| Year |
Citation |
Score |
| 2022 |
Ouadhi S, López DMV, Mohideen FI, Kwan DH. Engineering the Enzyme Toolbox to Tailor Glycosylation in Small Molecule Natural Products and Protein Biologics. Protein Engineering, Design & Selection : Peds. PMID 36444941 DOI: 10.1093/protein/gzac010 |
0.324 |
|
| 2020 |
Zhao J, Si Y, Han Z, Li J, Guo W, Fu Y, Tegl G, Hanson J, Chen HM, Kwan DH, Santana AG, Withers SG. Corrigendum: Facile Formation of β-thioGlcNAc Linkages to Thiol-Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase. Angewandte Chemie (International Ed. in English). 59: 8752. PMID 32449594 DOI: 10.1002/anie.202001582 |
0.384 |
|
| 2020 |
Soroko M, Kwan DH. Enzymatic Synthesis of a Fluorogenic Reporter Substrate and the Development of a High-Throughput Assay for Fucosyltransferase VIII Provide a Toolkit to Probe and Inhibit Core Fucosylation. Biochemistry. PMID 32441090 DOI: 10.1021/Acs.Biochem.0C00286 |
0.429 |
|
| 2019 |
Leclerc LMY, Soffer G, Kwan DH, Shih SCC. A fucosyltransferase inhibition assay using image-analysis and digital microfluidics. Biomicrofluidics. 13: 034106. PMID 31123538 DOI: 10.1063/1.5088517 |
0.339 |
|
| 2019 |
Zhang X, Chen F, Petrella A, Chacón-Huete F, Covone J, Tsai TW, Yu CC, Forgione P, Kwan DH. A high-throughput glycosyltransferase inhibition assay to identify molecules targeting fucosylation in cancer cell-surface modification. Acs Chemical Biology. PMID 30831024 DOI: 10.1021/Acschembio.8B01123 |
0.411 |
|
| 2018 |
Tegl G, Hanson J, Chen HM, Kwan DH, Santana AG, Withers SG. Facile Formation of β-thioGlcNAc Linkages to Thiol-Containing Sugars, Peptides, and Proteins using a Mutant GH20 Hexosaminidase. Angewandte Chemie (International Ed. in English). PMID 30549167 DOI: 10.1002/Anie.201809928 |
0.554 |
|
| 2017 |
Kwan DH. Structure-Guided Directed Evolution of Glycosidases: A Case Study in Engineering a Blood Group Antigen-Cleaving Enzyme. Methods in Enzymology. 597: 25-53. PMID 28935105 DOI: 10.1016/Bs.Mie.2017.06.002 |
0.434 |
|
| 2016 |
Kwan DH, Jin Y, Jiang J, Chen HM, Kötzler MP, Overkleeft HS, Davies G, Withers SG. Chemoenzymatic synthesis of 6-phospho-cyclophellitol as a novel probe of 6-phospho-β-glucosidases. Febs Letters. PMID 26790390 DOI: 10.1002/1873-3468.12059 |
0.564 |
|
| 2015 |
Volkers G, Worrall LJ, Kwan DH, Yu CC, Baumann L, Lameignere E, Wasney GA, Scott NE, Wakarchuk W, Foster LJ, Withers SG, Strynadka NC. Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation. Nature Structural & Molecular Biology. 22: 627-35. PMID 26192331 DOI: 10.1038/Nsmb.3060 |
0.521 |
|
| 2015 |
Kwan DH, Ernst S, Kötzler MP, Withers SG. Chemoenzymatic Synthesis of a Type 2 Blood Group A Tetrasaccharide and Development of High-throughput Assays Enables a Platform for Screening Blood Group Antigen-cleaving Enzymes. Glycobiology. 25: 806-11. PMID 25964111 DOI: 10.1093/Glycob/Cwv031 |
0.51 |
|
| 2015 |
Kwan DH, Constantinescu I, Chapanian R, Higgins MA, Kötzler MP, Samain E, Boraston AB, Kizhakkedathu JN, Withers SG. Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution. Journal of the American Chemical Society. 137: 5695-705. PMID 25870881 DOI: 10.1021/Ja5116088 |
0.514 |
|
| 2015 |
Volkers G, Worrall LJ, Kwan DH, Yu CC, Baumann L, Lameignere E, Wasney GA, Scott NE, Wakarchuk W, Foster LJ, Withers SG, Strynadka NCJ. Structure of human ST8SiaIII sialyltransferase provides insight into cell-surface polysialylation Nature Structural and Molecular Biology. DOI: 10.1038/nsmb.3060 |
0.472 |
|
| 2014 |
Chapanian R, Kwan DH, Constantinescu I, Shaikh FA, Rossi NA, Withers SG, Kizhakkedathu JN. Enhancement of biological reactions on cell surfaces via macromolecular crowding. Nature Communications. 5: 4683. PMID 25140641 DOI: 10.1038/Ncomms5683 |
0.489 |
|
| 2014 |
Kwan DH, Withers SG. Periplasmic de-acylase helps bacteria don their biofilm coat. Proceedings of the National Academy of Sciences of the United States of America. 111: 10904-5. PMID 25006258 DOI: 10.1073/Pnas.1410789111 |
0.487 |
|
| 2014 |
Yu CC, Hill T, Kwan DH, Chen HM, Lin CC, Wakarchuk W, Withers SG. A plate-based high-throughput activity assay for polysialyltransferase from Neisseria meningitidis. Analytical Biochemistry. 444: 67-74. PMID 24121013 DOI: 10.1016/J.Ab.2013.09.030 |
0.511 |
|
| 2013 |
Yu CC, Huang LD, Kwan DH, Wakarchuk WW, Withers SG, Lin CC. A glyco-gold nanoparticle based assay for α-2,8-polysialyltransferase from Neisseria meningitidis. Chemical Communications (Cambridge, England). 49: 10166-8. PMID 24051967 DOI: 10.1039/C3Cc45147J |
0.438 |
|
| 2011 |
Kwan DH, Schulz F. The stereochemistry of complex polyketide biosynthesis by modular polyketide synthases. Molecules (Basel, Switzerland). 16: 6092-115. PMID 21775938 DOI: 10.3390/Molecules16076092 |
0.662 |
|
| 2011 |
Kwan DH, Tosin M, Schläger N, Schulz F, Leadlay PF. Insights into the stereospecificity of ketoreduction in a modular polyketide synthase. Organic & Biomolecular Chemistry. 9: 2053-6. PMID 21340070 DOI: 10.1039/C1Ob00022E |
0.669 |
|
| 2011 |
Kwan DH, Chen HM, Ratananikom K, Hancock SM, Watanabe Y, Kongsaeree PT, Samuels AL, Withers SG. Self-immobilizing fluorogenic imaging agents of enzyme activity. Angewandte Chemie (International Ed. in English). 50: 300-3. PMID 21184404 DOI: 10.1002/Anie.201005705 |
0.478 |
|
| 2011 |
Kwan DH, Withers SG. Toward efficient enzymatic glycan synthesis: Directed evolution and enzyme engineering Journal of Carbohydrate Chemistry. 30: 181-205. DOI: 10.1080/07328303.2011.604457 |
0.546 |
|
| 2010 |
Kwan DH, Leadlay PF. Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity. Acs Chemical Biology. 5: 829-38. PMID 20666435 DOI: 10.1021/Cb100175A |
0.633 |
|
| 2008 |
Kwan DH, Sun Y, Schulz F, Hong H, Popovic B, Sim-Stark JC, Haydock SF, Leadlay PF. Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases. Chemistry & Biology. 15: 1231-40. PMID 19022183 DOI: 10.1016/J.Chembiol.2008.09.012 |
0.644 |
|
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