, Alho H, Costa E, Guidotti A. Excitatory amino acid receptors coupled with guanylate cyclase in primary cultures of cerebellar granule cells The Journal of Neuroscience. 7: 40-47. DOI: 10.1523/JNEUROSCI.07-01-00040.1987  0.753
1986 Ferrero P, Costa E, Conti-Tronconi B, Guidotti A. A diazepam binding inhibitor (DBI)-like neuropeptide is detected in human brain. Brain Research. 399: 136-42. PMID 3801915 DOI: 10.1016/0006-8993(86)90607-4  0.678
1986 Ferrero P, Santi MR, Conti-Tronconi B, Costa E, Guidotti A. Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain. Proceedings of the National Academy of Sciences of the United States of America. 83: 827-31. PMID 3456171 DOI: 10.1073/Pnas.83.3.827  0.699
1986 Vicini S, Alho H, Costa E, Mienville JM, Santi MR, Vaccarino FM. Modulation of gamma-aminobutyric acid-mediated inhibitory synaptic currents in dissociated cortical cell cultures. Proceedings of the National Academy of Sciences of the United States of America. 83: 9269-73. PMID 3097650 DOI: 10.1073/Pnas.83.23.9269  0.593
1986 Nicoletti F, Wroblewski JT, Iadarola MJ, Costa E. Serine-O-phosphate, an endogenous metabolite, inhibits the stimulation of inositol phospholipid hydrolysis elicited by ibotenic acid in rat hippocampal slices. Neuropharmacology. 25: 335-8. PMID 3084992 DOI: 10.1016/0028-3908(86)90262-5  0.74
1986 Costa E, Alho H, Santi MR, Ferrero P, Guidotti A. Cotransmission at GABAergic synapses. Progress in Brain Research. 68: 343-56. PMID 3031734 DOI: 10.1016/S0079-6123(08)60250-2  0.711
1986 Barbaccia ML, Costa E, Ferrero P, Guidotti A, Roy A, Sunderland T, Pickar D, Paul SM, Goodwin FK. Diazepam-binding inhibitor. A brain neuropeptide present in human spinal fluid: studies in depression, schizophrenia, and Alzheimer's disease. Archives of General Psychiatry. 43: 1143-7. PMID 3022663 DOI: 10.1001/Archpsyc.1986.01800120029007  0.69
1986 Gray PW, Glaister D, Seeburg PH, Guidotti A, Costa E. Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma-aminobutyric acid type A receptor. Proceedings of the National Academy of Sciences of the United States of America. 83: 7547-51. PMID 3020548 DOI: 10.1073/pnas.83.19.7547  0.656
1986 Vicini S, Wroblewski JT, Costa E. Pharmacological modulation of GABAergic transmission in cultured cerebellar neurons. Neuropharmacology. 25: 207-11. PMID 3010162 DOI: 10.1016/0028-3908(86)90043-2  0.729
1986 Nicoletti F, Iadarola MJ, Wroblewski JT, Costa E. Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors. Proceedings of the National Academy of Sciences of the United States of America. 83: 1931-5. PMID 2869493 DOI: 10.1073/Pnas.83.6.1931  0.764
1986 Nicoletti F, Meek JL, Iadarola MJ, Chuang DM, Roth BL, Costa E. Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. Journal of Neurochemistry. 46: 40-6. PMID 2866236 DOI: 10.1111/J.1471-4159.1986.Tb12922.X  0.71
1986 Nicoletti F, Wroblewski J, Novelli A, Alho H, Guidotti A, Costa E. The activation of inositol phospholipid metabolism as a signal- transducing system for excitatory amino acids in primary cultures of cerebellar granule cells The Journal of Neuroscience. 6: 1905-1911. DOI: 10.1523/Jneurosci.06-07-01905.1986  0.765
1985 Vaccarino F, Tronconi BM, Panula P, Guidotti A, Costa E. GABA-modulin: a synaptosomal basic protein that differs from small myelin basic protein of rat brain. Journal of Neurochemistry. 44: 278-90. PMID 3964832 DOI: 10.1111/J.1471-4159.1985.Tb07142.X  0.674
1985 Alho H, Costa E, Ferrero P, Fujimoto M, Cosenza-Murphy D, Guidotti A. Diazepam-binding inhibitor: a neuropeptide located in selected neuronal populations of rat brain. Science (New York, N.Y.). 229: 179-82. PMID 3892688 DOI: 10.1126/Science.3892688  0.709
1985 Bormann J, Ferrero P, Guidotti A, Costa E. Neuropeptide modulation of GABA receptor C1- channels. Regulatory Peptides. Supplement. 4: 33-8. PMID 2414820 DOI: 10.1016/0167-0115(85)90215-0  0.65
1985 Guidotti A, Ferrero P, Santi MR, Alho H, Vicini S, Costa E. Gamma-aminobutyric acid and chloride channels: regulation by neuropeptides. Regulatory Peptides. Supplement. 4: 172-81. PMID 2414813  0.699
1985 Wroblewski JT, Nicoletti F, Costa E. Different coupling of excitatory amino acid receptors with Ca2+ channels in primary cultures of cerebellar granule cells. Neuropharmacology. 24: 919-21. PMID 2414684 DOI: 10.1016/0028-3908(85)90046-2  0.636
1985 Costa E, Guidotti A. Endogenous ligands for benzodiazepine recognition sites. Biochemical Pharmacology. 34: 3399-403. PMID 2413860 DOI: 10.1016/0006-2952(85)90709-9  0.605
1985 Mocchetti I, Guidotti A, Schwartz J, Costa E. Reserpine changes the dynamic state of enkephalin stores in rat striatum and adrenal medulla by different mechanisms The Journal of Neuroscience. 5: 3379-3385. DOI: 10.1523/Jneurosci.05-12-03379.1985  0.66
1984 Kataoka Y, Gutman Y, Guidotti A, Panula P, Wroblewski J, Cosenza-Murphy D, Wu JY, Costa E. Intrinsic GABAergic system of adrenal chromaffin cells. Proceedings of the National Academy of Sciences of the United States of America. 81: 3218-22. PMID 6328506 DOI: 10.1073/Pnas.81.10.3218  0.786
1984 Ferrero P, Guidotti A, Costa E. Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam. Proceedings of the National Academy of Sciences of the United States of America. 81: 2247-51. PMID 6326115  0.683
1984 Ferrero P, Guidotti A, Conti-Tronconi B, Costa E. A brain octadecaneuropeptide generated by tryptic digestion of DBI (diazepam binding inhibitor) functions as a proconflict ligand of benzodiazepine recognition sites. Neuropharmacology. 23: 1359-62. PMID 6098849  0.654
1984 Costa E, Ferrari M, Ferrero P, Guidotti A. Multiple signals in GABAergic transmission: pharmacological consequences. Neuropharmacology. 23: 989-91. PMID 6090970 DOI: 10.1016/0028-3908(84)90016-9  0.635
1984 Corda MG, Ferrari M, Guidotti A, Konkel D, Costa E. Isolation, purification and partial sequence of a neuropeptide (diazepam-binding inhibitor) precursor of an anxiogenic putative ligand for benzodiazepine recognition site. Neuroscience Letters. 47: 319-24. PMID 6089051  0.635
1984 Zsilla G, Held G, Szekely AM, Knoll J, Barbaccia ML, Cheney DL, Gandolfi O, Costa E. Modification Of Synaptic Receptor Functions By (-) Deprenyl Clinical Neuropharmacology. 7. DOI: 10.1097/00002826-198406001-00154  0.314
1983 Guidotti A, Konkel DR, Ebstein B, Corda MG, Wise BC, Krutzsch H, Meek JL, Costa E. Isolation, characterization, and purification to homogeneity of a rat brain protein (GABA-modulin). Proceedings of the National Academy of Sciences of the United States of America. 79: 6084-8. PMID 6964401 DOI: 10.1073/PNAS.79.19.6084  0.666
1983 Ferrero P, Vaccarino F, Guidotti A, Costa E, Di Chiro G. In vivo modulation of brain dopamine recognition sites: a possible model for emission computed tomography studies. Neuropharmacology. 22: 791-5. PMID 6604240 DOI: 10.1016/0028-3908(83)90105-3  0.655
1983 Costa E, Corda MG, Guidotti A. On a brain polypeptide functioning as a putative effector for the recognition sites of benzodiazepine and beta-carboline derivatives. Neuropharmacology. 22: 1481-92. PMID 6322042  0.655
1983 Guidotti A, Corda MG, Wise BC, Vaccarino F, Costa E. GABAergic synapses. Supramolecular organization and biochemical regulation. Neuropharmacology. 22: 1471-9. PMID 6322041 DOI: 10.1016/0028-3908(83)90115-6  0.671
1983 Guidotti A, Forchetti CM, Corda MG, Konkel D, Bennett CD, Costa E. Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors. Proceedings of the National Academy of Sciences of the United States of America. 80: 3531-5. PMID 6304714 DOI: 10.1073/PNAS.80.11.3531  0.645
1983 Barbaccia ML, Brunello N, Chuang DM, Costa E. On the mode of action of imipramine: relationship between serotonergic axon terminal function and down-regulation of beta-adrenergic receptors. Neuropharmacology. 22: 373-83. PMID 6304555 DOI: 10.1016/0028-3908(83)90186-7  0.307
1983 Corda MG, Blaker WD, Mendelson WB, Guidotti A, Costa E. beta-Carbolines enhance shock-induced suppression of drinking in rats. Proceedings of the National Academy of Sciences of the United States of America. 80: 2072-6. PMID 6300891 DOI: 10.1073/PNAS.80.7.2072  0.665
1983 Wise BC, Guidotti A, Costa E. Phosphorylation induces a decrease in the biological activity of the protein inhibitor (GABA-modulin) of gamma-aminobutyric acid binding sites. Proceedings of the National Academy of Sciences of the United States of America. 80: 886-90. PMID 6298780 DOI: 10.1073/PNAS.80.3.886  0.664
1982 Brunello N, Cheney DL, Costa E. Increase in exogenous choline fails to elevate the content or turnover rate of cortical, striatal, or hippocampal acetylcholine. Journal of Neurochemistry. 38: 1160-3. PMID 7062035 DOI: 10.1111/J.1471-4159.1982.Tb05364.X  0.302
1982 Brunello N, Chuang DM, Costa E. Different synaptic location of mianserin and imipramine binding sites. Science (New York, N.Y.). 215: 1112-5. PMID 6278586 DOI: 10.1126/Science.6278586  0.308
1982 Corda MG, Costa E, Guidotti A. Specific proconvulsant action of an imidazobenzodiazepine (RO 15-1788) on isoniazid convulsions. Neuropharmacology. 21: 91-4. PMID 6278356 DOI: 10.1016/0028-3908(82)90217-9  0.615
1981 Massotti M, Mazzari S, Schmid R, Guidotti A, Costa E. Endogenous inhibitors of Na+-independent [3H]GABA binding to crude synaptic membranes. Neurochemical Research. 6: 551-65. PMID 6269013 DOI: 10.1007/BF00964393  0.659
1981 Massotti M, Guidotti A, Costa E. Characterization of benzodiazepine and gamma-aminobutyric recognition sites and their endogenous modulators The Journal of Neuroscience. 1: 409-418. DOI: 10.1523/Jneurosci.01-04-00409.1981  0.687
1980 Kinnier WJ, Chuang DM, Costa E. Down regulation of dihydroalprenolol and imipramine binding sites in brain of rats repeatedly treated with imipramine. European Journal of Pharmacology. 67: 289-94. PMID 6257531 DOI: 10.1016/0014-2999(80)90510-5  0.327
1980 Cananzi AR, Costa E, Guidotti A. Potentiation by intraventricular muscimol of the anticonflict effect of benzodiazepines. Brain Research. 196: 447-53. PMID 6249449 DOI: 10.1016/0006-8993(80)90408-4  0.656
1980 Kumakura K, Karoum F, Guidotti A, Costa E. Modulation of nicotinic receptors by opiate receptor agonists in cultured adrenal chromaffin cells. Nature. 283: 489-92. PMID 6243403 DOI: 10.1038/283489A0  0.647
1980 Guidotti A, Baraldi M, Costa E. 1,4-Benzodiazepines and gamma-aminobutyric acid: pharmacological and biochemical correlates. Pharmacology. 19: 267-77. PMID 538081 DOI: 10.1159/000137322  0.675
1980 COSTA E, GUIDOTTI A, SAIANI L. Opiate receptors and adrenal medullary function (reply) Nature. 288: 304-304. DOI: 10.1038/288304A0  0.636
1980 Kumakura K, Guidotti A, Takemura H, Costa E. 94) Nicotinic cholinergic receptors of bovine adrenal chromaffin cells in the primary cultures. Japanese Journal of Pharmacology. 30: 105. DOI: 10.1016/s0021-5198(19)53428-x  0.63
1979 Baraldi M, Guidotti A, Schwartz JP, Costa E. GABA receptors in clonal cell lines: a model for study of benzodiazepine action at molecular level. Science. 205: 821-823. PMID 462192 DOI: 10.1126/Science.462192  0.669
1979 Costa E, Guidotti A. Recent studies on the mechanism whereby benzodiazepines facilitate GABA-ergic transmission Advances in Experimental Medicine and Biology. 123: 371-378. PMID 42282 DOI: 10.1007/978-1-4899-5199-1_23  0.641
1979 Guidotti A, Baraldi M, Schwartz JP, Costa E. Molecular mechanisms regulating the interactions between the benzodiazepines and GABA receptors in the central nervous system Pharmacology, Biochemistry and Behavior. 10: 803-807. PMID 40254 DOI: 10.1016/0091-3057(79)90338-1  0.681
1979 Costa E, Guidotti A. Molecular mechanisms in the receptor action of benzodiazepines Annual Review of Pharmacology and Toxicology. 19: 531-545. PMID 36830 DOI: 10.1146/Annurev.Pa.19.040179.002531  0.64
1978 Toffano G, Guidotti A, Costa E. Purification of an endogenous protein inhibitor of the high affinity binding of gamma-aminobutyric acid to synaptic membranes of rat brain. Proceedings of the National Academy of Sciences of the United States of America. 75: 4024-8. PMID 279020 DOI: 10.1073/PNAS.75.8.4024  0.669
1978 Costa E, Guidotti A, Toffano G. Molecular mechanisms mediating the action of diazepam on GABA receptors. The British Journal of Psychiatry : the Journal of Mental Science. 133: 239-48. PMID 212152 DOI: 10.1192/BJP.133.3.239  0.681
1978 Guidotti A, Toffano G, Costa E. An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brain. Nature. 275: 553-5. PMID 211441 DOI: 10.1038/275553A0  0.681
1978 Lucchelli A, Guidotti A, Costa E. Stratial content of Ca2+-dependent regulator protein and dopaminergic receptor function. Brain Research. 155: 130-5. PMID 28815 DOI: 10.1016/0006-8993(78)90313-X  0.635
1977 Biggio G, Costa E, Guidotti A. Regulation of 3', 5'-cyclic guanosine monophosphate content in deep cerebellar nuclei. Neuroscience. 2: 49-52. PMID 199855 DOI: 10.1016/0306-4522(77)90067-7  0.73
1977 Biggio G, Brodie BB, Costa E, Guidotti A. Mechanisms by which diazepam, muscimol, and other drugs change the content of cGMP in cerebellar cortex. Proceedings of the National Academy of Sciences of the United States of America. 74: 3592-6. PMID 198792 DOI: 10.1073/Pnas.74.8.3592  0.756
1977 Biggio G, Guidotti A, Costa E. On the mechanism of the decrease in cerebellar cyclic GMP content elicited by opiate receptor agonists. Naunyn-Schmiedeberg's Archives of Pharmacology. 296: 117-21. PMID 189228  0.707
1977 Guidotti A, Costa E. Trans-synaptic regulation of tyrosine 3-mono-oxygenase biosynthesis in rat adrenal medulla Biochemical Pharmacology. 26: 817-823. PMID 16614 DOI: 10.1016/0006-2952(77)90393-8  0.633
1977 Gale K, Guidotti A, Costa E. Dopamine-sensitive adenylate cyclase: location in substantia nigra. Science (New York, N.Y.). 195: 503-5. PMID 13499 DOI: 10.1126/Science.13499  0.743
1977 Guidotti A, Kurosawa A, Costa E. Association between the increase of cAMP content and the trans-synaptic induction of tyrosine hydroxylase in rat adrenal medulla. Studies with dexamethasone and reserpine. Naunyn-Schmiedeberg's Archives of Pharmacology. 295: 135-40. PMID 11421 DOI: 10.1007/BF00499445  0.64
1977 Szmigielski A, Guidotti A, Costa E. Endogenous protein kinase inhibitors. Purification, characterization, and distribution in different tissues. Journal of Biological Chemistry. 252: 3848-3853. DOI: 10.1016/s0021-9258(17)40329-2  0.598
1976 Naik SR, Guidotti A, Costa E. Central GABA receptor agonists: comparison of muscimol and baclofen. Neuropharmacology. 15: 479-84. PMID 185540 DOI: 10.1016/0028-3908(76)90058-7  0.665
1976 Kurosawa A, Guidotti A, Costa E. Induction of tyrosine 3-monooxygenase in adrenal medulla: role of protein kinase activation and translocation. Science. 193: 691-693. PMID 7836 DOI: 10.1126/Science.7836  0.617
1976 Racagni G, Zsilla G, Guidotti A, Costa E. Accumulation of cGMP in striatum of rats injected with narcotic analgesics: antagonism by naltrexone. The Journal of Pharmacy and Pharmacology. 28: 258-60. PMID 6708 DOI: 10.1111/j.2042-7158.1976.tb04146.x  0.612
1976 Costa E, Kurosawa A, Guidotti A. Activation and nuclear translocation of protein kinase during transsynaptic induction of tyrosine 3-monooxygenase. Proceedings of the National Academy of Sciences of the United States of America. 73: 1058-62. PMID 4793 DOI: 10.1073/PNAS.73.4.1058  0.624
1976 Zivkovic B, Guidotti A, Costa E. The regulation of striatal tyrosine hydroxylase. Effects of gamma hydroxybutric acid and healperidol. Naunyn-Schmiedeberg's Archives of Pharmacology. 291: 193-200. PMID 629 DOI: 10.1007/BF00500049  0.642
1975 Mao CC, Guidotti A, Costa E. The regulation of cyclic guanosine monophosphate in rat cerebellum: possible involvement of putative amino acid neurotransmitters. Brain Research. 79: 510-4. PMID 4371516 DOI: 10.1016/0006-8993(74)90449-1  0.643
1975 Zivkovic B, Guidotti A, Costa E. The regulation of the kinetic state of striatal tyrosine hydroxylase and the role of postsynaptic dopamine receptors. Brain Research. 92: 516-21. PMID 240486 DOI: 10.1016/0006-8993(75)90340-6  0.635
1975 Mao CC, Guidotti A, Costa E. Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action diazepam. Naunyn-Schmiedeberg's Archives of Pharmacology. 289: 369-78. PMID 240134 DOI: 10.1007/BF00508411  0.665
1975 Zivkovic B, Guidotti A, Costa E. Stereospecificity of dopamine receptors involved in the regulation of the kinetic state of tyrosine hydroxylase in striatum and nucleus accumbens. The Journal of Pharmacy and Pharmacology. 27: 359-60. PMID 239138 DOI: 10.1111/j.2042-7158.1975.tb09455.x  0.628
1975 Hanbauer I, Guidotti A, Costa E. Dexamethasone induces tyrosine hydroxylase in sympathetic ganglia but not in adrenal medulla. Brain Research. 85: 527-31. PMID 236074 DOI: 10.1016/0006-8993(75)90826-4  0.625
1975 Guidotti A, Biggio G, Costa E. 3-Acetylpyridine: a tool to inhibit the tremor and the increase of cGMP content in cerebellar cortex elicited by harmaline. Brain Research. 96: 201-5. PMID 169960  0.686
1975 Costa E, Guidotti A, Mao CC, Suria A. New concepts on the mechanism of action of benzodiazepines. Life Sciences. 17: 167-85. PMID 169445 DOI: 10.1016/0024-3205(75)90501-9  0.601
1975 Mao CC, Guidotti A, Costa E. Inhibition by diazepam of the tremor and the increase of cerebellar cGMD content elicited by harmaline. Brain Research. 83: 516-9. PMID 163118 DOI: 10.1016/0006-8993(75)90846-X  0.626
1974 Karoum F, Wyatt R, Costa E. Estimation of the contribution of peripheral and central noradrenergic neurones to urinary 3-methoxy-4-hydroxyphenylglycol in the rat Neuropharmacology. 13: 165-176. PMID 4840872 DOI: 10.1016/0028-3908(74)90104-X  0.315
1974 Guidotti A, Costa E. Association between increase in cyclic AMP and subsequent induction of tyrosine hydroxylase in rat adrenal medulla. Experiments with swimming stress. Naunyn-Schmiedeberg's Archives of Pharmacology. 282: 217-21. PMID 4152787 DOI: 10.1007/BF00499036  0.609
1974 Costa E, Guidotti A, Hanbauer I. Do cyclic nucleotides promote the trans-synaptic induction of tyrosine hydroxylase? Life Sciences. 14: 1169-88. PMID 4150901 DOI: 10.1016/0024-3205(74)90425-1  0.623
1973 Zivkovic B, Guidotti A, Costa E. Increase of tryptophan hydroxylase activity elicited by reserpine. Brain Research. 57: 522-6. PMID 4722068 DOI: 10.1016/0006-8993(73)90160-1  0.612
1973 Guidotti A, Costa E. Involvement of Adenosine 3',5'-Monophosphate in the Activation of Tyrosine Hydroxylase Elicited by Drugs Science. 179: 902-904. PMID 4405771 DOI: 10.1126/Science.179.4076.902  0.63
1973 Guidotti A, Zivkovic B, Pfeiffer R, Costa E. Involvement of 3',5'-cyclic adenosine monophosphate in the increase of tyrosine hydroxylase activity elicited by cold exposure. Naunyn-Schmiedeberg's Archives of Pharmacology. 278: 195-206. PMID 4146165 DOI: 10.1007/BF00500650  0.61
1973 Guidotti A, Mao C, Costa E. Trans-synaptic regulation of tyrosine hydroxylase in adrenal medulla: Possible role of cyclic nucleotides Life Sciences. 13: lxiii-lxv. DOI: 10.1016/0024-3205(73)90298-1  0.629
Low-probability matches (unlikely to be authored by this person)
1994 de Erausquin G, Brooker G, Costa E, Hanbauer I. Persistent AMPA receptor stimulation alters [Ca2+]i homeostasis in cultures of embryonic dopaminergic neurons Molecular Brain Research. 21: 303-311. PMID 7513376 DOI: 10.1016/0169-328X(94)90261-5  0.3
1980 Kinnier WJ, Chuang DM, Cheney DL, Costa E. Hippocampal distribution of acetylcholine, muscarinic receptors and cyclic GMP. Neuropharmacology. 19: 1119-23. PMID 6255362 DOI: 10.1016/0028-3908(80)90111-2  0.298
1993 Fohrman EB, de Erausquin G, Costa E, Wojcik WJ. Muscarinic m3 receptors and dynamics of intracellular Ca2+ cerebellar granule neurons European Journal of Pharmacology: Molecular Pharmacology. 245: 263-271. PMID 8101492 DOI: 10.1016/0922-4106(93)90106-J  0.297
1988 Naranjo JR, Wise BC, Mellstrom B, Costa E. Negative feedback regulation of the content of proenkephalin MRNA in chromaffin cell cultures Neuropharmacology. 27: 337-343. PMID 3419535 DOI: 10.1016/0028-3908(88)90140-2  0.291
1985 Gandolfi O, Barbaccia ML, Costa E. Different effects of serotonin antagonists on 3H-mianserin and 3H-ketanserin recognition sites. Life Sciences. 36: 713-721. PMID 2983168 DOI: 10.1016/0024-3205(85)90190-0  0.29
1983 Tang J, Chou J, Zhang AZ, Yang HY, Costa E. Met5-enkephalin-arg6-phe7 and its receptor in lung. Life Sciences. 32: 2371-7. PMID 6302430 DOI: 10.1016/0024-3205(83)90768-3  0.289
1981 Brunello N, Tagliamonte A, Cheney DL, Costa E. Effects of immobilization and cold exposure on the turnover rate of acetylcholine in rat brain areas. Neuroscience. 6: 1759-64. PMID 7301123 DOI: 10.1016/0306-4522(81)90210-4  0.287
1991 Costa E. 'Prolegomena' to the biology of the diazepam binding inhibitor (DBI) Neuropharmacology. 30: 1357-1364. PMID 1664065 DOI: 10.1016/S0028-3908(11)80002-X  0.287
1986 Iadorola MJ, Nicoletti F, Naranjo JR, Putnam F, Costa E. Kindling enhances the stimulation of inositol phospholipid hydrolysis elicited by ibotenic acid in rat hippocampal slices Brain Research. 374: 174-178. PMID 3719324 DOI: 10.1016/0006-8993(86)90407-5  0.283
1989 Mocchetti I, De Bernardi MA, Szekely AM, Alho H, Brooker G, Costa E. Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: a potential role of c-Fos protein. Proceedings of the National Academy of Sciences of the United States of America. 86: 3891-5. PMID 2542953 DOI: 10.1073/Pnas.86.10.3891  0.279
1987 Costa E, Mocchetti I, Supattapone S, Snyder SH. Opioid peptide biosynthesis: Enzymatic selectivity and regulation mechanisms Faseb Journal. 1: 16-21. PMID 3111927 DOI: 10.1096/Fasebj.1.1.3111927  0.276
1984 Tang J, Yang HY, Costa E. Inhibition of spontaneous and opiate-modified nociception by an endogenous neuropeptide with Phe-Met-Arg-Phe-NH2-like immunoreactivity. Proceedings of the National Academy of Sciences of the United States of America. 81: 5002-5. PMID 6589644 DOI: 10.1073/pnas.81.15.5002  0.275
1984 Tang F, Tang J, Chou J, Costa E. Age-related and diurnal changes in met5-enk-arg6-phe7 and met5-enkephalin contents of pituitary and rat brain structures Life Sciences. 35: 1005-1014. PMID 6088930 DOI: 10.1016/0024-3205(84)90667-2  0.273
1991 Costa E, Papadopoulos V, Krueger KE. The mitochondrial benzodiazepine receptor (MBR): biochemistry and function European Neuropsychopharmacology. 1: 288-289. DOI: 10.1016/0924-977X(91)90532-Y  0.272
1988 Dal Toso R, De Bernardi MA, Costa E, Mocchetti I. Beta-adrenergic receptor regulation of NGF-mRNA content in rat C6-2B glioma cells. Neuropharmacology. 26: 1783-6. PMID 2830556 DOI: 10.1016/0028-3908(87)90133-X  0.272
1990 Wojcik WJ, Travagli RA, Costa E, Bertolino M. Baclofen inhibits with high affinity an L-type-like voltage-dependent calcium channel in cerebellar granule cell cultures. Neuropharmacology. 29: 969-72. PMID 2175017 DOI: 10.1016/0028-3908(90)90150-P  0.27
1982 Brunello N, Chuang DM, Costa E. Specific binding of [3H]mianserin and [3H]imipramine to structures of rat hippocampus. European Journal of Pharmacology. 78: 383-4. PMID 7067734 DOI: 10.1016/0014-2999(82)90045-0  0.269
1988 Karoum F, Freed WJ, Chuang LW, Cannon-Spoor E, Wyatt RJ, Costa E. D-dopa and L-dopa similarly elevate brain dopamine and produce turning behavior in rats. Brain Research. 440: 190-4. PMID 3129126 DOI: 10.1016/0006-8993(88)91176-6  0.263
1974 Karoum F, Costa E. Excretion of norepinephrine and dopamine alcoholic metabolites after 6-hydroxydopamine Biochemical Pharmacology. 23: 533-538. PMID 4822740 DOI: 10.1016/0006-2952(74)90618-2  0.253
1993 Szekely AM, Grayson D, Costa E. Nuclear signal transduction via immediate early genes in neurons and glia Biochemical Society Transactions. 21: 61-65. PMID 8449344 DOI: 10.1042/Bst0210061  0.251
1984 Barbaccia ML, Karoum F, Gandolfi O, Chuang D-, Costa E. PUTATIVE ENDOGENOUS LIGANDS FOR ANTIDEPRESSANT RECOGNMON SITES Clinical Neuropharmacology. 7: S163. DOI: 10.1097/00002826-198406001-00152  0.235
1983 Tong J, Chou J, Yang H-T, Costa E. Substance P stimulates the release of Met5-enkephalin-Arg6-Phe7 and Met5-enkephalin from rat spinal cord. Neuropharmacology. 22: 1147-1150. PMID 6195549 DOI: 10.1016/0028-3908(83)90052-7  0.234
1987 NARANJO JR, WISE BC, MOCCHETTI I, COSTA E. Neuronotrophic Activity in Adrenal Glands: Effect of Denervation Annals of the New York Academy of Sciences. 493: 273-275. DOI: 10.1111/J.1749-6632.1987.Tb27211.X  0.23
1983 Chou J, Tang J, Costa E. Met5-enkephalin-arg6-phe7 content of human and rabbit plasma Life Sciences. 32: 2589-2595. PMID 6343745 DOI: 10.1016/0024-3205(83)90243-6  0.218
1988 Costa E. The Pennsylvania State University College of Medicine 1987 B.B. Brodie lecture "polytypic signaling at GABAergic synapses" Life Sciences. 42: 1407-1417. PMID 2832676 DOI: 10.1016/0024-3205(88)90050-1  0.21
1984 Blaker WD, Peruzzi G, Costa E. Behavioral and neurochemical differentiation of specific projections in the septal-hippocampal cholinergic pathway of the rat. Proceedings of the National Academy of Sciences of the United States of America. 81: 1880-2. PMID 6200885 DOI: 10.1073/PNAS.81.6.1880  0.205
1992 Kozikowski AP, Ma D, Romeo E, Auta J, Papadopoulos V, Puia G, Costa E, Guidotti A. Synthese von (2-Arylindol-3-yl)acetamiden als Sonden zur Untersuchung der mitochondrialen Steroidbildung - ein neuer Mechanismus für die GABAA-Rezeptormodulation Angewandte Chemie. 104: 1092-1094. DOI: 10.1002/Ange.19921040837  0.193
2000 Rodriguez MA, Pesold C, Liu WS, Kriho V, Guidotti A, Pappas GD, Costa E. Colocalization of integrin receptors and reelin in dendritic spine postsynaptic densities of adult nonhuman primate cortex Proceedings of the National Academy of Sciences. 97: 3550-3555. DOI: 10.1073/PNAS.97.7.3550  0.161
1990 Papadopoulos V, Mukhin AG, Costa E, Krueger KE. The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis. Journal of Biological Chemistry. 265: 3772-3779. DOI: 10.1016/s0021-9258(19)39661-9  0.153
1992 Guarneri P, Papadopoulos V, Pan B, Costa E. Regulation of pregnenolone synthesis in C6-2B glioma cells by 4′-chlorodiazepam Proceedings of the National Academy of Sciences of the United States of America. 89: 5118-5122. PMID 1317582 DOI: 10.1073/Pnas.89.11.5118  0.126
1985 Wise BC, Costa E. Ca2+ and phospholipid-dependent protein kinase activity and phosphorylation of endogenous proteins in bovine adrenal medulla. Journal of Neurochemistry. 45: 227-34. PMID 2987412 DOI: 10.1111/j.1471-4159.1985.tb05497.x  0.112
1985 Carboni E, Wojcik WJ, Costa E. Dihydropyridines change the uptake of calcium induced by depolarization into primary cultures of cerebellar granule cells. Neuropharmacology. 24: 1123-6. PMID 2417155 DOI: 10.1016/0028-3908(85)90202-3  0.109
1997 Chen ZW, Bergman T, Jörnvall H, Bonetto V, Norberg A, Mutt V, Longone P, Costa E, Efendic S, Östenson CG. Full-length and N-terminally truncated chicken intestinal diazepam- binding inhibitor. Purification, structural characterization and influence on insulin release Regulatory Peptides. 69: 63-68. PMID 9178347 DOI: 10.1016/S0167-0115(97)02126-5  0.107
2017 Gambardella C, Morgana S, Ferrando S, Bramini M, Piazza V, Costa E, Garaventa F, Faimali M. Effects of polystyrene microbeads in marine planktonic crustaceans. Ecotoxicology and Environmental Safety. 145: 250-257. PMID 28750293 DOI: 10.1016/j.ecoenv.2017.07.036  0.1
2011 Blanquer J, Chilet M, Benet I, Aguilar G, Muñoz-Cobo B, Tellez A, Costa E, Bravo D, Navarro D. Immunological insights into the pathogenesis of active CMV infection in non-immunosuppressed critically ill patients. Journal of Medical Virology. 83: 1966-71. PMID 21915872 DOI: 10.1002/jmv.22202  0.072
2017 Bortoli PM, Alves C, Costa E, Vanin AP, Sofiatti JR, Siqueira DP, Dallago RM, Treichel H, Vargas GDLP, Kaizer RR. Ilex paraguariensis: Potential antioxidant on aluminium toxicity, in an experimental model of Alzheimer's disease. Journal of Inorganic Biochemistry. PMID 29150325 DOI: 10.1016/j.jinorgbio.2017.11.001  0.059
2017 Meola G, Biasini F, Valaperta R, Costa E, Cardani R. Biomolecular diagnosis of myotonic dystrophy type 2: a challenging approach. Journal of Neurology. PMID 28550479 DOI: 10.1007/s00415-017-8504-1  0.049
2017 Bousquet J, Agache I, Aliberti MR, Angles R, Annesi-Maesano I, Anto JM, Arnavielhe S, Asayag E, Bacci E, Bedbrook A, Bachert C, Baroni I, Barreto BA, Bedolla-Barajas M, Bergmann KC, ... ... Costa E, et al. Transfer of innovation on allergic rhinitis and asthma multimorbidity in the elderly (MACVIA-ARIA) - Reference Site Twinning (EIP on AHA). Allergy. PMID 28600902 DOI: 10.1111/all.13218  0.044
2017 Saad Sultan M, Martins N, Costa E, Veiga D, Ferreira MJ, Mattos S, Tavares Coimbra M. Tracking large Anterior Mitral Leaflet displacements by incorporating optical flow in an active contours framework. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2017: 3244-3247. PMID 29060589 DOI: 10.1109/EMBC.2017.8037548  0.039
1989 Costa E, Karczmar AG, Vesell ES. Bernard B. Brodie and the rise of chemical pharmacology. Annual Review of Pharmacology and Toxicology. 29: 1-21. PMID 2658766 DOI: 10.1146/ANNUREV.PA.29.040189.000245  0.036
2008 Tueting P, Pinna G, Costa E. Homozygous and heterozygous Reeler mouse mutants Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease. 291-309. DOI: 10.1007/978-0-387-76761-1_20  0.035
2017 Poveda V, Filgueiras M, Miranda V, Santos-Silva A, Paúl C, Costa E. Frailty in End-Stage Renal Disease Patients under Dialysis and Its Association with Clinical and Biochemical Markers. The Journal of Frailty & Aging. 6: 103-106. PMID 28555712 DOI: 10.14283/jfa.2017.14  0.031
2017 Bronsart E, Dureau S, Xu HP, Bazire L, Chilles A, Costa E, Logerot C, Falcou MC, Campana F, Berger F, Fourquet A, Kirova YM. Whole breast radiotherapy in the lateral isocentric lateral decubitus position: Long-term efficacy and toxicity results. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 28734546 DOI: 10.1016/j.radonc.2017.07.001  0.024
2017 Grellier Adedjouma N, Chevrier M, Fourquet A, Costa E, Xu H, Berger F, Campana F, Laki F, Beuzeboc P, Lefeuvre D, Fournier-Bidoz N, Kirova YM. Long-Term Results of a Highly Performing Conformal Electron Therapy Technique for Chest Wall Irradiation After Mastectomy. International Journal of Radiation Oncology, Biology, Physics. 98: 206-214. PMID 28586961 DOI: 10.1016/j.ijrobp.2017.01.205  0.012
2017 Coimbra S, Catarino C, Nascimento H, Alves AI, Medeiros AF, Bronze-da-Rocha E, Costa E, Rocha-Pereira P, Aires L, Seabra A, Mota J, Mansilha HF, Rêgo C, Santos-Silva A, Belo L. Physical exercise intervention at school improved hepcidin, inflammation and iron metabolism in overweight and obese children and adolescents. Pediatric Research. PMID 28604755 DOI: 10.1038/pr.2017.139  0.01
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